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The map label for this gene is cirA [H]

Identifier: 238895719

GI number: 238895719

Start: 3648572

End: 3650545

Strand: Reverse

Name: cirA [H]

Synonym: KP1_3820

Alternate gene names: 238895719

Gene position: 3650545-3648572 (Counterclockwise)

Preceding gene: 238895720

Following gene: 238895717

Centisome position: 69.55

GC content: 58.56

Gene sequence:

>1974_bases
ATGTTCAGGTTAAACCCTTTTATCCGGGCGGGATTGTCTGCGTCCGTCGTATCGTTGGCGTTTCCGGCTCTGGCCGATGT
GAATGAAGAAACGCTGGTGGTGACCGCCTCGGCCACTGAACAGAATGTCAAAGACGCGCCGGCGAGCATCAGCGTCATCA
CCCAACAGGATTTACAACGCAAGCCTGTTCAGAACCTGAAAGACGTGCTGCGCGATGTGCCTGGGGTCCAGCTCACCAAC
GAAGGGGATAACCGCAAGGGCGTTAGCATCCGCGGTCTGAGCAGCAGCTATACCCTGATCCTGGTCGACGGCAAGCGCGT
TAACTCGCGGAACGCCGTCTTCCGCCACAATGACTTCGACCTTAACTGGATCCCGGTGGATGCTATTGAGCGTATCGAAG
TGGTGCGCGGCCCGATGTCCTCCCTCTACGGCTCCGATGCGCTCGGTGGGGTGGTCAACATTATTACCAAAAAAATCGGC
CAGAAATGGACCGGGACGCTGAGTGCTGATACCACTATTCAGGAGCACCGCGATCGCGGGGATACCTGGAACGGCCAGTT
CTTCACCAGCGGCCCGCTGATCGACGGCGTACTTGGAATGAAGGCCTACGGCAGCCTGGCAAAACGCGCCAAGGACGATC
CGCAGTCATCCAGTAATGCCACCGGCGAGACGCCGCGCATCGAGGGCTTCACCAGCCGCGATGGCAATGTTGAATTCGCC
TGGACGCCGAACGAAAACCACGATTTTACCGCAGGCTACGGCTTTGACCGTCAGGATCGCGATTCCGATTCCCTTGACCG
CAACCGCCTTGAGCGGGAGAACTACTCTCTGAGCCATAACGGCCGCTGGGATATCGGCAATAGCGAGCTCAAGTTCTACG
GCGAAAAGGTGGATAACAAAAATCCAGGGCAGAGCGGGACTATTACCTCGGAAAGCAATGCCATCGACGGCAAGTATGTC
CTGCCGCTGGGCATGATTAACCAGCTGGTGACCTTCGGCGGCGAATGGCGCCACGACAAACTTAAAGATCCGGTCAACCT
GAGCAGCGGCGGCCAGTCAACGTCGGCCAGCCAGTACGCCCTGTTTATCGAAGACGAATGGCGCATCATCGAGCCGCTGG
CGCTGACCACCGGCATTCGTATGGACGACCATCAGACCTATGGCGATCACTGGAGCCCGCGCGCCTATCTGGTGTATAAC
GCCACCGATACCGTCACCGTCAAAGGCGGCTGGGCGACGGCGTTTAAAGCCCCGTCGCTGCTGCAGCTTAACCCCGACTG
GACCACCAACTCCTGCCGCGGCTCGTGCAGCATCGTCGGTAACCCGGATCTGAAACCGGAAACCAGCGAAAGCTTCGAGC
TCGGTCTCTACTACCGCGGGGAAGAGGGCTGGCTTGAAAATGTCGAAGGCAGCATCACCACCTTCCAGAATAATGTCGAC
GACATGATCGACGTTCTGCGCACCTCCAGCGCCAGCGAAGCGCCGGGCTACCCGAACTTTGTCGGCTGGAAAACTGTCAA
CGGCAAGCGCGTGCCGATCTTCCGCTATTTCAACGTCAACAAAGCCCGCATCAAAGGGGTGGAGACGGAGGTGAAGATCC
CGTTTGGCGATGAGTGGAAGCTGACGGTGAACTACACCTACAACGATGGTCGCGATCTGAGCAATGGCGGCGACAAACCG
CTGCAGACGCTGCCGTTCCATACCGCCAACGGCACGCTCGACTGGAAACCGCTGGACGACTGGTCCTTCTACGTGACGGC
CAACTATACCGGCCAGCAGCGCGCGGTGAGCGCCACCGGCAAAACGCCGGGCGGCTACACCCTGTTTGACGTTGGCGCGG
CATGGCAGGTGACCAAAAACGTGAAACTGCGCTCCGGGGTGCAGAACGTGGGTGATAAAGATCTGAGCCGGGACGACTAC
AGCTATACCGAAGAAGGCCGTCGCTACTTTATGGCGGTGGATTATCGCTTCTGA

Upstream 100 bases:

>100_bases
GAAAACAGCGCGAGCATGCCGCCGACAGAGCGGCAAGCCGCCAGCGCGTGTGAGCAGCACCTTGTTGTTTGTTTGGTTGT
ACACCTCATGGAGATTTGGA

Downstream 100 bases:

>100_bases
TTGCCGGCGCTAAAACGCGTCCTGTAGGCCTGAACATGCGCCGCGAAGCAGCTTCGCGGCGCATTGGCGTTTAGCCAAAG
AGATGCTGCGCATGGAAGCG

Product: colicin I receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MFRLNPFIRAGLSASVVSLAFPALADVNEETLVVTASATEQNVKDAPASISVITQQDLQRKPVQNLKDVLRDVPGVQLTN
EGDNRKGVSIRGLSSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKIG
QKWTGTLSADTTIQEHRDRGDTWNGQFFTSGPLIDGVLGMKAYGSLAKRAKDDPQSSSNATGETPRIEGFTSRDGNVEFA
WTPNENHDFTAGYGFDRQDRDSDSLDRNRLERENYSLSHNGRWDIGNSELKFYGEKVDNKNPGQSGTITSESNAIDGKYV
LPLGMINQLVTFGGEWRHDKLKDPVNLSSGGQSTSASQYALFIEDEWRIIEPLALTTGIRMDDHQTYGDHWSPRAYLVYN
ATDTVTVKGGWATAFKAPSLLQLNPDWTTNSCRGSCSIVGNPDLKPETSESFELGLYYRGEEGWLENVEGSITTFQNNVD
DMIDVLRTSSASEAPGYPNFVGWKTVNGKRVPIFRYFNVNKARIKGVETEVKIPFGDEWKLTVNYTYNDGRDLSNGGDKP
LQTLPFHTANGTLDWKPLDDWSFYVTANYTGQQRAVSATGKTPGGYTLFDVGAAWQVTKNVKLRSGVQNVGDKDLSRDDY
SYTEEGRRYFMAVDYRF

Sequences:

>Translated_657_residues
MFRLNPFIRAGLSASVVSLAFPALADVNEETLVVTASATEQNVKDAPASISVITQQDLQRKPVQNLKDVLRDVPGVQLTN
EGDNRKGVSIRGLSSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKIG
QKWTGTLSADTTIQEHRDRGDTWNGQFFTSGPLIDGVLGMKAYGSLAKRAKDDPQSSSNATGETPRIEGFTSRDGNVEFA
WTPNENHDFTAGYGFDRQDRDSDSLDRNRLERENYSLSHNGRWDIGNSELKFYGEKVDNKNPGQSGTITSESNAIDGKYV
LPLGMINQLVTFGGEWRHDKLKDPVNLSSGGQSTSASQYALFIEDEWRIIEPLALTTGIRMDDHQTYGDHWSPRAYLVYN
ATDTVTVKGGWATAFKAPSLLQLNPDWTTNSCRGSCSIVGNPDLKPETSESFELGLYYRGEEGWLENVEGSITTFQNNVD
DMIDVLRTSSASEAPGYPNFVGWKTVNGKRVPIFRYFNVNKARIKGVETEVKIPFGDEWKLTVNYTYNDGRDLSNGGDKP
LQTLPFHTANGTLDWKPLDDWSFYVTANYTGQQRAVSATGKTPGGYTLFDVGAAWQVTKNVKLRSGVQNVGDKDLSRDDY
SYTEEGRRYFMAVDYRF
>Mature_657_residues
MFRLNPFIRAGLSASVVSLAFPALADVNEETLVVTASATEQNVKDAPASISVITQQDLQRKPVQNLKDVLRDVPGVQLTN
EGDNRKGVSIRGLSSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKIG
QKWTGTLSADTTIQEHRDRGDTWNGQFFTSGPLIDGVLGMKAYGSLAKRAKDDPQSSSNATGETPRIEGFTSRDGNVEFA
WTPNENHDFTAGYGFDRQDRDSDSLDRNRLERENYSLSHNGRWDIGNSELKFYGEKVDNKNPGQSGTITSESNAIDGKYV
LPLGMINQLVTFGGEWRHDKLKDPVNLSSGGQSTSASQYALFIEDEWRIIEPLALTTGIRMDDHQTYGDHWSPRAYLVYN
ATDTVTVKGGWATAFKAPSLLQLNPDWTTNSCRGSCSIVGNPDLKPETSESFELGLYYRGEEGWLENVEGSITTFQNNVD
DMIDVLRTSSASEAPGYPNFVGWKTVNGKRVPIFRYFNVNKARIKGVETEVKIPFGDEWKLTVNYTYNDGRDLSNGGDKP
LQTLPFHTANGTLDWKPLDDWSFYVTANYTGQQRAVSATGKTPGGYTLFDVGAAWQVTKNVKLRSGVQNVGDKDLSRDDY
SYTEEGRRYFMAVDYRF

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=663, Percent_Identity=80.9954751131222, Blast_Score=1120, Evalue=0.0,
Organism=Escherichia coli, GI1786798, Length=744, Percent_Identity=31.4516129032258, Blast_Score=278, Evalue=8e-76,
Organism=Escherichia coli, GI1790405, Length=695, Percent_Identity=27.3381294964029, Blast_Score=172, Evalue=8e-44,
Organism=Escherichia coli, GI1787723, Length=145, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 73022; Mature: 73022

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00430 TONB_DEPENDENT_REC_1 ; PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRLNPFIRAGLSASVVSLAFPALADVNEETLVVTASATEQNVKDAPASISVITQQDLQR
CCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEEHHHHHC
KPVQNLKDVLRDVPGVQLTNEGDNRKGVSIRGLSSSYTLILVDGKRVNSRNAVFRHNDFD
CHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCEEEEEEECCEECCCCCEEEECCCC
LNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWTGTLSADTTIQEHRDRG
CEEEEHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCC
DTWNGQFFTSGPLIDGVLGMKAYGSLAKRAKDDPQSSSNATGETPRIEGFTSRDGNVEFA
CCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCEEEE
WTPNENHDFTAGYGFDRQDRDSDSLDRNRLERENYSLSHNGRWDIGNSELKFYGEKVDNK
ECCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCC
NPGQSGTITSESNAIDGKYVLPLGMINQLVTFGGEWRHDKLKDPVNLSSGGQSTSASQYA
CCCCCCCEECCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LFIEDEWRIIEPLALTTGIRMDDHQTYGDHWSPRAYLVYNATDTVTVKGGWATAFKAPSL
EEEECCCEEECCEEHHCCCEECCCCCCCCCCCCCEEEEECCCCEEEEECCEEEEECCCCE
LQLNPDWTTNSCRGSCSIVGNPDLKPETSESFELGLYYRGEEGWLENVEGSITTFQNNVD
EEECCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEECCCHH
DMIDVLRTSSASEAPGYPNFVGWKTVNGKRVPIFRYFNVNKARIKGVETEVKIPFGDEWK
HHHHHHHCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCHHHEECCCEEEECCCCCCEE
LTVNYTYNDGRDLSNGGDKPLQTLPFHTANGTLDWKPLDDWSFYVTANYTGQQRAVSATG
EEEEEEECCCCCCCCCCCCCCEECCEECCCCEEEEEECCCCEEEEEEECCCCCEEEEECC
KTPGGYTLFDVGAAWQVTKNVKLRSGVQNVGDKDLSRDDYSYTEEGRRYFMAVDYRF
CCCCCEEEEECCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MFRLNPFIRAGLSASVVSLAFPALADVNEETLVVTASATEQNVKDAPASISVITQQDLQR
CCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEEHHHHHC
KPVQNLKDVLRDVPGVQLTNEGDNRKGVSIRGLSSSYTLILVDGKRVNSRNAVFRHNDFD
CHHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCCCEEEEEEECCEECCCCCEEEECCCC
LNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWTGTLSADTTIQEHRDRG
CEEEEHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCC
DTWNGQFFTSGPLIDGVLGMKAYGSLAKRAKDDPQSSSNATGETPRIEGFTSRDGNVEFA
CCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCEEEE
WTPNENHDFTAGYGFDRQDRDSDSLDRNRLERENYSLSHNGRWDIGNSELKFYGEKVDNK
ECCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCC
NPGQSGTITSESNAIDGKYVLPLGMINQLVTFGGEWRHDKLKDPVNLSSGGQSTSASQYA
CCCCCCCEECCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LFIEDEWRIIEPLALTTGIRMDDHQTYGDHWSPRAYLVYNATDTVTVKGGWATAFKAPSL
EEEECCCEEECCEEHHCCCEECCCCCCCCCCCCCEEEEECCCCEEEEECCEEEEECCCCE
LQLNPDWTTNSCRGSCSIVGNPDLKPETSESFELGLYYRGEEGWLENVEGSITTFQNNVD
EEECCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEECCCHH
DMIDVLRTSSASEAPGYPNFVGWKTVNGKRVPIFRYFNVNKARIKGVETEVKIPFGDEWK
HHHHHHHCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCHHHEECCCEEEECCCCCCEE
LTVNYTYNDGRDLSNGGDKPLQTLPFHTANGTLDWKPLDDWSFYVTANYTGQQRAVSATG
EEEEEEECCCCCCCCCCCCCCEECCEECCCCEEEEEECCCCEEEEEEECCCCCEEEEECC
KTPGGYTLFDVGAAWQVTKNVKLRSGVQNVGDKDLSRDDYSYTEEGRRYFMAVDYRF
CCCCCEEEEECCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]