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The map label for this gene is manC [H]

Identifier: 238916064

GI number: 238916064

Start: 108174

End: 109280

Strand: Direct

Name: manC [H]

Synonym: EUBELI_00097

Alternate gene names: 238916064

Gene position: 108174-109280 (Clockwise)

Preceding gene: 238916063

Following gene: 238916065

Centisome position: 5.04

GC content: 40.11

Gene sequence:

>1107_bases
ATGGTTAAAACAATATGGCAGAACAAGGAGGAATTTATGAAGACTACAGCACTTATTATGGCAGGTGGTAAGGGAGAGCG
ATTCTGGCCAAAGAGCCGTGTTAATATGCCAAAACAGTTCCTTTCTCTTACAGATGACGGAAAGACTATGATACAGCTCA
CGGTAGAGCGAATCAGCCCATTGGTTGATATTAAGGATGTTTATGTTGCTACTAACAAGAACTACAGAGAACTTGTAAAG
CAGCAGCTTCCAGGTATTCCAGAGGAGAATATCTTATGTGAGCCTGTTGGAAGAAATACAGCACCATGTGTAGGTCTTGG
AGCAGTTCATGTTGCAAGCAAATATGATGATGCAGTTATGATTGTACTTCCATCAGACCACCTTATTAAGAATAATGAGG
TGTTTGCAGATACATTTAAAGAAGCTGTTCAGATTGCAGAAGAGGGGGCTAACCTTGTAACGGTAGGTATTACTCCGAAT
TATCCAGAGACAGGCTATGGTTATATTAAGTATAATCAGGATGACAAGAAGAATAATGCTTATTCAGTTGAAAAGTTCGT
TGAGAAGCCAGACCTTGAGACAGCTAAATCATACCTTGCTGACGGAACATATCTGTGGAACAGTGGAATGTTCGTATGGA
AGGTATCTACAATATTAGACTGCTTTAAGAAGTTCATGCCGGATACATATGAAGGCTTATTAAAGATTAAGGCAGCAGTT
GGAACAGCAGATGAAAATGCAGTGCTTGAGGCAGAATTCCCTAATCTTGAGTCACAGTCAGTTGACTACGGTATTATGGA
GAAGGCAGATTCTATCTACACACTTCCAGGCAACTTCGGTTGGGATGATGTAGGTTCATGGCTTGCAGTAGGAAGAATCA
AGAAGAATGATGATAACAGCAATGTAATTAACGGCAATGTAGTTGCAGTTAATACTAGGGGCTGTGTAATAGAAGGTGGC
GAAAAACTTATTGCCACAGTTGGTTTAAGAGATATCGTAGTTGTTGATACTAAAGATGCAACTCTTATTACAACTAAAGA
GAATGCAGGCGAAATCAAGCAGGTGCTTGCAAAGCTTCGTGAAGAAGGAAAGAATGAGTATCTGTAG

Upstream 100 bases:

>100_bases
TTTTGTGGAATAGATACAACGGATATGGAAAGCGGCACATATAGATGTGCTATCAGAGCTGATGGTAAATATTATGATGC
ACAGACAGATGTCGTAATTG

Downstream 100 bases:

>100_bases
AAGATAGTATGAAAATACATATGCTTAAAACAAGGCGTTTGGAGGAACTATAATGACAAAGGAACATGTCAATACTAATC
ATACATTTGCGATATGCGCT

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MVKTIWQNKEEFMKTTALIMAGGKGERFWPKSRVNMPKQFLSLTDDGKTMIQLTVERISPLVDIKDVYVATNKNYRELVK
QQLPGIPEENILCEPVGRNTAPCVGLGAVHVASKYDDAVMIVLPSDHLIKNNEVFADTFKEAVQIAEEGANLVTVGITPN
YPETGYGYIKYNQDDKKNNAYSVEKFVEKPDLETAKSYLADGTYLWNSGMFVWKVSTILDCFKKFMPDTYEGLLKIKAAV
GTADENAVLEAEFPNLESQSVDYGIMEKADSIYTLPGNFGWDDVGSWLAVGRIKKNDDNSNVINGNVVAVNTRGCVIEGG
EKLIATVGLRDIVVVDTKDATLITTKENAGEIKQVLAKLREEGKNEYL

Sequences:

