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The map label for this gene is nikR [H]

Identifier: 238896952

GI number: 238896952

Start: 4925748

End: 4926149

Strand: Direct

Name: nikR [H]

Synonym: KP1_5194

Alternate gene names: 238896952

Gene position: 4925748-4926149 (Clockwise)

Preceding gene: 238896951

Following gene: 238896954

Centisome position: 93.85

GC content: 59.45

Gene sequence:

>402_bases
ATGCAGCGCGTAACCCTGACCCTTGATGATGACCTGCTGGCCGCCCTCGATGCGCTCAGCGCCCGCCGCGGCTACCACAA
CCGTTCGGAGGCGGTACGCGATATTCTGCGCGACGCCCTCAACCAGGATCCTCCGTCGCCGGAATCACGGCGCGGGTATG
CCGTTCTGTCGTACGTGTATGAACATGAGAAACGCGAACTGGCGAGCCGGCTGGTGGCCACCCAGCATCATCATCACGAT
CTCTCCGTCGCCACGCTGCATGTACATATCAGTCATGACGACTGCCTGGAGATTGCGGTGCTGAAAGGTGATATGGCCGA
GGTACAGCATTTTGCCGACGACGTGATTGCCCAGCGCGGCGTGCGCCATGGGCATTTGCAGTGTTTAGCGGATGAAAATT
AA

Upstream 100 bases:

>100_bases
CGGTTAGTCTACCGCTACGCCTGCGTTCCCCTGCCGGACAGGCGCTCCAGCAGGCGGTGCTCCCCCCTTTTCCTGCCACT
CTGCTTAACGAGGCCATGCC

Downstream 100 bases:

>100_bases
AACGATAACGATCTGCTGCAGGCTGTTTTAAGCCTGTTTGAGACGTTCATTGAGCGTCTCAAGGATCCAGGTATTTACGG
AAACCTGCTCCTCCGCAGCG

Product: nickel responsive regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MQRVTLTLDDDLLAALDALSARRGYHNRSEAVRDILRDALNQDPPSPESRRGYAVLSYVYEHEKRELASRLVATQHHHHD
LSVATLHVHISHDDCLEIAVLKGDMAEVQHFADDVIAQRGVRHGHLQCLADEN

Sequences:

>Translated_133_residues
MQRVTLTLDDDLLAALDALSARRGYHNRSEAVRDILRDALNQDPPSPESRRGYAVLSYVYEHEKRELASRLVATQHHHHD
LSVATLHVHISHDDCLEIAVLKGDMAEVQHFADDVIAQRGVRHGHLQCLADEN
>Mature_133_residues
MQRVTLTLDDDLLAALDALSARRGYHNRSEAVRDILRDALNQDPPSPESRRGYAVLSYVYEHEKRELASRLVATQHHHHD
LSVATLHVHISHDDCLEIAVLKGDMAEVQHFADDVIAQRGVRHGHLQCLADEN

Specific function: Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel [H]

COG id: COG0864

COG function: function code K; Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transcriptional regulatory CopG/NikR family [H]

Homologues:

Organism=Escherichia coli, GI1789892, Length=133, Percent_Identity=78.9473684210526, Blast_Score=196, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013321
- InterPro:   IPR002145
- InterPro:   IPR022988
- InterPro:   IPR014160
- InterPro:   IPR010985
- InterPro:   IPR014864 [H]

Pfam domain/function: PF08753 NikR_C; PF01402 RHH_1 [H]

EC number: NA

Molecular weight: Translated: 15029; Mature: 15029

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRVTLTLDDDLLAALDALSARRGYHNRSEAVRDILRDALNQDPPSPESRRGYAVLSYVY
CCEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
EHEKRELASRLVATQHHHHDLSVATLHVHISHDDCLEIAVLKGDMAEVQHFADDVIAQRG
HHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCC
VRHGHLQCLADEN
CCCCCEEEEECCC
>Mature Secondary Structure
MQRVTLTLDDDLLAALDALSARRGYHNRSEAVRDILRDALNQDPPSPESRRGYAVLSYVY
CCEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
EHEKRELASRLVATQHHHHDLSVATLHVHISHDDCLEIAVLKGDMAEVQHFADDVIAQRG
HHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCC
VRHGHLQCLADEN
CCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA