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The map label for this gene is yfhK [H]

Identifier: 238896007

GI number: 238896007

Start: 3966266

End: 3967705

Strand: Reverse

Name: yfhK [H]

Synonym: KP1_4135

Alternate gene names: 238896007

Gene position: 3967705-3966266 (Counterclockwise)

Preceding gene: 238896008

Following gene: 238896006

Centisome position: 75.6

GC content: 60.49

Gene sequence:

>1440_bases
ATGATTGAGACAACATCCTTGAAGCGACTCTCTCTTTTCCCCCGTTCGCTGCGTCAGCTGGTGACGCTCTCTTTTGTGCT
GATCCTGCTGCCATTGCTGGTGCTGGCCTGGCAGGCCTGGCAGAGCCTGAACGCCCTTAGCGCCCAGGCGGCGCATATTA
ACCGTACCACCCTGGTCGACGCCCGACGCAGCGAGGCGATGATCAATGCCGCACTGGAGATGGAGCGCAGCTATCGCCAG
TACTGCGTGCTGGACGATCCGACGCTGGCGCGCGTCTATCAAAACCAGCGGCAGCGCTACAGCCAGATGCTGGACGCCCA
CGCCGGCGTGCTGCCGGACGAGAAGCTCTGGCAGGCGCTGCGTCAGGATGTCAGCGATCTGGCGCAGCTGCAGTGTAAAA
ATAGCGGACCCGATGCCCAGGCAGCCGCCAGACTGGAAGTTTTCGCCAGTAATAACAGCGATATGGTGCAGGCGACCCGG
GCGGTCGTCTATTCTCGTGGCCAACAGCTGCAGCAGGAGATAGCCGAACGCGGCCAGTTTTTTGGCTGGCAGGCGCTGGT
GCTGTTTCTGCTGAGCCTGGCGCTGGTGCTACTCTTCACCCGCATGATTATCGGCCCGGTGAAAGGCATCGAAAGAATGA
TCAATCAGCTGGGGGCAGGGAAGTCGCTGGACGACGCCGCATTGTTTACCGGCCCGCGCGAGCTGCGATCGGTGGGCAAG
CGCATCATCTGGCTCAGCGAGCGCCTGGCGTGGCTGGAGTCGCAGCGGCATCAATTTCTTCGCCATCTGTCGCATGAGCT
GAAAACCCCGTTGGCCAGTATGCGTGAAGGTACCGAGCTGTTGGCCGACCGGGTCGCGGGGCCCCTGACCCCTGAGCAGC
AGGAGATTGTCGAGATCCTCGACAGCAGTAGCCGTAACCTGCAAAAGCTGATTGAACAGCTGCTGGACTATAACCGAAAA
CAGGCCGACGGCCCGGTGGCTCGCGAAGCGGTGGACCTGGTGGACCTGGTGGAAAACGTCGTGGCGGCGCACAGCCTGCC
CGCGCGGGCTAAACTGATGCATACCGAACTGACGCTGCAGGCGCGGCGTTGCCTGGCAGAGCCTGCGCTATTGATAAGCG
TAATGGATAATCTCTACTCCAATGCGGTGCACTATGGCGCTGAATCCGGTAACATCCGTATCCATAGCTACCGGTACGGA
GAGCAGGTGCGTATTGATGTCGCCAACAGCGGCGAACCGATCCCGGCCGCGGAAAAAAACATGATATTCGAGCCTTTTTA
CCAGGGGAGTCACCAGCGTAAAGGGGCCGTTAAGGGCAGTGGACTGGGGTTGAGTATCGCCCGCGACTGCGTCCGGCAGA
TGCAAGGGGAGCTCAGCTTAGTTGATGCGCCCGCCGGGCAGGTCTGTTTTCGCATTACGCTTCCCTCAGCGCCGGAATAA

Upstream 100 bases:

>100_bases
AAAGCCAGGCCTTGCGCCTGGCTTTGTTGTTTCTGCGGCGCAGCACTCAGCGGTAGCGCTTTTCTCCGGCGCGCTCCTCA
GTTAGCATCGACCAGAGCTA

Downstream 100 bases:

>100_bases
TCCAACTTATGAATCGATATCGGGGAACTATGTCCCAATTCCTGGCCTGGCGCCGTTCCCTCAGTGGATGGCTGCTTTCA
GGCATTGCTTGTCTTACGCT

Product: putative 2-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MIETTSLKRLSLFPRSLRQLVTLSFVLILLPLLVLAWQAWQSLNALSAQAAHINRTTLVDARRSEAMINAALEMERSYRQ
YCVLDDPTLARVYQNQRQRYSQMLDAHAGVLPDEKLWQALRQDVSDLAQLQCKNSGPDAQAAARLEVFASNNSDMVQATR
AVVYSRGQQLQQEIAERGQFFGWQALVLFLLSLALVLLFTRMIIGPVKGIERMINQLGAGKSLDDAALFTGPRELRSVGK
RIIWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADRVAGPLTPEQQEIVEILDSSSRNLQKLIEQLLDYNRK
QADGPVAREAVDLVDLVENVVAAHSLPARAKLMHTELTLQARRCLAEPALLISVMDNLYSNAVHYGAESGNIRIHSYRYG
EQVRIDVANSGEPIPAAEKNMIFEPFYQGSHQRKGAVKGSGLGLSIARDCVRQMQGELSLVDAPAGQVCFRITLPSAPE

