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The map label for this gene is gyrA [H]

Identifier: 238895767

GI number: 238895767

Start: 3706978

End: 3709611

Strand: Reverse

Name: gyrA [H]

Synonym: KP1_3874

Alternate gene names: 238895767

Gene position: 3709611-3706978 (Counterclockwise)

Preceding gene: 238895772

Following gene: 238895766

Centisome position: 70.68

GC content: 58.31

Gene sequence:

>2634_bases
ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTTAAGAACTCTTATCTGGATTATGCGATGTC
GGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACG
TATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCAGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCACCCGCAC
GGCGACTCCGCGGTATACGACACCATCGTGCGTATGGCGCAGCCGTTCTCGCTGCGTTACATGCTGGTGGACGGCCAGGG
TAACTTTGGTTCCATCGACGGCGACTCCGCCGCGGCGATGCGTTATACCGAAATTCGTCTGGCGAAAATCGCTCATGAGC
TGATGGCCGATCTTGAAAAAGAGACGGTCGATTTCGTCGACAACTATGACGGTACGGAGCGTATTCCGGACGTCATGCCG
ACCAAAATTCCTAACCTGCTGGTGAACGGCGCCTCCGGGATCGCCGTAGGGATGGCCACCAACATACCGCCGCATAACCT
GACGGAAGTGATTAACGGCTGTCTGGCGTATGTTGACGATGAAGACATCAGCATTGAAGGGCTGATGGCGCATATTCCTG
GCCCTGATTTCCCGACCGCCGCCATTATCAATGGCCGTCGCGGCATCGAAGAGGCCTACCGCACCGGTCGCGGTAAAGTG
TACATCCGCGCGCGCGCGGAAGTGGAAGTGGACGCGAAATCCGGCCGCGAAACCATCATCGTGCACGAAATTCCGTATCA
GGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTCAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTG
ACGAGTCTGATAAAGACGGGATGCGCATCGTGATTGAAGTGAAGCGCGATGCGGTAGGGGAAGTGGTGCTTAACAACCTC
TATTCCCAGACCCAGCTGCAGGTCTCCTTCGGCATCAACATGGTAGCTCTGCACCATGGTCAGCCGAAGATCATGAACCT
GAAGGACATTATCGCCGCGTTTGTACGCCACCGCCGTGAAGTGGTGACCCGTCGTACGATTTTCGAACTGCGCAAAGCGC
GCGACCGGGCGCATATCCTCGAAGCGCTGGCCGTTGCGCTGGCCAACATCGACCCGATTATCGAACTGATCCGTCGCGCG
CCGACCCCGGCAGAAGCGAAAACGGCGCTGGTTGCCCAGGCGTGGGATCTCGGTAACGTTGCGGCGATGCTGGAGCGCGC
CGGGGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAGTTCGGCGTACGCGACGGTAAATACTACCTGACCGAGCAGC
AGGCTCAGGCGATTCTGGATCTGCGTCTGCAGAAACTGACCGGCCTTGAGCATGAAAAACTGCTCGACGAATATAAAGAG
CTGCTGGAGCAGATCGCGGAGCTGCTGCACATTCTCGGCAGCGCCGACCGTCTGATGGAAGTGATTCGCGAAGAGCTGGA
GCTGATCCGCGACCAGTTCGGCGACGAACGTCGTACCGAAATCACCGCCAACAGCGCTGATATTAACATCGAAGATCTGA
TCAACCAGGAAGATGTGGTGGTCACCCTGTCGCATCAGGGGTATGTGAAGTATCAGCCGCTGACCGACTACGAAGCACAG
CGTCGTGGCGGTAAAGGCAAATCGGCAGCGCGCATTAAAGAAGAAGACTTTATCGACCGTCTGCTGGTGGCCAACACCCA
TGACACCATCCTCTGCTTCTCAAGCCGCGGCCGTCTGTACTGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCG
CGCGCGGTCGGCCGATCGTCAACCTGCTGCCGCTGGAAGCCGATGAGCGCATCACCGCCATCCTGCCGGTCCGCGAGTAC
GAAGAGGGCGTCAACGTCTTTATGGCCACCGCTAGCGGTACCGTGAAGAAAACCGCGCTGACCGAGTTCAGCCGTCCGCG
TTCCGCTGGTATCATCGCGGTCAACCTGAACGAAGGCGATGAGCTGATCGGCGTCGATCTGACCTCTGGTCAGGATGAAG
TGATGCTGTTCTCCGCGGCCGGTAAGGTTGTACGCTTCAAAGAAGACGCCGTTCGCGCCATGGGCCGTACCGCCACCGGC
GTACGCGGTATTAAGCTTGCGGAAAACGACAGCGTCGTCTCGCTGATTATTCCACGCGGCGAAGGCGCGATCCTGACGGT
GACGCAAAACGGTTACGGTAAACGTACCGCGGCGGCGGAGTATCCGACCAAGTCGCGTGCCACCCAGGGCGTTATTTCGA
TCAAAGTCACCGAGCGTAACGGTTCCGTGGTCGGCGCCGTGCAGGTGGATGACTGCGATCAGATCATGATGATCACCGAC
GCCGGGACGCTGGTGCGTACCCGCGTTTCCGAAGTGAGCATCGTGGGCCGTAACACCCAGGGCGTGATCCTCATCCGCAC
CGCGGAAGATGAAAACGTGGTGGGTCTGCAGCGCGTGGCTGAGCCGGTGGATGATGAAGAGCTGGATGCCATCGACGGTA
GCGCGGCGGAAGGCGATGACGATATCGCCCCGGAAGCGGATACCGATGACGACATCGCCGAAGACGAAGAATAA

Upstream 100 bases:

>100_bases
GCGCGCCATGAATAAACCGTATTGCTTTACCTCTATTAGCGCGGCTGTGTTATAATTTGCGACCTTTGAATCCGGGATAC
AGTAGAGGGATAGCGGTTAG

Downstream 100 bases:

>100_bases
TCGTCCGAGGTAAATGTTCTGGAAGGGCCGGGTATTTTCCCGGCCCTTTTTGCATTAACATTGCGGCAAAGCCGGTTTAC
CGCTACCTTAACCGCATTCT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 877; Mature: 876

Protein sequence:

>877_residues
MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMP
TKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
YIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNL
YSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRA
PTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREY
EEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATG
VRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITD
AGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE

Sequences:

>Translated_877_residues
MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMP
TKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
YIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNL
YSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRA
PTPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREY
EEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATG
VRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITD
AGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE
>Mature_876_residues
SDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHG
DSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPT
KIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVY
IRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLY
SQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAP
TPAEAKTALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKEL
LEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQR
RGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYE
EGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGV
RGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDA
GTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=353, Percent_Identity=25.2124645892351, Blast_Score=84, Evalue=9e-16,
Organism=Homo sapiens, GI19913408, Length=341, Percent_Identity=27.5659824046921, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1788562, Length=875, Percent_Identity=92.3428571428571, Blast_Score=1645, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=715, Percent_Identity=35.9440559440559, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=286, Percent_Identity=29.3706293706294, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=285, Percent_Identity=29.1228070175439, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=348, Percent_Identity=25.5747126436782, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96957; Mature: 96826

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHEEECCCCEEEEEEC
NIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
CCCCCHHHHHHHHHEEEECCCCCEEEEEEEECCCCCCCCEEEECCCCCHHHHHHCCCCEE
YIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
EEEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHH
VVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHH
AAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECHHHHHCCCEEEEEECCCCCHHHHH
TEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATG
HHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCEEEEHHHHHHHHCCCCCC
VRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERN
CCCEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC
GSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVA
CCEEEEEEECCCCEEEEEECCCHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCHHHHHC
EPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE
CCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHEEECCCCEEEEEEC
NIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
CCCCCHHHHHHHHHEEEECCCCCEEEEEEEECCCCCCCCEEEECCCCCHHHHHHCCCCEE
YIRARAEVEVDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
EEEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHH
VVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKTALVAQAWDLGNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHH
AAMLERAGDDAARPEWLEPEFGVRDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECHHHHHCCCEEEEEECCCCCHHHHH
TEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATG
HHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCEEEEHHHHHHHHCCCCCC
VRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERN
CCCEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC
GSVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVA
CCEEEEEEECCCCEEEEEECCCHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCHHHHHC
EPVDDEELDAIDGSAAEGDDDIAPEADTDDDIAEDEE
CCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]