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The map label for this gene is hisC [C]

Identifier: 238916078

GI number: 238916078

Start: 125800

End: 127611

Strand: Direct

Name: hisC [C]

Synonym: EUBELI_00111

Alternate gene names: 238916078

Gene position: 125800-127611 (Clockwise)

Preceding gene: 238916077

Following gene: 238916079

Centisome position: 5.87

GC content: 34.44

Gene sequence:

>1812_bases
ATGCAGGCAATTATTTTAGCAGCAGGAATGGGAAAGCGTTTAAAAGAACTTACCCAGAATAATACCAAATGTATGGTAAA
GGTTAATGGAGTATCGCTTATAGATAGGCTTTTGCATCAGCTTGAGAAACATCATCTCTCAAGAATAGTGATTGTTGTGG
GTTATGAAGGACAGAAGCTGATTGATTATATAGCGACATTAGGAATTAAGACACCAATTTCATATGTTGACAATGCGGTA
TATGATAAGACAAACAATATTTATTCACTTGCGCTGGCAAAGAATTATCTTATGGAAGAAGATACTCTGCTTTTTGAATC
AGATGTAATTATTGAGGATTCTGCAATTGATGAACTTGTAAAAGATCCGAGAGATACACTTGCCATGGTAGATAAATATG
AGAGCTGGATGGATGGTACATGTGTAAAGCTTGACGAATATGATAACATTGTTGCATTTGTTCCAGGAAAGAGCTTTGAT
TTTAAGGAAAAAGAGGAATACTATAAAACTGTAAATATCTACAAATTCAGCAAACATTTTTCACAGGATATATATGTTCC
TTTCCTTGAGGCATATTGTAGTGCATTGGGAGAAAATGAATATTATGAACAGGTTCTTAGAGTTATAACGATGCTGGACA
CACCTGGAATTAAAGGTATGAGATTATCAGGTCAGAAATGGTATGAAATAGACGATGAGCAGGATCTTGATATAGCAACA
ACACTTTTTGCTCCGGATGATGAGACAAGAATTAACCTTATGCATAAAAGATATGGAGGATTCTGGAGATATCCGGGATT
GTTGGATTTCTGTTATCTTGTTAATCCTTATTATCCGCCTAAAAAGCTTAAGGATGAACTGCGTGCGAGCTTTGATACAC
TTTTGACAGAATATCCTTCAGGTATGGGAGTTAATTCTTTACTTGCAGCTAAGAATTTTGGTGTTCATAAAGACAACATA
ATAGTTGGAAATGGAGCAGCAGAACTTATTAAGTCTCTTATGGAGAGCTTTTCTGGAAAGACAGGCGTTATCAGACCTAC
ATTTGAAGAATATCCTAACAGATATGCTGTTGAAGACGAAGTGGTATTTACACCGGTAAATGACAATTATACATATTCGG
TTGAAGAACTGATAGAGTTCTATACATGCAACAAGGTAGATAATATTATTATTATTAATCCTGATAATCCATCTGGTAAT
TATCTGAAAAAGGAAGAGATTATAAGGTTAATAAAATGGACAGACAGTCAGGGAATCAAGCTGGTGGTTGATGAGTCGTT
TGCTGATTTCTCCGATGAACCGGATAATTCTCTTATAGAACAGAAACTTATTGAAACATATAGCAGATTATATGTTATGA
AAAGTATATCTAAATCATACGGTGTGCCGGGACTGAGGCTTGGAGTCCTTGTTTCCTCAGATACAGAAGCGATTGCAGCA
ATGAAAAAAGATGTTGCAATATGGAATATTAATTCATTTGGAGAGTATTATCTTCAGGTTGCAGAAAAGTATAAGAAAGA
TTATGCAGCTGCAATGGACAAATTCCGCGTAGAAAGAAAAAGGTTCTATAATGAACTGGAGCAGATATCTGGTATAAGGG
TCATCCCATCACAGGCTAATTATTTTATGATTGAGATAACTAATGGAATGACAGCAAAGGAACTTATGATAAAACTGTTT
AAGAATCATTATCTTCTTATAAAGGATCTTACATCAAAAGTACATGATGGAAAACAGTATATAAGAATTGCAATCAGAAA
TGATGTAGATAACAACAAGATGATTGAAGCATTAAAAAAAGAACTTAATTAA

Upstream 100 bases:

