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The map label for this gene is aaeR [H]

Identifier: 238897139

GI number: 238897139

Start: 5136406

End: 5137320

Strand: Direct

Name: aaeR [H]

Synonym: KP1_5400

Alternate gene names: 238897139

Gene position: 5136406-5137320 (Clockwise)

Preceding gene: 238897136

Following gene: 238897141

Centisome position: 97.86

GC content: 65.36

Gene sequence:

>915_bases
ATGGATCGATTAAGCGCGATGGCGCTGCTGGTGAAAGTGACCGAGCTGGGGAGCATGTCGGCAGCGGCGCGGGCGCTGAA
TATGCCGTTGACCACCGTCAGCCGCCATATTGGCGAACTGGAGAGCGCGCTGGGCGTACGCCTGCTGGCGCGAACCACCC
GCAAACTGACGCTCACCGACGCCGGGGTCGATTATGTTGCCGCCGCGCGGCGGATCCTTGAGGAGGTGGAAAACGCCGAA
CGCCAGGCGACGGGCGAATATCAGGAGCCAAAGGGTGAGCTGGTGATCTCCGCGCCGACGATGTTTGGACGCCAGCACGT
TCTTCCGGTAATCAGTGAATTTATCGCCCGCTACCCGCTAATTCGCGTCCGTTTGCTGCTCAGCGATCGCAATGCCGACC
TGGTGAGCGACCATGTCGATCTGGCGGTGCGGATTGGCGACCTGGCGGACAGCAGCATGGTGGCCACCCGCCTCGGCACC
ATGCGGATTGTGGCCTGCGCCCATCCGGCGCTGCTGGCGAAATACGGCGAGCCGCAGCGGCCGCGCGATCTGGCGGCGCT
GCCGATCATCCGCATTGAATCGCCGATGCCCTATCGCGGCTGGCGCTTTCGCGCCGCTGAGCGCGAGGACCAGCTGATTA
ACCTGCCGCCGGTGCTATCCGTCACCACGCCAGAGAGCGCCGCCGATGCCGCGCGGCTGGGGGTGGGGGTGGCCCGCTTA
CTGCATTATCAGGCGCTGGATGGCCTGCGCCACGGGGAGCTCCGTCTGCTGCTGGAAAACGTCGAGCCGGATCCGGCGCC
GGTCCATTTGCTGTATACCGCTCGGGATCTGGCGCCGCTTAAGCTGCGCAAATTTATCGATTTTGCCGCACCGGCGCTGC
GTCAGGCACTGCTGCGCATCGCCGGGGCCGCTTAA

Upstream 100 bases:

>100_bases
GCCATAGCGCCTCCTGTTGTCTGGCGCCATCATGGACTGTACTGTGAAGAATGATAATACGGGTAAAGTGGCAATCATCT
TTCCGCAAAACGGGAGAATA

Downstream 100 bases:

>100_bases
TGCGTCGCGGTCTTCAGCGGCGCCTCCTTTAACAGCCATGAGAGGACAAACGCCACCGCCATAATGCCGGCCGCCATCAG
AAACGCCGCGTGGATCGCCG

Product: putative LysR-family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MDRLSAMALLVKVTELGSMSAAARALNMPLTTVSRHIGELESALGVRLLARTTRKLTLTDAGVDYVAAARRILEEVENAE
RQATGEYQEPKGELVISAPTMFGRQHVLPVISEFIARYPLIRVRLLLSDRNADLVSDHVDLAVRIGDLADSSMVATRLGT
MRIVACAHPALLAKYGEPQRPRDLAALPIIRIESPMPYRGWRFRAAEREDQLINLPPVLSVTTPESAADAARLGVGVARL
LHYQALDGLRHGELRLLLENVEPDPAPVHLLYTARDLAPLKLRKFIDFAAPALRQALLRIAGAA

Sequences:

>Translated_304_residues
MDRLSAMALLVKVTELGSMSAAARALNMPLTTVSRHIGELESALGVRLLARTTRKLTLTDAGVDYVAAARRILEEVENAE
RQATGEYQEPKGELVISAPTMFGRQHVLPVISEFIARYPLIRVRLLLSDRNADLVSDHVDLAVRIGDLADSSMVATRLGT
MRIVACAHPALLAKYGEPQRPRDLAALPIIRIESPMPYRGWRFRAAEREDQLINLPPVLSVTTPESAADAARLGVGVARL
LHYQALDGLRHGELRLLLENVEPDPAPVHLLYTARDLAPLKLRKFIDFAAPALRQALLRIAGAA
>Mature_304_residues
MDRLSAMALLVKVTELGSMSAAARALNMPLTTVSRHIGELESALGVRLLARTTRKLTLTDAGVDYVAAARRILEEVENAE
RQATGEYQEPKGELVISAPTMFGRQHVLPVISEFIARYPLIRVRLLLSDRNADLVSDHVDLAVRIGDLADSSMVATRLGT
MRIVACAHPALLAKYGEPQRPRDLAALPIIRIESPMPYRGWRFRAAEREDQLINLPPVLSVTTPESAADAARLGVGVARL
LHYQALDGLRHGELRLLLENVEPDPAPVHLLYTARDLAPLKLRKFIDFAAPALRQALLRIAGAA

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=288, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI145693193, Length=298, Percent_Identity=30.5369127516779, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786401, Length=291, Percent_Identity=32.3024054982818, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI87081978, Length=292, Percent_Identity=31.1643835616438, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1789440, Length=292, Percent_Identity=29.1095890410959, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787128, Length=289, Percent_Identity=27.3356401384083, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787589, Length=284, Percent_Identity=27.4647887323944, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789173, Length=168, Percent_Identity=30.3571428571429, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786448, Length=186, Percent_Identity=27.9569892473118, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=120, Percent_Identity=35, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI157672245, Length=166, Percent_Identity=30.1204819277108, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693105, Length=178, Percent_Identity=29.7752808988764, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33328; Mature: 33328

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLSAMALLVKVTELGSMSAAARALNMPLTTVSRHIGELESALGVRLLARTTRKLTLTD
CCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
AGVDYVAAARRILEEVENAERQATGEYQEPKGELVISAPTMFGRQHVLPVISEFIARYPL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHCHHHHHHHHHHHHHHCHH
IRVRLLLSDRNADLVSDHVDLAVRIGDLADSSMVATRLGTMRIVACAHPALLAKYGEPQR
HEEEEEECCCCCCHHHHHHHEEEEECCCCCCHHHHHHHHHHEEEECCCHHHHHHCCCCCC
PRDLAALPIIRIESPMPYRGWRFRAAEREDQLINLPPVLSVTTPESAADAARLGVGVARL
CCCHHHCCEEEECCCCCCCCEEEECCCCCCCEECCCCEEEEECCCHHHHHHHHHHHHHHH
LHYQALDGLRHGELRLLLENVEPDPAPVHLLYTARDLAPLKLRKFIDFAAPALRQALLRI
HHHHHHCCCCCCHHHEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AGAA
HCCC
>Mature Secondary Structure
MDRLSAMALLVKVTELGSMSAAARALNMPLTTVSRHIGELESALGVRLLARTTRKLTLTD
CCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
AGVDYVAAARRILEEVENAERQATGEYQEPKGELVISAPTMFGRQHVLPVISEFIARYPL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHCHHHHHHHHHHHHHHCHH
IRVRLLLSDRNADLVSDHVDLAVRIGDLADSSMVATRLGTMRIVACAHPALLAKYGEPQR
HEEEEEECCCCCCHHHHHHHEEEEECCCCCCHHHHHHHHHHEEEECCCHHHHHHCCCCCC
PRDLAALPIIRIESPMPYRGWRFRAAEREDQLINLPPVLSVTTPESAADAARLGVGVARL
CCCHHHCCEEEECCCCCCCCEEEECCCCCCCEECCCCEEEEECCCHHHHHHHHHHHHHHH
LHYQALDGLRHGELRLLLENVEPDPAPVHLLYTARDLAPLKLRKFIDFAAPALRQALLRI
HHHHHHCCCCCCHHHEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
AGAA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]