Click here to switch to the map view.

The map label for this gene is tolC [H]

Identifier: 238896543

GI number: 238896543

Start: 4521955

End: 4523430

Strand: Direct

Name: tolC [H]

Synonym: KP1_4730

Alternate gene names: 238896543

Gene position: 4521955-4523430 (Clockwise)

Preceding gene: 238896537

Following gene: 238896544

Centisome position: 86.16

GC content: 57.11

Gene sequence:

>1476_bases
ATGCAAATGAAGAAATTGCTCCCCATTCTTATCGGCCTGAGCCTGACCGGGTTCAGCGCCATGAGCCAGGCGGAAAACCT
GCTTCAGGTTTACCAGCAGGCACGCATCAGCAACCCCGATCTGCGTAAATCGGCAGCCGATCGTGACGCCGCGTTCGAAA
AGATCAACGAAGCGCGCAGTCCATTACTGCCTCAGCTTGGGCTGGGAGCGGATTATACCTATACCAATGGCTATCGCGAC
AGCAACGGCGTCAACTCTAACGTCACCAGCGGTTCGCTGCAGTTAACGCAGGTTCTGTTTGATATGTCGAAATGGCGCGC
CCTGACGCTGCAGGAAAAAACGGCAGGGATTCAGGATGTCACGTATCAGACCGATCAGCAAACACTGATTCTGAATACCG
CGACGGCCTATTTTAAAGTGCTGGCCGCCATCGACACGCTCTCCTATACCGAAGCGCAGAAACAGGCCATTTACCGCCAG
TTGGATCAAACCACGCAGCGCTTTAACGTAGGCCTGGTGGCGATCACCGACGTACAGAACGCCCGTTCACAATACGATGC
CGTGCTGGCGAACGAAGTCACCGCGCGTAACGATCTCGACAACGCCGTCGAAGGACTGCGTCAGGTCACCGGTAATTACT
ATCCGGAGCTGGCCTCCCTGAACGTGAATGGCTTTAAAACCAACAAGCCGCAGGCGGTCAACGCCCTGCTGAAGGAAGCG
GAGAACCGCAACCTGTCGTTGCTGCAGGCGCGTCTGAGCCAGGACCTGGCCCGCGAGCAGATTCGTCAGGCGCAGGACGG
CCATTTGCCGACCCTGAACCTTTCCGCCTCTACCGGGGTCTCGAATACGCGTTACAACGGTTCGAAAACCAATACCCCGC
TCGCCTACAACGACAGTGATAACGGGCAGAACCAAATCGGCCTGAACTTCTCTCTGCCACTGTATCAGGGCGGCGCGGTG
ACCTCGCAGGTCAAACAGGCGCAATACAACTTCGTTGGCGCCAGCGAGCAGCTGGAAAGCGCCCACCGCAGCGTAGTGCA
GACTGTGCGTTCATCGTTTAACAACGTGAACGCCTCCATCAGCAGCATCAACGCCTACAAACAGGCGGTGGTCTCTGCGC
AAAGCTCCCTGGATGCCATGGAAGCAGGCTACTCGGTGGGTACACGTACTATCGTTGACGTCCTCGACGCCACCACTACG
CTGTATAACGCTAAGCAGCAGCTTTCGAATGCGCGCTACAACTACCTGATCAACGAGCTGAACATTAAGTCGGCGTTAGG
TACCCTGAACGAGCAGGATCTGGTCGCCCTGAACAACACGCTGGGTAAACCCATCTCCACCTCCGCAGATAGCGTCGCGC
CGGAAAATCCGCAACAGGATGCCACCGCTGATGGCTACGGCAACACTACCGCGGCGGTGAAGCCGGCGTCTGCACGGACC
ACCCAGAGCAGCGGCAGCAATCCGTTCCGTCAGTAA

Upstream 100 bases:

>100_bases
CGGATGGCACGTAACGCCAACTTTTTACGGCGGCAGAATCGATACAATCAGCGGAATTTTTCTTAGAATTAGACCAGCGC
TAAATGCTTCACAACAAGGA

Downstream 100 bases:

>100_bases
TTCTCATACTGTGATGCGCATCGCCTGTCCGTCGGACAGGCGATACGTTAAACGTAAGGCAACGTAAAGATCCCCCGCTT
AGCGCCCCTCTTCGCTTCAT

Product: outer membrane channel protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MQMKKLLPILIGLSLTGFSAMSQAENLLQVYQQARISNPDLRKSAADRDAAFEKINEARSPLLPQLGLGADYTYTNGYRD
SNGVNSNVTSGSLQLTQVLFDMSKWRALTLQEKTAGIQDVTYQTDQQTLILNTATAYFKVLAAIDTLSYTEAQKQAIYRQ
LDQTTQRFNVGLVAITDVQNARSQYDAVLANEVTARNDLDNAVEGLRQVTGNYYPELASLNVNGFKTNKPQAVNALLKEA
ENRNLSLLQARLSQDLAREQIRQAQDGHLPTLNLSASTGVSNTRYNGSKTNTPLAYNDSDNGQNQIGLNFSLPLYQGGAV
TSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNVNASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTT
LYNAKQQLSNARYNYLINELNIKSALGTLNEQDLVALNNTLGKPISTSADSVAPENPQQDATADGYGNTTAAVKPASART
TQSSGSNPFRQ

Sequences:

>Translated_491_residues
MQMKKLLPILIGLSLTGFSAMSQAENLLQVYQQARISNPDLRKSAADRDAAFEKINEARSPLLPQLGLGADYTYTNGYRD
SNGVNSNVTSGSLQLTQVLFDMSKWRALTLQEKTAGIQDVTYQTDQQTLILNTATAYFKVLAAIDTLSYTEAQKQAIYRQ
LDQTTQRFNVGLVAITDVQNARSQYDAVLANEVTARNDLDNAVEGLRQVTGNYYPELASLNVNGFKTNKPQAVNALLKEA
ENRNLSLLQARLSQDLAREQIRQAQDGHLPTLNLSASTGVSNTRYNGSKTNTPLAYNDSDNGQNQIGLNFSLPLYQGGAV
TSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNVNASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTT
LYNAKQQLSNARYNYLINELNIKSALGTLNEQDLVALNNTLGKPISTSADSVAPENPQQDATADGYGNTTAAVKPASART
TQSSGSNPFRQ
>Mature_491_residues
MQMKKLLPILIGLSLTGFSAMSQAENLLQVYQQARISNPDLRKSAADRDAAFEKINEARSPLLPQLGLGADYTYTNGYRD
SNGVNSNVTSGSLQLTQVLFDMSKWRALTLQEKTAGIQDVTYQTDQQTLILNTATAYFKVLAAIDTLSYTEAQKQAIYRQ
LDQTTQRFNVGLVAITDVQNARSQYDAVLANEVTARNDLDNAVEGLRQVTGNYYPELASLNVNGFKTNKPQAVNALLKEA
ENRNLSLLQARLSQDLAREQIRQAQDGHLPTLNLSASTGVSNTRYNGSKTNTPLAYNDSDNGQNQIGLNFSLPLYQGGAV
TSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNVNASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTT
LYNAKQQLSNARYNYLINELNIKSALGTLNEQDLVALNNTLGKPISTSADSVAPENPQQDATADGYGNTTAAVKPASART
TQSSGSNPFRQ

Specific function: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=492, Percent_Identity=83.3333333333333, Blast_Score=806, Evalue=0.0,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 53300; Mature: 53300

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMKKLLPILIGLSLTGFSAMSQAENLLQVYQQARISNPDLRKSAADRDAAFEKINEARS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PLLPQLGLGADYTYTNGYRDSNGVNSNVTSGSLQLTQVLFDMSKWRALTLQEKTAGIQDV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHHCCCCCC
TYQTDQQTLILNTATAYFKVLAAIDTLSYTEAQKQAIYRQLDQTTQRFNVGLVAITDVQN
EEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
ARSQYDAVLANEVTARNDLDNAVEGLRQVTGNYYPELASLNVNGFKTNKPQAVNALLKEA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCHHHHHHHHHH
ENRNLSLLQARLSQDLAREQIRQAQDGHLPTLNLSASTGVSNTRYNGSKTNTPLAYNDSD
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCC
NGQNQIGLNFSLPLYQGGAVTSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNVNASI
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
SSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQQLSNARYNYLINEL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NIKSALGTLNEQDLVALNNTLGKPISTSADSVAPENPQQDATADGYGNTTAAVKPASART
HHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
TQSSGSNPFRQ
CCCCCCCCCCC
>Mature Secondary Structure
MQMKKLLPILIGLSLTGFSAMSQAENLLQVYQQARISNPDLRKSAADRDAAFEKINEARS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PLLPQLGLGADYTYTNGYRDSNGVNSNVTSGSLQLTQVLFDMSKWRALTLQEKTAGIQDV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHHCCCCCC
TYQTDQQTLILNTATAYFKVLAAIDTLSYTEAQKQAIYRQLDQTTQRFNVGLVAITDVQN
EEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
ARSQYDAVLANEVTARNDLDNAVEGLRQVTGNYYPELASLNVNGFKTNKPQAVNALLKEA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCHHHHHHHHHH
ENRNLSLLQARLSQDLAREQIRQAQDGHLPTLNLSASTGVSNTRYNGSKTNTPLAYNDSD
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCC
NGQNQIGLNFSLPLYQGGAVTSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNVNASI
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
SSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQQLSNARYNYLINEL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NIKSALGTLNEQDLVALNNTLGKPISTSADSVAPENPQQDATADGYGNTTAAVKPASART
HHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
TQSSGSNPFRQ
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8801424 [H]