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The map label for this gene is ffh [H]

Identifier: 238896056

GI number: 238896056

Start: 4023235

End: 4024599

Strand: Reverse

Name: ffh [H]

Synonym: KP1_4189

Alternate gene names: 238896056

Gene position: 4024599-4023235 (Counterclockwise)

Preceding gene: 238896059

Following gene: 238896055

Centisome position: 76.68

GC content: 59.27

Gene sequence:

>1365_bases
ATGTTTGATAATTTAACCGATCGTTTGTCGCGTACGCTGCGCAACATTAGCGGCCGCGGACGCCTTACAGAAGACAATAT
TAAAGACACCCTGCGCGAAGTGCGCATGGCGCTGCTGGAAGCGGACGTTGCGCTTCCGGTGGTCCGTGATTTCATCAGCC
GCGTCAAAGAGAGCGCGGTAGGCCATGAAGTCAATAAAAGCCTGACGCCGGGTCAGGAGTTCGTCAAAATCGTCCGCAAC
GAGCTGGTGGCGGCGATGGGCGAAGAGAACCAGACGCTCGACCTGGCGGCGCAGCCGCCGGCCGTGGTGCTGATGGCGGG
CCTGCAAGGTGCTGGTAAAACCACCAGCGTCGGTAAGCTGGGGAAATTCCTGCGCGAGAAGCACAAGAAGAAAGTGCTGG
TCGTTTCCGCGGACGTTTACCGCCCGGCGGCGATCAAACAGCTGGAAACCCTGGCCGAGCAGGTCGGCGTCGATTTCTTC
CCGTCTGACGTCGGGCAGAAGCCGGTTGATATCGTCAACGCGGCGCTGAAAGAAGCGAAACTCAAATTCTACGACGTGCT
GCTGGTGGATACCGCCGGTCGTCTGCACGTTGACGAAGCGATGATGGACGAAATCAAGCACGTCCACGCCGCCATTAACC
CGGTTGAAACCCTGTTCGTCGTTGATGCGATGACCGGTCAGGATGCGGCGAATACCGCGAAGGCCTTTAACGAAGCGCTG
CCGCTGACCGGCGTGGTGCTGACCAAAGTGGACGGCGACGCCCGCGGCGGCGCGGCGCTGTCGATTCGCCATATTACCGG
CAAGCCGATTAAATTCCTCGGCGTCGGCGAGAAAACCGAAGCTCTGGAGCCGTTCCATCCGGACCGCGTCGCTTCCCGTA
TCCTCGGCATGGGCGACGTGCTGTCGCTGATCGAAGATATCGAGAGCAAGGTTGACCGCGCGCAGGCCGAGAAGCTGGCC
TCCAAGCTGAAGAAAGGCGACGGTTTCGACCTCACCGACTTCCTTGAGCAGCTGCGCCAGATGAAAAACATGGGCGGCAT
GGCCAGCCTGATGGGCAAGCTGCCGGGCATGGGGCAGATCCCGGACAACGTGAAAGCGCAGATGGACGACAAAGTGCTGG
TGCGTATGGAAGCGATCATCAACTCGATGACCCTGAAAGAGCGCGCTAAGCCGGAAATCATCAAAGGTTCGCGTAAGCGC
CGTATCGCCGCCGGCTGCGGCATGCAGGTGCAGGATGTGAACCGTCTGCTCAAGCAGTTCGACGACATGCAGCGCATGAT
GAAGAAGATGAAGTCGAAAGGCGGCATGATGAAGATGATGCGCGGGATGAAAGGGATGATGCCGCCAGGCTTCCCGGGTC
GTTAA

Upstream 100 bases:

>100_bases
ACCGTTGCAGCACATTCAGATTGATGTCGTGTTATACTCCGCCACATTCGTTTTGTGTGTCGCTGCGGCGACCGACCGTT
TCCACCTCAGGCGAGAGACA

Downstream 100 bases:

>100_bases
AAACAAGGGCATAAGGCTATCTTGTTTGCCATTTTAGCGCCGGGGTGTGCTCGCCATCCTCACGTACTACCTGTACGTTA
CAGTGGTTGCGCACACGCTG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MFDNLTDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVRDFISRVKESAVGHEVNKSLTPGQEFVKIVRN
ELVAAMGEENQTLDLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFF
PSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKHVHAAINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDIESKVDRAQAEKLA
SKLKKGDGFDLTDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKAQMDDKVLVRMEAIINSMTLKERAKPEIIKGSRKR
RIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKSKGGMMKMMRGMKGMMPPGFPGR

Sequences:

>Translated_454_residues
MFDNLTDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVRDFISRVKESAVGHEVNKSLTPGQEFVKIVRN
ELVAAMGEENQTLDLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFF
PSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKHVHAAINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDIESKVDRAQAEKLA
SKLKKGDGFDLTDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKAQMDDKVLVRMEAIINSMTLKERAKPEIIKGSRKR
RIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKSKGGMMKMMRGMKGMMPPGFPGR
>Mature_454_residues
MFDNLTDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVRDFISRVKESAVGHEVNKSLTPGQEFVKIVRN
ELVAAMGEENQTLDLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFF
PSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKHVHAAINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDIESKVDRAQAEKLA
SKLKKGDGFDLTDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKAQMDDKVLVRMEAIINSMTLKERAKPEIIKGSRKR
RIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKSKGGMMKMMRGMKGMMPPGFPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=448, Percent_Identity=32.1428571428571, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI226371618, Length=346, Percent_Identity=34.393063583815, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=38.125, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI295424842, Length=315, Percent_Identity=26.3492063492064, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI23308697, Length=315, Percent_Identity=26.3492063492064, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1788963, Length=454, Percent_Identity=96.4757709251101, Blast_Score=856, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=33.8582677165354, Blast_Score=151, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=439, Percent_Identity=30.2961275626424, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193206261, Length=311, Percent_Identity=29.2604501607717, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=436, Percent_Identity=30.2752293577982, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320498, Length=311, Percent_Identity=26.0450160771704, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647949, Length=444, Percent_Identity=29.7297297297297, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=30, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49770; Mature: 49770

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLTDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVRDFISRVKESAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLDLAAQPPAVVLMAGLQGAGKTTSVGKL
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCCCHHHHH
GKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHH
LKFYDVLLVDTAGRLHVDEAMMDEIKHVHAAINPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHHEEEEECCCCEEHHHHHHHHHHHHHHHHCHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRAQAEKLASKLKKGDGFDLTDFLEQLRQMKNMGGMASLMGKLPGMGQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PDNVKAQMDDKVLVRMEAIINSMTLKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQF
CCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCHHHHHHHHHHH
DDMQRMMKKMKSKGGMMKMMRGMKGMMPPGFPGR
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MFDNLTDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVRDFISRVKESAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLDLAAQPPAVVLMAGLQGAGKTTSVGKL
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCCCHHHHH
GKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHH
LKFYDVLLVDTAGRLHVDEAMMDEIKHVHAAINPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHHEEEEECCCCEEHHHHHHHHHHHHHHHHCHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRAQAEKLASKLKKGDGFDLTDFLEQLRQMKNMGGMASLMGKLPGMGQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PDNVKAQMDDKVLVRMEAIINSMTLKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQF
CCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCHHHHHHHHHHH
DDMQRMMKKMKSKGGMMKMMRGMKGMMPPGFPGR
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]