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The map label for this gene is lysP [H]

Identifier: 238895720

GI number: 238895720

Start: 3651044

End: 3652513

Strand: Reverse

Name: lysP [H]

Synonym: KP1_3821

Alternate gene names: 238895720

Gene position: 3652513-3651044 (Counterclockwise)

Preceding gene: 238895721

Following gene: 238895719

Centisome position: 69.59

GC content: 57.89

Gene sequence:

>1470_bases
ATGGTTTCGGAAACTAAAACCACAGAAGCGCCCACGCTACGTCGTGAACTGAAGGCGCGCCACTTGACCATGATCGCCAT
CGGCGGTTCCATCGGTACGGGTCTTTTTGTTGCCTCTGGCGCAACCATTTCGCAAGCAGGTCCCGGCGGGGCGCTGCTGT
CTTATATTCTGATCGGTTTGATGGTCTATTTCCTGATGACCAGCCTCGGCGAGCTGGCGGCGTTTATGCCGGTATCCGGT
TCCTTCGCCACCTACGGGCAGAATTATGTTGAAGAAGGCTTCGGCTTCGCGCTGGGCTGGAACTACTGGTACAACTGGGC
GGTGACGATCGCCGTTGACCTCGTGGCCTCACAGCTGGTGATGAGCTACTGGTTCCCCGACACTCCGGGCTGGATCTGGA
GCGCCTTGTTCCTCGGCATCATGTTCCTGCTGAACTGGATCTCGGTGCGCGGCTTTGGCGAGGCGGAATACTGGTTCTCG
CTGATAAAGGTAGCCACCGTCATTATCTTTATCATCGTCGGCGTGATGATGATTGTCGGCATCTTCAAAGGGGCGCAGCC
AGCCGGCTGGAGCAACTGGGGGATCGCGGATGCGCCGTTCGCCGGCGGTTTCTCGGCGATGATTGGCGTGGCGATGATTG
TCGGCTTCTCGTTCCAGGGCACCGAGCTTATCGGCATCGCTGCCGGTGAATCTGAAAATCCGGAGAAGAACATTCCGCGC
GCGGTGCGCCAGGTCTTCTGGCGTATCCTGCTGTTTTACGTCTTCGCGATCCTGATTATCAGCCTGATCATTCCGTATAC
CGATCCGAGTCTGCTGCGCAACGATGTGAAGGATATCTCCGTCAGCCCGTTCACCCTGGTGTTCCAGCATGCTGGTTTGC
TGTCGGCGGCGGCAATCATGAACGCCGTTATCCTGACTGCCGTGCTGTCGGCGGGTAACTCCGGGATGTACGCCTCCACG
CGTATGCTGTACACCCTGGCCTGCGACGGTAAAGCGCCGCGTATTTTCTCGAAGCTGTCGCGTGGCGGCGTGCCGCGTAA
CGCGCTGTACGCGACCACCGTGATCGCGGCGCTTTGCTTCCTGACTTCCATGTTTGGCAACCAGACGGTGTACCTGTGGC
TGCTGAACACCTCCGGGATGACGGGCTTTATCGCCTGGCTGGGTATTGCGATCAGCCACTATCGTTTCCGTCGCGGCTAC
GTCCAGCAGGGTAACGATATTAATAATCTGCCGTATCGTTCCGGGTTCTTCCCGCTGGGGCCGATCTTCGCCTTCGTGCT
GTGCCTGATCATCACCCTCGGACAGAACTACGAAGCGTTCCTCAAGGACACCATTGACTGGGGCGGCGTGGCGGCGACCT
ACATTGGTATTCCGCTGTTCCTCGTCATCTGGTTTGGTTACAAGCTGGCGAAAGGCACCCGCTTTGTTCGCTACAGCGAA
ATGACCTTCCCGGATCGCTTTAAGCGTTAA

Upstream 100 bases:

>100_bases
GCGATCATGAAGCTCTCTTATAACTTTGCATTTGTACCGGATGGAACCCCGATCGTCTGCTACAATCGCGCCTCATTTTT
TGGATGGATAGCATTATCAC

Downstream 100 bases:

>100_bases
TCTTCGCGATTGTGCGATAAAAGCCCTCTGTGAAGAGGGCTTTATATTGCTGGCAAAGTGCAATCTTCAGGGATTGCCCG
GCGGCGCTGCGCTTGCGCGG

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MVSETKTTEAPTLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGLMVYFLMTSLGELAAFMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVASQLVMSYWFPDTPGWIWSALFLGIMFLLNWISVRGFGEAEYWFS
LIKVATVIIFIIVGVMMIVGIFKGAQPAGWSNWGIADAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAIMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFSKLSRGGVPRNALYATTVIAALCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VQQGNDINNLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLVIWFGYKLAKGTRFVRYSE
MTFPDRFKR

Sequences:

>Translated_489_residues
MVSETKTTEAPTLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGLMVYFLMTSLGELAAFMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVASQLVMSYWFPDTPGWIWSALFLGIMFLLNWISVRGFGEAEYWFS
LIKVATVIIFIIVGVMMIVGIFKGAQPAGWSNWGIADAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAIMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFSKLSRGGVPRNALYATTVIAALCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VQQGNDINNLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLVIWFGYKLAKGTRFVRYSE
MTFPDRFKR
>Mature_489_residues
MVSETKTTEAPTLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGLMVYFLMTSLGELAAFMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVASQLVMSYWFPDTPGWIWSALFLGIMFLLNWISVRGFGEAEYWFS
LIKVATVIIFIIVGVMMIVGIFKGAQPAGWSNWGIADAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAIMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFSKLSRGGVPRNALYATTVIAALCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VQQGNDINNLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLVIWFGYKLAKGTRFVRYSE
MTFPDRFKR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=369, Percent_Identity=24.390243902439, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788480, Length=489, Percent_Identity=93.2515337423313, Blast_Score=926, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=40.6392694063927, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=38.8505747126437, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1786789, Length=418, Percent_Identity=38.0382775119617, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1786302, Length=412, Percent_Identity=35.4368932038835, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1789017, Length=403, Percent_Identity=33.7468982630273, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1790653, Length=427, Percent_Identity=34.192037470726, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87081915, Length=401, Percent_Identity=34.6633416458853, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1786602, Length=395, Percent_Identity=39.2405063291139, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87081869, Length=403, Percent_Identity=22.8287841191067, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082023, Length=335, Percent_Identity=23.5820895522388, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082250, Length=237, Percent_Identity=29.1139240506329, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=390, Percent_Identity=23.8461538461538, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=474, Percent_Identity=37.7637130801688, Blast_Score=325, Evalue=9e-90,
Organism=Saccharomyces cerevisiae, GI6324061, Length=498, Percent_Identity=35.7429718875502, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6324990, Length=498, Percent_Identity=33.9357429718875, Blast_Score=306, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6324059, Length=478, Percent_Identity=37.0292887029289, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6322892, Length=475, Percent_Identity=36.8421052631579, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6324924, Length=479, Percent_Identity=33.6116910229645, Blast_Score=276, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=480, Percent_Identity=30.8333333333333, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6324553, Length=429, Percent_Identity=34.7319347319347, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319824, Length=472, Percent_Identity=29.4491525423729, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6322967, Length=471, Percent_Identity=31.2101910828025, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6320717, Length=483, Percent_Identity=27.536231884058, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6321053, Length=463, Percent_Identity=28.9416846652268, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319543, Length=477, Percent_Identity=29.559748427673, Blast_Score=223, Evalue=7e-59,
Organism=Saccharomyces cerevisiae, GI6319542, Length=472, Percent_Identity=27.7542372881356, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320251, Length=480, Percent_Identity=27.0833333333333, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6324981, Length=485, Percent_Identity=33.1958762886598, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6319608, Length=472, Percent_Identity=28.6016949152542, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6320364, Length=554, Percent_Identity=26.8953068592058, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24666159, Length=356, Percent_Identity=24.1573033707865, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221512776, Length=356, Percent_Identity=24.1573033707865, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366235, Length=385, Percent_Identity=23.1168831168831, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI116007820, Length=385, Percent_Identity=23.1168831168831, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53698; Mature: 53698

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSETKTTEAPTLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGL
CCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHH
MVYFLMTSLGELAAFMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVASQLV
HHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHH
MSYWFPDTPGWIWSALFLGIMFLLNWISVRGFGEAEYWFSLIKVATVIIFIIVGVMMIVG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGAQPAGWSNWGIADAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAIM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFSKLSRGGVPRNALYATTVIAALCF
HHHHHHHHHHCCCCCCEEHHEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVQQGNDINNLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCHH
PIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLVIWFGYKLAKGTRFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
MTFPDRFKR
CCCCHHHCC
>Mature Secondary Structure
MVSETKTTEAPTLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGL
CCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHH
MVYFLMTSLGELAAFMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVASQLV
HHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHH
MSYWFPDTPGWIWSALFLGIMFLLNWISVRGFGEAEYWFSLIKVATVIIFIIVGVMMIVG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGAQPAGWSNWGIADAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAIM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFSKLSRGGVPRNALYATTVIAALCF
HHHHHHHHHHCCCCCCEEHHEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVQQGNDINNLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCHH
PIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLVIWFGYKLAKGTRFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
MTFPDRFKR
CCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]