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The map label for this gene is yhcS [H]

Identifier: 238896749

GI number: 238896749

Start: 4726614

End: 4727543

Strand: Direct

Name: yhcS [H]

Synonym: KP1_4968

Alternate gene names: 238896749

Gene position: 4726614-4727543 (Clockwise)

Preceding gene: 238896744

Following gene: 238896759

Centisome position: 90.06

GC content: 56.56

Gene sequence:

>930_bases
ATGGAACGATTAAAACGCATGTCCGTTTTCGCCAAAGTGGTCGAATTAGGTTCATTCACCGCAGCGGCCCGCCAGCTTCA
GATGAGCGTTTCCTCGATCAGTCAGACCGTCGCCAAACTGGAAGATGAGCTGCAGGTAAAGCTGCTCAACCGCAGCACCC
GCAGCCTTGGCTTAACTGAAGCAGGTAAAATCTATTACCAGGGCTGCCGTAGGATGCTGTTTGAAGCGCAGGATGTCCAT
GAGCAATTATACGCATTTAACAATACCCCCATCGGGACGCTGCGCATCGGCTGCTCTTCAACTATGGCACAGAATGTTCT
GGCGCGCATAACGGCGAAAATGCTCAAAGAATACCCCGGGCTCTCTGTTAATCTGGTCACCGGCATACCTGCGCCAGACC
TGATCGCCGACGGCCTTGACGTGGTGATCCGCGTGGGCGCCCTGCAGGATTCCAGCCTTTTTTCCCGCCGTCTGGGCTCA
ATGCCGATGGTATTATGCGCCGCTAAAAGCTATCTGGCGCAGGCTGGCAATCCAGAGAAACCGGCCGACCTTGCCGGACA
TGCCTGGCTGGAATATAGCGTGCGGCCGGACAATGAGTTTGTCATTATCGCGCCGGAAGGGATCTCGACCCGCCTGACCC
CGCAGGGGCGCTTCGTGACCAACGACCCTATGACGCTGGTGCGCTGGCTGACCGCCGGGGTGGGTATCGCCTATGTACCC
TTAATGTGGGCGATCGAAGAGATCAACCGCGGTGAACTTGAGATCCTGCTGCCCAGCTATCAGTCCGATCCGCGACCGGT
CTACGCCCTGTATACGGAAAAGGATAAACTGCCGCTGAAAGTGCAGGTCTGTATCAACTATCTGACGGAGTATTTTGTCG
ACGTGGCGAAGATCTATCAGGGCATGCACGGGCGCGGGATCGCCCGGTGA

Upstream 100 bases:

>100_bases
GAGCAGATGCGTTTATTATGTAGCTAACAATATATTAACGTAACGATTGCCGCATTATCTACAATGTGTGATCTAAATCA
CTTTTAAGCCAGAGTGAATA

Downstream 100 bases:

>100_bases
AGCGGTTCCCGGCAGCGCCGGGAACCAGGTCAGGATCAGGCGGTGCCGCCGACGGTAAGGTTATCGACCTTCAGGGTCGG
CTGGCCGACGCCCACCGGCA

Product: putative DNA-binding transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MERLKRMSVFAKVVELGSFTAAARQLQMSVSSISQTVAKLEDELQVKLLNRSTRSLGLTEAGKIYYQGCRRMLFEAQDVH
EQLYAFNNTPIGTLRIGCSSTMAQNVLARITAKMLKEYPGLSVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGS
MPMVLCAAKSYLAQAGNPEKPADLAGHAWLEYSVRPDNEFVIIAPEGISTRLTPQGRFVTNDPMTLVRWLTAGVGIAYVP
LMWAIEEINRGELEILLPSYQSDPRPVYALYTEKDKLPLKVQVCINYLTEYFVDVAKIYQGMHGRGIAR

Sequences:

