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The map label for this gene is bisC [H]

Identifier: 238897009

GI number: 238897009

Start: 4999227

End: 5001590

Strand: Reverse

Name: bisC [H]

Synonym: KP1_5254

Alternate gene names: 238897009

Gene position: 5001590-4999227 (Counterclockwise)

Preceding gene: 238897016

Following gene: 238897006

Centisome position: 95.3

GC content: 62.48

Gene sequence:

>2364_bases
ATGACACCTGCATTCGCTGACCAGGAGCCGCCCTTGCCAACCTCATCTGCAACCAAAACCATCTTAACCGCCGCCCACTG
GGGACCGATGCTGGTGGAAACGGACGGGGAAAACGTCCTCTCTTCCCGCGGCGCGCTGGCGACACCGTTTGCCAACTCGC
TGCAAACGGCAGTGCGCGATCAGGTGCACAGCAAAACCCGCGTGCGCTATCCAATGGTGCGTAAAGGCTTCCTTGCTTCA
CCGGACAAGCCCCAGGGGGTCCGCGGTCAGGATGAATTCGTGCGGGTGAGCTGGGAGCAGGCGCTGGATCTGATCGATGC
CCAGCATCGGCGGATCCGCGACAGCTACGGTCCGGCCTCCATTTTTGCCGGCTCCTACGGCTGGCGCTCTAACGGCGTAT
TGCATAAGGCGGCGACGCTGCTGCAGCGCTATATGAGCCTGGCGGGCGGCTATACCGGCCATCTTGGCGATTACTCCACC
GGCGCGGCGCAGGCGATCATGCCTTATGTCGTTGGCGGCAATGAGGTGTATCAGCAGCAGACCAGTTGGCCGCTGGTGCT
CGAGCACAGCGAAGTGGTGGTGCTGTGGAGCGCCAACCCGCTGAACACGCTGAAAATTGCCTGGAATGCCTCCGACGAGC
AAGGGATCCCGTGGTTTGATCGGCTGCGCCAGAGCGGTAAGCGGCTGATCTGCATCGATCCGATGCGATCGGAAACCGTC
GATTTCTTTGGCGATTCGATGGAGTGGATCGCGCCGCATATGGGCACCGACGTCGCGCTGATGCTGGGGATCGCCCATAC
GCTGGTGGAAAATGACTGGCAGGATGATGCGTTTCTTACCCGCTGCACCAGCGGCTACGATATTTTTGCCCGCTATCTGA
CCGGCGAAAGCGACGGCGTAGCGAAAACCGCTGAGTGGGCAGCAGCGATCTGCGGCGTTAAAGCAGATAAAATCCGCGAA
CTGGCGAAACTTTTCCACGAAAATACCACTATGCTGATGGCCGGCTGGGGCATGCAGCGTCAGCAGTATGGCGAGCAGAA
ACACTGGATGCTGGTCACTCTGGCCGCCATGCTGGGACAGATCGGCACCCCCGGTGGCGGATTTGGTCTTTCCTACCATT
TTGCCAACGGCGGCAACCCGACCCGCCGCGCGGCGGTGCTGGGCTCGATGCAGGGGAGCGTGGCCGGAGGCGTGGACGCG
GTGGAGAAGATCCCGGTCGCACGAATTGTCGAGGCGCTGGAGAATCCGGGGGCGGAGTATCAGCACAACGGCATGGCGCG
GCGCTTTCCCGATATTCGCTTTATCTGGTGGGCCGGCGGCGCCAACTTTACTCATCATCAGGATACCAACCGACTGATTC
AGGCGTGGCAGAAACCGGAGCTTATCGTTATTTCCGAATGCTTCTGGACCGCCGCCGCGCGCCATGCCGATATCGTCCTG
CCGGCGACCACCTCGTTTGAGCGCAACGATCTGACCATGACCGGGGACTACAGTAACCAGCATCTGGTGCCGATGAAGCA
GGTGGTTGCCCCGCGAGATGAAGCGCGCGACGATTTCGCGGTCTTTGCCGACCTCAGCGAACGCTGGGAGGCGGGTGGCC
GCGAACGCTTCACCGAAGGGAAGAGTGATTTGCAGTGGCTGGAGACTTTCTATCAGATGGCCGCCCGGCGCGGCGCCCAG
CAGCAGGTGACGCTGCCGCCATTTGCCGAATTCTGGCAGGCTAACCAGCTGATTGAGATGCCGGAGGAGCCGGAGAATGC
CCGTTTTGCGCGTTTCGCCGCCTTCCGCGCCGATCCCCAGGCCAACCCGCTGAAAACGGCGAGCGGTAAAATAGAGATCC
ACTCGCCGACCATCGCCGCTTTTGGTTACGCCGACTGTCCGCCGCATCCGATGTGGCTGGAGCCCGACGAGTGGCATGGC
AACGCAGAGGCGGGGCAGCTGCAGCTGCTGTCGGCCCATCCGGCCCACCGTCTGCACAGTCAACTGAACCACACCGCGCT
GCGCGAGCGCTATGCCGTCGCCGGGCGCGAACCGGTGACTATTCATCCGCAGGATGCGCAGGCGCGCGGGATTGTCGATG
GCGATCTGGTGCGGGTGTGGAACGCCCGCGGTCAGGTGCTGGCCGGCGCCGTGGTGACGGAGGGGATCCGCCCGGGGGTG
ATTTGCCTGCATGAAGGAGCGTGGCCCGACCTGGATCCGCAGGTCGGCATCTGCAAAAACGGGGCGGTGAACGTCTTAAC
CAAAGATATTCCGACATCCCGGCTGGGCAACGGCTGTGCCGGGAACACCGCCCTGGCGTGGCTGGAGAAATATACCGGCC
CGGCGCTGCCGCTTACGGCATTTGATCCGCCGGCCAACGCATAA