>100_bases
AGTAGTGCATCGGTTGGAGCTAAATATATTATTCAGGAAATTCAAAAAGCAATAAAAAGACATAAGGAACAAGAGTAGAG
TCAGATTATAGGAGGGGATT

Downstream 100 bases:

>100_bases
AAAGGAGATAAAAAGTATGTTGACATTATTAAATTTAAATGTAGCAGGTTACATTGACCCATCTGTTATGACTTATGCCA
TTCAGGCTATTGCCGGAGTG

Product: threonine-phosphate decarboxylase

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MQAIILAAGMGKRLKELTQNNTKCMVKVNGVSLIDRLLHQLEKHHLSRIVIVVGYEGQKLIDYIATLGIKTPISYVDNAV
YDKTNNIYSLALAKNYLMEEDTLLFESDVIIEDSAIDELVKDPRDTLAMVDKYESWMDGTCVKLDEYDNIVAFVPGKSFD
FKEKEEYYKTVNIYKFSKHFSQDIYVPFLEAYCSALGENEYYEQVLRVITMLDTPGIKGMRLSGQKWYEIDDEQDLDIAT
TLFAPDDETRINLMHKRYGGFWRYPGLLDFCYLVNPYYPPKKLKDELRASFDTLLTEYPSGMGVNSLLAAKNFGVHKDNI
IVGNGAAELIKSLMESFSGKTGVIRPTFEEYPNRYAVEDEVVFTPVNDNYTYSVEELIEFYTCNKVDNIIIINPDNPSGN
YLKKEEIIRLIKWTDSQGIKLVVDESFADFSDEPDNSLIEQKLIETYSRLYVMKSISKSYGVPGLRLGVLVSSDTEAIAA
MKKDVAIWNINSFGEYYLQVAEKYKKDYAAAMDKFRVERKRFYNELEQISGIRVIPSQANYFMIEITNGMTAKELMIKLF
KNHYLLIKDLTSKVHDGKQYIRIAIRNDVDNNKMIEALKKELN

Sequences:

>Translated_603_residues
MQAIILAAGMGKRLKELTQNNTKCMVKVNGVSLIDRLLHQLEKHHLSRIVIVVGYEGQKLIDYIATLGIKTPISYVDNAV
YDKTNNIYSLALAKNYLMEEDTLLFESDVIIEDSAIDELVKDPRDTLAMVDKYESWMDGTCVKLDEYDNIVAFVPGKSFD
FKEKEEYYKTVNIYKFSKHFSQDIYVPFLEAYCSALGENEYYEQVLRVITMLDTPGIKGMRLSGQKWYEIDDEQDLDIAT
TLFAPDDETRINLMHKRYGGFWRYPGLLDFCYLVNPYYPPKKLKDELRASFDTLLTEYPSGMGVNSLLAAKNFGVHKDNI
IVGNGAAELIKSLMESFSGKTGVIRPTFEEYPNRYAVEDEVVFTPVNDNYTYSVEELIEFYTCNKVDNIIIINPDNPSGN
YLKKEEIIRLIKWTDSQGIKLVVDESFADFSDEPDNSLIEQKLIETYSRLYVMKSISKSYGVPGLRLGVLVSSDTEAIAA
MKKDVAIWNINSFGEYYLQVAEKYKKDYAAAMDKFRVERKRFYNELEQISGIRVIPSQANYFMIEITNGMTAKELMIKLF
KNHYLLIKDLTSKVHDGKQYIRIAIRNDVDNNKMIEALKKELN
>Mature_603_residues
MQAIILAAGMGKRLKELTQNNTKCMVKVNGVSLIDRLLHQLEKHHLSRIVIVVGYEGQKLIDYIATLGIKTPISYVDNAV
YDKTNNIYSLALAKNYLMEEDTLLFESDVIIEDSAIDELVKDPRDTLAMVDKYESWMDGTCVKLDEYDNIVAFVPGKSFD
FKEKEEYYKTVNIYKFSKHFSQDIYVPFLEAYCSALGENEYYEQVLRVITMLDTPGIKGMRLSGQKWYEIDDEQDLDIAT
TLFAPDDETRINLMHKRYGGFWRYPGLLDFCYLVNPYYPPKKLKDELRASFDTLLTEYPSGMGVNSLLAAKNFGVHKDNI
IVGNGAAELIKSLMESFSGKTGVIRPTFEEYPNRYAVEDEVVFTPVNDNYTYSVEELIEFYTCNKVDNIIIINPDNPSGN
YLKKEEIIRLIKWTDSQGIKLVVDESFADFSDEPDNSLIEQKLIETYSRLYVMKSISKSYGVPGLRLGVLVSSDTEAIAA
MKKDVAIWNINSFGEYYLQVAEKYKKDYAAAMDKFRVERKRFYNELEQISGIRVIPSQANYFMIEITNGMTAKELMIKLF
KNHYLLIKDLTSKVHDGKQYIRIAIRNDVDNNKMIEALKKELN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To Rhizobium NGR234A y4qD [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322075, Length=306, Percent_Identity=26.1437908496732, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 69360; Mature: 69360

