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The map label for this gene is ggt [H]

Identifier: 238896904

GI number: 238896904

Start: 4878562

End: 4880304

Strand: Reverse

Name: ggt [H]

Synonym: KP1_5141

Alternate gene names: 238896904

Gene position: 4880304-4878562 (Counterclockwise)

Preceding gene: 238896906

Following gene: 238896901

Centisome position: 92.98

GC content: 60.13

Gene sequence:

>1743_bases
ATAAAAACAACAATATGGCGTCAGGTGGTCATCGCTGCGTTGCTGGCGGGGGGCAGCTTTACCGTCGCCGCCAATCCGCC
ACCGCCGCCGCCGGTCTCTTATGGCGTAGAGGAAGATGTGTTCCACCCGGTACGCGCCCGGCAGGGGATGGTGGCCTCGG
TGGACGCGCTGGCGACCCGCGTCGGCGTGGATATCCTGCGCCAGGGCGGTAACGCTGTCGATGCGGCGGTAGCGGTAGGC
TACGCGCTGGCGGTCACCCATCCGCAGGCCGGGAATATTGGCGGCGGCGGTTTTATGATGCTGCGGACTAAAGACGGCAA
GACCACGGCGATCGATTTCCGCGAAATGGCGCCAGAGCAGGCCACCCGCGACATGTTCCTTGACGACCAGGGCAACCCGG
ACAGTAAAAAATCACTGACTTCGCATCTGGCCTCCGGCACGCCAGGCAGCGTCGCCGGTTTCTCCCTCGCGCTGGAAAAG
TATGGCACCATGCCGTTGAACAAAGTGATCCGTCCGGCGATTAAGCTGGCGGAAGAGGGGTTTATCGTTAACGATGCGCT
GGCGGACGATCTGAAGACCTACGGCAGCGAAGTGATCCCGCAGCATGAAAATAGTAAAGCGATCTTCTGGAAGAACGGCG
AGCCGCTGAAGAAGGGCGATCGGCTGGTGCAGAAGAACCTCGGTAAGAGCCTGGAGCTGATTGCCGAGCACGGCCCGGAC
GCCTTCTATAAAGGGGCCATCGCCGACCAGATCGCTGACGAGATGAAAAAGCACGGCGGGCTAATCACCAAAGCCGATCT
CGCCGGCTATAAGGCTGTGGAGCGTACGCCGGTTAGCGGCGAGTATCGCGGGTATGAGGTTTACTCTATGCCGCCGCCGT
CCTCCGGCGGGATCCACATCGTGCAGATCCTCAATATCCTCGAAAACTTCGATATGCAGAAATATGGCTTTGGCAGCGCC
GACGCCATGCAGGTGATGGCGGAGGCGGAGAAACATGCCTATGCCGACCGTTCCGAATATCTCGGCGATCCTGACTTCGT
CAACGTGCCGTGGCAGGCGCTGACCAGCAAGGCTTACGCCAAAGCGATCGCCGCCGAGATTGATGTCAACAAGGCGAAGC
CTTCCAGCCAGATCCGTCCGGGCAAGCTGGCGCCCTATGAAAGCAACCAGACCACCCACTTCTCGGTGGTCGATAAAGAC
GGCAATGCGGTGGCGGTGACCTATACGCTGAATACCACCTTCGGTACCGGCATTGTGGCCGGTGATTCCGGCATTCTGCT
CAATAACCAGATGGATGATTTCTCGGCGAAGCCCGGCGTGCCTAACGTCTATGGTCTGGTGGGCGGCGACGCCAATGCGG
TGGAGCCGAAAAAACGCCCGCTGTCGTCAATGTCGCCGACCATTGTGGTGAAAGACGGCAAAACCTGGCTGGTAACCGGC
AGCCCGGGCGGCAGTCGGATCATCACCACCGTACTGCAGATGGTGGTCAATACCATCGATTTCGGGATGAACGTCGCGGA
AGCCACCAACGCGCCGCGTTTCCACCATCAATGGCTGCCGGATGAGCTGCGGGTGGAGAAAGGCTTTAGCCCGGATACCC
TGAAGCTGCTGGAGGCGAAGGGGCAGAAAGTGGCGCTGAAAGAGGCGATGGGCAGTACCCAGAGCATCATGGTGGGGCCG
GACGGCATGCTGTATGGCGCCTCCGATCCGCGTTCGCCGGATGATTTAACGGCGGGGTATTGA