Upstream 100 bases:

>100_bases
GCGAACGTGACGGTTGATTATGACGCGCGATTACGGAGAAAATTCCCCGGATACCATCTCTTTTTGTAAATAACATTGAA
CGGTTGCCCATCACGCCGTC

Downstream 100 bases:

>100_bases
TCCACGTCGGGTGCTGAGTATCGTCCTGCCATGCGCAGTCTTCAATCCGGAAGCCCTGCGCATGGTAGAAACTGACCGCC
GATTCGTTCTTCTGATAAAC

Product: biotin sulfoxide reductase

Products: Biotin. [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 787; Mature: 786

Protein sequence:

>787_residues
MTPAFADQEPPLPTSSATKTILTAAHWGPMLVETDGENVLSSRGALATPFANSLQTAVRDQVHSKTRVRYPMVRKGFLAS
PDKPQGVRGQDEFVRVSWEQALDLIDAQHRRIRDSYGPASIFAGSYGWRSNGVLHKAATLLQRYMSLAGGYTGHLGDYST
GAAQAIMPYVVGGNEVYQQQTSWPLVLEHSEVVVLWSANPLNTLKIAWNASDEQGIPWFDRLRQSGKRLICIDPMRSETV
DFFGDSMEWIAPHMGTDVALMLGIAHTLVENDWQDDAFLTRCTSGYDIFARYLTGESDGVAKTAEWAAAICGVKADKIRE
LAKLFHENTTMLMAGWGMQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLGSMQGSVAGGVDA
VEKIPVARIVEALENPGAEYQHNGMARRFPDIRFIWWAGGANFTHHQDTNRLIQAWQKPELIVISECFWTAAARHADIVL
PATTSFERNDLTMTGDYSNQHLVPMKQVVAPRDEARDDFAVFADLSERWEAGGRERFTEGKSDLQWLETFYQMAARRGAQ
QQVTLPPFAEFWQANQLIEMPEEPENARFARFAAFRADPQANPLKTASGKIEIHSPTIAAFGYADCPPHPMWLEPDEWHG
NAEAGQLQLLSAHPAHRLHSQLNHTALRERYAVAGREPVTIHPQDAQARGIVDGDLVRVWNARGQVLAGAVVTEGIRPGV
ICLHEGAWPDLDPQVGICKNGAVNVLTKDIPTSRLGNGCAGNTALAWLEKYTGPALPLTAFDPPANA

Sequences:

>Translated_787_residues
MTPAFADQEPPLPTSSATKTILTAAHWGPMLVETDGENVLSSRGALATPFANSLQTAVRDQVHSKTRVRYPMVRKGFLAS
PDKPQGVRGQDEFVRVSWEQALDLIDAQHRRIRDSYGPASIFAGSYGWRSNGVLHKAATLLQRYMSLAGGYTGHLGDYST
GAAQAIMPYVVGGNEVYQQQTSWPLVLEHSEVVVLWSANPLNTLKIAWNASDEQGIPWFDRLRQSGKRLICIDPMRSETV
DFFGDSMEWIAPHMGTDVALMLGIAHTLVENDWQDDAFLTRCTSGYDIFARYLTGESDGVAKTAEWAAAICGVKADKIRE
LAKLFHENTTMLMAGWGMQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLGSMQGSVAGGVDA
VEKIPVARIVEALENPGAEYQHNGMARRFPDIRFIWWAGGANFTHHQDTNRLIQAWQKPELIVISECFWTAAARHADIVL
PATTSFERNDLTMTGDYSNQHLVPMKQVVAPRDEARDDFAVFADLSERWEAGGRERFTEGKSDLQWLETFYQMAARRGAQ
QQVTLPPFAEFWQANQLIEMPEEPENARFARFAAFRADPQANPLKTASGKIEIHSPTIAAFGYADCPPHPMWLEPDEWHG
NAEAGQLQLLSAHPAHRLHSQLNHTALRERYAVAGREPVTIHPQDAQARGIVDGDLVRVWNARGQVLAGAVVTEGIRPGV
ICLHEGAWPDLDPQVGICKNGAVNVLTKDIPTSRLGNGCAGNTALAWLEKYTGPALPLTAFDPPANA
>Mature_786_residues
TPAFADQEPPLPTSSATKTILTAAHWGPMLVETDGENVLSSRGALATPFANSLQTAVRDQVHSKTRVRYPMVRKGFLASP
DKPQGVRGQDEFVRVSWEQALDLIDAQHRRIRDSYGPASIFAGSYGWRSNGVLHKAATLLQRYMSLAGGYTGHLGDYSTG
AAQAIMPYVVGGNEVYQQQTSWPLVLEHSEVVVLWSANPLNTLKIAWNASDEQGIPWFDRLRQSGKRLICIDPMRSETVD
FFGDSMEWIAPHMGTDVALMLGIAHTLVENDWQDDAFLTRCTSGYDIFARYLTGESDGVAKTAEWAAAICGVKADKIREL
AKLFHENTTMLMAGWGMQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLGSMQGSVAGGVDAV
EKIPVARIVEALENPGAEYQHNGMARRFPDIRFIWWAGGANFTHHQDTNRLIQAWQKPELIVISECFWTAAARHADIVLP
ATTSFERNDLTMTGDYSNQHLVPMKQVVAPRDEARDDFAVFADLSERWEAGGRERFTEGKSDLQWLETFYQMAARRGAQQ
QVTLPPFAEFWQANQLIEMPEEPENARFARFAAFRADPQANPLKTASGKIEIHSPTIAAFGYADCPPHPMWLEPDEWHGN
AEAGQLQLLSAHPAHRLHSQLNHTALRERYAVAGREPVTIHPQDAQARGIVDGDLVRVWNARGQVLAGAVVTEGIRPGVI
CLHEGAWPDLDPQVGICKNGAVNVLTKDIPTSRLGNGCAGNTALAWLEKYTGPALPLTAFDPPANA

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI145693196, Length=777, Percent_Identity=82.8828828828829, Blast_Score=1360, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=783, Percent_Identity=64.1123882503193, Blast_Score=1059, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=790, Percent_Identity=42.4050632911392, Blast_Score=583, Evalue=1e-167,
Organism=Escherichia coli, GI87081797, Length=750, Percent_Identity=33.3333333333333, Blast_Score=310, Evalue=3e-85,
Organism=Escherichia coli, GI1787870, Length=754, Percent_Identity=30.6366047745358, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI171474008, Length=760, Percent_Identity=29.6052631578947, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI3868721, Length=474, Percent_Identity=21.9409282700422, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 86657; Mature: 86525