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIILAAGMGKRLKELTQNNTKCMVKVNGVSLIDRLLHQLEKHHLSRIVIVVGYEGQKL
CCEEEEECCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCHHH
IDYIATLGIKTPISYVDNAVYDKTNNIYSLALAKNYLMEEDTLLFESDVIIEDSAIDELV
HHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCEEEECCEEEEHHHHHHHH
KDPRDTLAMVDKYESWMDGTCVKLDEYDNIVAFVPGKSFDFKEKEEYYKTVNIYKFSKHF
HCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHEEEEHHHC
SQDIYVPFLEAYCSALGENEYYEQVLRVITMLDTPGIKGMRLSGQKWYEIDDEQDLDIAT
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCCCEEE
TLFAPDDETRINLMHKRYGGFWRYPGLLDFCYLVNPYYPPKKLKDELRASFDTLLTEYPS
EEECCCCCHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
GMGVNSLLAAKNFGVHKDNIIVGNGAAELIKSLMESFSGKTGVIRPTFEEYPNRYAVEDE
CCCHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEECCC
VVFTPVNDNYTYSVEELIEFYTCNKVDNIIIINPDNPSGNYLKKEEIIRLIKWTDSQGIK
EEEEECCCCCEECHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEE
LVVDESFADFSDEPDNSLIEQKLIETYSRLYVMKSISKSYGVPGLRLGVLVSSDTEAIAA
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHH
MKKDVAIWNINSFGEYYLQVAEKYKKDYAAAMDKFRVERKRFYNELEQISGIRVIPSQAN
HHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
YFMIEITNGMTAKELMIKLFKNHYLLIKDLTSKVHDGKQYIRIAIRNDVDNNKMIEALKK
EEEEEECCCCCHHHHHHHHHHCCEEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
ELN
HCC
>Mature Secondary Structure
MQAIILAAGMGKRLKELTQNNTKCMVKVNGVSLIDRLLHQLEKHHLSRIVIVVGYEGQKL
CCEEEEECCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCHHH
IDYIATLGIKTPISYVDNAVYDKTNNIYSLALAKNYLMEEDTLLFESDVIIEDSAIDELV
HHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCEEEECCEEEEHHHHHHHH
KDPRDTLAMVDKYESWMDGTCVKLDEYDNIVAFVPGKSFDFKEKEEYYKTVNIYKFSKHF
HCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHEEEEHHHC
SQDIYVPFLEAYCSALGENEYYEQVLRVITMLDTPGIKGMRLSGQKWYEIDDEQDLDIAT
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCCCEEE
TLFAPDDETRINLMHKRYGGFWRYPGLLDFCYLVNPYYPPKKLKDELRASFDTLLTEYPS
EEECCCCCHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
GMGVNSLLAAKNFGVHKDNIIVGNGAAELIKSLMESFSGKTGVIRPTFEEYPNRYAVEDE
CCCHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEECCC
VVFTPVNDNYTYSVEELIEFYTCNKVDNIIIINPDNPSGNYLKKEEIIRLIKWTDSQGIK
EEEEECCCCCEECHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEE
LVVDESFADFSDEPDNSLIEQKLIETYSRLYVMKSISKSYGVPGLRLGVLVSSDTEAIAA
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHH
MKKDVAIWNINSFGEYYLQVAEKYKKDYAAAMDKFRVERKRFYNELEQISGIRVIPSQAN
HHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
YFMIEITNGMTAKELMIKLFKNHYLLIKDLTSKVHDGKQYIRIAIRNDVDNNKMIEALKK
EEEEEECCCCCHHHHHHHHHHCCEEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
ELN
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]