Upstream 100 bases:

>100_bases
ACTTAAGTGTACCTCGAATCTGCCATAACAATGATTTTTTAGGAGTTATCAACCAGGCTTAAGCGGGGAATGAAACCTAC
CTTTCAGGAGTAAGACAATG

Downstream 100 bases:

>100_bases
TGTGTTGCCCGGCGGCGCTGCTGCGCTTACCGGGCCTACAACTGTGCGAACGCAGGCCGGGTAAGGCGAAGCCGCCACCC
GGCAACACGCTACTTCATTC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MKTTIWRQVVIAALLAGGSFTVAANPPPPPPVSYGVEEDVFHPVRARQGMVASVDALATRVGVDILRQGGNAVDAAVAVG
YALAVTHPQAGNIGGGGFMMLRTKDGKTTAIDFREMAPEQATRDMFLDDQGNPDSKKSLTSHLASGTPGSVAGFSLALEK
YGTMPLNKVIRPAIKLAEEGFIVNDALADDLKTYGSEVIPQHENSKAIFWKNGEPLKKGDRLVQKNLGKSLELIAEHGPD
AFYKGAIADQIADEMKKHGGLITKADLAGYKAVERTPVSGEYRGYEVYSMPPPSSGGIHIVQILNILENFDMQKYGFGSA
DAMQVMAEAEKHAYADRSEYLGDPDFVNVPWQALTSKAYAKAIAAEIDVNKAKPSSQIRPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGDSGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNTIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP
DGMLYGASDPRSPDDLTAGY

Sequences:

>Translated_580_residues
MKTTIWRQVVIAALLAGGSFTVAANPPPPPPVSYGVEEDVFHPVRARQGMVASVDALATRVGVDILRQGGNAVDAAVAVG
YALAVTHPQAGNIGGGGFMMLRTKDGKTTAIDFREMAPEQATRDMFLDDQGNPDSKKSLTSHLASGTPGSVAGFSLALEK
YGTMPLNKVIRPAIKLAEEGFIVNDALADDLKTYGSEVIPQHENSKAIFWKNGEPLKKGDRLVQKNLGKSLELIAEHGPD
AFYKGAIADQIADEMKKHGGLITKADLAGYKAVERTPVSGEYRGYEVYSMPPPSSGGIHIVQILNILENFDMQKYGFGSA
DAMQVMAEAEKHAYADRSEYLGDPDFVNVPWQALTSKAYAKAIAAEIDVNKAKPSSQIRPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGDSGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNTIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP
DGMLYGASDPRSPDDLTAGY
>Mature_580_residues
MKTTIWRQVVIAALLAGGSFTVAANPPPPPPVSYGVEEDVFHPVRARQGMVASVDALATRVGVDILRQGGNAVDAAVAVG
YALAVTHPQAGNIGGGGFMMLRTKDGKTTAIDFREMAPEQATRDMFLDDQGNPDSKKSLTSHLASGTPGSVAGFSLALEK
YGTMPLNKVIRPAIKLAEEGFIVNDALADDLKTYGSEVIPQHENSKAIFWKNGEPLKKGDRLVQKNLGKSLELIAEHGPD
AFYKGAIADQIADEMKKHGGLITKADLAGYKAVERTPVSGEYRGYEVYSMPPPSSGGIHIVQILNILENFDMQKYGFGSA
DAMQVMAEAEKHAYADRSEYLGDPDFVNVPWQALTSKAYAKAIAAEIDVNKAKPSSQIRPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGDSGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNTIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP
DGMLYGASDPRSPDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=523, Percent_Identity=33.0783938814532, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI73915090, Length=523, Percent_Identity=33.0783938814532, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI73915096, Length=523, Percent_Identity=33.0783938814532, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI73915094, Length=523, Percent_Identity=33.0783938814532, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI113429324, Length=537, Percent_Identity=31.6573556797021, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI113429326, Length=542, Percent_Identity=30.9963099630996, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI109148539, Length=551, Percent_Identity=31.7604355716878, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI153266901, Length=549, Percent_Identity=28.2331511839709, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI153266885, Length=550, Percent_Identity=27.8181818181818, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI153266907, Length=546, Percent_Identity=26.1904761904762, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=34.703196347032, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=34.703196347032, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=31.0502283105023, Blast_Score=97, Evalue=5e-20,
Organism=Escherichia coli, GI1789856, Length=580, Percent_Identity=87.5862068965517, Blast_Score=1038, Evalue=0.0,
Organism=Caenorhabditis elegans, GI72000294, Length=579, Percent_Identity=33.5060449050086, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI212646519, Length=579, Percent_Identity=33.5060449050086, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI193208245, Length=560, Percent_Identity=32.5, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI193208247, Length=560, Percent_Identity=32.8571428571429, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17542894, Length=497, Percent_Identity=35.2112676056338, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17506189, Length=548, Percent_Identity=31.021897810219, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=26.86230248307, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI72001495, Length=225, Percent_Identity=27.5555555555556, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI72001497, Length=225, Percent_Identity=27.5555555555556, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=496, Percent_Identity=30.241935483871, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI161077878, Length=539, Percent_Identity=32.2820037105751, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI161077880, Length=539, Percent_Identity=32.2820037105751, Blast_Score=253, Evalue=4e-67,
Organism=Drosophila melanogaster, GI45551474, Length=539, Percent_Identity=32.2820037105751, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24642670, Length=539, Percent_Identity=32.2820037105751, Blast_Score=252, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24642666, Length=539, Percent_Identity=32.2820037105751, Blast_Score=252, Evalue=5e-67,
Organism=Drosophila melanogaster, GI161077496, Length=511, Percent_Identity=30.5283757338552, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=30.8880308880309, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI18859741, Length=554, Percent_Identity=28.5198555956679, Blast_Score=189, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61896; Mature: 61896

