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The map label for this gene is nuoL [H]

Identifier: 238895795

GI number: 238895795

Start: 3741689

End: 3743530

Strand: Reverse

Name: nuoL [H]

Synonym: KP1_3910

Alternate gene names: 238895795

Gene position: 3743530-3741689 (Counterclockwise)

Preceding gene: 238895796

Following gene: 238895794

Centisome position: 71.33

GC content: 59.39

Gene sequence:

>1842_bases
ATGAACATGCTTGCCTTAACCATTCTTTTGCCATTGATTGGCTTTGTGCTGCTGGCCTTCTCCCGCGGGCGCTGGTCGGA
AAATCTTTCCGCCGCCGTTGGCATGGGCTCGGTAGGCCTGGCGGCGCTGGTCACCGCGTACGTTGGCGTCGACTTTTTCG
CTAACGGCAAACAGGCGGTCAGCGTGCCGCTGTGGACCTGGATGTCGGTCGGTGATTTCAACATCGGCTTCAACCTGGTG
TTGGACGGCCTGTCGCTGACCATGCTCTCCGTAGTTACCGGCGTCGGCTTCCTGATCCACATGTTCGCCTCCTGGTACAT
GCGCGGTGAAGAGGGATATTCCCGCTTCTTCGCCTATACCAACCTGTTTATCGCCAGCATGGTGGTTCTGGTACTGGCCG
ATAACCTGCTGCTGATGTACCTCGGTTGGGAAGGCGTGGGCCTCTGTTCTTACCTGCTGATCGGTTTCTACTACACCGAT
CCGAAGAACGGCGCCGCAGCGATGAAAGCGTTTGTGGTGACCCGCGTCGGCGACGTGTTCCTCGCCTTCGCGCTGTTCAT
TCTTTATAACGAACTGGGCACCCTGAACTTCCGCGAAATGGTGGAGCTGGCGCCGCAGCACTTCGCTAACGGCAGCACCA
CGCTGCAGTGGGCGACGCTGATGCTGCTTGGCGGCGCGGTCGGTAAATCCGCCCAGCTGCCGCTGCAAACGTGGCTTGCC
GATGCGATGGCGGGTCCGACGCCGGTCTCTGCGCTGATCCACGCCGCGACCATGGTCACCGCGGGCGTCTATCTGATCGC
CCGTACCCACGGCCTGTTCCTGATGACGCCGGAAGTGCTGCATCTGGTCGGTATCGTCGGGGCGGTCACCCTGGTGTTGG
CGGGCTTCGCCGCGCTGGTGCAGACCGATATCAAACGCGTTCTCGCCTACTCTACCATGAGCCAGATTGGCTACATGTTC
CTCGCGCTGGGCGTGCAGGCATGGGACGCGGCGATTTTCCACCTGATGACTCACGCGTTCTTTAAAGCGCTGCTGTTCCT
GTCGTCTGGTTCGGTCATTCTGGCCTGCCATCACGAACAGAACATCTTCAAGATGGGCGGCCTGCGCAAATCGATTCCGC
TGGTATATGTCTGCTTCCTGGTGGGGGGCGCGGCGCTGTCCGCACTGCCGCTTATCACCGCAGGCTTCTTCAGTAAGGAT
GAGATTCTGGCAGGCGCGATGGCCAATGGCCATATCAATCTGATGGTGGCAGGCCTGGTCGGCGCCTTTATGACCTCGCT
GTACACCTTCCGGATGATTTTCATCGTATTCCACGGTAAAGAGCAAATTCACGCGCACGCAGGGAAGGGGATTACCCATC
ATCTGCCGCTGATTGTGCTGCTGGTACTATCCACCTTCGTTGGCGCGCTGATTGTGCCGCCGCTGGAAGGCGTACTGCCG
CAGACCACTGAGCTCGCCCACGGTAGCGTGATGACGCTGGAGATTGCCTCCGGGATCATCGCCATTGCCGGGATTCTGAT
CGCCGCATGGCTGTGGCTGGGCAAACGCACGCTGGTGACCTCCATCGCCAACAGTGCGCCTGGCCGCTTCTTCGGTACCT
GGTGGTTCCATGCCTGGGGCTTCGACTGGTTATACGACAAGGTGTTCGTAAAACCATTCCTCGGTATTGCCTGGCTGCTG
AAACGCGATCCGCTGAACTCGTTGATGAATATCCCGGCGATCCTTTCCCGCTTCGCAGGCAAAGGCCTGCTGGTGAGCGA
GAACGGTTATCTGCGCTGGTATGTGGCTTCAATGAGCATCGGCGCGGTGGTGGTGCTGGCGCTGCTGATGGTATTGCGTT
GA

