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The map label for this gene is dhaT [H]

Identifier: 238896585

GI number: 238896585

Start: 4565921

End: 4567084

Strand: Direct

Name: dhaT [H]

Synonym: KP1_4785

Alternate gene names: 238896585

Gene position: 4565921-4567084 (Clockwise)

Preceding gene: 238896584

Following gene: 238896586

Centisome position: 86.99

GC content: 61.25

Gene sequence:

>1164_bases
ATGAGCTATCGTATGTTTGATTATCTGGTGCCAAACGTTAACTTTTTTGGCCCCAACGCCATTTCCGTAGTCGGCGAACG
CTGCCAGCTGCTGGGGGGGAAAAAAGCCCTGCTGGTCACCGACAAAGGCCTGCGGGCAATTAAAGATGGAGCGGTGGACA
AAACCCTGCATTATCTGCGGGAGGCCGGGATCGAGGTGGCGATCTTTGACGGCGTCGAGCCGAACCCGAAAGACACCAAC
GTGCGCGACGGCCTCGCCGTGTTTCGCCGCGAACAGTGCGACATCATCGTCACCGTGGGCGGCGGCAGCCCGCACGATTG
CGGCAAAGGCATCGGCATCGCCGCCACCCATGAGGGCGATCTGTACCAGTATGCCGGAATCGAGACCCTGACCAACCCGC
TGCCACCTATCGTCGCGGTCAATACCACCGCCGGCACCGCCAGCGAGGTCACCCGCCACTGCGTCCTGACCAACACCGAA
ACCAAAGTGAAGTTTGTGATCGTCAGCTGGCGCAACCTGCCGTCGGTCTCTATCAACGATCCGCTGCTGATGATCGGTAA
ACCGGCCGCCCTGACCGCGGCGACCGGGATGGATGCCCTGACCCACGCCGTAGAGGCCTATATCTCCAAAGACGCTAACC
CGGTGACGGACGCCGCCGCCATGCAGGCGATCCGCCTCATCGCCCGCAACCTGCGCCAGGCCGTGGCCCTCGGCAGCAAT
CTGCAGGCGCGGGAAAACATGGCCTATGCTTCTCTGCTGGCCGGGATGGCTTTCAATAACGCCAACCTCGGCTACGTGCA
CGCCATGGCGCACCAGCTGGGCGGCCTGTACGACATGCCGCACGGCGTGGCCAACGCTGTCCTGCTGCCGCATGTGGCCC
GCTACAACCTGATCGCCAACCCGGAGAAATTCGCCGATATCGCTGAACTGATGGGCGAAAATATCACCGGACTGTCCACT
CTCGACGCGGCGGAAAAAGCCATCGCCGCCATCACGCGTCTGTCGATGGATATCGGTATTCCGCAGCATCTGCGCGATCT
GGGGGTAAAAGAGGCCGACTTCCCCTACATGGCGGAGATGGCTCTGAAAGACGGCAATGCGTTCTCGAACCCGCGTAAAG
GCAACGAGCAGGAGATTGCCGCGATTTTCCGCCAGGCATTCTGA

Upstream 100 bases:

>100_bases
CGTCGGCGTTAGCGGCGGTACGGTCGAGCAGGATCAATTATTAGCCCAGTGCGCCCTGGATTGTTTTTCCGCATTATAAC
CTGAAGCGAGAAGGTATATT

Downstream 100 bases:

>100_bases
GTGTTAACGAGGGGGCCGTCATGTCGCTTTCACCGCCAGGCGTACGCCTGTTTTACGATCCGCGTGGGCACCACGCCGGC
GCCATCAATGAGCTGTGCTG

Product: 1,3-propanediol oxidoreductase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSYRMFDYLVPNVNFFGPNAISVVGERCQLLGGKKALLVTDKGLRAIKDGAVDKTLHYLREAGIEVAIFDGVEPNPKDTN
VRDGLAVFRREQCDIIVTVGGGSPHDCGKGIGIAATHEGDLYQYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVLTNTE
TKVKFVIVSWRNLPSVSINDPLLMIGKPAALTAATGMDALTHAVEAYISKDANPVTDAAAMQAIRLIARNLRQAVALGSN
LQARENMAYASLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAVLLPHVARYNLIANPEKFADIAELMGENITGLST
LDAAEKAIAAITRLSMDIGIPQHLRDLGVKEADFPYMAEMALKDGNAFSNPRKGNEQEIAAIFRQAF

Sequences:

>Translated_387_residues
MSYRMFDYLVPNVNFFGPNAISVVGERCQLLGGKKALLVTDKGLRAIKDGAVDKTLHYLREAGIEVAIFDGVEPNPKDTN
VRDGLAVFRREQCDIIVTVGGGSPHDCGKGIGIAATHEGDLYQYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVLTNTE
TKVKFVIVSWRNLPSVSINDPLLMIGKPAALTAATGMDALTHAVEAYISKDANPVTDAAAMQAIRLIARNLRQAVALGSN
LQARENMAYASLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAVLLPHVARYNLIANPEKFADIAELMGENITGLST
LDAAEKAIAAITRLSMDIGIPQHLRDLGVKEADFPYMAEMALKDGNAFSNPRKGNEQEIAAIFRQAF
>Mature_386_residues
SYRMFDYLVPNVNFFGPNAISVVGERCQLLGGKKALLVTDKGLRAIKDGAVDKTLHYLREAGIEVAIFDGVEPNPKDTNV
RDGLAVFRREQCDIIVTVGGGSPHDCGKGIGIAATHEGDLYQYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVLTNTET
KVKFVIVSWRNLPSVSINDPLLMIGKPAALTAATGMDALTHAVEAYISKDANPVTDAAAMQAIRLIARNLRQAVALGSNL
QARENMAYASLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAVLLPHVARYNLIANPEKFADIAELMGENITGLSTL
DAAEKAIAAITRLSMDIGIPQHLRDLGVKEADFPYMAEMALKDGNAFSNPRKGNEQEIAAIFRQAF

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=418, Percent_Identity=27.2727272727273, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI48994951, Length=380, Percent_Identity=48.6842105263158, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1789163, Length=389, Percent_Identity=43.1876606683805, Blast_Score=300, Evalue=9e-83,
Organism=Escherichia coli, GI87082107, Length=384, Percent_Identity=35.15625, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787493, Length=399, Percent_Identity=33.8345864661654, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1789386, Length=359, Percent_Identity=25.9052924791086, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537053, Length=414, Percent_Identity=25.1207729468599, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321181, Length=382, Percent_Identity=42.9319371727749, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24657991, Length=410, Percent_Identity=25.609756097561, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41466; Mature: 41335

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYRMFDYLVPNVNFFGPNAISVVGERCQLLGGKKALLVTDKGLRAIKDGAVDKTLHYLR
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCHHHHHHHHH
EAGIEVAIFDGVEPNPKDTNVRDGLAVFRREQCDIIVTVGGGSPHDCGKGIGIAATHEGD
HCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCC
LYQYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVLTNTETKVKFVIVSWRNLPSVSIND
CEECCCHHHHCCCCCCEEEEECCCCCHHHHHHHEEEECCCCEEEEEEEEECCCCCCCCCC
PLLMIGKPAALTAATGMDALTHAVEAYISKDANPVTDAAAMQAIRLIARNLRQAVALGSN
CEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LQARENMAYASLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAVLLPHVARYNLIAN
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
PEKFADIAELMGENITGLSTLDAAEKAIAAITRLSMDIGIPQHLRDLGVKEADFPYMAEM
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHH
ALKDGNAFSNPRKGNEQEIAAIFRQAF
HHCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SYRMFDYLVPNVNFFGPNAISVVGERCQLLGGKKALLVTDKGLRAIKDGAVDKTLHYLR
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCHHHHHHHHH
EAGIEVAIFDGVEPNPKDTNVRDGLAVFRREQCDIIVTVGGGSPHDCGKGIGIAATHEGD
HCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCC
LYQYAGIETLTNPLPPIVAVNTTAGTASEVTRHCVLTNTETKVKFVIVSWRNLPSVSIND
CEECCCHHHHCCCCCCEEEEECCCCCHHHHHHHEEEECCCCEEEEEEEEECCCCCCCCCC
PLLMIGKPAALTAATGMDALTHAVEAYISKDANPVTDAAAMQAIRLIARNLRQAVALGSN
CEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LQARENMAYASLLAGMAFNNANLGYVHAMAHQLGGLYDMPHGVANAVLLPHVARYNLIAN
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
PEKFADIAELMGENITGLSTLDAAEKAIAAITRLSMDIGIPQHLRDLGVKEADFPYMAEM
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHH
ALKDGNAFSNPRKGNEQEIAAIFRQAF
HHCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]