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The map label for this gene is cbs [H]

Identifier: 238896503

GI number: 238896503

Start: 4483066

End: 4484436

Strand: Direct

Name: cbs [H]

Synonym: KP1_4684

Alternate gene names: 238896503

Gene position: 4483066-4484436 (Clockwise)

Preceding gene: 238896498

Following gene: 238896504

Centisome position: 85.42

GC content: 60.9

Gene sequence:

>1371_bases
ATGTCACTGTTTCATTCCGTGAGCGACCTGATCGGTCATACTCCCCTGCTCCAGTTGCACAAACTGGATACCGGGCCCTG
CAGTCTGTTTTTAAAACTGGAAAATCAGAACCCCGGCGGGTCAATTAAAGATCGGGTTGCGCTGTCGATGATTAATGAAG
CCGAGCGCCAGGGAAAACTGGCGCCCGGGGGAACGATTATCGAAGCCACCGCCGGCAACACCGGTCTCGGCCTGGCGCTG
ATCGCGGCGCAGAAAAATTACCGCCTGATCCTGGTGGTGCCGGACAAAATGAGCCGCGAGAAAATCTTTCATCTGCGGGC
GCTGGGCGCGACGGTGCTGCTCACCCGCTCCGACGTCAATAAAGGCCACCCGGCCTACTACCAGGATTATGCCCGCCGCC
TTGCCGATGAAACGCCGGGCGCCTTTTATATCGACCAGTTTAACAACGACGCTAATCCGCTGGCCCATGCCACCTCCACT
GCGCCGGAGCTTTATCAGCAGCTGGAGGGCGACATCGACGCCATCATCGTCGGCGTCGGCTCCGGCGGCACGCTGGGTGG
GCTTCAGGCCTGGTTTGCTGAGCACTCGCCGAAAACGGAATTTATTCTCGCCGATCCGGCGGGTTCGATCCTAGCCGATC
AGGTCGACACCGGACGCTACGGCGAAACGGGATCCTGGCTGGTCGAAGGGATCGGCGAAGATTTTATCCCGCCGCTGGCC
AGGCTGGAGGGGGTACATACCGCGTATCGCGTCAGCGACCGCGAAGCATTCCAGACTGCGCGCCAGCTGCTGCAGGTCGA
AGGCGTGCTGGCCGGTTCTTCCACCGGCACCCTGCTCAGCGCCGCGCTGCGCTACTGCCGGGCGCAAAGCCGTCCGAAAC
GGGTAGTAACCTTCGCCTGCGACAGCGGCAATAAATACCTGTCCAAAATGTTCAACGACGACTGGATGCGCCAGCAAGGA
CTGATTGCCCGCCCCGAACAGGGCGATCTCAGTGATTTTATCGCCCTGCGCCATGACGAAGGCGCTACCGTCACGGCCGC
GCCGGACGACACCCTGGCCGCGGTCTTTACCCGCATGCGGCTGTATGACATCTCCCAGCTGCCGGTTCTGGAGGATGGCC
GCGTGGTCGGCATCGTCGATGAGTGGGATTTGATCCGCCACGTACAGGGCGATCGCCAACGCTTCTCCCTGCCGGTTAGC
GAAGCGATGAGTCGCCATGTTGAAACCCTCGATAAGCATGCGCCCGAGAGCGAACTGCAGGCCATTCTCGATCGCGGTCT
GGTGGCGGTGATCGCTGACAACGCGCGTTTTCTTGGCCTGGTCACCCGCAGCGATGTATTGACCGCCTGGCGTAACCGAG
TCGCACAATAA

Upstream 100 bases:

>100_bases
TATATTCCATTTTGCGCTAAATGACAGAGAAATATTCTTTAAATAACCGTTTTCACAGTTCTAGCATGCAAAAATATCTT
AAACGAGTGGGTAAATGGTT

Downstream 100 bases:

>100_bases
GGAATTTTTTATGTCATCTATCCACACCCTGAGTGTACATAGCGGAACCTTCACCGACAGCCACGGCGCAGTGATGCCGC
CGATTTATGCCACCTCCACT

Product: putative pyridoxal-5'-phosphate-dependent enzyme beta subunit

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSLFHSVSDLIGHTPLLQLHKLDTGPCSLFLKLENQNPGGSIKDRVALSMINEAERQGKLAPGGTIIEATAGNTGLGLAL
IAAQKNYRLILVVPDKMSREKIFHLRALGATVLLTRSDVNKGHPAYYQDYARRLADETPGAFYIDQFNNDANPLAHATST
APELYQQLEGDIDAIIVGVGSGGTLGGLQAWFAEHSPKTEFILADPAGSILADQVDTGRYGETGSWLVEGIGEDFIPPLA
RLEGVHTAYRVSDREAFQTARQLLQVEGVLAGSSTGTLLSAALRYCRAQSRPKRVVTFACDSGNKYLSKMFNDDWMRQQG
LIARPEQGDLSDFIALRHDEGATVTAAPDDTLAAVFTRMRLYDISQLPVLEDGRVVGIVDEWDLIRHVQGDRQRFSLPVS
EAMSRHVETLDKHAPESELQAILDRGLVAVIADNARFLGLVTRSDVLTAWRNRVAQ

Sequences:

>Translated_456_residues
MSLFHSVSDLIGHTPLLQLHKLDTGPCSLFLKLENQNPGGSIKDRVALSMINEAERQGKLAPGGTIIEATAGNTGLGLAL
IAAQKNYRLILVVPDKMSREKIFHLRALGATVLLTRSDVNKGHPAYYQDYARRLADETPGAFYIDQFNNDANPLAHATST
APELYQQLEGDIDAIIVGVGSGGTLGGLQAWFAEHSPKTEFILADPAGSILADQVDTGRYGETGSWLVEGIGEDFIPPLA
RLEGVHTAYRVSDREAFQTARQLLQVEGVLAGSSTGTLLSAALRYCRAQSRPKRVVTFACDSGNKYLSKMFNDDWMRQQG
LIARPEQGDLSDFIALRHDEGATVTAAPDDTLAAVFTRMRLYDISQLPVLEDGRVVGIVDEWDLIRHVQGDRQRFSLPVS
EAMSRHVETLDKHAPESELQAILDRGLVAVIADNARFLGLVTRSDVLTAWRNRVAQ
>Mature_455_residues
SLFHSVSDLIGHTPLLQLHKLDTGPCSLFLKLENQNPGGSIKDRVALSMINEAERQGKLAPGGTIIEATAGNTGLGLALI
AAQKNYRLILVVPDKMSREKIFHLRALGATVLLTRSDVNKGHPAYYQDYARRLADETPGAFYIDQFNNDANPLAHATSTA
PELYQQLEGDIDAIIVGVGSGGTLGGLQAWFAEHSPKTEFILADPAGSILADQVDTGRYGETGSWLVEGIGEDFIPPLAR
LEGVHTAYRVSDREAFQTARQLLQVEGVLAGSSTGTLLSAALRYCRAQSRPKRVVTFACDSGNKYLSKMFNDDWMRQQGL
IARPEQGDLSDFIALRHDEGATVTAAPDDTLAAVFTRMRLYDISQLPVLEDGRVVGIVDEWDLIRHVQGDRQRFSLPVSE
AMSRHVETLDKHAPESELQAILDRGLVAVIADNARFLGLVTRSDVLTAWRNRVAQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=380, Percent_Identity=38.9473684210526, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI295821200, Length=380, Percent_Identity=38.9473684210526, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4557415, Length=380, Percent_Identity=38.9473684210526, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI2367138, Length=322, Percent_Identity=36.6459627329193, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1788754, Length=322, Percent_Identity=36.0248447204969, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17534315, Length=330, Percent_Identity=38.7878787878788, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI25147552, Length=329, Percent_Identity=36.1702127659575, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=35.1437699680511, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=36.4238410596026, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=36.0655737704918, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI115535073, Length=342, Percent_Identity=34.2105263157895, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17561720, Length=314, Percent_Identity=32.8025477707006, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=227, Percent_Identity=31.7180616740088, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17539800, Length=347, Percent_Identity=24.4956772334294, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=343, Percent_Identity=27.9883381924198, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321594, Length=494, Percent_Identity=34.0080971659919, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6321449, Length=336, Percent_Identity=34.2261904761905, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24643623, Length=461, Percent_Identity=34.4902386117137, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI20129101, Length=461, Percent_Identity=34.4902386117137, Blast_Score=235, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49838; Mature: 49707

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFHSVSDLIGHTPLLQLHKLDTGPCSLFLKLENQNPGGSIKDRVALSMINEAERQGKL
CCHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
APGGTIIEATAGNTGLGLALIAAQKNYRLILVVPDKMSREKIFHLRALGATVLLTRSDVN
CCCCEEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCC
KGHPAYYQDYARRLADETPGAFYIDQFNNDANPLAHATSTAPELYQQLEGDIDAIIVGVG
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHCCCCHHHHHHHHCCCEEEEEEECC
SGGTLGGLQAWFAEHSPKTEFILADPAGSILADQVDTGRYGETGSWLVEGIGEDFIPPLA
CCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHH
RLEGVHTAYRVSDREAFQTARQLLQVEGVLAGSSTGTLLSAALRYCRAQSRPKRVVTFAC
HHCCCHHHHCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEE
DSGNKYLSKMFNDDWMRQQGLIARPEQGDLSDFIALRHDEGATVTAAPDDTLAAVFTRMR
CCCCHHHHHHHCHHHHHHCCCEECCCCCCHHHHHEEEECCCCEEEECCCHHHHHHHHHHH
LYDISQLPVLEDGRVVGIVDEWDLIRHVQGDRQRFSLPVSEAMSRHVETLDKHAPESELQ
HHCCCCCCEECCCCEEEEECHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
AILDRGLVAVIADNARFLGLVTRSDVLTAWRNRVAQ
HHHHCCEEEEEECCCEEEEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLFHSVSDLIGHTPLLQLHKLDTGPCSLFLKLENQNPGGSIKDRVALSMINEAERQGKL
CHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
APGGTIIEATAGNTGLGLALIAAQKNYRLILVVPDKMSREKIFHLRALGATVLLTRSDVN
CCCCEEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCC
KGHPAYYQDYARRLADETPGAFYIDQFNNDANPLAHATSTAPELYQQLEGDIDAIIVGVG
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHCCCCHHHHHHHHCCCEEEEEEECC
SGGTLGGLQAWFAEHSPKTEFILADPAGSILADQVDTGRYGETGSWLVEGIGEDFIPPLA
CCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHH
RLEGVHTAYRVSDREAFQTARQLLQVEGVLAGSSTGTLLSAALRYCRAQSRPKRVVTFAC
HHCCCHHHHCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEE
DSGNKYLSKMFNDDWMRQQGLIARPEQGDLSDFIALRHDEGATVTAAPDDTLAAVFTRMR
CCCCHHHHHHHCHHHHHHCCCEECCCCCCHHHHHEEEECCCCEEEECCCHHHHHHHHHHH
LYDISQLPVLEDGRVVGIVDEWDLIRHVQGDRQRFSLPVSEAMSRHVETLDKHAPESELQ
HHCCCCCCEECCCCEEEEECHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
AILDRGLVAVIADNARFLGLVTRSDVLTAWRNRVAQ
HHHHCCEEEEEECCCEEEEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]