Upstream 100 bases:

>100_bases
GCCTCGCGGCTGCGGAAGCGAGTATCGGCCTGGCGCTGCTGCTGCAGCTCCATCGTCGCCGCCAGAACCTGAACATCGAT
TCAGTAAGTGAGTTGCGTGG

Downstream 100 bases:

>100_bases
TTTGATCGCGCGGTTTTGCCCGGTGGCGCTTCGCTTACCGGGCCTACGAGACCGTAGGTCGGGTAAGCGAAGCGCCACCC
GACACAACAAACCGCACTCA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L; NUO12 [H]

Number of amino acids: Translated: 613; Mature: 613

Protein sequence:

>613_residues
MNMLALTILLPLIGFVLLAFSRGRWSENLSAAVGMGSVGLAALVTAYVGVDFFANGKQAVSVPLWTWMSVGDFNIGFNLV
LDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLADNLLLMYLGWEGVGLCSYLLIGFYYTD
PKNGAAAMKAFVVTRVGDVFLAFALFILYNELGTLNFREMVELAPQHFANGSTTLQWATLMLLGGAVGKSAQLPLQTWLA
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEVLHLVGIVGAVTLVLAGFAALVQTDIKRVLAYSTMSQIGYMF
LALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFFSKD
EILAGAMANGHINLMVAGLVGAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLLVLSTFVGALIVPPLEGVLP
QTTELAHGSVMTLEIASGIIAIAGILIAAWLWLGKRTLVTSIANSAPGRFFGTWWFHAWGFDWLYDKVFVKPFLGIAWLL
KRDPLNSLMNIPAILSRFAGKGLLVSENGYLRWYVASMSIGAVVVLALLMVLR

Sequences:

>Translated_613_residues
MNMLALTILLPLIGFVLLAFSRGRWSENLSAAVGMGSVGLAALVTAYVGVDFFANGKQAVSVPLWTWMSVGDFNIGFNLV
LDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLADNLLLMYLGWEGVGLCSYLLIGFYYTD
PKNGAAAMKAFVVTRVGDVFLAFALFILYNELGTLNFREMVELAPQHFANGSTTLQWATLMLLGGAVGKSAQLPLQTWLA
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEVLHLVGIVGAVTLVLAGFAALVQTDIKRVLAYSTMSQIGYMF
LALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFFSKD
EILAGAMANGHINLMVAGLVGAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLLVLSTFVGALIVPPLEGVLP
QTTELAHGSVMTLEIASGIIAIAGILIAAWLWLGKRTLVTSIANSAPGRFFGTWWFHAWGFDWLYDKVFVKPFLGIAWLL
KRDPLNSLMNIPAILSRFAGKGLLVSENGYLRWYVASMSIGAVVVLALLMVLR
>Mature_613_residues
MNMLALTILLPLIGFVLLAFSRGRWSENLSAAVGMGSVGLAALVTAYVGVDFFANGKQAVSVPLWTWMSVGDFNIGFNLV
LDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLADNLLLMYLGWEGVGLCSYLLIGFYYTD
PKNGAAAMKAFVVTRVGDVFLAFALFILYNELGTLNFREMVELAPQHFANGSTTLQWATLMLLGGAVGKSAQLPLQTWLA
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEVLHLVGIVGAVTLVLAGFAALVQTDIKRVLAYSTMSQIGYMF
LALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFFSKD
EILAGAMANGHINLMVAGLVGAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLLVLSTFVGALIVPPLEGVLP
QTTELAHGSVMTLEIASGIIAIAGILIAAWLWLGKRTLVTSIANSAPGRFFGTWWFHAWGFDWLYDKVFVKPFLGIAWLL
KRDPLNSLMNIPAILSRFAGKGLLVSENGYLRWYVASMSIGAVVVLALLMVLR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=391, Percent_Identity=38.8746803069054, Blast_Score=255, Evalue=7e-68,
Organism=Escherichia coli, GI1788614, Length=601, Percent_Identity=93.1780366056572, Blast_Score=1136, Evalue=0.0,
Organism=Escherichia coli, GI1788829, Length=427, Percent_Identity=35.1288056206089, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1788827, Length=463, Percent_Identity=28.7257019438445, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788831, Length=443, Percent_Identity=27.9909706546275, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1788613, Length=480, Percent_Identity=25.625, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI2367154, Length=288, Percent_Identity=29.5138888888889, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI145693160, Length=404, Percent_Identity=25, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66326; Mature: 66326

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLALTILLPLIGFVLLAFSRGRWSENLSAAVGMGSVGLAALVTAYVGVDFFANGKQAV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEE
SVPLWTWMSVGDFNIGFNLVLDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYT
EEEHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NLFIASMVVLVLADNLLLMYLGWEGVGLCSYLLIGFYYTDPKNGAAAMKAFVVTRVGDVF
HHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHH
LAFALFILYNELGTLNFREMVELAPQHFANGSTTLQWATLMLLGGAVGKSAQLPLQTWLA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEVLHLVGIVGAVTLVLAGFAALV
HHHCCCCHHHHHHHHHHHHHHHHHHEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
QTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
NIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFFSKDEILAGAMANGHINLMVAGLV
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEHHHHHH
GAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLLVLSTFVGALIVPPLEGVLP
HHHHHHHHHHHHHHHEECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QTTELAHGSVMTLEIASGIIAIAGILIAAWLWLGKRTLVTSIANSAPGRFFGTWWFHAWG
CCHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEHHHHHCC
FDWLYDKVFVKPFLGIAWLLKRDPLNSLMNIPAILSRFAGKGLLVSENGYLRWYVASMSI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEHHHH
GAVVVLALLMVLR
HHHHHHHHHHHHC
>Mature Secondary Structure
MNMLALTILLPLIGFVLLAFSRGRWSENLSAAVGMGSVGLAALVTAYVGVDFFANGKQAV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEE
SVPLWTWMSVGDFNIGFNLVLDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYT
EEEHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NLFIASMVVLVLADNLLLMYLGWEGVGLCSYLLIGFYYTDPKNGAAAMKAFVVTRVGDVF
HHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHH
LAFALFILYNELGTLNFREMVELAPQHFANGSTTLQWATLMLLGGAVGKSAQLPLQTWLA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
DAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEVLHLVGIVGAVTLVLAGFAALV
HHHCCCCHHHHHHHHHHHHHHHHHHEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
QTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
NIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFFSKDEILAGAMANGHINLMVAGLV
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEHHHHHH
GAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLLVLSTFVGALIVPPLEGVLP
HHHHHHHHHHHHHHHEECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QTTELAHGSVMTLEIASGIIAIAGILIAAWLWLGKRTLVTSIANSAPGRFFGTWWFHAWG
CCHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEHHHHHCC
FDWLYDKVFVKPFLGIAWLLKRDPLNSLMNIPAILSRFAGKGLLVSENGYLRWYVASMSI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEHHHH
GAVVVLALLMVLR
HHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7690854; 9205837; 9278503 [H]