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The map label for this gene is argA [H]

Identifier: 238896332

GI number: 238896332

Start: 4307150

End: 4308481

Strand: Direct

Name: argA [H]

Synonym: KP1_4495

Alternate gene names: 238896332

Gene position: 4307150-4308481 (Clockwise)

Preceding gene: 238896329

Following gene: 238896333

Centisome position: 82.06

GC content: 58.41

Gene sequence:

>1332_bases
ATGGTGAAGGAACGTCGCACTGAACTGGTAGAAGGATTCCGCCATTCTGTTCCCTATATTAATGCCCATCGGGGAAAAAC
GTTTGTCATCATGCTGGGCGGCGAAGCCATTGAGCATGAAAATTTCTCAAATATTGTCAATGACATAGGATTATTGCATA
GCCTGGGCATTCGCCTGGTGGTGGTCTATGGCGCCCGCCCGCAGATTGACGCTAACCTCGCCGAGCACCATCACGAGCCG
GTCTATCACAAGCAGACGCGAGTGACTGACGCCAAAACGCTGGAGCTGGTTAAGCAGGCGGCGGGGATGCTGCAGCTGGA
GATCACCGCCCGTCTGTCGATGAGCCTCAACAACACCCCGCTGCAGGGGGCCCATATCAACGTTGTCAGCGGCAACTTTA
TCATTGCCCAGCCGCTGGGCGTCGATGACGGCGTCGATTATTGCCACAGCGGACGCATTCGCCGCATTGACGAAGAGGCG
ATTCATCGTCAGCTCGACAGCGGCGCCATTGTCCTGATGGGGCCGGTCGCGGTGTCGGTCACCGGCGAGAGCTTTAACCT
GACTTCGGAAGAGATCGCTACCCAGCTGGCCATCAAGCTGAAGGCGGAGAAAATGATCGGCTTCTGTTCGTCGCAAGGGG
TTTACAACCAGGCCGGGGAAATTGTCTCCGAACTGTTCCCTAATGAGGCGCAGGCCCGCGTCGAAGAGCTGGAAGCAGAC
GAAGACTATAACTCCGGCACCGTGCGCTTCCTGCGCGGGGCGGTGAAGGCCTGCCGCAGCGGCGTACGGCGCTGCCACCT
GATCAGCTATCAGGAAAATGGCGCGCTGCTGCAGGAGCTGTTTTCACGCGACGGCATCGGCACCCAGATCGTCATGGAGA
GCGCGGAGCAGATCCGTCGGGCGACCATCAATGATATCGGCGGTATTCTTGAGCTGATAAGCCCGCTCGAGCAGCAGGGC
ATTCTGGTACGCCGTTCCCGCGAACAGCTGGAGATGGAGATCGACAAATTCACCATTATTCAGCGCGATAACACCACCAT
CGCCTGCGCCGCCCTCTATCCTTTCCCGGAAGAGAAGATCGGCGAAATGGCCTGCGTGGCGGTGCATCCGGATTACCGGA
GCTCGTCGCGGGGAGAGGTGCTGCTGGAGCGTATTGCCGCTCAGGCCAGGCAGATGGGACTGAGCAAGCTGTTCGTGTTA
ACCACCCGCAGCATCCACTGGTTCCAGGAGCGCGGCTTCACGCCGGTGGATATCGACCTGCTGCCGGAGAGTAAAAAGCA
GATGTATAACTATCAGCGCCGGTCGAAGGTGCTGATGGCCGACCTCGCTTAA

Upstream 100 bases:

>100_bases
CATGTTTTTCGCGGCTTAGCCTCAAATTGGGGCTTGCGTTTAACGGCAAAACAGAATAAAAATACAATAATTACGAATAA
TAATGCATTGAGGGTTTGTC

Downstream 100 bases:

>100_bases
GCCCTTCTCCTCTCTATCTAACGGCCCGGGATAGCGCGACGCTTATCGCTTTATCCCCGGCCGGTCTCCCGCCCCTCTTC
CCGCCAGCCTGGCGTACGCA

Product: N-acetylglutamate synthase

Products: NA

Alternate protein names: N-acetylglutamate synthase; AGS; NAGS [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MVKERRTELVEGFRHSVPYINAHRGKTFVIMLGGEAIEHENFSNIVNDIGLLHSLGIRLVVVYGARPQIDANLAEHHHEP
VYHKQTRVTDAKTLELVKQAAGMLQLEITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGVDDGVDYCHSGRIRRIDEEA
IHRQLDSGAIVLMGPVAVSVTGESFNLTSEEIATQLAIKLKAEKMIGFCSSQGVYNQAGEIVSELFPNEAQARVEELEAD
EDYNSGTVRFLRGAVKACRSGVRRCHLISYQENGALLQELFSRDGIGTQIVMESAEQIRRATINDIGGILELISPLEQQG
ILVRRSREQLEMEIDKFTIIQRDNTTIACAALYPFPEEKIGEMACVAVHPDYRSSSRGEVLLERIAAQARQMGLSKLFVL
TTRSIHWFQERGFTPVDIDLLPESKKQMYNYQRRSKVLMADLA

Sequences:

>Translated_443_residues
MVKERRTELVEGFRHSVPYINAHRGKTFVIMLGGEAIEHENFSNIVNDIGLLHSLGIRLVVVYGARPQIDANLAEHHHEP
VYHKQTRVTDAKTLELVKQAAGMLQLEITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGVDDGVDYCHSGRIRRIDEEA
IHRQLDSGAIVLMGPVAVSVTGESFNLTSEEIATQLAIKLKAEKMIGFCSSQGVYNQAGEIVSELFPNEAQARVEELEAD
EDYNSGTVRFLRGAVKACRSGVRRCHLISYQENGALLQELFSRDGIGTQIVMESAEQIRRATINDIGGILELISPLEQQG
ILVRRSREQLEMEIDKFTIIQRDNTTIACAALYPFPEEKIGEMACVAVHPDYRSSSRGEVLLERIAAQARQMGLSKLFVL
TTRSIHWFQERGFTPVDIDLLPESKKQMYNYQRRSKVLMADLA
>Mature_443_residues
MVKERRTELVEGFRHSVPYINAHRGKTFVIMLGGEAIEHENFSNIVNDIGLLHSLGIRLVVVYGARPQIDANLAEHHHEP
VYHKQTRVTDAKTLELVKQAAGMLQLEITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGVDDGVDYCHSGRIRRIDEEA
IHRQLDSGAIVLMGPVAVSVTGESFNLTSEEIATQLAIKLKAEKMIGFCSSQGVYNQAGEIVSELFPNEAQARVEELEAD
EDYNSGTVRFLRGAVKACRSGVRRCHLISYQENGALLQELFSRDGIGTQIVMESAEQIRRATINDIGGILELISPLEQQG
ILVRRSREQLEMEIDKFTIIQRDNTTIACAALYPFPEEKIGEMACVAVHPDYRSSSRGEVLLERIAAQARQMGLSKLFVL
TTRSIHWFQERGFTPVDIDLLPESKKQMYNYQRRSKVLMADLA

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

Organism=Escherichia coli, GI1789181, Length=443, Percent_Identity=94.1309255079007, Blast_Score=860, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320913, Length=303, Percent_Identity=22.7722772277228, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR001048
- InterPro:   IPR010167 [H]

Pfam domain/function: PF00696 AA_kinase; PF00583 Acetyltransf_1 [H]

EC number: =2.3.1.1 [H]

Molecular weight: Translated: 49476; Mature: 49476

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKERRTELVEGFRHSVPYINAHRGKTFVIMLGGEAIEHENFSNIVNDIGLLHSLGIRLV
CCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCHHCCCCHHHHHHHHHHHHHCCEEEE
VVYGARPQIDANLAEHHHEPVYHKQTRVTDAKTLELVKQAAGMLQLEITARLSMSLNNTP
EEECCCCCCCCCHHHHCCCCCHHHHHCCCHHHHHHHHHHHCCEEEEEEEEEEEEECCCCC
LQGAHINVVSGNFIIAQPLGVDDGVDYCHSGRIRRIDEEAIHRQLDSGAIVLMGPVAVSV
CCCCEEEEEECCEEEEECCCCCCCCHHHCCCCCEECCHHHHHHHCCCCCEEEEECEEEEE
TGESFNLTSEEIATQLAIKLKAEKMIGFCSSQGVYNQAGEIVSELFPNEAQARVEELEAD
ECCCCCCCHHHHHHHHHHHEEHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCC
EDYNSGTVRFLRGAVKACRSGVRRCHLISYQENGALLQELFSRDGIGTQIVMESAEQIRR
CCCCCCHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
ATINDIGGILELISPLEQQGILVRRSREQLEMEIDKFTIIQRDNTTIACAALYPFPEEKI
HHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCEEEEEEECCCEEEEEEECCCCHHHH
GEMACVAVHPDYRSSSRGEVLLERIAAQARQMGLSKLFVLTTRSIHWFQERGFTPVDIDL
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHEEEEEECCHHHHHHCCCCEEEEEE
LPESKKQMYNYQRRSKVLMADLA
CCCHHHHHHHHHHHHHEEEECCC
>Mature Secondary Structure
MVKERRTELVEGFRHSVPYINAHRGKTFVIMLGGEAIEHENFSNIVNDIGLLHSLGIRLV
CCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCHHCCCCHHHHHHHHHHHHHCCEEEE
VVYGARPQIDANLAEHHHEPVYHKQTRVTDAKTLELVKQAAGMLQLEITARLSMSLNNTP
EEECCCCCCCCCHHHHCCCCCHHHHHCCCHHHHHHHHHHHCCEEEEEEEEEEEEECCCCC
LQGAHINVVSGNFIIAQPLGVDDGVDYCHSGRIRRIDEEAIHRQLDSGAIVLMGPVAVSV
CCCCEEEEEECCEEEEECCCCCCCCHHHCCCCCEECCHHHHHHHCCCCCEEEEECEEEEE
TGESFNLTSEEIATQLAIKLKAEKMIGFCSSQGVYNQAGEIVSELFPNEAQARVEELEAD
ECCCCCCCHHHHHHHHHHHEEHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCC
EDYNSGTVRFLRGAVKACRSGVRRCHLISYQENGALLQELFSRDGIGTQIVMESAEQIRR
CCCCCCHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
ATINDIGGILELISPLEQQGILVRRSREQLEMEIDKFTIIQRDNTTIACAALYPFPEEKI
HHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCEEEEEEECCCEEEEEEECCCCHHHH
GEMACVAVHPDYRSSSRGEVLLERIAAQARQMGLSKLFVLTTRSIHWFQERGFTPVDIDL
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHEEEEEECCHHHHHHCCCCEEEEEE
LPESKKQMYNYQRRSKVLMADLA
CCCHHHHHHHHHHHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]