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The map label for this gene is metB [H]

Identifier: 238896504

GI number: 238896504

Start: 4484447

End: 4485595

Strand: Direct

Name: metB [H]

Synonym: KP1_4685

Alternate gene names: 238896504

Gene position: 4484447-4485595 (Clockwise)

Preceding gene: 238896503

Following gene: 238896506

Centisome position: 85.44

GC content: 63.53

Gene sequence:

>1149_bases
ATGTCATCTATCCACACCCTGAGTGTACATAGCGGAACCTTCACCGACAGCCACGGCGCAGTGATGCCGCCGATTTATGC
CACCTCCACTTTTGCTCAGCTAGCGCCGGGGCAGCATACCGGTTATGAATATTCCCGCAGCGGGAATCCCACCCGCCACG
CGCTGGAGACGGCGATCGCCGACCTGGAAAACGGCACGCGCGGCTACGCGTTCGCCTCAGGGCTGGCCGCCATCTCCACC
GTGCTGGAGCTGCTGGATAAGGACAGTCACCTGGTGGCGGTCGATGATGTGTATGGCGGCACTTACCGCCTGCTGGAAAA
CGTTCGCCGCCGTAGCGCTGGTCTGCAGGTGAGCTGGGTGAAACCCGACGACCTGGCGGGAATTGAAGCGGCGATCCGCC
CCGACACCCGCATGATCTGGGTGGAAACGCCCACCAACCCGCTGCTGAAGCTCGCGGATCTCAGCGCCATCGCCGCCATC
GCGCGCCGCCATAACCTGATCAGCGTCGCCGATAACACCTTCGCTTCGCCGGCGATCCATCGCCCGCTGGAGCATGAGTT
TGATATTGTGGTGCACTCCGCGACCAAGTACCTCAACGGCCATTCCGATGTCGTCGCCGGCCTGGCGGTGGTTGGCGATA
ACTCCGAGCTCGCGGAAAAGCTTGGCTATCTGCAGAATGCGGTAGGCGGCGTGCTTGACCCGTTCAGCAGCTTCCTGACG
CTGCGCGGCATCCGTACCCTGGCGCTGCGGATGGAGCGCCACAGCGCGAACGCGCTGCAGCTCGCCGAATGGCTGGAACA
GCAGCCGGAAGTGGAGCGAGTCTGGTTTCCCTGGCTGGCCTCGCACCCGCATCATCAGCTGGCGCGCCGGCAAATGGCCC
TGCCCGGCGGCATGATTTCGGTGGTGGTGAAGGGCGATGAAGGTTACGCCGAGCGCATTATCAGCAAGCTGCGCTGGTTT
ACGCTTGCGGAGAGCCTGGGCGGCGTGGAGAGTCTGGTGAGCCAGCCCTTCAGCATGACCCATGCCTCGATCCCGCTGGA
GAAACGCCTGGCGAACGGTATCACACCGCAGCTGATCCGCCTGTCGGTGGGGATCGAAGATCCTCACGATCTGATTGCCG
ACTGGCAGCAGGCGCTGCGGGCGGAGTGA

Upstream 100 bases:

>100_bases
GTGGCGGTGATCGCTGACAACGCGCGTTTTCTTGGCCTGGTCACCCGCAGCGATGTATTGACCGCCTGGCGTAACCGAGT
CGCACAATAAGGAATTTTTT

Downstream 100 bases:

>100_bases
TTATTCCGACGCGCGGGTCGTTGTCAGCGCGTCGGCCATTCCCTGCTGAAGGTGGGCGATAAACTGCGTCAGCTTCGGCA
GGGGCCGACGATCCTGGCGC

Product: putative cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSSIHTLSVHSGTFTDSHGAVMPPIYATSTFAQLAPGQHTGYEYSRSGNPTRHALETAIADLENGTRGYAFASGLAAIST
VLELLDKDSHLVAVDDVYGGTYRLLENVRRRSAGLQVSWVKPDDLAGIEAAIRPDTRMIWVETPTNPLLKLADLSAIAAI
ARRHNLISVADNTFASPAIHRPLEHEFDIVVHSATKYLNGHSDVVAGLAVVGDNSELAEKLGYLQNAVGGVLDPFSSFLT
LRGIRTLALRMERHSANALQLAEWLEQQPEVERVWFPWLASHPHHQLARRQMALPGGMISVVVKGDEGYAERIISKLRWF
TLAESLGGVESLVSQPFSMTHASIPLEKRLANGITPQLIRLSVGIEDPHDLIADWQQALRAE

Sequences:

>Translated_382_residues
MSSIHTLSVHSGTFTDSHGAVMPPIYATSTFAQLAPGQHTGYEYSRSGNPTRHALETAIADLENGTRGYAFASGLAAIST
VLELLDKDSHLVAVDDVYGGTYRLLENVRRRSAGLQVSWVKPDDLAGIEAAIRPDTRMIWVETPTNPLLKLADLSAIAAI
ARRHNLISVADNTFASPAIHRPLEHEFDIVVHSATKYLNGHSDVVAGLAVVGDNSELAEKLGYLQNAVGGVLDPFSSFLT
LRGIRTLALRMERHSANALQLAEWLEQQPEVERVWFPWLASHPHHQLARRQMALPGGMISVVVKGDEGYAERIISKLRWF
TLAESLGGVESLVSQPFSMTHASIPLEKRLANGITPQLIRLSVGIEDPHDLIADWQQALRAE
>Mature_381_residues
SSIHTLSVHSGTFTDSHGAVMPPIYATSTFAQLAPGQHTGYEYSRSGNPTRHALETAIADLENGTRGYAFASGLAAISTV
LELLDKDSHLVAVDDVYGGTYRLLENVRRRSAGLQVSWVKPDDLAGIEAAIRPDTRMIWVETPTNPLLKLADLSAIAAIA
RRHNLISVADNTFASPAIHRPLEHEFDIVVHSATKYLNGHSDVVAGLAVVGDNSELAEKLGYLQNAVGGVLDPFSSFLTL
RGIRTLALRMERHSANALQLAEWLEQQPEVERVWFPWLASHPHHQLARRQMALPGGMISVVVKGDEGYAERIISKLRWFT
LAESLGGVESLVSQPFSMTHASIPLEKRLANGITPQLIRLSVGIEDPHDLIADWQQALRAE

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=363, Percent_Identity=49.0358126721763, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI299473759, Length=363, Percent_Identity=44.6280991735537, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI25453487, Length=362, Percent_Identity=43.646408839779, Blast_Score=269, Evalue=4e-72,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=41.7989417989418, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1789383, Length=338, Percent_Identity=31.0650887573964, Blast_Score=161, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17538055, Length=362, Percent_Identity=48.3425414364641, Blast_Score=332, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17560056, Length=362, Percent_Identity=46.9613259668508, Blast_Score=324, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=38.0053908355795, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319307, Length=383, Percent_Identity=45.9530026109661, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6321254, Length=408, Percent_Identity=34.0686274509804, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323333, Length=436, Percent_Identity=33.256880733945, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321170, Length=328, Percent_Identity=32.6219512195122, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6321904, Length=349, Percent_Identity=28.3667621776504, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI19922554, Length=383, Percent_Identity=47.5195822454308, Blast_Score=356, Evalue=1e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41773; Mature: 41642

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIHTLSVHSGTFTDSHGAVMPPIYATSTFAQLAPGQHTGYEYSRSGNPTRHALETAIA
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
DLENGTRGYAFASGLAAISTVLELLDKDSHLVAVDDVYGGTYRLLENVRRRSAGLQVSWV
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEE
KPDDLAGIEAAIRPDTRMIWVETPTNPLLKLADLSAIAAIARRHNLISVADNTFASPAIH
CCCCCCCCHHEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHC
RPLEHEFDIVVHSATKYLNGHSDVVAGLAVVGDNSELAEKLGYLQNAVGGVLDPFSSFLT
CCCCCCHHEEEEHHHHHHCCCHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGIRTLALRMERHSANALQLAEWLEQQPEVERVWFPWLASHPHHQLARRQMALPGGMIS
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHEEECHHHCCCCHHHHHHHHHCCCCCEEE
VVVKGDEGYAERIISKLRWFTLAESLGGVESLVSQPFSMTHASIPLEKRLANGITPQLIR
EEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHCCCCHHHHHHCCCCCEEEE
LSVGIEDPHDLIADWQQALRAE
EEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSIHTLSVHSGTFTDSHGAVMPPIYATSTFAQLAPGQHTGYEYSRSGNPTRHALETAIA
CCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
DLENGTRGYAFASGLAAISTVLELLDKDSHLVAVDDVYGGTYRLLENVRRRSAGLQVSWV
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEE
KPDDLAGIEAAIRPDTRMIWVETPTNPLLKLADLSAIAAIARRHNLISVADNTFASPAIH
CCCCCCCCHHEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHC
RPLEHEFDIVVHSATKYLNGHSDVVAGLAVVGDNSELAEKLGYLQNAVGGVLDPFSSFLT
CCCCCCHHEEEEHHHHHHCCCHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGIRTLALRMERHSANALQLAEWLEQQPEVERVWFPWLASHPHHQLARRQMALPGGMIS
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHEEECHHHCCCCHHHHHHHHHCCCCCEEE
VVVKGDEGYAERIISKLRWFTLAESLGGVESLVSQPFSMTHASIPLEKRLANGITPQLIR
EEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHCCCCHHHHHHCCCCCEEEE
LSVGIEDPHDLIADWQQALRAE
EEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]