>Translated_309_residues
MERLKRMSVFAKVVELGSFTAAARQLQMSVSSISQTVAKLEDELQVKLLNRSTRSLGLTEAGKIYYQGCRRMLFEAQDVH
EQLYAFNNTPIGTLRIGCSSTMAQNVLARITAKMLKEYPGLSVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGS
MPMVLCAAKSYLAQAGNPEKPADLAGHAWLEYSVRPDNEFVIIAPEGISTRLTPQGRFVTNDPMTLVRWLTAGVGIAYVP
LMWAIEEINRGELEILLPSYQSDPRPVYALYTEKDKLPLKVQVCINYLTEYFVDVAKIYQGMHGRGIAR
>Mature_309_residues
MERLKRMSVFAKVVELGSFTAAARQLQMSVSSISQTVAKLEDELQVKLLNRSTRSLGLTEAGKIYYQGCRRMLFEAQDVH
EQLYAFNNTPIGTLRIGCSSTMAQNVLARITAKMLKEYPGLSVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGS
MPMVLCAAKSYLAQAGNPEKPADLAGHAWLEYSVRPDNEFVIIAPEGISTRLTPQGRFVTNDPMTLVRWLTAGVGIAYVP
LMWAIEEINRGELEILLPSYQSDPRPVYALYTEKDKLPLKVQVCINYLTEYFVDVAKIYQGMHGRGIAR

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=306, Percent_Identity=89.8692810457516, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI145693193, Length=293, Percent_Identity=30.7167235494881, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786401, Length=289, Percent_Identity=31.4878892733564, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787128, Length=270, Percent_Identity=28.5185185185185, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI87081978, Length=297, Percent_Identity=29.2929292929293, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789440, Length=288, Percent_Identity=26.0416666666667, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787589, Length=274, Percent_Identity=27.007299270073, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788481, Length=146, Percent_Identity=31.5068493150685, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI157672245, Length=205, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=257, Percent_Identity=26.8482490272374, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790262, Length=259, Percent_Identity=25.4826254826255, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788706, Length=142, Percent_Identity=28.8732394366197, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787601, Length=126, Percent_Identity=23.8095238095238, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788297, Length=123, Percent_Identity=30.8943089430894, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34263; Mature: 34263

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLKRMSVFAKVVELGSFTAAARQLQMSVSSISQTVAKLEDELQVKLLNRSTRSLGLTE
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCH
AGKIYYQGCRRMLFEAQDVHEQLYAFNNTPIGTLRIGCSSTMAQNVLARITAKMLKEYPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
LSVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGSMPMVLCAAKSYLAQAGNPEK
CEEEEEECCCCHHHHHCCHHHEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
PADLAGHAWLEYSVRPDNEFVIIAPEGISTRLTPQGRFVTNDPMTLVRWLTAGVGIAYVP
CCHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHCCHHHHHH
LMWAIEEINRGELEILLPSYQSDPRPVYALYTEKDKLPLKVQVCINYLTEYFVDVAKIYQ
HHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
GMHGRGIAR
CCCCCCCCC
>Mature Secondary Structure
MERLKRMSVFAKVVELGSFTAAARQLQMSVSSISQTVAKLEDELQVKLLNRSTRSLGLTE
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCH
AGKIYYQGCRRMLFEAQDVHEQLYAFNNTPIGTLRIGCSSTMAQNVLARITAKMLKEYPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
LSVNLVTGIPAPDLIADGLDVVIRVGALQDSSLFSRRLGSMPMVLCAAKSYLAQAGNPEK
CEEEEEECCCCHHHHHCCHHHEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
PADLAGHAWLEYSVRPDNEFVIIAPEGISTRLTPQGRFVTNDPMTLVRWLTAGVGIAYVP
CCHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHCCHHHHHH
LMWAIEEINRGELEILLPSYQSDPRPVYALYTEKDKLPLKVQVCINYLTEYFVDVAKIYQ
HHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
GMHGRGIAR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]