>Translated_368_residues
MVKTIWQNKEEFMKTTALIMAGGKGERFWPKSRVNMPKQFLSLTDDGKTMIQLTVERISPLVDIKDVYVATNKNYRELVK
QQLPGIPEENILCEPVGRNTAPCVGLGAVHVASKYDDAVMIVLPSDHLIKNNEVFADTFKEAVQIAEEGANLVTVGITPN
YPETGYGYIKYNQDDKKNNAYSVEKFVEKPDLETAKSYLADGTYLWNSGMFVWKVSTILDCFKKFMPDTYEGLLKIKAAV
GTADENAVLEAEFPNLESQSVDYGIMEKADSIYTLPGNFGWDDVGSWLAVGRIKKNDDNSNVINGNVVAVNTRGCVIEGG
EKLIATVGLRDIVVVDTKDATLITTKENAGEIKQVLAKLREEGKNEYL
>Mature_368_residues
MVKTIWQNKEEFMKTTALIMAGGKGERFWPKSRVNMPKQFLSLTDDGKTMIQLTVERISPLVDIKDVYVATNKNYRELVK
QQLPGIPEENILCEPVGRNTAPCVGLGAVHVASKYDDAVMIVLPSDHLIKNNEVFADTFKEAVQIAEEGANLVTVGITPN
YPETGYGYIKYNQDDKKNNAYSVEKFVEKPDLETAKSYLADGTYLWNSGMFVWKVSTILDCFKKFMPDTYEGLLKIKAAV
GTADENAVLEAEFPNLESQSVDYGIMEKADSIYTLPGNFGWDDVGSWLAVGRIKKNDDNSNVINGNVVAVNTRGCVIEGG
EKLIATVGLRDIVVVDTKDATLITTKENAGEIKQVLAKLREEGKNEYL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=363, Percent_Identity=39.1184573002755, Blast_Score=239, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 40845; Mature: 40845

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKTIWQNKEEFMKTTALIMAGGKGERFWPKSRVNMPKQFLSLTDDGKTMIQLTVERISP
CCCCHHCCHHHHHHHHEEEEECCCCCCCCCHHHCCCCHHHHCCCCCCCEEEEEEHHHHCC
LVDIKDVYVATNKNYRELVKQQLPGIPEENILCEPVGRNTAPCVGLGAVHVASKYDDAVM
CCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEECCCCCCCCCEEECCHHEECCCCCCEEE
IVLPSDHLIKNNEVFADTFKEAVQIAEEGANLVTVGITPNYPETGYGYIKYNQDDKKNNA
EEECCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCC
YSVEKFVEKPDLETAKSYLADGTYLWNSGMFVWKVSTILDCFKKFMPDTYEGLLKIKAAV
HHHHHHHCCCCHHHHHHHHCCCEEEECCCEEEEEHHHHHHHHHHHCCHHHHHHEEEHHHH
GTADENAVLEAEFPNLESQSVDYGIMEKADSIYTLPGNFGWDDVGSWLAVGRIKKNDDNS
CCCCCCCEEEECCCCCCCCCCCCHHHHCCCCEEECCCCCCHHHHHHHHEECEEECCCCCC
NVINGNVVAVNTRGCVIEGGEKLIATVGLRDIVVVDTKDATLITTKENAGEIKQVLAKLR
CEECCCEEEEECCCEEEECCCEEEEEECCCEEEEEECCCCEEEEECCCHHHHHHHHHHHH
EEGKNEYL
HCCCCCCC
>Mature Secondary Structure
MVKTIWQNKEEFMKTTALIMAGGKGERFWPKSRVNMPKQFLSLTDDGKTMIQLTVERISP
CCCCHHCCHHHHHHHHEEEEECCCCCCCCCHHHCCCCHHHHCCCCCCCEEEEEEHHHHCC
LVDIKDVYVATNKNYRELVKQQLPGIPEENILCEPVGRNTAPCVGLGAVHVASKYDDAVM
CCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEECCCCCCCCCEEECCHHEECCCCCCEEE
IVLPSDHLIKNNEVFADTFKEAVQIAEEGANLVTVGITPNYPETGYGYIKYNQDDKKNNA
EEECCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCC
YSVEKFVEKPDLETAKSYLADGTYLWNSGMFVWKVSTILDCFKKFMPDTYEGLLKIKAAV
HHHHHHHCCCCHHHHHHHHCCCEEEECCCEEEEEHHHHHHHHHHHCCHHHHHHEEEHHHH
GTADENAVLEAEFPNLESQSVDYGIMEKADSIYTLPGNFGWDDVGSWLAVGRIKKNDDNS
CCCCCCCEEEECCCCCCCCCCCCHHHHCCCCEEECCCCCCHHHHHHHHEECEEECCCCCC
NVINGNVVAVNTRGCVIEGGEKLIATVGLRDIVVVDTKDATLITTKENAGEIKQVLAKLR
CEECCCEEEEECCCEEEECCCEEEEEECCCEEEEEECCCCEEEEECCCHHHHHHHHHHHH
EEGKNEYL
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]