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The map label for this gene is prlC [H]

Identifier: 238896961

GI number: 238896961

Start: 4934743

End: 4936785

Strand: Reverse

Name: prlC [H]

Synonym: KP1_5203

Alternate gene names: 238896961

Gene position: 4936785-4934743 (Counterclockwise)

Preceding gene: 238896962

Following gene: 238896960

Centisome position: 94.06

GC content: 60.16

Gene sequence:

>2043_bases
ATGACCAATCCATTATTGACGCCTTTCTCCCTGCCGCCTTTTTCTGCGATCAAACCAGAGCACGTGGTCCCTGCGGTCAC
CAAAGCGCTGGAGGATTGCCGGGCCGCGGTGGAAAGCGCGGTGGCGCATGGCGCGCCGTATAGCTGGGAAAATCTTTGCC
AGCCGCTGGCGGAAGTGGACGATGTGCTGGGACGCATCTTCTCGCCTGTCAGCCATCTGAATTCGGTTAAAAACAGCCCT
GAACTGCGTGAGGCCTACGAACAGACGCTGCCGCTGCTCTCCGAGTACAGCACCTGGGTCGGCCAGCATGAAGGCCTGTA
TAAAGCCTATCGCGACCTGCGCGATGGCGATAACTACGCCACGCTGAATACCGCGCAGAAAAAAGCGGTTGATAACGCGC
TGCGCGATTTTGAATTATCCGGGATTGGCCTGCCGCCGGAGGCGCAGAAACGCTACGGTGAAATCGCCGCGCGCCTCTCT
GAGCTGGGCAACCAGTACAGCAACAACGTCCTCGACGCCACCATGGGCTGGAACAAGCTGGTGACCGATGTCGCCGATCT
GGCCGGCATGCCGGAAAGCGCGCTGGCCGCCGCTCAGGCTCAGGCGCAGGCCAAAGAGCAGGAAGGGTATCTGCTGACCC
TGGATATTCCGAGCTATCTGCCGGTGATGACCTACTGCGATAACCAGGCGCTGCGCGAAGAGATGTATCGCGCCTATTCC
ACCCGCGCCTCCGATCAGGGCCCGAACGCCGGGAAATGGGATAACAGCCCGGTGATGGCGGAGATCCTCGCCCTGCGTCA
CGAGCTGGCGCAGCTGTTGGGCTTTGACAGCTATGCGTTTAAATCCCTCGCCACCAAAATGGCGAAGGATCCGCAGCAGG
TGCTCGACTTCCTCACCGACCTGGCAAAACGCGCCCGTCCGCAGGGCGAAAAAGAGCTGGCCCAGCTGCGCGCCTTCGCC
AAAGCCGAGTTTGGCGTCGATGAGCTGCAGCCGTGGGACATTGCCTACTACAGCGAAAAACAGAAGCAGCACCTCTACAG
CATTAGCGATGAGCAGCTGCGCCCCTATTTCCCGGAAAACAAAGCCGTTAGCGGCCTGTTTGAAGTGGTTAAGCGCATTT
ACGGTATTACCGCTAAAGAGCGTACCGATGTCGATGTGTGGCATCCGGAAGTGCGCTTCTTCGAGCTGTATGACGAACAC
AACGAGCTGCGCGGTAGCTTCTATCTCGACCTGTATGCCCGCGAGCATAAGCGCGGCGGGGCGTGGATGGACGACTGCGT
CGGCCAGATGCGTAAACTGGATGGTTCCCTGCAGAAGCCGGTCGCCTACCTGACCTGTAACTTCAACCGCCCGGTCAACG
GCAAGCCGGCGCTGTTCACCCATGACGAAGTGATCACCCTGTTCCACGAGTTCGGCCACGGTCTGCACCATATGCTGACC
CGCATCGACACCGCCGGGGTTTCCGGCATCAGCGGGGTGCCGTGGGATGCGGTCGAGCTGCCGAGCCAGTTTATGGAGAA
CTGGTGCTGGGAGCCGGAAGCGCTGGCGTTTATCTCCGGCCATTATGAAACCGGTGAACCGCTGCCGCAGGAGCTGCTGG
AGAAAATGCTGGCGGCGAAAAACTACCAGGCGGCGATGTTTATTCTGCGCCAGCTGGAGTTCGGCCTGTTCGATTTCCGC
CTGCATGCGGAGTACAAACCGGAGCAGGGAGCGAAAATCCTTGAGACCCTGGCCGAGATTAAAAAGCAGGTCGCCGTGGT
GCCGGGGCCGACCTGGGGCCGCTTCCCGCACGCCTTCAGCCACATCTTCGCTGGCGGCTATGCGGCAGGTTACTACAGCT
ACCTGTGGGCCGACGTGCTGGCGGCAGACGCCTTCTCACGCTTCGAAGAAGAGGGGATTTTCAACCGTGAAACCGGTCAG
TCGTTCCTCGACAATATCCTGAGCCGCGGCGGTTCCGAAGAGCCGATGGAGCTGTTCAAACGCTTCCGCGGGCGTGAGCC
GCAGCTGGACGCGATGCTGGAGCATTACGGGATCAAAGGCTGA

Upstream 100 bases:

>100_bases
CCGCCCGTCATTGAAATTCCCCCAACTATCCCCCATTCTAGATCTCATGCATAAGCGCCGGACGCGCGCTTCATTCACCC
TTTTCAACAGGACAGCGCAT

Downstream 100 bases:

>100_bases
TTGCTACGTGAAGATCTGCTTAATTGATGAAACAGGCGCCGGTGACGGCGCCTTATCTGTTTTAGCCGCCCGCTGGGGGC
TGGAGCAGGATGACGATAAC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTPFSLPPFSAIKPEHVVPAVTKALEDCRAAVESAVAHGAPYSWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDNYATLNTAQKKAVDNALRDFELSGIGLPPEAQKRYGEIAARLS
ELGNQYSNNVLDATMGWNKLVTDVADLAGMPESALAAAQAQAQAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSPVMAEILALRHELAQLLGFDSYAFKSLATKMAKDPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVSGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDEH
NELRGSFYLDLYAREHKRGGAWMDDCVGQMRKLDGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPQELLEKMLAAKNYQAAMFILRQLEFGLFDFR
LHAEYKPEQGAKILETLAEIKKQVAVVPGPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTPFSLPPFSAIKPEHVVPAVTKALEDCRAAVESAVAHGAPYSWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDNYATLNTAQKKAVDNALRDFELSGIGLPPEAQKRYGEIAARLS
ELGNQYSNNVLDATMGWNKLVTDVADLAGMPESALAAAQAQAQAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSPVMAEILALRHELAQLLGFDSYAFKSLATKMAKDPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVSGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDEH
NELRGSFYLDLYAREHKRGGAWMDDCVGQMRKLDGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPQELLEKMLAAKNYQAAMFILRQLEFGLFDFR
LHAEYKPEQGAKILETLAEIKKQVAVVPGPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG
>Mature_679_residues
TNPLLTPFSLPPFSAIKPEHVVPAVTKALEDCRAAVESAVAHGAPYSWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPE
LREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDNYATLNTAQKKAVDNALRDFELSGIGLPPEAQKRYGEIAARLSE
LGNQYSNNVLDATMGWNKLVTDVADLAGMPESALAAAQAQAQAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYST
RASDQGPNAGKWDNSPVMAEILALRHELAQLLGFDSYAFKSLATKMAKDPQQVLDFLTDLAKRARPQGEKELAQLRAFAK
AEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVSGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDEHN
ELRGSFYLDLYAREHKRGGAWMDDCVGQMRKLDGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTR
IDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPQELLEKMLAAKNYQAAMFILRQLEFGLFDFRL
HAEYKPEQGAKILETLAEIKKQVAVVPGPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQS
FLDNILSRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=641, Percent_Identity=31.5132605304212, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI14149738, Length=643, Percent_Identity=31.5707620528771, Blast_Score=291, Evalue=2e-78,
Organism=Homo sapiens, GI156105687, Length=667, Percent_Identity=26.0869565217391, Blast_Score=195, Evalue=1e-49,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=93.5294117647059, Blast_Score=1303, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=32.0232896652111, Blast_Score=322, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI71999758, Length=542, Percent_Identity=26.0147601476015, Blast_Score=150, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32565901, Length=637, Percent_Identity=23.3908948194662, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319793, Length=690, Percent_Identity=28.9855072463768, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6322715, Length=564, Percent_Identity=25.531914893617, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21356111, Length=694, Percent_Identity=28.3861671469741, Blast_Score=255, Evalue=6e-68,
Organism=Drosophila melanogaster, GI20129717, Length=614, Percent_Identity=24.9185667752443, Blast_Score=189, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76688; Mature: 76557

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTPFSLPPFSAIKPEHVVPAVTKALEDCRAAVESAVAHGAPYSWENLCQPLAEVD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDNYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPPEAQKRYGEIAARLSELGNQYSNNVLDATMGWNKL
ECHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDVADLAGMPESALAAAQAQAQAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSPVMAEILALRHELAQLLGFDSYAFKSLATKMAKDPQQVLDFLTD
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVSGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDEHNELRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHCCCC
AWMDDCVGQMRKLDGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHHCCHHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPQELLEKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAAMFILRQLEFGLFDFRLHAEYKPEQGAKILETLAEIKKQVAVVPGPTWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMELFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTPFSLPPFSAIKPEHVVPAVTKALEDCRAAVESAVAHGAPYSWENLCQPLAEVD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDNYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPPEAQKRYGEIAARLSELGNQYSNNVLDATMGWNKL
ECHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDVADLAGMPESALAAAQAQAQAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSPVMAEILALRHELAQLLGFDSYAFKSLATKMAKDPQQVLDFLTD
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVSGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDEHNELRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHCCCC
AWMDDCVGQMRKLDGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHHCCHHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIDTAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPQELLEKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAAMFILRQLEFGLFDFRLHAEYKPEQGAKILETLAEIKKQVAVVPGPTWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMELFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]