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAFADQEPPLPTSSATKTILTAAHWGPMLVETDGENVLSSRGALATPFANSLQTAVRD
CCCCCCCCCCCCCCCCHHHHHEEEECCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHH
QVHSKTRVRYPMVRKGFLASPDKPQGVRGQDEFVRVSWEQALDLIDAQHRRIRDSYGPAS
HHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHH
IFAGSYGWRSNGVLHKAATLLQRYMSLAGGYTGHLGDYSTGAAQAIMPYVVGGNEVYQQQ
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCEEECCHHHHHHC
TSWPLVLEHSEVVVLWSANPLNTLKIAWNASDEQGIPWFDRLRQSGKRLICIDPMRSETV
CCCCEEEECCCEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHCCCEEEEECCCCHHHH
DFFGDSMEWIAPHMGTDVALMLGIAHTLVENDWQDDAFLTRCTSGYDIFARYLTGESDGV
HHHCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHCCCCCCC
AKTAEWAAAICGVKADKIRELAKLFHENTTMLMAGWGMQRQQYGEQKHWMLVTLAAMLGQ
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHC
IGTPGGGFGLSYHFANGGNPTRRAAVLGSMQGSVAGGVDAVEKIPVARIVEALENPGAEY
CCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCH
QHNGMARRFPDIRFIWWAGGANFTHHQDTNRLIQAWQKPELIVISECFWTAAARHADIVL
HCCCCHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCEEE
PATTSFERNDLTMTGDYSNQHLVPMKQVVAPRDEARDDFAVFADLSERWEAGGRERFTEG
ECCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCC
KSDLQWLETFYQMAARRGAQQQVTLPPFAEFWQANQLIEMPEEPENARFARFAAFRADPQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHEEEECCCC
ANPLKTASGKIEIHSPTIAAFGYADCPPHPMWLEPDEWHGNAEAGQLQLLSAHPAHRLHS
CCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHH
QLNHTALRERYAVAGREPVTIHPQDAQARGIVDGDLVRVWNARGQVLAGAVVTEGIRPGV
HHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCEEEHHHHHCCCCCCE
ICLHEGAWPDLDPQVGICKNGAVNVLTKDIPTSRLGNGCAGNTALAWLEKYTGPALPLTA
EEEECCCCCCCCCCCCEECCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEE
FDPPANA
CCCCCCC
>Mature Secondary Structure 
TPAFADQEPPLPTSSATKTILTAAHWGPMLVETDGENVLSSRGALATPFANSLQTAVRD
CCCCCCCCCCCCCCCHHHHHEEEECCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHH
QVHSKTRVRYPMVRKGFLASPDKPQGVRGQDEFVRVSWEQALDLIDAQHRRIRDSYGPAS
HHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHH
IFAGSYGWRSNGVLHKAATLLQRYMSLAGGYTGHLGDYSTGAAQAIMPYVVGGNEVYQQQ
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCEEECCHHHHHHC
TSWPLVLEHSEVVVLWSANPLNTLKIAWNASDEQGIPWFDRLRQSGKRLICIDPMRSETV
CCCCEEEECCCEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHCCCEEEEECCCCHHHH
DFFGDSMEWIAPHMGTDVALMLGIAHTLVENDWQDDAFLTRCTSGYDIFARYLTGESDGV
HHHCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHCCCCCCC
AKTAEWAAAICGVKADKIRELAKLFHENTTMLMAGWGMQRQQYGEQKHWMLVTLAAMLGQ
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHC
IGTPGGGFGLSYHFANGGNPTRRAAVLGSMQGSVAGGVDAVEKIPVARIVEALENPGAEY
CCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCH
QHNGMARRFPDIRFIWWAGGANFTHHQDTNRLIQAWQKPELIVISECFWTAAARHADIVL
HCCCCHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCEEE
PATTSFERNDLTMTGDYSNQHLVPMKQVVAPRDEARDDFAVFADLSERWEAGGRERFTEG
ECCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCC
KSDLQWLETFYQMAARRGAQQQVTLPPFAEFWQANQLIEMPEEPENARFARFAAFRADPQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHEEEECCCC
ANPLKTASGKIEIHSPTIAAFGYADCPPHPMWLEPDEWHGNAEAGQLQLLSAHPAHRLHS
CCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHH
QLNHTALRERYAVAGREPVTIHPQDAQARGIVDGDLVRVWNARGQVLAGAVVTEGIRPGV
HHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCEEEHHHHHCCCCCCE
ICLHEGAWPDLDPQVGICKNGAVNVLTKDIPTSRLGNGCAGNTALAWLEKYTGPALPLTA
EEEECCCCCCCCCCCCEECCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCCCCEEEE
FDPPANA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: Reduction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180922; 8041620; 9278503 [H]