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The map label for this gene is guaD [H]

Identifier: 238895863

GI number: 238895863

Start: 3807267

End: 3807731

Strand: Direct

Name: guaD [H]

Synonym: KP1_3983

Alternate gene names: 238895863

Gene position: 3807267-3807731 (Clockwise)

Preceding gene: 238895861

Following gene: 238895864

Centisome position: 72.54

GC content: 58.28

Gene sequence:

>465_bases
GTGACTATGTCCGCTCACGATCGTTATCTTCAGCGCGCATTAGTGCTGGCAAAACAAAACATTGCTGACGGTGGGCGCCC
CTTCGGCGCCGTGCTGGTGCGGAATGATGAGATTGTCGCTGAAAGCGTCAATACCTTTCATCTGAGCGGTGACCCAACGG
CGCATGCCGAACTGAACGCCGTTCGCGATCTTGCCGCCAGACTGGGAAGCGCGGTGTTGCGTGAATGCGTCATCTATGCC
AGCGGACAACCTTGCCCTATGTGCCTGAGCGCGCTCTATTTAACCGGCGTGCGGGAAGTGTTTTTCGCCAATAGCAATCA
GGACGGGGAGCCTTTTCAGCTCTCGACCGCCGCGATTTATCAGCAGCTGCAGCAGCCGCTGGCCCAGCAAACGCTGCCGA
TCCATCATCGCCCGCAGCCGGAGGGAACTGAACTTTATCAGCGCTGGGCGGAACGGCAGTCATGA

Upstream 100 bases:

>100_bases
GGCATTATCATAAATAAGTCTTTTAACTTATGAAACAAGAGACGTACCCTCTTCGCACGACCCTCAACATATTTCACCTT
TAACATCGTTTTATGCAGGA

Downstream 100 bases:

>100_bases
CACCAGCGCTGCGACAGAACCTGACGCTGGCAGTCCTGGTACTGACTGGGATCAATATGCGGCCGCTGCTTACCTCCATT
GGTCCTTTGCTGCCGGACAT

Product: putative adenosine deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MTMSAHDRYLQRALVLAKQNIADGGRPFGAVLVRNDEIVAESVNTFHLSGDPTAHAELNAVRDLAARLGSAVLRECVIYA
SGQPCPMCLSALYLTGVREVFFANSNQDGEPFQLSTAAIYQQLQQPLAQQTLPIHHRPQPEGTELYQRWAERQS

Sequences:

>Translated_154_residues
MTMSAHDRYLQRALVLAKQNIADGGRPFGAVLVRNDEIVAESVNTFHLSGDPTAHAELNAVRDLAARLGSAVLRECVIYA
SGQPCPMCLSALYLTGVREVFFANSNQDGEPFQLSTAAIYQQLQQPLAQQTLPIHHRPQPEGTELYQRWAERQS
>Mature_153_residues
TMSAHDRYLQRALVLAKQNIADGGRPFGAVLVRNDEIVAESVNTFHLSGDPTAHAELNAVRDLAARLGSAVLRECVIYAS
GQPCPMCLSALYLTGVREVFFANSNQDGEPFQLSTAAIYQQLQQPLAQQTLPIHHRPQPEGTELYQRWAERQS

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=99, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554608, Length=148, Percent_Identity=27.027027027027, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555996, Length=149, Percent_Identity=26.1744966442953, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17541138, Length=108, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17032; Mature: 16901

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMSAHDRYLQRALVLAKQNIADGGRPFGAVLVRNDEIVAESVNTFHLSGDPTAHAELNA
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHCCCEEEECCCCCCHHHHHH
VRDLAARLGSAVLRECVIYASGQPCPMCLSALYLTGVREVFFANSNQDGEPFQLSTAAIY
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHH
QQLQQPLAQQTLPIHHRPQPEGTELYQRWAERQS
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TMSAHDRYLQRALVLAKQNIADGGRPFGAVLVRNDEIVAESVNTFHLSGDPTAHAELNA
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHCCCEEEECCCCCCHHHHHH
VRDLAARLGSAVLRECVIYASGQPCPMCLSALYLTGVREVFFANSNQDGEPFQLSTAAIY
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHH
QQLQQPLAQQTLPIHHRPQPEGTELYQRWAERQS
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]