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The map label for this gene is tdh [H]

Identifier: 238897060

GI number: 238897060

Start: 5055654

End: 5056679

Strand: Reverse

Name: tdh [H]

Synonym: KP1_5311

Alternate gene names: 238897060

Gene position: 5056679-5055654 (Counterclockwise)

Preceding gene: 238897061

Following gene: 238897059

Centisome position: 96.34

GC content: 58.38

Gene sequence:

>1026_bases
ATGAAAGCGTTATCCAAACTGAAAGCGGAAGAAGGCATCTGGATGACCGACGTACCGGAACCGGAAGTCGGCCATAACGA
TCTGCTGATTAAAATCCGCAAGACCGCCATTTGCGGGACCGACGTGCACATCTATAACTGGGATGAGTGGTCGCAGAAGA
CCATTCCGGTGCCGATGGTGGTCGGTCACGAATATGTCGGCGAAGTGGTGGGGATTGGTCAGGAAGTGCGCGGCTTTAAG
ATTGGCGACCGCGTCTCCGGCGAAGGGCATATCACCTGCGGCCACTGCCGTAACTGCCGCGCGGGCCGCACCCATCTGTG
CCGCAACACCATCGGCGTGGGCGTCAACCGCCCGGGCTGCTTTGCTGAGTATCTGGTGATCCCGGCCTTTAACGCCTTTA
AAATCCCCGACAATATCTCTGATGACCTGGCGTCTATCTTCGACCCGTTCGGCAACGCGGTGCACACCGCGCTCTCCTTC
GATCTGGTCGGGGAAGACGTGCTGGTTTCCGGCGCCGGTCCGATCGGCGTGATGGCGGCGGCGGTAGCGAAACACGTCGG
CGCGCGTAACGTGGTGATCACCGACGTCAACGAGTACCGTCTTGAGCTGGCGCGCAAAATGGGCGTTACCCGCGCGGTGA
ACGTGGCCAAAGAGAACCTTAATGACGTGATGGCCGAGCTGGGGATGACCGAAGGTTTCGATGTGGGTCTGGAGATGTCC
GGCGCGCCGCCGGCGTTTCGCAGCATGCTGGATACCATGAACCACGGCGGCCGTATCGCGATGCTGGGTATCCCGCCGTC
GGATATGTCCATCGACTGGACCAAGGTCATCTTCAAAGGGCTGTTTATCAAAGGTATCTATGGTCGCGAAATGTTCGAAA
CCTGGTACAAGATGGCGGCGCTGATCCAGTCTGGTCTGGATCTCTCACCGATCATCACCCACCGCTTCGGCATTGATGAC
TTCCAGAAAGGTTTTGACGCGATGCGCTCCGGCCAGTCCGGTAAAGTGGTTTTGAGCTGGGACTAA

Upstream 100 bases:

>100_bases
GATGTCGGCGGCGCATACCCCTGAACAAATTGAGCGTGCGGTGGAAGCCTTTACCCGCATCGGCAAACAACTGGGCGTCA
TCGCCTAATAAGGGTATGAG

Downstream 100 bases:

>100_bases
CCCCCCATGCTGGCGTAAAAATCAGCAAAAAAGGCGCCTGCGGGCGCCTTAATTTAGATTTGGATAACATTTTTAGCCTG
CTTAATATTAAGCGCACAAT

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRGFK
IGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGVMAAAVAKHVGARNVVITDVNEYRLELARKMGVTRAVNVAKENLNDVMAELGMTEGFDVGLEMS
GAPPAFRSMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFGIDD
FQKGFDAMRSGQSGKVVLSWD

Sequences:

>Translated_341_residues
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRGFK
IGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGVMAAAVAKHVGARNVVITDVNEYRLELARKMGVTRAVNVAKENLNDVMAELGMTEGFDVGLEMS
GAPPAFRSMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFGIDD
FQKGFDAMRSGQSGKVVLSWD
>Mature_341_residues
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRGFK
IGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGVMAAAVAKHVGARNVVITDVNEYRLELARKMGVTRAVNVAKENLNDVMAELGMTEGFDVGLEMS
GAPPAFRSMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFGIDD
FQKGFDAMRSGQSGKVVLSWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=335, Percent_Identity=27.1641791044776, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=25.201072386059, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI34577061, Length=350, Percent_Identity=25.1428571428571, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=24.3967828418231, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71743840, Length=353, Percent_Identity=26.628895184136, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI262073058, Length=353, Percent_Identity=26.628895184136, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI156523966, Length=349, Percent_Identity=23.4957020057307, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI71565154, Length=347, Percent_Identity=25.3602305475504, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=97.0674486803519, Blast_Score=690, Evalue=0.0,
Organism=Escherichia coli, GI1788075, Length=366, Percent_Identity=30.327868852459, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=29.1793313069909, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787863, Length=318, Percent_Identity=29.874213836478, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=31.728045325779, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI226510992, Length=267, Percent_Identity=31.0861423220974, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87081918, Length=284, Percent_Identity=31.3380281690141, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=26.2390670553936, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=26.1682242990654, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786825, Length=400, Percent_Identity=27.5, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786552, Length=358, Percent_Identity=27.6536312849162, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786518, Length=282, Percent_Identity=26.5957446808511, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=32.4404761904762, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=31.1377245508982, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71988145, Length=233, Percent_Identity=31.3304721030043, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=25.668449197861, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=287, Percent_Identity=26.8292682926829, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=273, Percent_Identity=26.7399267399267, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=352, Percent_Identity=24.7159090909091, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=323, Percent_Identity=31.2693498452012, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322619, Length=307, Percent_Identity=28.9902280130293, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6319955, Length=307, Percent_Identity=28.6644951140065, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=372, Percent_Identity=26.3440860215054, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6319257, Length=361, Percent_Identity=27.1468144044321, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=324, Percent_Identity=29.6296296296296, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=358, Percent_Identity=27.3743016759777, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=331, Percent_Identity=29.9093655589124, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=326, Percent_Identity=28.5276073619632, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=338, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=258, Percent_Identity=30.2325581395349, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=288, Percent_Identity=27.4305555555556, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=25.9036144578313, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=25.9036144578313, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=25.1989389920424, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45550770, Length=175, Percent_Identity=26.8571428571429, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221457811, Length=175, Percent_Identity=26.2857142857143, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45551930, Length=175, Percent_Identity=26.2857142857143, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37227; Mature: 37227

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVRGFKIGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRPGC
ECHHHHHHHHCCCCHHCCEECCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCH
FAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAA
HHHHHHEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVAKHVGARNVVITDVNEYRLELARKMGVTRAVNVAKENLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRSMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLSPIITHRFGIDDFQKGFDAMRSGQSGKVVLSWD
HHHCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVRGFKIGDRVSGEGHITCGHCRNCRAGRTHLCRNTIGVGVNRPGC
ECHHHHHHHHCCCCHHCCEECCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCH
FAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAA
HHHHHHEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVAKHVGARNVVITDVNEYRLELARKMGVTRAVNVAKENLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRSMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLSPIITHRFGIDDFQKGFDAMRSGQSGKVVLSWD
HHHCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA