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The map label for this gene is envZ [H]

Identifier: 238896871

GI number: 238896871

Start: 4836129

End: 4837484

Strand: Reverse

Name: envZ [H]

Synonym: KP1_5105

Alternate gene names: 238896871

Gene position: 4837484-4836129 (Counterclockwise)

Preceding gene: 238896872

Following gene: 238896865

Centisome position: 92.17

GC content: 60.47

Gene sequence:

>1356_bases
ATGAAACGCGTGCGCTTTTCGCCGCGCAGCTCCTTTGCTCGCACACTGCTCCTGATCGTCACCTTGCTGTTCGTCAGCCT
GGTGACGACCTATCTGGTGGTACTGAATTTCGCGATCCTGCCGAGTCTCCAGCAGTTTAATAAAGTGTTAGCCTACGAAG
TGCGTATGCTGATGACCGACAAACTGCAGCTGGAGGATGGCACCCAGCTGGTGGTGCCCCCGGCGTTTCGTCGTGAAATT
TATCGCGAGCTGGGGATTTCGCTCTATTCCAATGAAGCGGCGGAAGACGCAGGCCTGCGCTGGGCGCAGCATTATGAATT
CTTAAGTCAGCAGATGGCCCATCAGCTTGGTGGCCCCACAGAGGTGCGGGTAGAGGTCAATAAAAGCTCCCCTGTGGTGT
GGCTGAAGACCTGGCTGTCGCCCAATATCTGGGTGCGGGTGCCGCTGACCGAGATCCATCAGGGCGACTTCTCGCCGCTG
TTCCGCTATACCCTGGCGATCATGCTGCTGGCGATAGGCGGCGCCTGGCTGTTTATTCGTATTCAGAACCGCCCGTTGGT
GGATCTGGAGCACGCGGCGCTGCAGGTCGGGCGCGGCATTATTCCGCCGCCGCTGCGCGAGTATGGCGCCTCCGAAGTGC
GTTCGGTGACGCGCGCCTTTAACCATATGGCGGCGGGCGTGAAGCAGTTGGCTGATGACCGTACGCTGCTGATGGCCGGG
GTCAGTCATGATTTACGAACCCCGCTGACCCGCATTCGTCTGGCCACCGAGATGATGGGCGAGCAGGACGGCTATCTCGC
GGAGTCGATCAACAAAGATATCGAAGAGTGCAACGCCATCATCGAGCAGTTTATCGACTATCTGCGCACCGGGCAGGAGA
TGCCGATGGAGCTGGCGGATCTGAATGCGGTGCTGGGGGAAGTGATCGCTGCGGAGAGTGGCTATGAGCGGGAAATCGCC
ACCGCCCTGCAGGCCGGCGAAATTCCGGTACGTATGCACCCGCTGTCTATCAAGCGCGCGCTGGCGAATATGGTGGTCAA
CGCGGCCCGCTATGGCAATGGCTGGATCAAGGTCAGCAGCGGCAGCGAAGCGAGCCGGGCCTGGTTCCAGGTAGAAGATG
ATGGACCGGGGATTAAACCTGAGCAGAGGGAGCACCTGTTTCAGCCGTTTGTTCGCGGCGACAGCGCCCGCAGCACCAGC
GGCACCGGGCTGGGGTTGGCGATTGTTCAGCGTATTATCGACAATCACAACGGCCGGCTGGAGATTGGCTCCAGCGAACG
CGGCGGGTTACTGATCCGCGCCTGGCTGCCGGTGCACCGGATGCTGGCGCCGATGAAACCCGCCAGGGAGAGCTGA

Upstream 100 bases:

>100_bases
CCCGCCTGCGCCGCATGGTGGAAGAGGACCCGGCGCATCCGCGCTACATCCAGACCGTCTGGGGTCTGGGCTACGTCTTC
GTCCCGGACGGTTCTAAGGC

Downstream 100 bases:

>100_bases
TCGCGCCCGCGGTTAGCTGCTCAGGATGTTGCACAATAAAAAGCCGGGCAAGCCCGGCTTTTTCACCTTTGCGCCCGTTA
GCGCTGCGGTCCTGCCGCCA

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKRVRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYSNEAAEDAGLRWAQHYEFLSQQMAHQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGRGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMGEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMELADLNAVLGEVIAAESGYEREIA
TALQAGEIPVRMHPLSIKRALANMVVNAARYGNGWIKVSSGSEASRAWFQVEDDGPGIKPEQREHLFQPFVRGDSARSTS
GTGLGLAIVQRIIDNHNGRLEIGSSERGGLLIRAWLPVHRMLAPMKPARES

Sequences:

>Translated_451_residues
MKRVRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYSNEAAEDAGLRWAQHYEFLSQQMAHQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGRGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMGEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMELADLNAVLGEVIAAESGYEREIA
TALQAGEIPVRMHPLSIKRALANMVVNAARYGNGWIKVSSGSEASRAWFQVEDDGPGIKPEQREHLFQPFVRGDSARSTS
GTGLGLAIVQRIIDNHNGRLEIGSSERGGLLIRAWLPVHRMLAPMKPARES
>Mature_451_residues
MKRVRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYSNEAAEDAGLRWAQHYEFLSQQMAHQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGRGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMGEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMELADLNAVLGEVIAAESGYEREIA
TALQAGEIPVRMHPLSIKRALANMVVNAARYGNGWIKVSSGSEASRAWFQVEDDGPGIKPEQREHLFQPFVRGDSARSTS
GTGLGLAIVQRIIDNHNGRLEIGSSERGGLLIRAWLPVHRMLAPMKPARES

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=438, Percent_Identity=93.6073059360731, Blast_Score=845, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=263, Percent_Identity=33.8403041825095, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=31.7164179104478, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=32.8767123287671, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=26.046511627907, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=25.085910652921, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790551, Length=278, Percent_Identity=28.0575539568345, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=29.6296296296296, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=251, Percent_Identity=27.4900398406374, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786783, Length=283, Percent_Identity=27.9151943462898, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=268, Percent_Identity=25.7462686567164, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789403, Length=242, Percent_Identity=26.4462809917355, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=29.535864978903, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=250, Percent_Identity=26, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=226, Percent_Identity=24.7787610619469, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI145693157, Length=249, Percent_Identity=23.2931726907631, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50515; Mature: 50515

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEDAGLRWAQHYEFLSQQMAHQLGGPT
CEEECCCCEEEECHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVDLEHAALQVGRGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
ECCCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
VSHDLRTPLTRIRLATEMMGEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMELAD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNAVLGEVIAAESGYEREIATALQAGEIPVRMHPLSIKRALANMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHCCCCEEEECC
GSEASRAWFQVEDDGPGIKPEQREHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNGRL
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
EIGSSERGGLLIRAWLPVHRMLAPMKPARES
EECCCCCCCEEEEEHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKRVRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEDAGLRWAQHYEFLSQQMAHQLGGPT
CEEECCCCEEEECHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVDLEHAALQVGRGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
ECCCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
VSHDLRTPLTRIRLATEMMGEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMELAD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNAVLGEVIAAESGYEREIATALQAGEIPVRMHPLSIKRALANMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHCCCCEEEECC
GSEASRAWFQVEDDGPGIKPEQREHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNGRL
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
EIGSSERGGLLIRAWLPVHRMLAPMKPARES
EECCCCCCCEEEEEHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]