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTIWRQVVIAALLAGGSFTVAANPPPPPPVSYGVEEDVFHPVRARQGMVASVDALATR
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHCHHHHCCCCHHHHHHHHHH
VGVDILRQGGNAVDAAVAVGYALAVTHPQAGNIGGGGFMMLRTKDGKTTAIDFREMAPEQ
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCCEEEEEHHHHCHHH
ATRDMFLDDQGNPDSKKSLTSHLASGTPGSVAGFSLALEKYGTMPLNKVIRPAIKLAEEG
HHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FIVNDALADDLKTYGSEVIPQHENSKAIFWKNGEPLKKGDRLVQKNLGKSLELIAEHGPD
CEEEHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCC
AFYKGAIADQIADEMKKHGGLITKADLAGYKAVERTPVSGEYRGYEVYSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHHCCCEEEHHHCCCHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMQKYGFGSADAMQVMAEAEKHAYADRSEYLGDPDFVNVPWQALTSKAYA
HHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEECCCHHHHHHHHHH
KAIAAEIDVNKAKPSSQIRPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GDSGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
CCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNTIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAK
CCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGMLYGASDPRSPDDLTAGY
CCEEEHHHHCCCCCEEEECCCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTTIWRQVVIAALLAGGSFTVAANPPPPPPVSYGVEEDVFHPVRARQGMVASVDALATR
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHCHHHHCCCCHHHHHHHHHH
VGVDILRQGGNAVDAAVAVGYALAVTHPQAGNIGGGGFMMLRTKDGKTTAIDFREMAPEQ
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCCEEEEEHHHHCHHH
ATRDMFLDDQGNPDSKKSLTSHLASGTPGSVAGFSLALEKYGTMPLNKVIRPAIKLAEEG
HHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FIVNDALADDLKTYGSEVIPQHENSKAIFWKNGEPLKKGDRLVQKNLGKSLELIAEHGPD
CEEEHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCC
AFYKGAIADQIADEMKKHGGLITKADLAGYKAVERTPVSGEYRGYEVYSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHHCCCEEEHHHCCCHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMQKYGFGSADAMQVMAEAEKHAYADRSEYLGDPDFVNVPWQALTSKAYA
HHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEECCCHHHHHHHHHH
KAIAAEIDVNKAKPSSQIRPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GDSGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
CCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNTIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAK
CCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGMLYGASDPRSPDDLTAGY
CCEEEHHHHCCCCCEEEECCCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]