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The map label for this gene is fucK [H]

Identifier: 238896275

GI number: 238896275

Start: 4258887

End: 4260305

Strand: Direct

Name: fucK [H]

Synonym: KP1_4434

Alternate gene names: 238896275

Gene position: 4258887-4260305 (Clockwise)

Preceding gene: 238896274

Following gene: 238896276

Centisome position: 81.14

GC content: 64.9

Gene sequence:

>1419_bases
ATGAAGCAAGACGTTATCCTGGTCCTCGACTGCGGCGCCACGAACGTGCGGGCGATGGCCGTGGATCGACAAGGGAACAT
TATCGCCCGCGCCGCAACGGCGAACGCCAGCGACATCGCGGCGGAAAAAAGCGACTGGCACCAGTGGTCGCTGGAGGCCA
TTATGCAGCGCTTTGCCGACTGCTGTCGGCAGATCCATGACCAGCTGGCCTCCTGCACGGTGCGCGGCATTACCGTCACG
ACCTTTGGCGTCGATGGCGCGCTGGTAGATGAGAAGGGTGCCCTGCTGTATCCGATCATCAGCTGGAAATGCCCGCGCAC
CGCGGCGGTGATGGAGAAAATCAGCCAGTATATGCCCGCGCGCCAGCTGCAGCAGATAGCCGGCGTCGGCGCGTTTGCGT
TCAACACCCTGTATAAGCTGGTGTGGCTGAAAGAGAACCACCCGCAGCTGCTGGCGCAGGCCCATGCCTGGCTGTTTATT
TCATCGCTGATCAACCATCGGCTGACCGGGGAGTTCACCACCGACCTCACCATGGCGGGCACCAGCCAGATGCTCGATCT
CCGGCAGCGCGATTTCAGCGCGCCGATCCTGCAGGCGACCGGCCTGCCGCGCCGCCTGTTCCCGCGGCTGGTTGAAGCAG
GCCAGCCGATCGGCGCCCTGCTGCCGGAGGCCGCTGCGCTGCTGGGCCTCCCCGTCGGGATCCCGGTTATCTCGGCCGGG
CATGACACCCAGTTCGCTCTGTTTGGCGCCGGCGCCGGGCAGGATGAGCCGGTGCTCTCCTCCGGGACCTGGGAGATCCT
GATGGTGCGCAGCGCGCAGGTCGACACCTCGCTGCTCTGTGACTACAGCGGCTCCACCTGCGAGCTGGACAGCCAGCCGG
GCCGCTATAACCCGGGGATGCAGTGGCTGGCCTCCGGCGTGCTCGAGTGGGTGCGCAAACTGCTGTATAGCGCTGACACC
CCATGGCAGACGCTGATTGACGAAGCGCAGGCGATCCCGCCCGGCGCCCAGGGCGTCAGGATGCAGTGCGACCTGCTCGC
CAGCCAGCACGCCGGCTGGCAGGGCGTCACGCTCAACACCACCCGCGGCCATTTTTACCGCGCCGCGCTGGAGGGGTTAA
GCGATCAGCTGGCGCAGCATCTGCAAACCCTGGAAAAAATCGGCGGCTTCAGGGCGAAAGAGCTGCTGCTGGTGGGCGGC
GGCAGCCGCAACGCGCTATGGAACCAGATCAAGGCCAACCGACTCGGGATACCGATCAAAGTCCTCGACGATGCCGAAAC
CACCGTGGCCGGCGCGGCGATGTTTGGCTGGTATGGCGTGGGCGAGTTCTCTTCGCCAGAACAGGCCAGAGCGCAGGTCG
CGTACCGCTACCGCTATTTCTGGCCGCAAACTGAACCTGAACTGATAGAGGAAGCCTGA

Upstream 100 bases:

>100_bases
GTTTCGCCCGGAAGCGCAGGCTTACCTGGCCTACAGACGCGCGCGGTCTGTAGGCCGGATAAGCGCTGCGCCATCCGGCA
ATGTTGTTTCGGGAGTCACT

Downstream 100 bases:

>100_bases
GATGCTCAAAACCATTTCCCCGCTTATATCGCCGGAACTACTGAAAGTGCTGGCCGAAATGGGCCATGGGGATGAAATCA
TTTTTTCCGATGCCCATTTC

Product: L-fuculokinase

Products: NA

Alternate protein names: L-fuculose kinase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MKQDVILVLDCGATNVRAMAVDRQGNIIARAATANASDIAAEKSDWHQWSLEAIMQRFADCCRQIHDQLASCTVRGITVT
TFGVDGALVDEKGALLYPIISWKCPRTAAVMEKISQYMPARQLQQIAGVGAFAFNTLYKLVWLKENHPQLLAQAHAWLFI
SSLINHRLTGEFTTDLTMAGTSQMLDLRQRDFSAPILQATGLPRRLFPRLVEAGQPIGALLPEAAALLGLPVGIPVISAG
HDTQFALFGAGAGQDEPVLSSGTWEILMVRSAQVDTSLLCDYSGSTCELDSQPGRYNPGMQWLASGVLEWVRKLLYSADT
PWQTLIDEAQAIPPGAQGVRMQCDLLASQHAGWQGVTLNTTRGHFYRAALEGLSDQLAQHLQTLEKIGGFRAKELLLVGG
GSRNALWNQIKANRLGIPIKVLDDAETTVAGAAMFGWYGVGEFSSPEQARAQVAYRYRYFWPQTEPELIEEA

Sequences:

>Translated_472_residues
MKQDVILVLDCGATNVRAMAVDRQGNIIARAATANASDIAAEKSDWHQWSLEAIMQRFADCCRQIHDQLASCTVRGITVT
TFGVDGALVDEKGALLYPIISWKCPRTAAVMEKISQYMPARQLQQIAGVGAFAFNTLYKLVWLKENHPQLLAQAHAWLFI
SSLINHRLTGEFTTDLTMAGTSQMLDLRQRDFSAPILQATGLPRRLFPRLVEAGQPIGALLPEAAALLGLPVGIPVISAG
HDTQFALFGAGAGQDEPVLSSGTWEILMVRSAQVDTSLLCDYSGSTCELDSQPGRYNPGMQWLASGVLEWVRKLLYSADT
PWQTLIDEAQAIPPGAQGVRMQCDLLASQHAGWQGVTLNTTRGHFYRAALEGLSDQLAQHLQTLEKIGGFRAKELLLVGG
GSRNALWNQIKANRLGIPIKVLDDAETTVAGAAMFGWYGVGEFSSPEQARAQVAYRYRYFWPQTEPELIEEA
>Mature_472_residues
MKQDVILVLDCGATNVRAMAVDRQGNIIARAATANASDIAAEKSDWHQWSLEAIMQRFADCCRQIHDQLASCTVRGITVT
TFGVDGALVDEKGALLYPIISWKCPRTAAVMEKISQYMPARQLQQIAGVGAFAFNTLYKLVWLKENHPQLLAQAHAWLFI
SSLINHRLTGEFTTDLTMAGTSQMLDLRQRDFSAPILQATGLPRRLFPRLVEAGQPIGALLPEAAALLGLPVGIPVISAG
HDTQFALFGAGAGQDEPVLSSGTWEILMVRSAQVDTSLLCDYSGSTCELDSQPGRYNPGMQWLASGVLEWVRKLLYSADT
PWQTLIDEAQAIPPGAQGVRMQCDLLASQHAGWQGVTLNTTRGHFYRAALEGLSDQLAQHLQTLEKIGGFRAKELLLVGG
GSRNALWNQIKANRLGIPIKVLDDAETTVAGAAMFGWYGVGEFSSPEQARAQVAYRYRYFWPQTEPELIEEA

Specific function: Fucose metabolism; second step. [C]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Escherichia coli, GI1789168, Length=471, Percent_Identity=80.2547770700637, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=481, Percent_Identity=22.6611226611227, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790338, Length=361, Percent_Identity=25.7617728531856, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789987, Length=418, Percent_Identity=25.8373205741627, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1789138, Length=493, Percent_Identity=21.9066937119675, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR013450 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.51 [H]

Molecular weight: Translated: 51640; Mature: 51640

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDVILVLDCGATNVRAMAVDRQGNIIARAATANASDIAAEKSDWHQWSLEAIMQRFAD
CCCCEEEEEECCCCCEEEEEEECCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHH
CCRQIHDQLASCTVRGITVTTFGVDGALVDEKGALLYPIISWKCPRTAAVMEKISQYMPA
HHHHHHHHHHHCEECCEEEEEECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCH
RQLQQIAGVGAFAFNTLYKLVWLKENHPQLLAQAHAWLFISSLINHRLTGEFTTDLTMAG
HHHHHHHCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEECCEEECC
TSQMLDLRQRDFSAPILQATGLPRRLFPRLVEAGQPIGALLPEAAALLGLPVGIPVISAG
HHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECC
HDTQFALFGAGAGQDEPVLSSGTWEILMVRSAQVDTSLLCDYSGSTCELDSQPGRYNPGM
CCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCEEEECCCCCCCCCCH
QWLASGVLEWVRKLLYSADTPWQTLIDEAQAIPPGAQGVRMQCDLLASQHAGWQGVTLNT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCCCEEEEC
TRGHFYRAALEGLSDQLAQHLQTLEKIGGFRAKELLLVGGGSRNALWNQIKANRLGIPIK
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEE
VLDDAETTVAGAAMFGWYGVGEFSSPEQARAQVAYRYRYFWPQTEPELIEEA
EECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEECCCCCHHHHCCC
>Mature Secondary Structure
MKQDVILVLDCGATNVRAMAVDRQGNIIARAATANASDIAAEKSDWHQWSLEAIMQRFAD
CCCCEEEEEECCCCCEEEEEEECCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHH
CCRQIHDQLASCTVRGITVTTFGVDGALVDEKGALLYPIISWKCPRTAAVMEKISQYMPA
HHHHHHHHHHHCEECCEEEEEECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCH
RQLQQIAGVGAFAFNTLYKLVWLKENHPQLLAQAHAWLFISSLINHRLTGEFTTDLTMAG
HHHHHHHCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEECCEEECC
TSQMLDLRQRDFSAPILQATGLPRRLFPRLVEAGQPIGALLPEAAALLGLPVGIPVISAG
HHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECC
HDTQFALFGAGAGQDEPVLSSGTWEILMVRSAQVDTSLLCDYSGSTCELDSQPGRYNPGM
CCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCEEEECCCCCCCCCCH
QWLASGVLEWVRKLLYSADTPWQTLIDEAQAIPPGAQGVRMQCDLLASQHAGWQGVTLNT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCCCEEEEC
TRGHFYRAALEGLSDQLAQHLQTLEKIGGFRAKELLLVGGGSRNALWNQIKANRLGIPIK
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEE
VLDDAETTVAGAAMFGWYGVGEFSSPEQARAQVAYRYRYFWPQTEPELIEEA
EECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEECCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]