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The map label for this gene is nuoC [H]

Identifier: 238895803

GI number: 238895803

Start: 3750519

End: 3752327

Strand: Reverse

Name: nuoC [H]

Synonym: KP1_3920

Alternate gene names: 238895803

Gene position: 3752327-3750519 (Counterclockwise)

Preceding gene: 238895804

Following gene: 238895802

Centisome position: 71.49

GC content: 58.98

Gene sequence:

>1809_bases
ATGGTGAACAATATGACCGATTTAACCGCGCATGACGCCGCACCAGCCTGGCAAACCCGCGATCACCTTGATGACCCGGT
GATTGGCGAACTGCGCAACCGCTTTGGGCCGGATGCCTTTACCGTTCAGCCAACCCGTACCGGCGTACCGGTGGTATGGG
TGAAGCGTGAACAGCTGCTGGAGGTGGGTGATTTCCTGAAGAAATTGCCGAAGCCTTACGTGATGCTGTTTGACCTGCAC
GGCATGGACGAACGTCTGCGCACGCACCGCGATGGCCTGCCCGCCGCGGATTTTTCCGTTTTCTATCACCTGATCTCCAT
CGATCGCAACCGCGACATCATGCTCAAGGTGGCGCTGTCGGAAAACGATCTGCATCTGCCGACCTTCACCAAACTGTTCC
CCAACGCCAACTGGTATGAGCGTGAAACCTGGGAAATGTTTGGCATTACCTTCGATGGTCACCCGAACCTGCGTCGCATC
ATGATGCCGCCGACCTGGGAAGGTCACCCGCTGCGTAAAGATTATCCGGCGCGTGCCACCGAGTTCGACCCGTTTGAGCT
GACCAAAGCCAAACAGGATCTGGAGATGGAGGCGCTGACCTTTAAACCGGAAGAGTGGGGCATGAAGCGCGGCACCGACA
ACGAGGACTTCATGTTCCTCAACCTCGGTCCGAACCACCCATCGGCGCATGGTGCGTTCCGCATTATTCTGCAACTGGAC
GGCGAAGAGATCGTCGACTGCGTACCGGATATCGGTTATCACCACCGCGGCGCCGAGAAGATGGGCGAGCGTCAGTCCTG
GCACAGCTACATCCCGTATACCGACCGTATTGAATATCTCGGCGGCTGCGTCAACGAGATGCCGTACGTGCTGGCGGTGG
AAAAACTGGCTGGGATCACCGTACCGGATCGCGTGAACGTGATCCGCGTGATGCTCTCCGAGCTGTTCCGCATCAACAGC
CACCTGCTGTATATCTCGACCTTTATTCAGGACGTCGGCGCGATGACGCCGGTCTTCTTCGCCTTTACCGATCGGCAGAA
AATTTACGATCTGGTGGAAGCGATTACCGGGTTCCGTATGCACCCGGCGTGGTTCCGCATCGGCGGCGTCGCGCACGATC
TGCCGCGTGGCTGGGATCGCCTGCTGCGTGAGTTCCTCGAGTGGATGCCGAAGCGTCTGGACTCCTATGAGAAGGCCGCC
CTGCGCAACACCATTCTGAAAGGCCGTTCCGTCGGCGTGGCAGCCTATACCGCCAAAGAGGCGCTGGAGTGGGGCACCAC
CGGCGCAGGCCTGCGCGCCACCGGTATCGACTTCGACGTGCGTAAATGGCGTCCTTACTCTGGCTATGAAAACTTCGACT
TCGAAGTCCCGACCGGGGGGGGCGTCTCAGACTGCTACACCCGCGTGATGCTGAAAGTAGAAGAGCTGCGCCAGAGCCTG
CGCATTCTTCAGCAGTGCCTCGATAACATGCCGGAAGGCCCGTTCAAAGCGGATCACCCGCTGACCACGCCGCCGCCGAA
AGAGCGCACGCTGCAGCATATCGAAACCCTGATCACCCACTTCCTGCAGGTATCGTGGGGCCCGGTGATGCCGGCCAACG
AATCTTTCCAGATGATTGAGGCGACCAAAGGGATCAACAGTTACTACCTGACCAGCGACGGCAGCACCATGAGCTACCGC
ACCCGCGTCCGTACGCCGAGCTTTGCGCACCTGCAGCAGATCCCGTCGGCGATCCGCGGCAGCCTGGTATCCGACCTGAT
CGTCTATCTGGGTAGTATCGATTTTGTTATGTCAGACGTGGACCGCTAA

Upstream 100 bases:

>100_bases
CGGACGAGATTTAATTTGCGCCTGCGGGCGGGAGAACCACTTCGCAAATCAATCTACAACAGCGCGAAGTCTCGCCGGCA
GTCACCACGGACCTTTTGCA

Downstream 100 bases:

>100_bases
TTATGCACGAGAATCAACAACCACAAACCGAGGCTTTTGAGCTGAGTGCGGCAGAGCGTGAGGCTATTGAGCACGAGAAG
CACCACTACGAAGACCCGCG

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MVNNMTDLTAHDAAPAWQTRDHLDDPVIGELRNRFGPDAFTVQPTRTGVPVVWVKREQLLEVGDFLKKLPKPYVMLFDLH
GMDERLRTHRDGLPAADFSVFYHLISIDRNRDIMLKVALSENDLHLPTFTKLFPNANWYERETWEMFGITFDGHPNLRRI
MMPPTWEGHPLRKDYPARATEFDPFELTKAKQDLEMEALTFKPEEWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLD
GEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINS
HLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAA
LRNTILKGRSVGVAAYTAKEALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPTGGGVSDCYTRVMLKVEELRQSL
RILQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYR
TRVRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR

Sequences:

>Translated_602_residues
MVNNMTDLTAHDAAPAWQTRDHLDDPVIGELRNRFGPDAFTVQPTRTGVPVVWVKREQLLEVGDFLKKLPKPYVMLFDLH
GMDERLRTHRDGLPAADFSVFYHLISIDRNRDIMLKVALSENDLHLPTFTKLFPNANWYERETWEMFGITFDGHPNLRRI
MMPPTWEGHPLRKDYPARATEFDPFELTKAKQDLEMEALTFKPEEWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLD
GEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINS
HLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAA
LRNTILKGRSVGVAAYTAKEALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPTGGGVSDCYTRVMLKVEELRQSL
RILQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYR
TRVRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR
>Mature_602_residues
MVNNMTDLTAHDAAPAWQTRDHLDDPVIGELRNRFGPDAFTVQPTRTGVPVVWVKREQLLEVGDFLKKLPKPYVMLFDLH
GMDERLRTHRDGLPAADFSVFYHLISIDRNRDIMLKVALSENDLHLPTFTKLFPNANWYERETWEMFGITFDGHPNLRRI
MMPPTWEGHPLRKDYPARATEFDPFELTKAKQDLEMEALTFKPEEWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLD
GEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINS
HLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAA
LRNTILKGRSVGVAAYTAKEALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPTGGGVSDCYTRVMLKVEELRQSL
RILQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYR
TRVRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=383, Percent_Identity=40.7310704960835, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI260898743, Length=373, Percent_Identity=40.4825737265416, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI4758788, Length=101, Percent_Identity=40.5940594059406, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI145693162, Length=598, Percent_Identity=95.4849498327759, Blast_Score=1192, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=565, Percent_Identity=26.9026548672566, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788832, Length=531, Percent_Identity=28.8135593220339, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17555284, Length=397, Percent_Identity=41.3098236775819, Blast_Score=329, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17568379, Length=402, Percent_Identity=40.2985074626866, Blast_Score=327, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI71990788, Length=127, Percent_Identity=31.496062992126, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32563621, Length=131, Percent_Identity=30.5343511450382, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=39.3229166666667, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24638644, Length=383, Percent_Identity=40.7310704960835, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24656494, Length=126, Percent_Identity=36.5079365079365, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR020396
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 69111; Mature: 69111

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00542 COMPLEX1_30K ; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNNMTDLTAHDAAPAWQTRDHLDDPVIGELRNRFGPDAFTVQPTRTGVPVVWVKREQLL
CCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCEEECCCCCCCCEEEECHHHHH
EVGDFLKKLPKPYVMLFDLHGMDERLRTHRDGLPAADFSVFYHLISIDRNRDIMLKVALS
HHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEC
ENDLHLPTFTKLFPNANWYERETWEMFGITFDGHPNLRRIMMPPTWEGHPLRKDYPARAT
CCCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCC
EFDPFELTKAKQDLEMEALTFKPEEWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLD
CCCCHHHHHHHHCCCCHHEEECCHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEC
GEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIT
CHHHHHHHCCCCCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCC
VPDRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRM
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCC
HPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAALRNTILKGRSVGVAAYTAKE
CCHHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
ALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPTGGGVSDCYTRVMLKVEELRQSL
HHHCCCCCCCCEECCCCCCHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
RILQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIE
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ATKGINSYYLTSDGSTMSYRTRVRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDV
HHCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DR
CC
>Mature Secondary Structure
MVNNMTDLTAHDAAPAWQTRDHLDDPVIGELRNRFGPDAFTVQPTRTGVPVVWVKREQLL
CCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCEEECCCCCCCCEEEECHHHHH
EVGDFLKKLPKPYVMLFDLHGMDERLRTHRDGLPAADFSVFYHLISIDRNRDIMLKVALS
HHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEC
ENDLHLPTFTKLFPNANWYERETWEMFGITFDGHPNLRRIMMPPTWEGHPLRKDYPARAT
CCCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCC
EFDPFELTKAKQDLEMEALTFKPEEWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLD
CCCCHHHHHHHHCCCCHHEEECCHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEC
GEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIT
CHHHHHHHCCCCCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCC
VPDRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRM
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCC
HPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAALRNTILKGRSVGVAAYTAKE
CCHHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
ALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPTGGGVSDCYTRVMLKVEELRQSL
HHHCCCCCCCCEECCCCCCHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHH
RILQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIE
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ATKGINSYYLTSDGSTMSYRTRVRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDV
HHCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA