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The map label for this gene is phoP [H]

Identifier: 238895642

GI number: 238895642

Start: 3557280

End: 3558059

Strand: Direct

Name: phoP [H]

Synonym: KP1_3736

Alternate gene names: 238895642

Gene position: 3557280-3558059 (Clockwise)

Preceding gene: 238895641

Following gene: 238895643

Centisome position: 67.78

GC content: 61.79

Gene sequence:

>780_bases
GTGGCTGGCCGAGCATGGCCCGGACGGCTGCACCTTTATTCTCACCCTCCCCACTGTTACTTAAGAGGAGAACGACGTAT
GGCTTTACGGCTGGCGATAATTGAAGATAACGCCGATCTGCTGGATGAACTGCTGGCCTGGCTGGGCTATCGCGGCTTCG
AGGTGTGGGGGACGCGTAGCGCCGAAGCCTTCTGGCGGCAACTGCACAGCCATCCGGTGGATATCGTGCTGGTTGATATC
GGCCTGCCCGGCGAGGATGGCTTCAGCGTACTGAACTATCTGCATGAGCTGGGGCACTACGGTCTGGTGGTGGTCAGCGC
CCGCGGTCAGCAACAGGATAAACTGCAGGCGCTGAGCCTTGGGGCCGATGCCTATCTGATCAAACCGGTAAACTTCGCCC
ATCTTGCCGAGACCCTCACCGCCCTCGGCGCGCGCCTGCGCCAGGACCGTCCGGCGGCTCCGCCTGCGGAGGCGATCGGC
ACGCCGCCGGCCGTCTCCCCCGGCAGCTGGCGTCTGCACGAGGATAAACTGATTTCACCCGACGCCCGGACGCTGGAGTT
AACCCAGCAGGAATATCGCCTGGTGGAGCTCCTGATGCGCAATCGCAACGAAGTGTGCAGCAAACTGGATCTCCATGCCT
GCCTGTTTTCCCATGAAAGCGAGCCTGACCTGCACCGGATCGACGTGGTGGTTAGCCGCCTGCGTCACAAGGCACGCCAG
CAGGGGATCCACCTGCCCGTTCGCGCAATCTTTGGTAAGGGACTGGCCTTTATTTCCTGA

Upstream 100 bases:

>100_bases
AGCGCTACCGCCGCGGCGAGCACACATCGCCGGTGCCAGGCGGCACTGGTCTCGGACTGTATGTTGCGCGTCAGATAGTG
CAGGCTCATGATGGCAAACT

Downstream 100 bases:

>100_bases
ACGACGGGGCGCGTCGGCGGCCGCGCGGGATATAAAAAACTCGTAAGTGTTAATTTTTCTCATTTTCTGAGAGAAATGAG
AGGAATGAGACTGACGATGA

Product: putative response regulator receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MAGRAWPGRLHLYSHPPHCYLRGERRMALRLAIIEDNADLLDELLAWLGYRGFEVWGTRSAEAFWRQLHSHPVDIVLVDI
GLPGEDGFSVLNYLHELGHYGLVVVSARGQQQDKLQALSLGADAYLIKPVNFAHLAETLTALGARLRQDRPAAPPAEAIG
TPPAVSPGSWRLHEDKLISPDARTLELTQQEYRLVELLMRNRNEVCSKLDLHACLFSHESEPDLHRIDVVVSRLRHKARQ
QGIHLPVRAIFGKGLAFIS

Sequences:

>Translated_259_residues
MAGRAWPGRLHLYSHPPHCYLRGERRMALRLAIIEDNADLLDELLAWLGYRGFEVWGTRSAEAFWRQLHSHPVDIVLVDI
GLPGEDGFSVLNYLHELGHYGLVVVSARGQQQDKLQALSLGADAYLIKPVNFAHLAETLTALGARLRQDRPAAPPAEAIG
TPPAVSPGSWRLHEDKLISPDARTLELTQQEYRLVELLMRNRNEVCSKLDLHACLFSHESEPDLHRIDVVVSRLRHKARQ
QGIHLPVRAIFGKGLAFIS
>Mature_258_residues
AGRAWPGRLHLYSHPPHCYLRGERRMALRLAIIEDNADLLDELLAWLGYRGFEVWGTRSAEAFWRQLHSHPVDIVLVDIG
LPGEDGFSVLNYLHELGHYGLVVVSARGQQQDKLQALSLGADAYLIKPVNFAHLAETLTALGARLRQDRPAAPPAEAIGT
PPAVSPGSWRLHEDKLISPDARTLELTQQEYRLVELLMRNRNEVCSKLDLHACLFSHESEPDLHRIDVVVSRLRHKARQQ
GIHLPVRAIFGKGLAFIS

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=31.7391304347826, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1787229, Length=209, Percent_Identity=27.7511961722488, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=26.1802575107296, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789402, Length=211, Percent_Identity=30.3317535545024, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=23.9130434782609, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082012, Length=188, Percent_Identity=26.5957446808511, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786599, Length=234, Percent_Identity=24.3589743589744, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=23.9130434782609, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1786784, Length=210, Percent_Identity=26.1904761904762, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1786911, Length=208, Percent_Identity=25, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790552, Length=235, Percent_Identity=24.6808510638298, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 29094; Mature: 28963

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRAWPGRLHLYSHPPHCYLRGERRMALRLAIIEDNADLLDELLAWLGYRGFEVWGTRS
CCCCCCCCEEEEECCCCCEEEECCCEEEEEEEEEECCHHHHHHHHHHHCCCCEEECCCCC
AEAFWRQLHSHPVDIVLVDIGLPGEDGFSVLNYLHELGHYGLVVVSARGQQQDKLQALSL
HHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHC
GADAYLIKPVNFAHLAETLTALGARLRQDRPAAPPAEAIGTPPAVSPGSWRLHEDKLISP
CCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCEECCCCCCCC
DARTLELTQQEYRLVELLMRNRNEVCSKLDLHACLFSHESEPDLHRIDVVVSRLRHKARQ
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
QGIHLPVRAIFGKGLAFIS
CCCCCHHHHHHCCCCHHCC
>Mature Secondary Structure 
AGRAWPGRLHLYSHPPHCYLRGERRMALRLAIIEDNADLLDELLAWLGYRGFEVWGTRS
CCCCCCCEEEEECCCCCEEEECCCEEEEEEEEEECCHHHHHHHHHHHCCCCEEECCCCC
AEAFWRQLHSHPVDIVLVDIGLPGEDGFSVLNYLHELGHYGLVVVSARGQQQDKLQALSL
HHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHC
GADAYLIKPVNFAHLAETLTALGARLRQDRPAAPPAEAIGTPPAVSPGSWRLHEDKLISP
CCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCEECCCCCCCC
DARTLELTQQEYRLVELLMRNRNEVCSKLDLHACLFSHESEPDLHRIDVVVSRLRHKARQ
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
QGIHLPVRAIFGKGLAFIS
CCCCCHHHHHHCCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA