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The map label for this gene is lysR [H]

Identifier: 238896362

GI number: 238896362

Start: 4343161

End: 4344087

Strand: Direct

Name: lysR [H]

Synonym: KP1_4527

Alternate gene names: 238896362

Gene position: 4343161-4344087 (Clockwise)

Preceding gene: 238896360

Following gene: 238896364

Centisome position: 82.75

GC content: 65.7

Gene sequence:

>927_bases
ATGCCAGCCGTCAATTTGCGTCATATCGAAATCTTTCACGCGGTGATGACCACCGGCAACCTGACCGAAGCGGCGCGGAT
GCTGCACACCTCGCAACCCACGGTCAGTCGCGAGCTGGCGCGCTTTGAGAAGGTGCTCGGCCTGCAGCTGTTTGAGCGGA
CCCGCGGTCGCCTGCAGCCGACGGTGCAGGGCCTGCGTTTGTTTGAGGAGGTTCAGCGCTCCTGGTATGGCCTGGACCGT
ATCGTCAGCGCCGCCGAGAGCCTGCGCGAGTTCCGCCAGGGCGAGCTGTCGATCGCCTGTCTGCCGGTGTTTTCCCAGTC
CTTTCTGCCGCTGCTGTTGCCGCCGTTTCTCTCTCGCTATCCGGAGGTCAGCCTGCAGATCGTCCCCCAGGAGTCGCCGC
TGCTGGAGGAGTGGCTCTCCGCCCAGCGCCATGACCTTGGCCTGACGGAGACCCTGCATACCCCCGCGGGCACCGAACGC
ACCCCGCTGCTGACGCTGAATGAAGTCTGCGTGCTGCCCGCCGGCCATCCGCTGGCGGCGCAGGCGACGCTGACCCCCGC
CGATTTTCAGGGCGAAAACTACATCAGCCTGTCGCGCACCGACAGCTATCGCCAGCTGCTCGACGCCCTGTTCCTTGAGC
ATCAGGTTAAACGGCGGATGGTGGTCGAAACCCACAGCGCGGCCTCGATCTGCGCCATGGTGCGCGCCGGCGCCGGGATC
TCGGTGGTGAATCCGTTAACCGCCCTGGACTATGCCGATAGCGGCGTGGTGGTGCGCCGCTTCAGCGTCGAGGTGCCGTT
TACCGTCAGCCTGATCCGCCCTCTCCACCGCCCGCGCTCGGCGCTGGTCGACGCCTTTGTTGCCCACCTGCAGCAGAGTC
TGCCGCAGATCCTCACGCCGCTGGCGTCGGTCCTGCAGAGAGCATAA

Upstream 100 bases:

>100_bases
TTTTCTGATTACGCCACAGTGACAGACGAATAAAAAATATCGTTTTATCGCGACTCTATGCAAAAATGATATGGTTCCAG
CCGAGCCTCACGGAGACCGC

Downstream 100 bases:

>100_bases
AGTTGACCGCGTCTTCCGCGTGGATCGCCGCGGTGTCAAAGACCGGCAGCGGACTGAGCTCGGCAGGCACCAGCAGGCCA
ATCTCCGTACAGCCGAAAAT

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MPAVNLRHIEIFHAVMTTGNLTEAARMLHTSQPTVSRELARFEKVLGLQLFERTRGRLQPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIACLPVFSQSFLPLLLPPFLSRYPEVSLQIVPQESPLLEEWLSAQRHDLGLTETLHTPAGTER
TPLLTLNEVCVLPAGHPLAAQATLTPADFQGENYISLSRTDSYRQLLDALFLEHQVKRRMVVETHSAASICAMVRAGAGI
SVVNPLTALDYADSGVVVRRFSVEVPFTVSLIRPLHRPRSALVDAFVAHLQQSLPQILTPLASVLQRA

Sequences:

>Translated_308_residues
MPAVNLRHIEIFHAVMTTGNLTEAARMLHTSQPTVSRELARFEKVLGLQLFERTRGRLQPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIACLPVFSQSFLPLLLPPFLSRYPEVSLQIVPQESPLLEEWLSAQRHDLGLTETLHTPAGTER
TPLLTLNEVCVLPAGHPLAAQATLTPADFQGENYISLSRTDSYRQLLDALFLEHQVKRRMVVETHSAASICAMVRAGAGI
SVVNPLTALDYADSGVVVRRFSVEVPFTVSLIRPLHRPRSALVDAFVAHLQQSLPQILTPLASVLQRA
>Mature_307_residues
PAVNLRHIEIFHAVMTTGNLTEAARMLHTSQPTVSRELARFEKVLGLQLFERTRGRLQPTVQGLRLFEEVQRSWYGLDRI
VSAAESLREFRQGELSIACLPVFSQSFLPLLLPPFLSRYPEVSLQIVPQESPLLEEWLSAQRHDLGLTETLHTPAGTERT
PLLTLNEVCVLPAGHPLAAQATLTPADFQGENYISLSRTDSYRQLLDALFLEHQVKRRMVVETHSAASICAMVRAGAGIS
VVNPLTALDYADSGVVVRRFSVEVPFTVSLIRPLHRPRSALVDAFVAHLQQSLPQILTPLASVLQRA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=308, Percent_Identity=84.7402597402597, Blast_Score=533, Evalue=1e-153,
Organism=Escherichia coli, GI157672245, Length=230, Percent_Identity=28.695652173913, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI145693105, Length=238, Percent_Identity=24.7899159663866, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788887, Length=306, Percent_Identity=27.1241830065359, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787530, Length=240, Percent_Identity=27.0833333333333, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788481, Length=283, Percent_Identity=25.7950530035336, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=26.6932270916335, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790262, Length=264, Percent_Identity=25.3787878787879, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081904, Length=148, Percent_Identity=30.4054054054054, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788297, Length=242, Percent_Identity=24.7933884297521, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=22.6337448559671, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34293; Mature: 34162

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVNLRHIEIFHAVMTTGNLTEAARMLHTSQPTVSRELARFEKVLGLQLFERTRGRLQP
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPLLLPPFLSRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCC
PEVSLQIVPQESPLLEEWLSAQRHDLGLTETLHTPAGTERTPLLTLNEVCVLPAGHPLAA
CCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEECCEEEECCCCCCCC
QATLTPADFQGENYISLSRTDSYRQLLDALFLEHQVKRRMVVETHSAASICAMVRAGAGI
CEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
SVVNPLTALDYADSGVVVRRFSVEVPFTVSLIRPLHRPRSALVDAFVAHLQQSLPQILTP
CHHCCHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LASVLQRA
HHHHHHCC
>Mature Secondary Structure 
PAVNLRHIEIFHAVMTTGNLTEAARMLHTSQPTVSRELARFEKVLGLQLFERTRGRLQP
CCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPLLLPPFLSRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCC
PEVSLQIVPQESPLLEEWLSAQRHDLGLTETLHTPAGTERTPLLTLNEVCVLPAGHPLAA
CCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEECCEEEECCCCCCCC
QATLTPADFQGENYISLSRTDSYRQLLDALFLEHQVKRRMVVETHSAASICAMVRAGAGI
CEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
SVVNPLTALDYADSGVVVRRFSVEVPFTVSLIRPLHRPRSALVDAFVAHLQQSLPQILTP
CHHCCHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LASVLQRA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]