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The map label for this gene is fadI [H]

Identifier: 238895855

GI number: 238895855

Start: 3798587

End: 3799897

Strand: Reverse

Name: fadI [H]

Synonym: KP1_3974

Alternate gene names: 238895855

Gene position: 3799897-3798587 (Counterclockwise)

Preceding gene: 238895856

Following gene: 238895854

Centisome position: 72.4

GC content: 62.62

Gene sequence:

>1311_bases
ATGAGTCAGGCATTACCGCTTATCACCCGTCAGGGCGATCGCATTGCCATTGTCACGGGGCTACGCACGCCATTTGCTCG
TCAGGCTACGGCTTTTCATGGCGTTCCGGCCATTGATTTAGGAAAAATGGTGGTTGGCGAGATGCTGGCGCGCAGCGACA
TTCCTGCCGAAGTCATCGAGCAACTGGTCTTTGGCCAGGTGGTGCAGATGCCGGAAGCGCCGAACATCGCCCGGGAAATT
GTGCTGGGTACCGGCATGAGCGTACATACCGACGCCTATAGCGTCAGCCGCGCCTGCGCCACCAGTTTCCAGGCCGTGGC
GAACGTCGCTGAAAGCCTGATGGCCGGCACCATCCGCGCCGGTATTGCCGGCGGCGCCGACTCCTCCTCTGTCCTGCCCA
TTGGGGTCAGTAAAACGCTGGCCCGCACGCTAGTGGATGCCAATAAGGCACGCACGCTGAGCCAAAAGCTGAAGCTGTTT
TCCCGTCTGCGGCCACGCGACCTGCTGCCGGTCCCCCCGGCGGTGGCTGAATATTCAACCGGATTGCGGATGGGCGATAC
CGCCGAGCAGATGGCGAAAAGCTGGGGGATCTCCCGCGAGCAACAGGATGCCCTGGCGCATCGTTCGCACCAGCTGGCAG
CGAAAGCCTGGGAAGAGGGTAAACTGTCCGCAGAGGTGATGACCGCCTATGCTCCCCCTTTCCGCGAACCGCTCGAGCAG
GACAACAATATTCGTAAAAATTCAACGCTCGCAGATTATCAGAAGTTACGCCCGGCCTTTGACCGCAAACATGGCACCGT
CACCGCTGCCAACAGTACGCCGCTGACGGACGGCGCGGCAGCGGTGATCCTGATGACCGAGTCGCGGGCTAAAGAGCTGG
GGCTGAGGCCGCTGGGCTATCTGCGCAGCTACGCCTTTACCGCCATCGACGTCTGGCAGGATATGCTGCTGGGGCCCGCG
TGGTCCACGCCGCTGGCGCTGGAGCGCGCTGGCCTGACGCTGGCGGATCTCACGCTTATCGATATGCACGAAGCTTTCGC
CGCGCAGACGCTGGCCAATCTCCAGTGTCTGGCAAGCGACCGCTTTGCCCGCGAGGTGCTGGGCCGCTCGCAGGCCACCG
GTGAGGTAGATGAAAGCAAGTTTAACGTCCTCGGCGGCTCTATCGCCTACGGTCACCCCTTCGCCGCCACCGGCGCGCGG
ATGATCACCCAGACGCTGCATGAGCTGCGGCGACGGGGCGGGGGATTTGGTTTGGTGACGGCCTGCGCGGCAGGTGGTCT
GGGTGCGGCGATGATCGTGGAGGCTGAATAA

Upstream 100 bases:

>100_bases
CTCGCAATTTTGCGCTTCTCCGATTGGCTTAATGTAAAAAATTAGTTAAGAATGTTATCAGGTCAGACCACTTGGTTGTC
TTGGTTAACAGGGGAGTGTT

Downstream 100 bases:

>100_bases
TGGATACTGTTTCCGCTTTTAAGCTTGAGGTCCGTGCGGACAAAATCGCGGTGATCACCATTGATGCCCCGGGTGAAAAA
ATGAATACCCTGAAAGCCGA

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSQALPLITRQGDRIAIVTGLRTPFARQATAFHGVPAIDLGKMVVGEMLARSDIPAEVIEQLVFGQVVQMPEAPNIAREI
VLGTGMSVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKTLARTLVDANKARTLSQKLKLF
SRLRPRDLLPVPPAVAEYSTGLRMGDTAEQMAKSWGISREQQDALAHRSHQLAAKAWEEGKLSAEVMTAYAPPFREPLEQ
DNNIRKNSTLADYQKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLRPLGYLRSYAFTAIDVWQDMLLGPA
WSTPLALERAGLTLADLTLIDMHEAFAAQTLANLQCLASDRFAREVLGRSQATGEVDESKFNVLGGSIAYGHPFAATGAR
MITQTLHELRRRGGGFGLVTACAAGGLGAAMIVEAE

Sequences:

>Translated_436_residues
MSQALPLITRQGDRIAIVTGLRTPFARQATAFHGVPAIDLGKMVVGEMLARSDIPAEVIEQLVFGQVVQMPEAPNIAREI
VLGTGMSVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKTLARTLVDANKARTLSQKLKLF
SRLRPRDLLPVPPAVAEYSTGLRMGDTAEQMAKSWGISREQQDALAHRSHQLAAKAWEEGKLSAEVMTAYAPPFREPLEQ
DNNIRKNSTLADYQKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLRPLGYLRSYAFTAIDVWQDMLLGPA
WSTPLALERAGLTLADLTLIDMHEAFAAQTLANLQCLASDRFAREVLGRSQATGEVDESKFNVLGGSIAYGHPFAATGAR
MITQTLHELRRRGGGFGLVTACAAGGLGAAMIVEAE
>Mature_435_residues
SQALPLITRQGDRIAIVTGLRTPFARQATAFHGVPAIDLGKMVVGEMLARSDIPAEVIEQLVFGQVVQMPEAPNIAREIV
LGTGMSVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKTLARTLVDANKARTLSQKLKLFS
RLRPRDLLPVPPAVAEYSTGLRMGDTAEQMAKSWGISREQQDALAHRSHQLAAKAWEEGKLSAEVMTAYAPPFREPLEQD
NNIRKNSTLADYQKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLRPLGYLRSYAFTAIDVWQDMLLGPAW
STPLALERAGLTLADLTLIDMHEAFAAQTLANLQCLASDRFAREVLGRSQATGEVDESKFNVLGGSIAYGHPFAATGARM
ITQTLHELRRRGGGFGLVTACAAGGLGAAMIVEAE

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=422, Percent_Identity=41.7061611374408, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI4557237, Length=423, Percent_Identity=29.5508274231678, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4501853, Length=430, Percent_Identity=32.5581395348837, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI167614485, Length=424, Percent_Identity=30.8962264150943, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI148539872, Length=427, Percent_Identity=29.9765807962529, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI194353979, Length=258, Percent_Identity=27.906976744186, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788683, Length=436, Percent_Identity=88.9908256880734, Blast_Score=785, Evalue=0.0,
Organism=Escherichia coli, GI1788554, Length=423, Percent_Identity=35.2245862884161, Blast_Score=204, Evalue=9e-54,
Organism=Escherichia coli, GI87082165, Length=422, Percent_Identity=31.5165876777251, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI48994986, Length=436, Percent_Identity=33.256880733945, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1787663, Length=423, Percent_Identity=33.3333333333333, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17551802, Length=422, Percent_Identity=39.5734597156398, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI133906874, Length=426, Percent_Identity=32.3943661971831, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25147385, Length=421, Percent_Identity=27.790973871734, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17535921, Length=423, Percent_Identity=27.8959810874704, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=427, Percent_Identity=23.6533957845433, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6325229, Length=433, Percent_Identity=30.4849884526559, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322031, Length=440, Percent_Identity=28.6363636363636, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=42.093023255814, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24655093, Length=424, Percent_Identity=29.7169811320755, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17648125, Length=430, Percent_Identity=28.8372093023256, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24640423, Length=426, Percent_Identity=26.5258215962441, Blast_Score=159, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46534; Mature: 46403

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQALPLITRQGDRIAIVTGLRTPFARQATAFHGVPAIDLGKMVVGEMLARSDIPAEVIE
CCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHH
QLVFGQVVQMPEAPNIAREIVLGTGMSVHTDAYSVSRACATSFQAVANVAESLMAGTIRA
HHHHHHHHCCCCCCCHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAGGADSSSVLPIGVSKTLARTLVDANKARTLSQKLKLFSRLRPRDLLPVPPAVAEYST
CCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHC
GLRMGDTAEQMAKSWGISREQQDALAHRSHQLAAKAWEEGKLSAEVMTAYAPPFREPLEQ
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHC
DNNIRKNSTLADYQKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLRPLGY
CCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEECHHHHHCCCCHHHH
LRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTLADLTLIDMHEAFAAQTLANLQCLASD
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
RFAREVLGRSQATGEVDESKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVT
HHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMIVEAE
HHHCCCCCEEEEEECC
>Mature Secondary Structure 
SQALPLITRQGDRIAIVTGLRTPFARQATAFHGVPAIDLGKMVVGEMLARSDIPAEVIE
CCCCCHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHH
QLVFGQVVQMPEAPNIAREIVLGTGMSVHTDAYSVSRACATSFQAVANVAESLMAGTIRA
HHHHHHHHCCCCCCCHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIAGGADSSSVLPIGVSKTLARTLVDANKARTLSQKLKLFSRLRPRDLLPVPPAVAEYST
CCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHC
GLRMGDTAEQMAKSWGISREQQDALAHRSHQLAAKAWEEGKLSAEVMTAYAPPFREPLEQ
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHC
DNNIRKNSTLADYQKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLRPLGY
CCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEECHHHHHCCCCHHHH
LRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTLADLTLIDMHEAFAAQTLANLQCLASD
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
RFAREVLGRSQATGEVDESKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVT
HHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMIVEAE
HHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA