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The map label for this gene is fucP [H]

Identifier: 238896273

GI number: 238896273

Start: 4255661

End: 4256971

Strand: Direct

Name: fucP [H]

Synonym: KP1_4432

Alternate gene names: 238896273

Gene position: 4255661-4256971 (Clockwise)

Preceding gene: 238896270

Following gene: 238896274

Centisome position: 81.08

GC content: 55.45

Gene sequence:

>1311_bases
ATGGGAAACACAACGATACCAACGCAAAGTTACCGCGCCATGGAGAGCGGGCAGAGTAAGAGCTACATTATTCCTTTCGC
TCTGCTGTGCTCCCTCTTTTTTCTGTGGGCCGTGGCTAATAATCTGAATGATATTTTATTACCGCAATTTCAACAGGCCT
TTACCCTGACTAACTTCCAGGCCGGATTAATTCAATCGGCCTTTTACTTTGGCTATTTTATTATTCCCATCCCCGCCGGG
ATGTTGATGAAAAAATTCAGCTACAAAGCCGGCATCCTTACGGGTCTGTTTTTATATGCCTGCGGCGCCGCGCTGTTCTG
GCCTGCCGCCGAAGTGATGAATTACACCTTATTTCTCATTGGATTATTTATTATCGCTGCCGGGCTTGGCTGTCTGGAAA
CCGCGGCCAACCCGTTTGTCACCGTCCTCGGTCCGGAAAGCGGCGGTCACTTCCGCCTTAATCTGGCCCAGACCTTTAAC
TCATTCGGCGCCATTATTGCCGTGGTATTTGGCCAGAGTCTTATTTTGTCTAACGTCCCGCATCAGTCGCAGGAGGTGCT
GGATAAAATGACGCCGGAACAGCTCAGCGCCTGGAAGCACAGTCTGGTCCTGTCGGTACAAACCCCCTATATGATTATCG
TGGCCATTGTCCTGCTGGTCGCCCTGCTGATCGTCTGCACCCGCTTCCCCTCCCTGCAAAGCGATGACCACAGCGACAGC
GCGCAGAGCACTTTTTTCGCCTCGCTGACGCGCCTGATGCGCATCCGCCACTGGCGCTGGGCGGTACTGGCCCAGTTCTG
CTACGTCGGCGCGCAAACCGCCTGCTGGAGCTACCTGATTCGCTACGCTATCGAAGAGATCCCGGGCATGACGGCCGGTT
TCGCCGCCAACTACCTGACCGCCACCATGGTCTGCTTCTTTATCGGCCGTTTTACCGGCACCTGGCTTATCCGCCGCTTC
GCGCCGCACAACGTGCTCGCTATCTATGCGTTTATCGCCATGCTGCTCTGCTTGCTCTCCGCCTTCAGCGGCGGCCACGT
CGGTCTGCTGGCCCTGACCCTGTGCAGCGCCTTTATGTCCATTCAGTACCCGACCATCTTCTCGCTGGGGATTAAGCATC
TGGGCCAGGACACCAAATATGGCTCGTCATTTATCGTCATGACCATTATCGGCGGCGGGATCGTTACCCCGGTGATGGGC
TTTGTCAGCGACGCCGCCGGCAATATCCCGACCGCCGAACTGGTCCCGGCGCTGTGCTTCGCCATCATCTTTATTTTTGC
CCGTTTCCGTTCACAAGCGGCGACGAACTAA

Upstream 100 bases:

>100_bases
ACCGGCGCGTCACCTGAGCTCACTTAATTTTGCGGTCTGCTGCAGCACCAGACTGCGCCCTGAATGCTGTTGTAAATGCT
TCTGAACTGATGAGGACGCT

Downstream 100 bases:

>100_bases
ACCTGTTATCCGCATAACCTGAGGGATCTGTAATGAAAAAAATCAGCTTACCGAAGATCGGTATTCGTCCGGTAATCGAT
GGTCGTCGCATGGGGGTCCG

Product: L-fucose transporter

Products: Proton [Cytoplasm]; L-fucose [Cytoplasm] [C]

Alternate protein names: 6-deoxy-L-galactose permease; L-fucose permease [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MGNTTIPTQSYRAMESGQSKSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAG
MLMKKFSYKAGILTGLFLYACGAALFWPAAEVMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFN
SFGAIIAVVFGQSLILSNVPHQSQEVLDKMTPEQLSAWKHSLVLSVQTPYMIIVAIVLLVALLIVCTRFPSLQSDDHSDS
AQSTFFASLTRLMRIRHWRWAVLAQFCYVGAQTACWSYLIRYAIEEIPGMTAGFAANYLTATMVCFFIGRFTGTWLIRRF
APHNVLAIYAFIAMLLCLLSAFSGGHVGLLALTLCSAFMSIQYPTIFSLGIKHLGQDTKYGSSFIVMTIIGGGIVTPVMG
FVSDAAGNIPTAELVPALCFAIIFIFARFRSQAATN

Sequences:

>Translated_436_residues
MGNTTIPTQSYRAMESGQSKSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAG
MLMKKFSYKAGILTGLFLYACGAALFWPAAEVMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFN
SFGAIIAVVFGQSLILSNVPHQSQEVLDKMTPEQLSAWKHSLVLSVQTPYMIIVAIVLLVALLIVCTRFPSLQSDDHSDS
AQSTFFASLTRLMRIRHWRWAVLAQFCYVGAQTACWSYLIRYAIEEIPGMTAGFAANYLTATMVCFFIGRFTGTWLIRRF
APHNVLAIYAFIAMLLCLLSAFSGGHVGLLALTLCSAFMSIQYPTIFSLGIKHLGQDTKYGSSFIVMTIIGGGIVTPVMG
FVSDAAGNIPTAELVPALCFAIIFIFARFRSQAATN
>Mature_435_residues
GNTTIPTQSYRAMESGQSKSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGM
LMKKFSYKAGILTGLFLYACGAALFWPAAEVMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNS
FGAIIAVVFGQSLILSNVPHQSQEVLDKMTPEQLSAWKHSLVLSVQTPYMIIVAIVLLVALLIVCTRFPSLQSDDHSDSA
QSTFFASLTRLMRIRHWRWAVLAQFCYVGAQTACWSYLIRYAIEEIPGMTAGFAANYLTATMVCFFIGRFTGTWLIRRFA
PHNVLAIYAFIAMLLCLLSAFSGGHVGLLALTLCSAFMSIQYPTIFSLGIKHLGQDTKYGSSFIVMTIIGGGIVTPVMGF
VSDAAGNIPTAELVPALCFAIIFIFARFRSQAATN

Specific function: Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-

COG id: COG0738

COG function: function code G; Fucose permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family [H]

Homologues:

Organism=Escherichia coli, GI1789166, Length=438, Percent_Identity=89.9543378995434, Blast_Score=810, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005275
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47733; Mature: 47602

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GNTTIPTQSYRAMESGQSKSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQ
CCCCCCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AGLIQSAFYFGYFIIPIPAGMLMKKFSYKAGILTGLFLYACGAALFWPAAEVMNYTLFLI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVP
HHHHHHHCCHHHHHCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHHCCC
HQSQEVLDKMTPEQLSAWKHSLVLSVQTPYMIIVAIVLLVALLIVCTRFPSLQSDDHSDS
CHHHHHHHHCCHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
AQSTFFASLTRLMRIRHWRWAVLAQFCYVGAQTACWSYLIRYAIEEIPGMTAGFAANYLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ATMVCFFIGRFTGTWLIRRFAPHNVLAIYAFIAMLLCLLSAFSGGHVGLLALTLCSAFMS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IQYPTIFSLGIKHLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGNIPTAELVPALCF
CCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AIIFIFARFRSQAATN
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-fucose [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-fucose [Periplasm] = Proton [Cytoplasm] + L-fucose [Cytoplasm] [C]

General reaction: Permease [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2664711; 9278503; 2553671; 8052131; 2829831; 7783647 [H]