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The map label for this gene is cscR [H]

Identifier: 238896372

GI number: 238896372

Start: 4354374

End: 4355369

Strand: Direct

Name: cscR [H]

Synonym: KP1_4539

Alternate gene names: 238896372

Gene position: 4354374-4355369 (Clockwise)

Preceding gene: 238896367

Following gene: 238896375

Centisome position: 82.96

GC content: 62.15

Gene sequence:

>996_bases
ATGGCGTCCCTGAAAGATGTAGCAAAACTGGCGAATGTATCTCTGATGACCGTCTCACGGGCGCTGAACACCCCGGAGCG
GCTGAAGCCTGAGACACTGGCCCGCGTGCAGGCCGCCATCGCCGAAACCAACTACGTCCCCGACCTGTCGGCGAAGAAGA
TCCGCGGGGCGCGCGCAACCCCCAGCACCATCGGCGTGCTGGCGCTGGATACCGTGACCACGCCCTTTTCGGTGGAGATC
ACCTTATCGATCGAAGAGACGGCCCGCGCCCACGGCTGGAATAGCTTTGTGGTCAATATGTTTTCTGACGATCGTCCGGA
AGCGGTGGTCGACCTGCTCCTCTCCCACCGTCCGGACGGCATTATCTTTACCACCATGGGCCTGCGCCAGGTACCACTGC
CGGAAAAACTGCTGACTCTGCCCTGCGTGCTGGCCAACTGCGAAAGCCTCAGCCAGCCGGTGGCCAGCTATATCCCGGAC
GATGAACAGGGGCAGTACGACGCGGTGAAAGCCCTGCTTGCCGCTGGCTATCGTCGTCCGCTGTGCCTGCACTTACCCGC
CAGCCAGCCGGCGACGATCCGCCGCCGCCTGGGGCTGGAGCGCGCCTGCCGGGAGGCCGGTATCGAACCGGACCATCTGA
GCCATTCGTATATGGGCCAGGGCGATGAGCATTACCACGATATCCCGGCGGTGGTGCTGGCGCATATCCGCGAGGGTAAA
CCTGGCTTTGACTCAGTGATCTGCGGCAACGATCGCATCGCGTTTATGGTCTACCAGACGCTGCTGGGCCAGGGGTTACG
CATTCCACAGGACGTGGCGGTAGTGGGATACGACAACATGGTGGGCATTGGCGATCTGTTTCTACCGCCGCTCTCCACAG
TGCAACTGCCGCATTATGACATCGGGCGCCTGAGCGCCCTGCATATCATTCACGGCGACAACCATCGGGAGACGCGCAAA
GTCGCCAGCCCGTGGTTGCCGCGCGCCTCACATTAA

Upstream 100 bases:

>100_bases
CAACATAGCTCACGACGGCGATAGCAGAAAATCGTTTCACTCTTTTACATCAGCGACTTAGTTGTATAGCCTGTACTCTG
CGGCAATGGCGGAGGAAAAA

Downstream 100 bases:

>100_bases
CGATTACCGATGTTGCGCAGCTTCTCGCCCGCCATCAGGTTGCGCTCAATGTGCTCGAGGGTGACATTCTTGGTTTCCGG
GATCAGCCAGAAGGTGATGC

Product: putative LacI family regulatory protein

Products: NA

Alternate protein names: Csc operon regulatory protein [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MASLKDVAKLANVSLMTVSRALNTPERLKPETLARVQAAIAETNYVPDLSAKKIRGARATPSTIGVLALDTVTTPFSVEI
TLSIEETARAHGWNSFVVNMFSDDRPEAVVDLLLSHRPDGIIFTTMGLRQVPLPEKLLTLPCVLANCESLSQPVASYIPD
DEQGQYDAVKALLAAGYRRPLCLHLPASQPATIRRRLGLERACREAGIEPDHLSHSYMGQGDEHYHDIPAVVLAHIREGK
PGFDSVICGNDRIAFMVYQTLLGQGLRIPQDVAVVGYDNMVGIGDLFLPPLSTVQLPHYDIGRLSALHIIHGDNHRETRK
VASPWLPRASH

Sequences:

>Translated_331_residues
MASLKDVAKLANVSLMTVSRALNTPERLKPETLARVQAAIAETNYVPDLSAKKIRGARATPSTIGVLALDTVTTPFSVEI
TLSIEETARAHGWNSFVVNMFSDDRPEAVVDLLLSHRPDGIIFTTMGLRQVPLPEKLLTLPCVLANCESLSQPVASYIPD
DEQGQYDAVKALLAAGYRRPLCLHLPASQPATIRRRLGLERACREAGIEPDHLSHSYMGQGDEHYHDIPAVVLAHIREGK
PGFDSVICGNDRIAFMVYQTLLGQGLRIPQDVAVVGYDNMVGIGDLFLPPLSTVQLPHYDIGRLSALHIIHGDNHRETRK
VASPWLPRASH
>Mature_330_residues
ASLKDVAKLANVSLMTVSRALNTPERLKPETLARVQAAIAETNYVPDLSAKKIRGARATPSTIGVLALDTVTTPFSVEIT
LSIEETARAHGWNSFVVNMFSDDRPEAVVDLLLSHRPDGIIFTTMGLRQVPLPEKLLTLPCVLANCESLSQPVASYIPDD
EQGQYDAVKALLAAGYRRPLCLHLPASQPATIRRRLGLERACREAGIEPDHLSHSYMGQGDEHYHDIPAVVLAHIREGKP
GFDSVICGNDRIAFMVYQTLLGQGLRIPQDVAVVGYDNMVGIGDLFLPPLSTVQLPHYDIGRLSALHIIHGDNHRETRKV
ASPWLPRASH

Specific function: Repressor for the csc operon. Binds D-fructose as an inducer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=313, Percent_Identity=29.3929712460064, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790194, Length=318, Percent_Identity=28.9308176100629, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787948, Length=310, Percent_Identity=28.7096774193548, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790715, Length=319, Percent_Identity=25.3918495297806, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI48994940, Length=311, Percent_Identity=27.3311897106109, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789202, Length=312, Percent_Identity=26.2820512820513, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786540, Length=314, Percent_Identity=27.3885350318471, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788474, Length=335, Percent_Identity=25.0746268656716, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789068, Length=313, Percent_Identity=25.5591054313099, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787906, Length=269, Percent_Identity=26.7657992565056, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36249; Mature: 36118

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLKDVAKLANVSLMTVSRALNTPERLKPETLARVQAAIAETNYVPDLSAKKIRGARAT
CCCHHHHHHHHCCHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
PSTIGVLALDTVTTPFSVEITLSIEETARAHGWNSFVVNMFSDDRPEAVVDLLLSHRPDG
CCCEEEEEEECCCCCEEEEEEEEEHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCC
IIFTTMGLRQVPLPEKLLTLPCVLANCESLSQPVASYIPDDEQGQYDAVKALLAAGYRRP
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
LCLHLPASQPATIRRRLGLERACREAGIEPDHLSHSYMGQGDEHYHDIPAVVLAHIREGK
EEEECCCCCCHHHHHHHCHHHHHHHCCCCHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCC
PGFDSVICGNDRIAFMVYQTLLGQGLRIPQDVAVVGYDNMVGIGDLFLPPLSTVQLPHYD
CCCCCEEECCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHCCCCCCEECCCCC
IGRLSALHIIHGDNHRETRKVASPWLPRASH
CCCEEEEEEEECCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ASLKDVAKLANVSLMTVSRALNTPERLKPETLARVQAAIAETNYVPDLSAKKIRGARAT
CCHHHHHHHHCCHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
PSTIGVLALDTVTTPFSVEITLSIEETARAHGWNSFVVNMFSDDRPEAVVDLLLSHRPDG
CCCEEEEEEECCCCCEEEEEEEEEHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCC
IIFTTMGLRQVPLPEKLLTLPCVLANCESLSQPVASYIPDDEQGQYDAVKALLAAGYRRP
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
LCLHLPASQPATIRRRLGLERACREAGIEPDHLSHSYMGQGDEHYHDIPAVVLAHIREGK
EEEECCCCCCHHHHHHHCHHHHHHHCCCCHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCC
PGFDSVICGNDRIAFMVYQTLLGQGLRIPQDVAVVGYDNMVGIGDLFLPPLSTVQLPHYD
CCCCCEEECCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHCCCCCCEECCCCC
IGRLSALHIIHGDNHRETRKVASPWLPRASH
CCCEEEEEEEECCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA