Click here to switch to the map view.

The map label for this gene is nuoF [H]

Identifier: 238895801

GI number: 238895801

Start: 3748682

End: 3750019

Strand: Reverse

Name: nuoF [H]

Synonym: KP1_3917

Alternate gene names: 238895801

Gene position: 3750019-3748682 (Counterclockwise)

Preceding gene: 238895802

Following gene: 238895800

Centisome position: 71.45

GC content: 60.76

Gene sequence:

>1338_bases
ATGAAAACCGTAATTCGTACTGCGGAAACGCATCCGCTCACCTGGCGCCTGCGCGACGACAAGCAGCCGGTGTGGCTGGA
CGAGTATCGCAGTAAAAATGGCTATGAAGGGGCGCGTAAAGCCCTGACCGGGATGGCCCCGGATGAGATTGTCACGGCGG
TAAAAGACGCTGGCCTGAAAGGGCGCGGCGGCGCGGGCTTCTCTACTGGTCTGAAGTGGAGCCTGATGCCGAAAGACGAA
TCCATGAACATCCGTTACCTGCTGTGTAACGCCGATGAAATGGAGCCGGGCACCTATAAAGACCGCCTGCTGATGGAGCA
GCTGCCGCACCTGCTGGTGGAAGGCATGCTGATCTCCGCGTTTGCGCTGAAAGCGTACCGCGGCTACATCTTCCTGCGCG
GAGAATATATTGAAGCGGCCCAGCATCTGCGTCGCGCGATTGCCGAAGCCACCGAAGCGGGTCTGTTGGGGAAAAACATC
CTCGGCACCGGGTTTGACTTCGAGCTGTTCGTGCACACCGGGGCAGGGCGCTATATCTGCGGCGAAGAGACGGCGCTGAT
CAACTCTCTGGAAGGCCGCCGCGCCAACCCGCGATCCAAGCCGCCGTTCCCGGCGAGCTCCGGCGTCTGGGGCAAGCCGA
CCTGCGTCAACAACGTAGAAACCCTGTGCAACGTGCCAGCGATCCTCGCCAACGGCGTCGAGTGGTACCAGAACATTTCC
ACCAGCAAAGATGCTGGCACCAAGCTGATGGGCTTCTCCGGCCGGGTGAAGAATCCGGGCGTCTGGGAGCTGCCGTTCGG
CACCACTGCCCGCGAGATCCTCGAAGATTACGCCGGCGGTATGCGCGATGGCCTGAAGTTTAAAGCCTGGCAACCGGGCG
GAGCAGGGACCGACTTCCTCACCGAAGCGCACCTCGATCTGCCGATGGAATTCGAAAGCATTGGTAAAGCGGGCAGCCGT
CTGGGCACCTCGCTGGCGATGGCCGTTGACCACGAGATCAACATGGTCTCGCTGGTGCGTAACCTTGAAGAGTTCTTTGC
CCGCGAGTCCTGCGGCTGGTGTACGCCGTGCCGCGATGGTCTGCCGTGGAGCGTGAAGATCCTGCGCGCCCTGGAGCGCG
GCGAAGGCCAGCCTGGCGATATCGAAACCCTTGAGCAACTGTGTCGATTCCTGGGCCCGGGTAAAACCTTCTGCGCGCAC
GCGCCGGGCGCGGTCGAGCCGCTACAGAGCGCGATTAAATATTTCCGCGAAGAATTCGAGGCTGGCATTAAGCAGCAGTT
CAGCAATACCCATGCAATCAACGGGATTCAGCCGAACCTGCTTAAGACGCGCTGGTAA

Upstream 100 bases:

>100_bases
GCCTGGGTAACTGCGACAAGGGACCGACCATGATGATTGATGAGGATACTCACAGCCATCTGACGCCGGAGGCAATTCCT
GACCTGCTGGAGCAGTACAA

Downstream 100 bases:

>100_bases
TCTAAAGGTTTTTTATTTTTGGAAGCACGCAAATGGCTACGATTCATGTAGACGGCAAAGAATACGAGGTCAACGGGGCG
GACAACCTGCTAGAGGCTTG

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F; NUO6 [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKTVIRTAETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGMAPDEIVTAVKDAGLKGRGGAGFSTGLKWSLMPKDE
SMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAQHLRRAIAEATEAGLLGKNI
LGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPASSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
TSKDAGTKLMGFSGRVKNPGVWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFLTEAHLDLPMEFESIGKAGSR
LGTSLAMAVDHEINMVSLVRNLEEFFARESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAH
APGAVEPLQSAIKYFREEFEAGIKQQFSNTHAINGIQPNLLKTRW

Sequences:

>Translated_445_residues
MKTVIRTAETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGMAPDEIVTAVKDAGLKGRGGAGFSTGLKWSLMPKDE
SMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAQHLRRAIAEATEAGLLGKNI
LGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPASSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
TSKDAGTKLMGFSGRVKNPGVWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFLTEAHLDLPMEFESIGKAGSR
LGTSLAMAVDHEINMVSLVRNLEEFFARESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAH
APGAVEPLQSAIKYFREEFEAGIKQQFSNTHAINGIQPNLLKTRW
>Mature_445_residues
MKTVIRTAETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGMAPDEIVTAVKDAGLKGRGGAGFSTGLKWSLMPKDE
SMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAQHLRRAIAEATEAGLLGKNI
LGTGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPASSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
TSKDAGTKLMGFSGRVKNPGVWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFLTEAHLDLPMEFESIGKAGSR
LGTSLAMAVDHEINMVSLVRNLEEFFARESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAH
APGAVEPLQSAIKYFREEFEAGIKQQFSNTHAINGIQPNLLKTRW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=376, Percent_Identity=43.8829787234042, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI260656005, Length=376, Percent_Identity=43.8829787234042, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI1788620, Length=445, Percent_Identity=95.9550561797753, Blast_Score=887, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17531727, Length=375, Percent_Identity=42.4, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI19920794, Length=375, Percent_Identity=44, Blast_Score=321, Evalue=8e-88,
Organism=Drosophila melanogaster, GI45550452, Length=385, Percent_Identity=43.1168831168831, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24653819, Length=382, Percent_Identity=34.0314136125654, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24653817, Length=352, Percent_Identity=32.3863636363636, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 49156; Mature: 49156

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVIRTAETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGMAPDEIVTAVKDAGLK
CCCCEECCCCCCEEEEECCCCCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCC
GRGGAGFSTGLKWSLMPKDESMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISA
CCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FALKAYRGYIFLRGEYIEAAQHLRRAIAEATEAGLLGKNILGTGFDFELFVHTGAGRYIC
HHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCCEEE
GEETALINSLEGRRANPRSKPPFPASSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCCHHHHHCCC
TSKDAGTKLMGFSGRVKNPGVWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFL
CCCCCCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHCCCHHCCCEEEEECCCCCCCHHH
TEAHLDLPMEFESIGKAGSRLGTSLAMAVDHEINMVSLVRNLEEFFARESCGWCTPCRDG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAHAPGAVEPLQSAIKYFREEFE
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHH
AGIKQQFSNTHAINGIQPNLLKTRW
HHHHHHHCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MKTVIRTAETHPLTWRLRDDKQPVWLDEYRSKNGYEGARKALTGMAPDEIVTAVKDAGLK
CCCCEECCCCCCEEEEECCCCCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCC
GRGGAGFSTGLKWSLMPKDESMNIRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISA
CCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FALKAYRGYIFLRGEYIEAAQHLRRAIAEATEAGLLGKNILGTGFDFELFVHTGAGRYIC
HHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCCEEE
GEETALINSLEGRRANPRSKPPFPASSGVWGKPTCVNNVETLCNVPAILANGVEWYQNIS
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCCHHHHHCCC
TSKDAGTKLMGFSGRVKNPGVWELPFGTTAREILEDYAGGMRDGLKFKAWQPGGAGTDFL
CCCCCCCEEECCCCCCCCCCEEECCCCCHHHHHHHHHCCCHHCCCEEEEECCCCCCCHHH
TEAHLDLPMEFESIGKAGSRLGTSLAMAVDHEINMVSLVRNLEEFFARESCGWCTPCRDG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPWSVKILRALERGEGQPGDIETLEQLCRFLGPGKTFCAHAPGAVEPLQSAIKYFREEFE
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHH
AGIKQQFSNTHAINGIQPNLLKTRW
HHHHHHHCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7690854; 8157582; 9205837; 9278503; 8366049 [H]