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The map label for this gene is ptxR [H]

Identifier: 238896218

GI number: 238896218

Start: 4191885

End: 4192793

Strand: Reverse

Name: ptxR [H]

Synonym: KP1_4370

Alternate gene names: 238896218

Gene position: 4192793-4191885 (Counterclockwise)

Preceding gene: 238896221

Following gene: 238896216

Centisome position: 79.89

GC content: 63.04

Gene sequence:

>909_bases
TTGACAATCATCCGGACGACGATGCTTAATCTTCAGCGCGTGACCATGTTTATCGCCGTGGTAGATGCCGGCAGTTTCAC
CCTTGCCGCAGCGGCGCTGGGGCAGACCAAGGCGGTGGTCAGCTTTAACGTACGGCAGCTGGAAAATGAGCTGGGGGTGA
CGCTGCTGCTGCGTTCGACGCGGCGTTTGCGGCTCACTGACGCCGGGGTGCTGTTCTATCAGCGCGGGGTGGCGCTCCTG
AACGCGGCGGAAAATCTCCAGGATGAAGTGCGGGCCAGCCATAGCGGCTTAAGCGGGGAGCTACGGATCACCACCACGCC
GGAGTATGGCGCGCAGGTTATCATTCCAGCGCTGGCCGCGTTCGCCCGTCGTCATCCGGCGCTGCGGGTGCGCCACGTCT
CCTCCTCCCATCATGCCGACCTCATTTCAGAACGATTTGACGTGGCGATACGCCTCGGTACGCTGGCCGATTCCCGCTAT
CGGGCGACGCGGATAGCCAGTTTCGCGATCCTGCCCGTCGCCTCTCCGGCCTGGCTGGCAAGCCATCCGGTGCAGACGCT
GTCCGATCTGGCGCAAGCTGAGTGGATTATTCACGAGCGCCTGCCGACGCCGCTGCGCTGGCAGCTGCGCACGGATCACC
AGACAGAGGTGGATTTCGCGATAGCCAGCGCGCCGCGGTTTTCTGCTGATAGCGCTACGGCGCTGATGAGCTTTGCTCTG
GCGGGATGCGGCGTCGCCTTGCTGCCCGCATGGCTGGTAGCCAAAAAGGTGGCGCAGCGGGAGCTGGTGCCGCTCCTGCC
GGAATACCATTTCCCACAGCAGGGCGTGTATGCCCTTTATCCCGACTCGCAGCATTTGCCGACCCGGGTGCGGGCATTTA
TTGACTTCCTGCGCGAGAAGGTCGGTTAA

Upstream 100 bases:

>100_bases
GGCGGTAGGTCATGGTTCACTCCCTCAGACAGGCGGCTACTGTAAACCTGCCGCAGCGAGGGATAAACGGGACTAATCGG
GATATACTGTCTGAATATTT

Downstream 100 bases:

>100_bases
GCGCCCGTTCAGGGCGCCATCATTTTGTGTACCAGCCGGGAGAACTGCTCGCGCTCGTCATCGCTCAGGCGGCCGAGAAA
CTCGTCATCGACCTCATTGC

Product: putative LysR-family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTIIRTTMLNLQRVTMFIAVVDAGSFTLAAAALGQTKAVVSFNVRQLENELGVTLLLRSTRRLRLTDAGVLFYQRGVALL
NAAENLQDEVRASHSGLSGELRITTTPEYGAQVIIPALAAFARRHPALRVRHVSSSHHADLISERFDVAIRLGTLADSRY
RATRIASFAILPVASPAWLASHPVQTLSDLAQAEWIIHERLPTPLRWQLRTDHQTEVDFAIASAPRFSADSATALMSFAL
AGCGVALLPAWLVAKKVAQRELVPLLPEYHFPQQGVYALYPDSQHLPTRVRAFIDFLREKVG

Sequences:

>Translated_302_residues
MTIIRTTMLNLQRVTMFIAVVDAGSFTLAAAALGQTKAVVSFNVRQLENELGVTLLLRSTRRLRLTDAGVLFYQRGVALL
NAAENLQDEVRASHSGLSGELRITTTPEYGAQVIIPALAAFARRHPALRVRHVSSSHHADLISERFDVAIRLGTLADSRY
RATRIASFAILPVASPAWLASHPVQTLSDLAQAEWIIHERLPTPLRWQLRTDHQTEVDFAIASAPRFSADSATALMSFAL
AGCGVALLPAWLVAKKVAQRELVPLLPEYHFPQQGVYALYPDSQHLPTRVRAFIDFLREKVG
>Mature_301_residues
TIIRTTMLNLQRVTMFIAVVDAGSFTLAAAALGQTKAVVSFNVRQLENELGVTLLLRSTRRLRLTDAGVLFYQRGVALLN
AAENLQDEVRASHSGLSGELRITTTPEYGAQVIIPALAAFARRHPALRVRHVSSSHHADLISERFDVAIRLGTLADSRYR
ATRIASFAILPVASPAWLASHPVQTLSDLAQAEWIIHERLPTPLRWQLRTDHQTEVDFAIASAPRFSADSATALMSFALA
GCGVALLPAWLVAKKVAQRELVPLLPEYHFPQQGVYALYPDSQHLPTRVRAFIDFLREKVG

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=294, Percent_Identity=32.9931972789116, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789639, Length=299, Percent_Identity=30.1003344481605, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789440, Length=286, Percent_Identity=28.3216783216783, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87081978, Length=294, Percent_Identity=31.6326530612245, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI145693193, Length=295, Percent_Identity=27.1186440677966, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1787589, Length=293, Percent_Identity=29.0102389078498, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787128, Length=298, Percent_Identity=24.1610738255034, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788706, Length=309, Percent_Identity=28.1553398058252, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786448, Length=322, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789173, Length=284, Percent_Identity=26.7605633802817, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI157672245, Length=143, Percent_Identity=37.0629370629371, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786713, Length=267, Percent_Identity=25.8426966292135, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788481, Length=304, Percent_Identity=25, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788297, Length=146, Percent_Identity=32.8767123287671, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787806, Length=123, Percent_Identity=39.0243902439024, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789492, Length=282, Percent_Identity=26.9503546099291, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33317; Mature: 33186

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIIRTTMLNLQRVTMFIAVVDAGSFTLAAAALGQTKAVVSFNVRQLENELGVTLLLRST
CEEEHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCEEEEEECC
RRLRLTDAGVLFYQRGVALLNAAENLQDEVRASHSGLSGELRITTTPEYGAQVIIPALAA
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHH
FARRHPALRVRHVSSSHHADLISERFDVAIRLGTLADSRYRATRIASFAILPVASPAWLA
HHHCCCCEEEEECCCCHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHEEEEECCCCHHHH
SHPVQTLSDLAQAEWIIHERLPTPLRWQLRTDHQTEVDFAIASAPRFSADSATALMSFAL
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHH
AGCGVALLPAWLVAKKVAQRELVPLLPEYHFPQQGVYALYPDSQHLPTRVRAFIDFLREK
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
VG
CC
>Mature Secondary Structure 
TIIRTTMLNLQRVTMFIAVVDAGSFTLAAAALGQTKAVVSFNVRQLENELGVTLLLRST
EEEHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCEEEEEECC
RRLRLTDAGVLFYQRGVALLNAAENLQDEVRASHSGLSGELRITTTPEYGAQVIIPALAA
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHH
FARRHPALRVRHVSSSHHADLISERFDVAIRLGTLADSRYRATRIASFAILPVASPAWLA
HHHCCCCEEEEECCCCHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHEEEEECCCCHHHH
SHPVQTLSDLAQAEWIIHERLPTPLRWQLRTDHQTEVDFAIASAPRFSADSATALMSFAL
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHH
AGCGVALLPAWLVAKKVAQRELVPLLPEYHFPQQGVYALYPDSQHLPTRVRAFIDFLREK
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
VG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]