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The map label for this gene is metC [H]

Identifier: 238896521

GI number: 238896521

Start: 4499712

End: 4500899

Strand: Direct

Name: metC [H]

Synonym: KP1_4707

Alternate gene names: 238896521

Gene position: 4499712-4500899 (Clockwise)

Preceding gene: 238896512

Following gene: 238896522

Centisome position: 85.73

GC content: 59.93

Gene sequence:

>1188_bases
ATGGCTGATAAACATCTTGATACCGCGCTGGTCAACGCCGGGCGGAGCAAAAAGTACACCCAGGGCTCAGTGAACAGCGT
TATCCAGCGCGCGTCATCGCTGGTTTTCGACACCGTCGAGGCCAAAAAGTACGCCACCCGCAATCGGGCCAACGGCGAGC
TGTTCTACGGTCGTCGCGGCACCCTGACCCATTTCTCGCTGCAGGAAGCGATGTGCGAGCTGGAAGGCGGCGCCGGCTGC
GCCCTCTTCCCCTGCGGCGCCGCGGCGGTGGCTAACACTATCCTGGCGTTTGTCGAGCAAGGCGACCATGTGCTGATGAC
CAATACCGCCTATGAGCCAAGCCAGGACTTTTGTACCAAAATTCTCGCCAAACTCGGCGTCACCACCAGCTGGTTCGATC
CCTTAATCGGTGCCGATATCGCCCGTCTGGTTCGCCCTGAGACCCGCGTGGTGTTCCTCGAATCGCCCGGCTCGATCACC
ATGGAAGTGCACGATGTGCCGGCGATAGTCGCCGCCGTGCGTCAGGTCGCCCCGGAAGCGATTATCATGATCGATAACAC
CTGGGCGGCGGGGATCCTGTTTAAAGCCCTGGATTTTGGCATTGATATTTCCATTCAGGCAGGCACCAAATACCTGATCG
GCCATTCCGACGCCATGGTGGGCACCGCGGTGGCTAACGCGCGCTGCTGGCCGCAGCTGCGTGAAAATGCCTACCTGATG
GGGCAAATGCTGGACGCCGATACTGCCTATATGACCAGCCGCGGCCTGCGCACCCTGGGCGTTCGCCTGCGTCAGCATCA
TGAAAGCAGCCTGCGCATCGCCGAGTGGCTGGCGCAGCACCCGCAGGTGGCGCGGGTAAACCACCCCGCCCTGCCCGGCA
GTAAAGGTCATGAGTTCTGGAAACGTGATTTCACCGGCAGCAGCGGGCTATTCTCGTTTGTGCTCAGCAAGCGCCTCAAT
GATGCCGAACTGGCGGAGTATCTCGACAATTTCAGCCTGTTCAGTATGGCCTATTCGTGGGGCGGCTTTGAGTCGCTGAT
TCTCGCCAACCAGCCGGAGCAAATCGCCCACATTCGACCGGATGCTGAAGTCGACTTCAGCGGCACGCTGATCCGCCTGC
ACATTGGTCTCGAAAATGTTGACGATCTGCAGGCGGATTTAGCAGCGGGCTTCGCGCGTATCGTGTAA

Upstream 100 bases:

>100_bases
GGCCGGGTAAAATTTTCGCCTGTATCGGCGGTGCGCTGGTACAGAAAAGCAGATTCATGTTAGTTTAGACGTCCAGACGT
ATAAAAACAGGTTCGTCAAC

Downstream 100 bases:

>100_bases
AGTGACAGTCAGTGGCAACAATAGCGGACGCTTTTTAGCAAAGCGGCCGCTTTTGTTGCGCCCGGGATCAAGGTGCTCGG
GCCTCTTCAGGAGTACACTA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MADKHLDTALVNAGRSKKYTQGSVNSVIQRASSLVFDTVEAKKYATRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGC
ALFPCGAAAVANTILAFVEQGDHVLMTNTAYEPSQDFCTKILAKLGVTTSWFDPLIGADIARLVRPETRVVFLESPGSIT
MEVHDVPAIVAAVRQVAPEAIIMIDNTWAAGILFKALDFGIDISIQAGTKYLIGHSDAMVGTAVANARCWPQLRENAYLM
GQMLDADTAYMTSRGLRTLGVRLRQHHESSLRIAEWLAQHPQVARVNHPALPGSKGHEFWKRDFTGSSGLFSFVLSKRLN
DAELAEYLDNFSLFSMAYSWGGFESLILANQPEQIAHIRPDAEVDFSGTLIRLHIGLENVDDLQADLAAGFARIV

Sequences:

>Translated_395_residues
MADKHLDTALVNAGRSKKYTQGSVNSVIQRASSLVFDTVEAKKYATRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGC
ALFPCGAAAVANTILAFVEQGDHVLMTNTAYEPSQDFCTKILAKLGVTTSWFDPLIGADIARLVRPETRVVFLESPGSIT
MEVHDVPAIVAAVRQVAPEAIIMIDNTWAAGILFKALDFGIDISIQAGTKYLIGHSDAMVGTAVANARCWPQLRENAYLM
GQMLDADTAYMTSRGLRTLGVRLRQHHESSLRIAEWLAQHPQVARVNHPALPGSKGHEFWKRDFTGSSGLFSFVLSKRLN
DAELAEYLDNFSLFSMAYSWGGFESLILANQPEQIAHIRPDAEVDFSGTLIRLHIGLENVDDLQADLAAGFARIV
>Mature_394_residues
ADKHLDTALVNAGRSKKYTQGSVNSVIQRASSLVFDTVEAKKYATRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGCA
LFPCGAAAVANTILAFVEQGDHVLMTNTAYEPSQDFCTKILAKLGVTTSWFDPLIGADIARLVRPETRVVFLESPGSITM
EVHDVPAIVAAVRQVAPEAIIMIDNTWAAGILFKALDFGIDISIQAGTKYLIGHSDAMVGTAVANARCWPQLRENAYLMG
QMLDADTAYMTSRGLRTLGVRLRQHHESSLRIAEWLAQHPQVARVNHPALPGSKGHEFWKRDFTGSSGLFSFVLSKRLND
AELAEYLDNFSLFSMAYSWGGFESLILANQPEQIAHIRPDAEVDFSGTLIRLHIGLENVDDLQADLAAGFARIV

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=326, Percent_Identity=31.9018404907975, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI299473759, Length=270, Percent_Identity=32.5925925925926, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI25453487, Length=326, Percent_Identity=28.5276073619632, Blast_Score=128, Evalue=8e-30,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=87.5949367088608, Blast_Score=739, Evalue=0.0,
Organism=Escherichia coli, GI1790375, Length=340, Percent_Identity=33.2352941176471, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71980708, Length=399, Percent_Identity=28.3208020050125, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17538055, Length=332, Percent_Identity=28.0120481927711, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17560056, Length=381, Percent_Identity=29.1338582677165, Blast_Score=164, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321170, Length=337, Percent_Identity=41.2462908011869, Blast_Score=272, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6319307, Length=347, Percent_Identity=30.5475504322767, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6321254, Length=267, Percent_Identity=28.4644194756554, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323333, Length=448, Percent_Identity=25.6696428571429, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6321904, Length=255, Percent_Identity=29.0196078431373, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922554, Length=337, Percent_Identity=29.673590504451, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43219; Mature: 43088

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKHLDTALVNAGRSKKYTQGSVNSVIQRASSLVFDTVEAKKYATRNRANGELFYGRRG
CCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
TLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGDHVLMTNTAYEPSQDFCTK
CEEHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
ILAKLGVTTSWFDPLIGADIARLVRPETRVVFLESPGSITMEVHDVPAIVAAVRQVAPEA
HHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHCCCE
IIMIDNTWAAGILFKALDFGIDISIQAGTKYLIGHSDAMVGTAVANARCWPQLRENAYLM
EEEEECCHHHHHHHHHHHCCEEEEEECCCEEEEECCCHHHHHHHHCCCCCHHHHCCCEEE
GQMLDADTAYMTSRGLRTLGVRLRQHHESSLRIAEWLAQHPQVARVNHPALPGSKGHEFW
HHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHH
KRDFTGSSGLFSFVLSKRLNDAELAEYLDNFSLFSMAYSWGGFESLILANQPEQIAHIRP
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHCCCHHEEEECCCCHHHHCCCC
DAEVDFSGTLIRLHIGLENVDDLQADLAAGFARIV
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADKHLDTALVNAGRSKKYTQGSVNSVIQRASSLVFDTVEAKKYATRNRANGELFYGRRG
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
TLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGDHVLMTNTAYEPSQDFCTK
CEEHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
ILAKLGVTTSWFDPLIGADIARLVRPETRVVFLESPGSITMEVHDVPAIVAAVRQVAPEA
HHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHCCCE
IIMIDNTWAAGILFKALDFGIDISIQAGTKYLIGHSDAMVGTAVANARCWPQLRENAYLM
EEEEECCHHHHHHHHHHHCCEEEEEECCCEEEEECCCHHHHHHHHCCCCCHHHHCCCEEE
GQMLDADTAYMTSRGLRTLGVRLRQHHESSLRIAEWLAQHPQVARVNHPALPGSKGHEFW
HHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHH
KRDFTGSSGLFSFVLSKRLNDAELAEYLDNFSLFSMAYSWGGFESLILANQPEQIAHIRP
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHCCCHHEEEECCCCHHHHCCCC
DAEVDFSGTLIRLHIGLENVDDLQADLAAGFARIV
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]