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The map label for this gene is pepB [H]

Identifier: 238895980

GI number: 238895980

Start: 3939411

End: 3940727

Strand: Reverse

Name: pepB [H]

Synonym: KP1_4107

Alternate gene names: 238895980

Gene position: 3940727-3939411 (Counterclockwise)

Preceding gene: 238895981

Following gene: 238895979

Centisome position: 75.08

GC content: 60.52

Gene sequence:

>1317_bases
GTGGCCCGTTTGCTAAGAAGGATAATGATAATGACCGAAGCTATGAAGATTACGCTTTCTACTCAGCCAGCCGATGGACG
CTGGGGAGAAAAAGCGACCTGGAGCATCAATAACGACGGCATCGCTCTACATCTCAACGGTAAAGACGACCTCGGGCTTA
TCCAGCGCGCGGCGCGCAAAATTGACGGCATGGGCATCAAGCACGTCGCCCTGAGCGGCGAAGGCTGGAACACCGATCGC
GCCTGGGCCTTTTGGGCCGGCTATAAAGGGCCGAAAGGTCAGCGTCAGGTCGAATGGCCATCCCTTGACGACGCGCAGCG
CAGCGAGCTGGATAACCGCCTGACGATCATCGACTGGGTGCGCGATACCATCAATGCGCCGGCGGAAGAGCTGGGTCCGG
AGCAGCTGGCGCAGCGCGCTGTCGACCTGCTGTGCGGCGTGGCGGGTGAGAAGATAAGCTATCGCATCACCAAAGGCGAA
GATCTGCGCGAGCAGGGCTATCTTGGTCTGCATACCGTGGGCCGCGGCTCCGAGCGTCCGCCGGTCCTGCTGGCGCTGGA
CTATAACCCGACCGGCGATAAAGAGGCGCCGGTATACGCCTGCCTGGTGGGCAAAGGCATCACCTTTGATTCCGGCGGCT
ACAGCATCAAGCAAAGCGCCTTTATGGATTCGATGAAATCCGATATGGGCGGTGCGGCGACTATCACCGGCGCGCTGGCT
TTCGCCATTACCCGCGGTCTGAACAAACGCGTGAAGCTCTACCTGTGCTGCGCCGACAACCTGATCAGCGGTAACGCCTT
CAAACTGGGCGATATTATTCATTATCGCAACGGCAAAACCGTTGAAGTTATGAACACTGACGCGGAAGGCCGCCTGGTGC
TGGCGGATGGCCTGATTGACGCCTCGGCGCAGAAGCCAGAGCTGCTCATCGACGCCGCCACCCTGACCGGCGCGGCGAAA
ACCGCGTTGGGCAATGATTACCACGCGCTGTTCAGCTTTGACGATGCGCTGGCGAATCGCCTGCTGGCGAGCGCTCAGGC
GGAAAACGAAGCCTTCTGGCGTCTGCCGCTGGCCGAGTTCCACCGCAACCAGCTGCCGTCCAACTTTGCTGACCTGAACA
ATACCGGCAGCGCGGCCTATCCGGCCGGCGCCAGCACCGCGGCGGGCTTCCTGTCCCACTTCGTGGAAAACTACCATCAG
GGTTGGCTGCATATCGACTGTTCGGCAACCTACCGCAAATCTGCCGTTGAGCAGTGGTCGGCGGGCGCCACCGGGCTTGG
CGTGCGTACCATTGCTAACCTGCTGACAGCTGAGTAA

Upstream 100 bases:

>100_bases
GCATCCAATGAAAAAATTCTCGAGGCGATTCTGCTAGTCTGGCTAGACGAGGCCGAATAATTTCGCGTTAAGCGAAAACA
TTTTAACGGGCTGCCATAGG

Downstream 100 bases:

>100_bases
TGGCCTTGCCGGGTGGCGCTGCGCTTACCCGGCCAGGAAAACCATATGCCCGCGTGGACGAATGGCCGCCGGGCAATTCA
TTGTGAAGTAGCCAAACTAT

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MARLLRRIMIMTEAMKITLSTQPADGRWGEKATWSINNDGIALHLNGKDDLGLIQRAARKIDGMGIKHVALSGEGWNTDR
AWAFWAGYKGPKGQRQVEWPSLDDAQRSELDNRLTIIDWVRDTINAPAEELGPEQLAQRAVDLLCGVAGEKISYRITKGE
DLREQGYLGLHTVGRGSERPPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATITGALA
FAITRGLNKRVKLYLCCADNLISGNAFKLGDIIHYRNGKTVEVMNTDAEGRLVLADGLIDASAQKPELLIDAATLTGAAK
TALGNDYHALFSFDDALANRLLASAQAENEAFWRLPLAEFHRNQLPSNFADLNNTGSAAYPAGASTAAGFLSHFVENYHQ
GWLHIDCSATYRKSAVEQWSAGATGLGVRTIANLLTAE

Sequences:

>Translated_438_residues
MARLLRRIMIMTEAMKITLSTQPADGRWGEKATWSINNDGIALHLNGKDDLGLIQRAARKIDGMGIKHVALSGEGWNTDR
AWAFWAGYKGPKGQRQVEWPSLDDAQRSELDNRLTIIDWVRDTINAPAEELGPEQLAQRAVDLLCGVAGEKISYRITKGE
DLREQGYLGLHTVGRGSERPPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATITGALA
FAITRGLNKRVKLYLCCADNLISGNAFKLGDIIHYRNGKTVEVMNTDAEGRLVLADGLIDASAQKPELLIDAATLTGAAK
TALGNDYHALFSFDDALANRLLASAQAENEAFWRLPLAEFHRNQLPSNFADLNNTGSAAYPAGASTAAGFLSHFVENYHQ
GWLHIDCSATYRKSAVEQWSAGATGLGVRTIANLLTAE
>Mature_437_residues
ARLLRRIMIMTEAMKITLSTQPADGRWGEKATWSINNDGIALHLNGKDDLGLIQRAARKIDGMGIKHVALSGEGWNTDRA
WAFWAGYKGPKGQRQVEWPSLDDAQRSELDNRLTIIDWVRDTINAPAEELGPEQLAQRAVDLLCGVAGEKISYRITKGED
LREQGYLGLHTVGRGSERPPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATITGALAF
AITRGLNKRVKLYLCCADNLISGNAFKLGDIIHYRNGKTVEVMNTDAEGRLVLADGLIDASAQKPELLIDAATLTGAAKT
ALGNDYHALFSFDDALANRLLASAQAENEAFWRLPLAEFHRNQLPSNFADLNNTGSAAYPAGASTAAGFLSHFVENYHQG
WLHIDCSATYRKSAVEQWSAGATGLGVRTIANLLTAE

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=317, Percent_Identity=38.801261829653, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI47155554, Length=284, Percent_Identity=35.5633802816901, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI87082123, Length=427, Percent_Identity=89.9297423887588, Blast_Score=799, Evalue=0.0,
Organism=Escherichia coli, GI1790710, Length=282, Percent_Identity=40.4255319148936, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=299, Percent_Identity=34.1137123745819, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=200, Percent_Identity=30.5, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357381, Length=345, Percent_Identity=31.8840579710145, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379063, Length=345, Percent_Identity=31.8840579710145, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379062, Length=345, Percent_Identity=31.8840579710145, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21355725, Length=322, Percent_Identity=30.4347826086957, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24661038, Length=322, Percent_Identity=30.4347826086957, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24662227, Length=321, Percent_Identity=29.9065420560748, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161077148, Length=348, Percent_Identity=31.0344827586207, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20130057, Length=348, Percent_Identity=31.0344827586207, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20129969, Length=294, Percent_Identity=30.2721088435374, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355645, Length=321, Percent_Identity=28.6604361370716, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24662223, Length=321, Percent_Identity=28.6604361370716, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI20129963, Length=337, Percent_Identity=29.080118694362, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI19922386, Length=292, Percent_Identity=28.4246575342466, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646701, Length=228, Percent_Identity=29.8245614035088, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646703, Length=228, Percent_Identity=29.8245614035088, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358201, Length=228, Percent_Identity=29.8245614035088, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 47474; Mature: 47343

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLLRRIMIMTEAMKITLSTQPADGRWGEKATWSINNDGIALHLNGKDDLGLIQRAARK
CHHHHHHHHHHHHEEEEEEECCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHH
IDGMGIKHVALSGEGWNTDRAWAFWAGYKGPKGQRQVEWPSLDDAQRSELDNRLTIIDWV
HCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCEECCCCCCCHHHHHHCCCEEHHHHH
RDTINAPAEELGPEQLAQRAVDLLCGVAGEKISYRITKGEDLREQGYLGLHTVGRGSERP
HHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCEEEEECCCCCCCC
PVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATITGALA
CEEEEEECCCCCCCCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
FAITRGLNKRVKLYLCCADNLISGNAFKLGDIIHYRNGKTVEVMNTDAEGRLVLADGLID
HHHHHCCCCEEEEEEEECCCCCCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCC
ASAQKPELLIDAATLTGAAKTALGNDYHALFSFDDALANRLLASAQAENEAFWRLPLAEF
CCCCCCCEEEEEHHHCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCCCCEEECCHHHH
HRNQLPSNFADLNNTGSAAYPAGASTAAGFLSHFVENYHQGWLHIDCSATYRKSAVEQWS
HHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHC
AGATGLGVRTIANLLTAE
CCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ARLLRRIMIMTEAMKITLSTQPADGRWGEKATWSINNDGIALHLNGKDDLGLIQRAARK
HHHHHHHHHHHHEEEEEEECCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHH
IDGMGIKHVALSGEGWNTDRAWAFWAGYKGPKGQRQVEWPSLDDAQRSELDNRLTIIDWV
HCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCEECCCCCCCHHHHHHCCCEEHHHHH
RDTINAPAEELGPEQLAQRAVDLLCGVAGEKISYRITKGEDLREQGYLGLHTVGRGSERP
HHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCEEEEECCCCCCCC
PVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQSAFMDSMKSDMGGAATITGALA
CEEEEEECCCCCCCCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
FAITRGLNKRVKLYLCCADNLISGNAFKLGDIIHYRNGKTVEVMNTDAEGRLVLADGLID
HHHHHCCCCEEEEEEEECCCCCCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCC
ASAQKPELLIDAATLTGAAKTALGNDYHALFSFDDALANRLLASAQAENEAFWRLPLAEF
CCCCCCCEEEEEHHHCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCCCCEEECCHHHH
HRNQLPSNFADLNNTGSAAYPAGASTAAGFLSHFVENYHQGWLHIDCSATYRKSAVEQWS
HHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHC
AGATGLGVRTIANLLTAE
CCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA