Click here to switch to the map view.

The map label for this gene is dld [H]

Identifier: 238895695

GI number: 238895695

Start: 3622831

End: 3624576

Strand: Direct

Name: dld [H]

Synonym: KP1_3796

Alternate gene names: 238895695

Gene position: 3622831-3624576 (Clockwise)

Preceding gene: 238895686

Following gene: 238895696

Centisome position: 69.03

GC content: 59.79

Gene sequence:

>1746_bases
ATGTCATCTGCACCCACTGACACCCATAAAACGTTTCTGGCTGACCTGGCGCGCCTGGTTGGCCCTTCGCATCTGCTGAC
CGACCCGGCAAAAACCCAGCGCTACCGCAAAGGCTTCCGCTCCGGTCAGGGCGAGGCCCTGGCGGTTGTCTTTCCCGGTA
CCCTGCTGGAGCTCTGGCGCGTGCTCAACGCCTGCGTAGACGCCGATAAAATTATTCTGATGCAGGCGGCCAACACCGGC
CTGACCGAAGGTTCGACCCCCAACGGCAATGATTACGATCGCGAGATCGTGATTATCAGCACCCTGCGCCTGGACAAACT
GCATCTGCTGGACAAAGGCGAGCAGGTGCTGGCCTGGCCCGGCACCACCCTCTATTCGCTGGAAAAAGCGCTCAAACCGC
TGGGACGCGAACCGCACTCGGTGATCGGTTCGTCATGCATCGGCGCGTCGGTCATCGGCGGGATCTGCAACAACTCCGGC
GGCTCGCTGGTGCAGCGCGGGCCGGCCTACACTGAGATGTCGCTGTTCGCGCAGATTGACGCCGACGGCAAGCTGAAGCT
GGTCAATCATCTGGGCATCGATCTCGGCAGCACGCCGGAGCAGATCCTCAGCCGCCTCGATGACGAACGGATTAGCGATA
GCGATGTCCTGCACGACGGCCGCCACGCCCACGATCACGACTATGTCACCCGCGTACGCGATGTCGATGCCGACACCCCG
GCGCGCTATAACGCCGACCCGGACCGCCTGTTCGAATCCTCCGGCTGCGCCGGCAAGCTGGCGGTTTTCGCCGTGCGTCT
CGATACTTTCCCGGCGGAAAAGCGCCAGCAGGTGTTTTACATTGGCACCAACCAGCCGCAGGTATTGACCGAGATCCGCC
GCCATATCCTCGCCGAGTTCCAGCATCTGCCGGTGGCGGGGGAATATATGCACCGCGATATTTACGATATCGCCGAGAAG
TATGGCAAAGACACCTTCCTGATGATCGACAAGCTCGGCACCGACAAAATGCCGTTCTTCTTCACCATGAAGGGGCGCAC
CGACGCGATGCTGGAGAAAGTCTCGCTGTTTAAGCCGCACTTTACCGACCGCTTTATGCAGAAGCTCGGCCACGTCTTCC
CGGCGCATTTACCGGAGCGGATGAAAACCTGGCGTGATAAATATGAACATCATCTGCTACTGAAGATGGCTGGCGACGGC
ATCGAAGAAGCGCAGCGTTGGTTGACGGAGTACTTCCAGCAGGCCGAGGGGGATTTCTTCGCCTGTACGCCGGAGGAAGG
CAGCAAGGCGTTCCTCCATCGCTTTGCCGCCGCCGGCGCGGCAATCCGCTATCAGGCGGTGCATGCCGACGAAGTCGAAG
ATATTCTGGCGCTGGATATCGCCCTGCGCCGTAACGATACCGAGTGGTTCGAACATCTGCCGCCCGAAATCGACAGCCAG
CTGGTGCATAAGCTCTACTATGGCCACTTTATGTGCCATGTGTTCCATCAGGATTACATCGTCAGGAAAGGGGTCGACGC
CCACGCGCTGAAGGAAAAAATGCTGGAGTTACTGAAAGCGCGCGGCGCCCAGTACCCGGCGGAGCATAACGTGGGTCATC
TGTATGAGGCCCCGGAGAGCCTGCAGCAGTTCTATCGCCAGAACGATCCCACCAACAGCATGAACCCGGGGATTGGTAAA
ACCAGCAAGCAGAAATACTGGGGTGAAGCGGCCCCGACGCCAGCCTCTCCGGCGGATCCGCAATAA

Upstream 100 bases:

>100_bases
GGTTCTTCTCTGATTTTTGCGAAACATTCATGCATCAAATTGTCATACAAAGCGCTATGCTTATCCTCGATATTTCGCGC
ACCACCACAAGGAGTGGAAC

Downstream 100 bases:

>100_bases
TCGACGGCAGGACTATTCAGCCTAGCGCTTCTGTATTACGCTGCACGCCGGAGAATGTTTCTCCGGCAGATTCAGGAGCG
CCGCCATGCCCGCAGAGGCC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MSSAPTDTHKTFLADLARLVGPSHLLTDPAKTQRYRKGFRSGQGEALAVVFPGTLLELWRVLNACVDADKIILMQAANTG
LTEGSTPNGNDYDREIVIISTLRLDKLHLLDKGEQVLAWPGTTLYSLEKALKPLGREPHSVIGSSCIGASVIGGICNNSG
GSLVQRGPAYTEMSLFAQIDADGKLKLVNHLGIDLGSTPEQILSRLDDERISDSDVLHDGRHAHDHDYVTRVRDVDADTP
ARYNADPDRLFESSGCAGKLAVFAVRLDTFPAEKRQQVFYIGTNQPQVLTEIRRHILAEFQHLPVAGEYMHRDIYDIAEK
YGKDTFLMIDKLGTDKMPFFFTMKGRTDAMLEKVSLFKPHFTDRFMQKLGHVFPAHLPERMKTWRDKYEHHLLLKMAGDG
IEEAQRWLTEYFQQAEGDFFACTPEEGSKAFLHRFAAAGAAIRYQAVHADEVEDILALDIALRRNDTEWFEHLPPEIDSQ
LVHKLYYGHFMCHVFHQDYIVRKGVDAHALKEKMLELLKARGAQYPAEHNVGHLYEAPESLQQFYRQNDPTNSMNPGIGK
TSKQKYWGEAAPTPASPADPQ

Sequences:

>Translated_581_residues
MSSAPTDTHKTFLADLARLVGPSHLLTDPAKTQRYRKGFRSGQGEALAVVFPGTLLELWRVLNACVDADKIILMQAANTG
LTEGSTPNGNDYDREIVIISTLRLDKLHLLDKGEQVLAWPGTTLYSLEKALKPLGREPHSVIGSSCIGASVIGGICNNSG
GSLVQRGPAYTEMSLFAQIDADGKLKLVNHLGIDLGSTPEQILSRLDDERISDSDVLHDGRHAHDHDYVTRVRDVDADTP
ARYNADPDRLFESSGCAGKLAVFAVRLDTFPAEKRQQVFYIGTNQPQVLTEIRRHILAEFQHLPVAGEYMHRDIYDIAEK
YGKDTFLMIDKLGTDKMPFFFTMKGRTDAMLEKVSLFKPHFTDRFMQKLGHVFPAHLPERMKTWRDKYEHHLLLKMAGDG
IEEAQRWLTEYFQQAEGDFFACTPEEGSKAFLHRFAAAGAAIRYQAVHADEVEDILALDIALRRNDTEWFEHLPPEIDSQ
LVHKLYYGHFMCHVFHQDYIVRKGVDAHALKEKMLELLKARGAQYPAEHNVGHLYEAPESLQQFYRQNDPTNSMNPGIGK
TSKQKYWGEAAPTPASPADPQ
>Mature_580_residues
SSAPTDTHKTFLADLARLVGPSHLLTDPAKTQRYRKGFRSGQGEALAVVFPGTLLELWRVLNACVDADKIILMQAANTGL
TEGSTPNGNDYDREIVIISTLRLDKLHLLDKGEQVLAWPGTTLYSLEKALKPLGREPHSVIGSSCIGASVIGGICNNSGG
SLVQRGPAYTEMSLFAQIDADGKLKLVNHLGIDLGSTPEQILSRLDDERISDSDVLHDGRHAHDHDYVTRVRDVDADTPA
RYNADPDRLFESSGCAGKLAVFAVRLDTFPAEKRQQVFYIGTNQPQVLTEIRRHILAEFQHLPVAGEYMHRDIYDIAEKY
GKDTFLMIDKLGTDKMPFFFTMKGRTDAMLEKVSLFKPHFTDRFMQKLGHVFPAHLPERMKTWRDKYEHHLLLKMAGDGI
EEAQRWLTEYFQQAEGDFFACTPEEGSKAFLHRFAAAGAAIRYQAVHADEVEDILALDIALRRNDTEWFEHLPPEIDSQL
VHKLYYGHFMCHVFHQDYIVRKGVDAHALKEKMLELLKARGAQYPAEHNVGHLYEAPESLQQFYRQNDPTNSMNPGIGKT
SKQKYWGEAAPTPASPADPQ

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=570, Percent_Identity=87.0175438596491, Blast_Score=1036, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 65322; Mature: 65191

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAPTDTHKTFLADLARLVGPSHLLTDPAKTQRYRKGFRSGQGEALAVVFPGTLLELWR
CCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHH
VLNACVDADKIILMQAANTGLTEGSTPNGNDYDREIVIISTLRLDKLHLLDKGEQVLAWP
HHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHCCCCEEEECC
GTTLYSLEKALKPLGREPHSVIGSSCIGASVIGGICNNSGGSLVQRGPAYTEMSLFAQID
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEHEEEEC
ADGKLKLVNHLGIDLGSTPEQILSRLDDERISDSDVLHDGRHAHDHDYVTRVRDVDADTP
CCCCEEEHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCC
ARYNADPDRLFESSGCAGKLAVFAVRLDTFPAEKRQQVFYIGTNQPQVLTEIRRHILAEF
CCCCCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
QHLPVAGEYMHRDIYDIAEKYGKDTFLMIDKLGTDKMPFFFTMKGRTDAMLEKVSLFKPH
HCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCC
FTDRFMQKLGHVFPAHLPERMKTWRDKYEHHLLLKMAGDGIEEAQRWLTEYFQQAEGDFF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHCCCCEE
ACTPEEGSKAFLHRFAAAGAAIRYQAVHADEVEDILALDIALRRNDTEWFEHLPPEIDSQ
EECCCCCHHHHHHHHHHCCHHHEEEECCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHH
LVHKLYYGHFMCHVFHQDYIVRKGVDAHALKEKMLELLKARGAQYPAEHNVGHLYEAPES
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHH
LQQFYRQNDPTNSMNPGIGKTSKQKYWGEAAPTPASPADPQ
HHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSAPTDTHKTFLADLARLVGPSHLLTDPAKTQRYRKGFRSGQGEALAVVFPGTLLELWR
CCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHH
VLNACVDADKIILMQAANTGLTEGSTPNGNDYDREIVIISTLRLDKLHLLDKGEQVLAWP
HHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHCCCCEEEECC
GTTLYSLEKALKPLGREPHSVIGSSCIGASVIGGICNNSGGSLVQRGPAYTEMSLFAQID
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEHEEEEC
ADGKLKLVNHLGIDLGSTPEQILSRLDDERISDSDVLHDGRHAHDHDYVTRVRDVDADTP
CCCCEEEHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCCC
ARYNADPDRLFESSGCAGKLAVFAVRLDTFPAEKRQQVFYIGTNQPQVLTEIRRHILAEF
CCCCCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
QHLPVAGEYMHRDIYDIAEKYGKDTFLMIDKLGTDKMPFFFTMKGRTDAMLEKVSLFKPH
HCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCC
FTDRFMQKLGHVFPAHLPERMKTWRDKYEHHLLLKMAGDGIEEAQRWLTEYFQQAEGDFF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHCCCCEE
ACTPEEGSKAFLHRFAAAGAAIRYQAVHADEVEDILALDIALRRNDTEWFEHLPPEIDSQ
EECCCCCHHHHHHHHHHCCHHHEEEECCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHH
LVHKLYYGHFMCHVFHQDYIVRKGVDAHALKEKMLELLKARGAQYPAEHNVGHLYEAPES
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHH
LQQFYRQNDPTNSMNPGIGKTSKQKYWGEAAPTPASPADPQ
HHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]