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The map label for this gene is hyi [H]

Identifier: 238896075

GI number: 238896075

Start: 4042924

End: 4043697

Strand: Reverse

Name: hyi [H]

Synonym: KP1_4209

Alternate gene names: 238896075

Gene position: 4043697-4042924 (Counterclockwise)

Preceding gene: 238896083

Following gene: 238896074

Centisome position: 77.04

GC content: 63.31

Gene sequence:

>774_bases
ATGTATTTGTCCGCATGTATTGAATGGCTGTTTCGTGAAGAGTATCCCGATTTCAGCGATCGGGTCCGGGCGGCGAAAGC
GCAGGGATTCAGCCACGTTGAGTTTCACCTCTGGCGCGATAAACCGCTGGCAGCGCTGGCGCAGGCGCTGGAAGAGACGG
GCGTGACGCTGTCGAGCTTCGTGGTAGAGCCCCGGCGCAGCCTGGTGGATCCGGCGGAGCATGAGCAGTTTCTGGCGGCA
GTGAGCGACAGCCTGGCGGTGTCACGTCAGCTGGGGTCGCCACCGCTGGTGGTAGCCTCCGGCTTCAGTCGTGAAGGGGT
CGATATTGCCGAGCAGCAGGCGCAGGCGGTCCACATCCTGCGTCAGGCAGCGACGCTGGCGGAAGCCGCCGGGGTCACCC
TGTTGCTGGAGCCGCTCAACACCCGCATCGATCATCCGGGGATGTTCTTAAACGATACCCGGCTGGCGCTGGACATTATC
GAGGCGGTCGACAGCCCACGGCTGCAGCTGCTGTTTGATGTCTATCATTCGATGGTAATGGAAGAGGAGATGGAGGAGGT
GCTCGGCGGCAGAATGCATCGGGTGGGGCACGTGCAGATAGCCCAGGCGCCGGATCGCAACGAACCGGATCCGCGCAGCG
GTGAGTGGCCAGCGCTGATCGCCAGGCTGCAACGGCTGGGCTACAACGGGGCCATTGGTCTGGAGTATAAACCGTCGCTG
CCCGCAGCGGCCTCGGTGGCTCGCGCCCGCGAAGCGACCGGCTTATCCTGTTAA

Upstream 100 bases:

>100_bases
AAGCCAGAGGGGAAGGCGTCACACTGCCGCTCCTAAACAGAATAAGAATTCTTATTCTAATTTTGTTTGTTTTGATCTGG
CAAGTAGAGAAGGGGGTCGG

Downstream 100 bases:

>100_bases
ACAACTTACCTGGTACTTTTATGACTCAGAAAATAAAACGCGGCGTCAGTCTGTATAGTTTTCAGAATGAGACCTACCTT
GGCAAAATGTCACTCGATCA

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MYLSACIEWLFREEYPDFSDRVRAAKAQGFSHVEFHLWRDKPLAALAQALEETGVTLSSFVVEPRRSLVDPAEHEQFLAA
VSDSLAVSRQLGSPPLVVASGFSREGVDIAEQQAQAVHILRQAATLAEAAGVTLLLEPLNTRIDHPGMFLNDTRLALDII
EAVDSPRLQLLFDVYHSMVMEEEMEEVLGGRMHRVGHVQIAQAPDRNEPDPRSGEWPALIARLQRLGYNGAIGLEYKPSL
PAAASVARAREATGLSC

Sequences:

>Translated_257_residues
MYLSACIEWLFREEYPDFSDRVRAAKAQGFSHVEFHLWRDKPLAALAQALEETGVTLSSFVVEPRRSLVDPAEHEQFLAA
VSDSLAVSRQLGSPPLVVASGFSREGVDIAEQQAQAVHILRQAATLAEAAGVTLLLEPLNTRIDHPGMFLNDTRLALDII
EAVDSPRLQLLFDVYHSMVMEEEMEEVLGGRMHRVGHVQIAQAPDRNEPDPRSGEWPALIARLQRLGYNGAIGLEYKPSL
PAAASVARAREATGLSC
>Mature_257_residues
MYLSACIEWLFREEYPDFSDRVRAAKAQGFSHVEFHLWRDKPLAALAQALEETGVTLSSFVVEPRRSLVDPAEHEQFLAA
VSDSLAVSRQLGSPPLVVASGFSREGVDIAEQQAQAVHILRQAATLAEAAGVTLLLEPLNTRIDHPGMFLNDTRLALDII
EAVDSPRLQLLFDVYHSMVMEEEMEEVLGGRMHRVGHVQIAQAPDRNEPDPRSGEWPALIARLQRLGYNGAIGLEYKPSL
PAAASVARAREATGLSC

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=250, Percent_Identity=32.4, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI300068964, Length=245, Percent_Identity=31.8367346938775, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1786718, Length=251, Percent_Identity=30.6772908366534, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1789095, Length=229, Percent_Identity=27.9475982532751, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17552022, Length=231, Percent_Identity=22.9437229437229, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17530883, Length=246, Percent_Identity=28.0487804878049, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 28289; Mature: 28289

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLSACIEWLFREEYPDFSDRVRAAKAQGFSHVEFHLWRDKPLAALAQALEETGVTLSSF
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHH
VVEPRRSLVDPAEHEQFLAAVSDSLAVSRQLGSPPLVVASGFSREGVDIAEQQAQAVHIL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHH
RQAATLAEAAGVTLLLEPLNTRIDHPGMFLNDTRLALDIIEAVDSPRLQLLFDVYHSMVM
HHHHHHHHHCCCEEEEECHHCCCCCCCCEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EEEMEEVLGGRMHRVGHVQIAQAPDRNEPDPRSGEWPALIARLQRLGYNGAIGLEYKPSL
HHHHHHHHCCHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCC
PAAASVARAREATGLSC
CHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYLSACIEWLFREEYPDFSDRVRAAKAQGFSHVEFHLWRDKPLAALAQALEETGVTLSSF
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHH
VVEPRRSLVDPAEHEQFLAAVSDSLAVSRQLGSPPLVVASGFSREGVDIAEQQAQAVHIL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHH
RQAATLAEAAGVTLLLEPLNTRIDHPGMFLNDTRLALDIIEAVDSPRLQLLFDVYHSMVM
HHHHHHHHHCCCEEEEECHHCCCCCCCCEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EEEMEEVLGGRMHRVGHVQIAQAPDRNEPDPRSGEWPALIARLQRLGYNGAIGLEYKPSL
HHHHHHHHCCHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCC
PAAASVARAREATGLSC
CHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]