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The map label for this gene is mdtD [H]

Identifier: 238896219

GI number: 238896219

Start: 4192881

End: 4194083

Strand: Direct

Name: mdtD [H]

Synonym: KP1_4371

Alternate gene names: 238896219

Gene position: 4192881-4194083 (Clockwise)

Preceding gene: 238896217

Following gene: 238896220

Centisome position: 79.89

GC content: 62.43

Gene sequence:

>1203_bases
ATGACCTACCGCCACCGCGTTGCCACCGTTTTTCTGTTCGGTTTTTTTCTCGATTTGATCAATATGTTTATCGCCAGCAT
CGCCTTTCCGGCAATCAGCCGCGCGCTGGCGGTTTCCGTCTCGCAACTGGCGTGGGTCAGTAATGCCTATATTCTCGGTC
TGACGGTCGTTGTGCCGTTCAGCGCCTGGCTCAGCGAGCGCTGGGGGGCGAAACGGCTGTTTTTACTCTCGCTGGGGCTG
TTCAGCCTCGGCGCGCTGGCGGCAGGGCTTGCCAACAGCCTGAACGAACTGATTTTATGGCGGACGCTGCAGGGGATGGG
CGGCGGGCTGTTAATCCCCCTCGGCCAGGCGCTGACGTGGCCGCTGTTTCAGCCGCATGAGCGGGCGAAGCTGTCGGCGG
CGGTGATGCTGGTCGGCCTGCTGGCCCCCGCCTGCTCGCCGGCGATCGGCGGCCTGTTAGTCGAGGCGTTCAGTTGGCGC
TGGGTCTTTTTCGCCAGCCTGCCTGTGGCTCTGCTAACCTTTGTGCTGGCGGTGCGATGGCTGAACGACACCCCCGGTCC
GGTTCGCCCGACTCGCTTTCTTCCACTGTCGCTGCTGGCCGATCCCCTGCTGCGCTTCGCGATGCTGATCTACCTCTGCG
TGCCGGGGATGTTTATTGGCGTCAACGTGGTGGGGATGTACTACCTGCAACGCGTCACCGGGATGGCGCCGGGGGCAATC
GGTGCCCTGATGGTGCCCTGGTCGCTGGCCTCGTTTGCCGCCATCACTTTTACCGGCAGATATTTCAACCGCTTCGGGCC
CCGGCCGCTGGTCGTCATCGGCTGCCTGCTTCAGGCGATGGGGATCATGCTGCTGCTGAAGATCGATGCGGACAGCCCGC
TGGCGCTGTTGATTCTGGCCTTTACGCTGATGGGCGGCGGAGGCAGCTTATGCAGCAGCACCGCGCAAAGCAGCGCTTTC
CTGCATACGCCTGCCGAAGAGATGCCTGACGCCAGCGCGCTATGGAATCTTAACCGCCAGCTCAGCTTCTTTGCCGGCAG
CGCCCTGCTCGCCCTGCTGCTGAGGGTATTCCCGCCGGCCTACGCCTGGCAGGGGGTATTTATTAGCGCCGCCGTCATTA
CCCTGTTGCCGCTGCTGTTTTGCCTGCGGCTGAATAATCGGGCGATTATCCATCGCCTGCACACCACTCTGGAGAAGTCA
TGA

Upstream 100 bases:

>100_bases
GGATGATTGTCAAAAATATTCAGACAGTATATCCCGATTAGTCCCGTTTATCCCTCGCTGCGGCAGGTTTACAGTAGCCG
CCTGTCTGAGGGAGTGAACC

Downstream 100 bases:

>100_bases
ATCCTTATCTGCAGGAAGTCCTTGATGCCCATGTCCTTATCGAACGCTGGTTAAGCCATGGCGAAGGAAGCGCTGAGGCG
CTGATGAAGCGTTTTGCCGC

Product: putative permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTYRHRVATVFLFGFFLDLINMFIASIAFPAISRALAVSVSQLAWVSNAYILGLTVVVPFSAWLSERWGAKRLFLLSLGL
FSLGALAAGLANSLNELILWRTLQGMGGGLLIPLGQALTWPLFQPHERAKLSAAVMLVGLLAPACSPAIGGLLVEAFSWR
WVFFASLPVALLTFVLAVRWLNDTPGPVRPTRFLPLSLLADPLLRFAMLIYLCVPGMFIGVNVVGMYYLQRVTGMAPGAI
GALMVPWSLASFAAITFTGRYFNRFGPRPLVVIGCLLQAMGIMLLLKIDADSPLALLILAFTLMGGGGSLCSSTAQSSAF
LHTPAEEMPDASALWNLNRQLSFFAGSALLALLLRVFPPAYAWQGVFISAAVITLLPLLFCLRLNNRAIIHRLHTTLEKS

Sequences:

>Translated_400_residues
MTYRHRVATVFLFGFFLDLINMFIASIAFPAISRALAVSVSQLAWVSNAYILGLTVVVPFSAWLSERWGAKRLFLLSLGL
FSLGALAAGLANSLNELILWRTLQGMGGGLLIPLGQALTWPLFQPHERAKLSAAVMLVGLLAPACSPAIGGLLVEAFSWR
WVFFASLPVALLTFVLAVRWLNDTPGPVRPTRFLPLSLLADPLLRFAMLIYLCVPGMFIGVNVVGMYYLQRVTGMAPGAI
GALMVPWSLASFAAITFTGRYFNRFGPRPLVVIGCLLQAMGIMLLLKIDADSPLALLILAFTLMGGGGSLCSSTAQSSAF
LHTPAEEMPDASALWNLNRQLSFFAGSALLALLLRVFPPAYAWQGVFISAAVITLLPLLFCLRLNNRAIIHRLHTTLEKS
>Mature_399_residues
TYRHRVATVFLFGFFLDLINMFIASIAFPAISRALAVSVSQLAWVSNAYILGLTVVVPFSAWLSERWGAKRLFLLSLGLF
SLGALAAGLANSLNELILWRTLQGMGGGLLIPLGQALTWPLFQPHERAKLSAAVMLVGLLAPACSPAIGGLLVEAFSWRW
VFFASLPVALLTFVLAVRWLNDTPGPVRPTRFLPLSLLADPLLRFAMLIYLCVPGMFIGVNVVGMYYLQRVTGMAPGAIG
ALMVPWSLASFAAITFTGRYFNRFGPRPLVVIGCLLQAMGIMLLLKIDADSPLALLILAFTLMGGGGSLCSSTAQSSAFL
HTPAEEMPDASALWNLNRQLSFFAGSALLALLLRVFPPAYAWQGVFISAAVITLLPLLFCLRLNNRAIIHRLHTTLEKS

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=164, Percent_Identity=32.3170731707317, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790195, Length=157, Percent_Identity=32.484076433121, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788710, Length=177, Percent_Identity=31.638418079096, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788392, Length=160, Percent_Identity=35, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081983, Length=410, Percent_Identity=23.4146341463415, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325455, Length=154, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43383; Mature: 43251

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TYRHRVATVFLFGFFLDLINMFIASIAFPAISRALAVSVSQLAWVSNAYILGLTVVVPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
SAWLSERWGAKRLFLLSLGLFSLGALAAGLANSLNELILWRTLQGMGGGLLIPLGQALTW
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHCC
PLFQPHERAKLSAAVMLVGLLAPACSPAIGGLLVEAFSWRWVFFASLPVALLTFVLAVRW
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNDTPGPVRPTRFLPLSLLADPLLRFAMLIYLCVPGMFIGVNVVGMYYLQRVTGMAPGAI
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHH
GALMVPWSLASFAAITFTGRYFNRFGPRPLVVIGCLLQAMGIMLLLKIDADSPLALLILA
HHHHHHHHHHHHHHHHEEHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHH
FTLMGGGGSLCSSTAQSSAFLHTPAEEMPDASALWNLNRQLSFFAGSALLALLLRVFPPA
HHHHCCCHHHHHHHHHCCCEEECCHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCH
YAWQGVFISAAVITLLPLLFCLRLNNRAIIHRLHTTLEKS
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA