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The map label for this gene is manC [H]

Identifier: 238895617

GI number: 238895617

Start: 3524309

End: 3525724

Strand: Reverse

Name: manC [H]

Synonym: KP1_3703

Alternate gene names: 238895617

Gene position: 3525724-3524309 (Counterclockwise)

Preceding gene: 238895618

Following gene: 238895616

Centisome position: 67.18

GC content: 61.37

Gene sequence:

>1416_bases
ATGTTGCTTCCTGTGATAATGGCTGGTGGTACCGGCAGTCGTCTCTGGCCGATGTCTCGCGAGCTTTATCCGAAACAGTT
CCTCCGCCTGTTCGGGCAGAACTCCATGCTACAGGAAACCATCACCCGACTCTCGGGCCTTGAAATCCATGAACCGATGG
TCATCTGTAACGAAGAGCACCGCTTCCTGGTGGCCGAACAGCTGCGCCAGCTCAACAAGCTGTCCAACAACATTATTCTT
GAGCCGGTCGGGCGCAACACCGCCCCGGCCATCGCCCTGGCGGCCCTCCAGGCCACCCGCCACGGCGACGACCCGCTGAT
GCTGGTCCTCGCCGCCGACCATATCATCAATAACCAGCCGGTCTTCCACGACGCCATCCGCGTCGCCGAGCAGTATGCCG
ATGAAGGCCATCTGGTCACCTTCGGTATCGTGCCGAACGCCCCGGAAACCGGCTACGGCTACATCCAGCGCGGCGTGGCC
CTCACCGACAGCGCCCATACTCCGTACCAGGTGGCCCGCTTCGTGGAGAAGCCGGACCGCGAGCGCGCCGAGGCTTACCT
CGCCTCCGGGGAGTACTACTGGAACAGCGGCATGTTTATGTTCCGCGCCAAAAAATACCTTTCCGAGCTGGCCAAATTCC
GCCCGGATATCCTCGAAGCCTGCCAGGCCGCGGTCAATGCCGCCGATAACGGCAGCGACTTCATCAGCATCCCGCATGAC
ATTTTCTGCGAGTGTCCGGACGAGTCTGTGGACTACGCGGTGATGGAGAAAACCGCCGACGCGGTGGTGGTCGGTCTTGA
TGCCGACTGGAGCGACGTCGGCTCCTGGTCCGCCCTGTGGGAGGTCAGCCCGAAAGACGGGCAGGGTAACGTCCTCAGCG
GCGACGCGTGGGTGCACAACAGCGAAAACTGCTACATCAACAGCGACGAGAAGCTGGTGGCGGCCATCGGCGTGGAGAAT
CTGGTGATTATCAGCACCAAGGACGCCGTGCTGGTGATGAACCGCGAGCGTTCCCAGGACGTGAAGAAGGCGGTCGAGTT
TCTCAAGCAGAACCAGCGCAGCGAGTACAAGCGCCACCGCGAGATTTACCGTCCCTGGGGCCGCTGCGACGTGGTGGTCC
AGACCCCGCGCTTCAACGTTAACCGCATTACGGTGAAACCGGGCGGCGCCTTCTCGATGCAGATGCATCACCACCGCGCC
GAGCACTGGGTCATTCTCGCCGGCACCGGCCAGGTGACCGTCAACGGCAAGCAGTTCCTGCTGACCGAGAACCAGTCCAC
CTTTATTCCGATTGGCGCCGAGCACAGCCTGGAAAACCCGGGCCGCATTCCGCTGGAAGTGCTGGAGATCCAGTCGGGGT
CGTACCTCGGCGAGGACGACATTATTCGTATTAAAGACCAGTATGGTCGTTGCTAA

Upstream 100 bases:

>100_bases
TTTGCCATATTTATACTTCTGTACATCTATAATAAGCTGCTTCTGGCCTCAGAATATATCTGGGTGTTTAATAACAGGGT
CTTAATTAAAGGATATTAAT

Downstream 100 bases:

>100_bases
TTTTTTCGGGACAAAACGCAGAATGACACAGTTAACATGCTTTAAGGCTTATGACATCCGTGGTGAACTGGGCGAGGAGC
TGAACGAGGACATCGCCTAC

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MLLPVIMAGGTGSRLWPMSRELYPKQFLRLFGQNSMLQETITRLSGLEIHEPMVICNEEHRFLVAEQLRQLNKLSNNIIL
EPVGRNTAPAIALAALQATRHGDDPLMLVLAADHIINNQPVFHDAIRVAEQYADEGHLVTFGIVPNAPETGYGYIQRGVA
LTDSAHTPYQVARFVEKPDRERAEAYLASGEYYWNSGMFMFRAKKYLSELAKFRPDILEACQAAVNAADNGSDFISIPHD
IFCECPDESVDYAVMEKTADAVVVGLDADWSDVGSWSALWEVSPKDGQGNVLSGDAWVHNSENCYINSDEKLVAAIGVEN
LVIISTKDAVLVMNRERSQDVKKAVEFLKQNQRSEYKRHREIYRPWGRCDVVVQTPRFNVNRITVKPGGAFSMQMHHHRA
EHWVILAGTGQVTVNGKQFLLTENQSTFIPIGAEHSLENPGRIPLEVLEIQSGSYLGEDDIIRIKDQYGRC

Sequences:

>Translated_471_residues
MLLPVIMAGGTGSRLWPMSRELYPKQFLRLFGQNSMLQETITRLSGLEIHEPMVICNEEHRFLVAEQLRQLNKLSNNIIL
EPVGRNTAPAIALAALQATRHGDDPLMLVLAADHIINNQPVFHDAIRVAEQYADEGHLVTFGIVPNAPETGYGYIQRGVA
LTDSAHTPYQVARFVEKPDRERAEAYLASGEYYWNSGMFMFRAKKYLSELAKFRPDILEACQAAVNAADNGSDFISIPHD
IFCECPDESVDYAVMEKTADAVVVGLDADWSDVGSWSALWEVSPKDGQGNVLSGDAWVHNSENCYINSDEKLVAAIGVEN
LVIISTKDAVLVMNRERSQDVKKAVEFLKQNQRSEYKRHREIYRPWGRCDVVVQTPRFNVNRITVKPGGAFSMQMHHHRA
EHWVILAGTGQVTVNGKQFLLTENQSTFIPIGAEHSLENPGRIPLEVLEIQSGSYLGEDDIIRIKDQYGRC
>Mature_471_residues
MLLPVIMAGGTGSRLWPMSRELYPKQFLRLFGQNSMLQETITRLSGLEIHEPMVICNEEHRFLVAEQLRQLNKLSNNIIL
EPVGRNTAPAIALAALQATRHGDDPLMLVLAADHIINNQPVFHDAIRVAEQYADEGHLVTFGIVPNAPETGYGYIQRGVA
LTDSAHTPYQVARFVEKPDRERAEAYLASGEYYWNSGMFMFRAKKYLSELAKFRPDILEACQAAVNAADNGSDFISIPHD
IFCECPDESVDYAVMEKTADAVVVGLDADWSDVGSWSALWEVSPKDGQGNVLSGDAWVHNSENCYINSDEKLVAAIGVEN
LVIISTKDAVLVMNRERSQDVKKAVEFLKQNQRSEYKRHREIYRPWGRCDVVVQTPRFNVNRITVKPGGAFSMQMHHHRA
EHWVILAGTGQVTVNGKQFLLTENQSTFIPIGAEHSLENPGRIPLEVLEIQSGSYLGEDDIIRIKDQYGRC

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=472, Percent_Identity=61.228813559322, Blast_Score=594, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 52807; Mature: 52807

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPVIMAGGTGSRLWPMSRELYPKQFLRLFGQNSMLQETITRLSGLEIHEPMVICNEEH
CCEEEEEECCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHHHHHCCCEECCCEEEECCCC
RFLVAEQLRQLNKLSNNIILEPVGRNTAPAIALAALQATRHGDDPLMLVLAADHIINNQP
CCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECHHCCCCC
VFHDAIRVAEQYADEGHLVTFGIVPNAPETGYGYIQRGVALTDSAHTPYQVARFVEKPDR
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHCCEEEECCCCCHHHHHHHHCCCCH
ERAEAYLASGEYYWNSGMFMFRAKKYLSELAKFRPDILEACQAAVNAADNGSDFISIPHD
HHHHHEEECCEEEECCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCHH
IFCECPDESVDYAVMEKTADAVVVGLDADWSDVGSWSALWEVSPKDGQGNVLSGDAWVHN
HEECCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEECCCEEEC
SENCYINSDEKLVAAIGVENLVIISTKDAVLVMNRERSQDVKKAVEFLKQNQRSEYKRHR
CCCEEECCCCCEEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
EIYRPWGRCDVVVQTPRFNVNRITVKPGGAFSMQMHHHRAEHWVILAGTGQVTVNGKQFL
HHHCCCCCEEEEEECCCCCCEEEEECCCCCEEEHHHHCCCCEEEEEEECCEEEECCEEEE
LTENQSTFIPIGAEHSLENPGRIPLEVLEIQSGSYLGEDDIIRIKDQYGRC
EECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MLLPVIMAGGTGSRLWPMSRELYPKQFLRLFGQNSMLQETITRLSGLEIHEPMVICNEEH
CCEEEEEECCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHHHHHCCCEECCCEEEECCCC
RFLVAEQLRQLNKLSNNIILEPVGRNTAPAIALAALQATRHGDDPLMLVLAADHIINNQP
CCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECHHCCCCC
VFHDAIRVAEQYADEGHLVTFGIVPNAPETGYGYIQRGVALTDSAHTPYQVARFVEKPDR
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHCCEEEECCCCCHHHHHHHHCCCCH
ERAEAYLASGEYYWNSGMFMFRAKKYLSELAKFRPDILEACQAAVNAADNGSDFISIPHD
HHHHHEEECCEEEECCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCHH
IFCECPDESVDYAVMEKTADAVVVGLDADWSDVGSWSALWEVSPKDGQGNVLSGDAWVHN
HEECCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEECCCEEEC
SENCYINSDEKLVAAIGVENLVIISTKDAVLVMNRERSQDVKKAVEFLKQNQRSEYKRHR
CCCEEECCCCCEEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
EIYRPWGRCDVVVQTPRFNVNRITVKPGGAFSMQMHHHRAEHWVILAGTGQVTVNGKQFL
HHHCCCCCEEEEEECCCCCCEEEEECCCCCEEEHHHHCCCCEEEEEEECCEEEECCEEEE
LTENQSTFIPIGAEHSLENPGRIPLEVLEIQSGSYLGEDDIIRIKDQYGRC
EECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042; 9004408 [H]