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The map label for this gene is actII-2 [H]

Identifier: 238896076

GI number: 238896076

Start: 4043918

End: 4045375

Strand: Direct

Name: actII-2 [H]

Synonym: KP1_4210

Alternate gene names: 238896076

Gene position: 4043918-4045375 (Clockwise)

Preceding gene: 238896071

Following gene: 238896077

Centisome position: 77.05

GC content: 66.53

Gene sequence:

>1458_bases
ATGCTCAATAACGCTTCGGCGGCCACAGTTCAGGCGCCTCCCTACACCAGCGAACGGCAGCGCACGCTGGCCACGCTGGT
GGTTTCGATAGCGCTGGTGCTGGAGATCATCGACGTTTCAATCATCAATGTCGCCATCCCGGTGGTACAGCGCGACCTGC
TCGCCAGCCCGCGGCAAATCGAATGGGTGGTAACCGGCTACCTGTTCTTTTTCTCCATTCTGCTGCTTACCGGCGGCCGT
CTCGGCGATCTGTATGGCTACCGGCGGATGTTCATTAGCGGCCTGCTGGCGTTTGGCGCCGCGTCGGCCGGCTGCGGGCT
GGCCATCAGCCCGGAGATGCTGGTCGCGATGCGTATTGCGCAGGGGGCCAGCGGGGCGATGATGGGCCCGCAAATCCTCT
CCCTGATGCAGGTTCTGTATCGCCCGCACGAACGTTTCCGGGTGATGAGTATTTTCGGCCTGCTCGGCGGCGCCGCCGGG
ATCCTCGGTCCGGTACTCGGCGGGATCATCATCGAAAGCAATCTTTTCGACCTCAGCTGGCGGCCGATCTTTTTGATCAA
CGTGCCGGTGATCGCCATCGCCGTCGCTCTGGCGTGGCGGGTGCTCCCGGCGGTGCGCAGTCCGGAGGCGAAAGGCATCG
ATCCGCTGGGAACCCTGCTGGCGGTGGTAGGCGGCGGCGCGCTGCTGCTCACCCTGATCGAGGGTCCCGCTCTGCGCTGG
CCGGCCTGGATGGTGCTGCCGCCGCTGCTGTCGGTCATCACGGTGTCACTCCTCTGGCGCCATCTGCTGGGACGCGAACG
CCGGGGCGGCACGCTGTTGTTGCCGCCAGCCGTACTGCGCGACCGCTTTTTTCGCGCCGGGATCATCATCACCCTGCTCT
ATCAGCTGACCACCGCCTCGCTGCTGCTGGCCACCGCGCTGGTGCTGCAGAGCGGACTGGGCTTCAGCCCGTTCCACACT
GCCCTGATGCATATCCCCTTCGCGCTCGGGGCGATGTTTTCCATCGCCGTCGCTGGACGCCGGCTGTCACTTCGTCTTGG
GCGCAACGTGACGCTGGTTGGGGTGGCGGTACAGATGAGCGGCCTGCTGCTGATGGGCTACGGGATCGCCGCAGCGCCGG
GGACGCTGCCGCTGACCGCGCTGGGTCTTGGGTTCGGCCTGTGCGGCTGTGGGATGGGGCTTATCTCCGCCCCGCTGCCG
GCCTTTGCTATGGCGGCGATACCGGTGGCCCACGCCGGCGCGGCGTCGGGATTATTTCGCACCGGCCAGCAGTTTGGCGC
CGCCCTCGGCATGGCGACCCTCGGCGGATTCTATCTGGCGCAAAGCGCCTCCGCACCGGATGCCTGGCGCGGGGCCTTTA
TCACCCTGCTGACCCTTGGCGCCCTGATCCTGCTGGCGATTGCCGCCCTCAGCCGCCTGCTGCCCGCCTCAGTGCTTCCC
CCGGCGGGTAAGCCATGA

Upstream 100 bases:

>100_bases
GACGCGGCATAACCAGAATGAGTGCTCTAATTCTAATCTCTGTTTGCTATAAATTGTCAATATTATTTAACAAGTTTTTA
ACTAAATCTAAAGGTACATC

Downstream 100 bases:

>100_bases
CCTATCGCGTCCGGCAATGGCTGCTATCATGAGGAACCATTTATCAGGACGCACCAGGCTGTAGTACCTATTTTCTGTAC
ACCTGCAACGGGCATACGCC

Product: major facilitator superfamily transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLNNASAATVQAPPYTSERQRTLATLVVSIALVLEIIDVSIINVAIPVVQRDLLASPRQIEWVVTGYLFFFSILLLTGGR
LGDLYGYRRMFISGLLAFGAASAGCGLAISPEMLVAMRIAQGASGAMMGPQILSLMQVLYRPHERFRVMSIFGLLGGAAG
ILGPVLGGIIIESNLFDLSWRPIFLINVPVIAIAVALAWRVLPAVRSPEAKGIDPLGTLLAVVGGGALLLTLIEGPALRW
PAWMVLPPLLSVITVSLLWRHLLGRERRGGTLLLPPAVLRDRFFRAGIIITLLYQLTTASLLLATALVLQSGLGFSPFHT
ALMHIPFALGAMFSIAVAGRRLSLRLGRNVTLVGVAVQMSGLLLMGYGIAAAPGTLPLTALGLGFGLCGCGMGLISAPLP
AFAMAAIPVAHAGAASGLFRTGQQFGAALGMATLGGFYLAQSASAPDAWRGAFITLLTLGALILLAIAALSRLLPASVLP
PAGKP

Sequences:

>Translated_485_residues
MLNNASAATVQAPPYTSERQRTLATLVVSIALVLEIIDVSIINVAIPVVQRDLLASPRQIEWVVTGYLFFFSILLLTGGR
LGDLYGYRRMFISGLLAFGAASAGCGLAISPEMLVAMRIAQGASGAMMGPQILSLMQVLYRPHERFRVMSIFGLLGGAAG
ILGPVLGGIIIESNLFDLSWRPIFLINVPVIAIAVALAWRVLPAVRSPEAKGIDPLGTLLAVVGGGALLLTLIEGPALRW
PAWMVLPPLLSVITVSLLWRHLLGRERRGGTLLLPPAVLRDRFFRAGIIITLLYQLTTASLLLATALVLQSGLGFSPFHT
ALMHIPFALGAMFSIAVAGRRLSLRLGRNVTLVGVAVQMSGLLLMGYGIAAAPGTLPLTALGLGFGLCGCGMGLISAPLP
AFAMAAIPVAHAGAASGLFRTGQQFGAALGMATLGGFYLAQSASAPDAWRGAFITLLTLGALILLAIAALSRLLPASVLP
PAGKP
>Mature_485_residues
MLNNASAATVQAPPYTSERQRTLATLVVSIALVLEIIDVSIINVAIPVVQRDLLASPRQIEWVVTGYLFFFSILLLTGGR
LGDLYGYRRMFISGLLAFGAASAGCGLAISPEMLVAMRIAQGASGAMMGPQILSLMQVLYRPHERFRVMSIFGLLGGAAG
ILGPVLGGIIIESNLFDLSWRPIFLINVPVIAIAVALAWRVLPAVRSPEAKGIDPLGTLLAVVGGGALLLTLIEGPALRW
PAWMVLPPLLSVITVSLLWRHLLGRERRGGTLLLPPAVLRDRFFRAGIIITLLYQLTTASLLLATALVLQSGLGFSPFHT
ALMHIPFALGAMFSIAVAGRRLSLRLGRNVTLVGVAVQMSGLLLMGYGIAAAPGTLPLTALGLGFGLCGCGMGLISAPLP
AFAMAAIPVAHAGAASGLFRTGQQFGAALGMATLGGFYLAQSASAPDAWRGAFITLLTLGALILLAIAALSRLLPASVLP
PAGKP

Specific function: Promotes the efflux of actinorhodin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=424, Percent_Identity=28.7735849056604, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790195, Length=477, Percent_Identity=26.6247379454927, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1788710, Length=421, Percent_Identity=27.3159144893112, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789042, Length=299, Percent_Identity=28.7625418060201, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788392, Length=310, Percent_Identity=31.6129032258064, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322958, Length=200, Percent_Identity=32, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50654; Mature: 50654

Theoretical pI: Translated: 11.34; Mature: 11.34

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNNASAATVQAPPYTSERQRTLATLVVSIALVLEIIDVSIINVAIPVVQRDLLASPRQI
CCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
EWVVTGYLFFFSILLLTGGRLGDLYGYRRMFISGLLAFGAASAGCGLAISPEMLVAMRIA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHH
QGASGAMMGPQILSLMQVLYRPHERFRVMSIFGLLGGAAGILGPVLGGIIIESNLFDLSW
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEECCC
RPIFLINVPVIAIAVALAWRVLPAVRSPEAKGIDPLGTLLAVVGGGALLLTLIEGPALRW
CCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHEEHHHCCCCCCC
PAWMVLPPLLSVITVSLLWRHLLGRERRGGTLLLPPAVLRDRFFRAGIIITLLYQLTTAS
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
LLLATALVLQSGLGFSPFHTALMHIPFALGAMFSIAVAGRRLSLRLGRNVTLVGVAVQMS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEEHHHHC
GLLLMGYGIAAAPGTLPLTALGLGFGLCGCGMGLISAPLPAFAMAAIPVAHAGAASGLFR
CCCEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHH
TGQQFGAALGMATLGGFYLAQSASAPDAWRGAFITLLTLGALILLAIAALSRLLPASVLP
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCC
PAGKP
CCCCC
>Mature Secondary Structure
MLNNASAATVQAPPYTSERQRTLATLVVSIALVLEIIDVSIINVAIPVVQRDLLASPRQI
CCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
EWVVTGYLFFFSILLLTGGRLGDLYGYRRMFISGLLAFGAASAGCGLAISPEMLVAMRIA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHH
QGASGAMMGPQILSLMQVLYRPHERFRVMSIFGLLGGAAGILGPVLGGIIIESNLFDLSW
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEECCC
RPIFLINVPVIAIAVALAWRVLPAVRSPEAKGIDPLGTLLAVVGGGALLLTLIEGPALRW
CCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHEEHHHCCCCCCC
PAWMVLPPLLSVITVSLLWRHLLGRERRGGTLLLPPAVLRDRFFRAGIIITLLYQLTTAS
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
LLLATALVLQSGLGFSPFHTALMHIPFALGAMFSIAVAGRRLSLRLGRNVTLVGVAVQMS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEEHHHHC
GLLLMGYGIAAAPGTLPLTALGLGFGLCGCGMGLISAPLPAFAMAAIPVAHAGAASGLFR
CCCEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHH
TGQQFGAALGMATLGGFYLAQSASAPDAWRGAFITLLTLGALILLAIAALSRLLPASVLP
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCC
PAGKP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1878971; 12000953 [H]