Sequences:

>Translated_479_residues
MIETTSLKRLSLFPRSLRQLVTLSFVLILLPLLVLAWQAWQSLNALSAQAAHINRTTLVDARRSEAMINAALEMERSYRQ
YCVLDDPTLARVYQNQRQRYSQMLDAHAGVLPDEKLWQALRQDVSDLAQLQCKNSGPDAQAAARLEVFASNNSDMVQATR
AVVYSRGQQLQQEIAERGQFFGWQALVLFLLSLALVLLFTRMIIGPVKGIERMINQLGAGKSLDDAALFTGPRELRSVGK
RIIWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADRVAGPLTPEQQEIVEILDSSSRNLQKLIEQLLDYNRK
QADGPVAREAVDLVDLVENVVAAHSLPARAKLMHTELTLQARRCLAEPALLISVMDNLYSNAVHYGAESGNIRIHSYRYG
EQVRIDVANSGEPIPAAEKNMIFEPFYQGSHQRKGAVKGSGLGLSIARDCVRQMQGELSLVDAPAGQVCFRITLPSAPE
>Mature_479_residues
MIETTSLKRLSLFPRSLRQLVTLSFVLILLPLLVLAWQAWQSLNALSAQAAHINRTTLVDARRSEAMINAALEMERSYRQ
YCVLDDPTLARVYQNQRQRYSQMLDAHAGVLPDEKLWQALRQDVSDLAQLQCKNSGPDAQAAARLEVFASNNSDMVQATR
AVVYSRGQQLQQEIAERGQFFGWQALVLFLLSLALVLLFTRMIIGPVKGIERMINQLGAGKSLDDAALFTGPRELRSVGK
RIIWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADRVAGPLTPEQQEIVEILDSSSRNLQKLIEQLLDYNRK
QADGPVAREAVDLVDLVENVVAAHSLPARAKLMHTELTLQARRCLAEPALLISVMDNLYSNAVHYGAESGNIRIHSYRYG
EQVRIDVANSGEPIPAAEKNMIFEPFYQGSHQRKGAVKGSGLGLSIARDCVRQMQGELSLVDAPAGQVCFRITLPSAPE

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=471, Percent_Identity=78.5562632696391, Blast_Score=725, Evalue=0.0,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=31.3253012048193, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790861, Length=212, Percent_Identity=32.0754716981132, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI87081816, Length=223, Percent_Identity=30.9417040358744, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1789808, Length=291, Percent_Identity=25.7731958762887, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=26.978417266187, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=292, Percent_Identity=24.6575342465753, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=27.3913043478261, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=28.8793103448276, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=238, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=28.0334728033473, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=27.3927392739274, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=26.1802575107296, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790300, Length=230, Percent_Identity=29.5652173913043, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788279, Length=293, Percent_Identity=23.8907849829352, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53533; Mature: 53533

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETTSLKRLSLFPRSLRQLVTLSFVLILLPLLVLAWQAWQSLNALSAQAAHINRTTLVD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ARRSEAMINAALEMERSYRQYCVLDDPTLARVYQNQRQRYSQMLDAHAGVLPDEKLWQAL
HHHHHHHHHHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RQDVSDLAQLQCKNSGPDAQAAARLEVFASNNSDMVQATRAVVYSRGQQLQQEIAERGQF
HHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGWQALVLFLLSLALVLLFTRMIIGPVKGIERMINQLGAGKSLDDAALFTGPRELRSVGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHH
RIIWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADRVAGPLTPEQQEIVEIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
DSSSRNLQKLIEQLLDYNRKQADGPVAREAVDLVDLVENVVAAHSLPARAKLMHTELTLQ
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ARRCLAEPALLISVMDNLYSNAVHYGAESGNIRIHSYRYGEQVRIDVANSGEPIPAAEKN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCC
MIFEPFYQGSHQRKGAVKGSGLGLSIARDCVRQMQGELSLVDAPAGQVCFRITLPSAPE
CEECHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCC
>Mature Secondary Structure
MIETTSLKRLSLFPRSLRQLVTLSFVLILLPLLVLAWQAWQSLNALSAQAAHINRTTLVD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ARRSEAMINAALEMERSYRQYCVLDDPTLARVYQNQRQRYSQMLDAHAGVLPDEKLWQAL
HHHHHHHHHHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RQDVSDLAQLQCKNSGPDAQAAARLEVFASNNSDMVQATRAVVYSRGQQLQQEIAERGQF
HHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGWQALVLFLLSLALVLLFTRMIIGPVKGIERMINQLGAGKSLDDAALFTGPRELRSVGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHH
RIIWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADRVAGPLTPEQQEIVEIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
DSSSRNLQKLIEQLLDYNRKQADGPVAREAVDLVDLVENVVAAHSLPARAKLMHTELTLQ
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ARRCLAEPALLISVMDNLYSNAVHYGAESGNIRIHSYRYGEQVRIDVANSGEPIPAAEKN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCC
MIFEPFYQGSHQRKGAVKGSGLGLSIARDCVRQMQGELSLVDAPAGQVCFRITLPSAPE
CEECHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]