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The map label for this gene is hisI [H]

Identifier: 238895603

GI number: 238895603

Start: 3506989

End: 3507588

Strand: Direct

Name: hisI [H]

Synonym: KP1_3687

Alternate gene names: 238895603

Gene position: 3506989-3507588 (Clockwise)

Preceding gene: 238895602

Following gene: 238895604

Centisome position: 66.82

GC content: 59.33

Gene sequence:

>600_bases
ATGTTGACTGAACAGCTGGACTGGGAAAAAACGGACGGCATGATGCCGGCCATCGTGCAGCACGCCGTATCCGGCGAAGT
GCTGATGCACGGCTACATGAACAAGGAGGCGCTGGAGAAAACCGAAGCCACCGGCAAGGTCACCTTTTACTCGCGCACCA
AGCAGCGGCTGTGGACCAAGGGTGAAACCTCGGGCCATGTCCTCAATGTAGTGAGCATCACGCCGGACTGTGACAACGAT
ACGCTGCTGGTGCTGGTAAACCCGATCGGACCGACCTGCCACAAAGGCACCACAAGCTGCTTCGGCGAAACCGGCCACCA
GTGGCTGTTCCTCTATCAGCTGGAGCAGCTGCTGGCCGAGCGTAAACACGCCGACCCGGAGAGCTCCTACACGGCGAAGC
TGTATGCCAGCGGCACCAAGCGTATTGCGCAGAAAGTGGGGGAAGAAGGCGTGGAGACCGCGCTGGCCGCCACGGTGAAC
GACCGCTTCGAGCTGAAGAATGAGGCGTCGGACCTGATGTACCACCTGCTGGTGCTGCTGCAGGACCAGGGGCTGGATCT
CGGGGAAGTGATTGATAATTTAAGAGCACGGCATAGGTAA

Upstream 100 bases:

>100_bases
ACGTTGACGGCGCGCTGGCGGCCTCGGTATTCCACAAACAGATTATTAATATTGGCGAACTGAAAGCGTACCTGGCGGCA
CAGGGCGTGGAGATAAGGGT

Downstream 100 bases:

>100_bases
TATAAGACATGGCGGTTATAAAGCCGCCATTAATTACTCTTTCTAAATGACCCCTTCACGCAGCACTCGAAATACCTCCC
AATATCCTTTACAACCTAAT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MLTEQLDWEKTDGMMPAIVQHAVSGEVLMHGYMNKEALEKTEATGKVTFYSRTKQRLWTKGETSGHVLNVVSITPDCDND
TLLVLVNPIGPTCHKGTTSCFGETGHQWLFLYQLEQLLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVN
DRFELKNEASDLMYHLLVLLQDQGLDLGEVIDNLRARHR

Sequences:

>Translated_199_residues
MLTEQLDWEKTDGMMPAIVQHAVSGEVLMHGYMNKEALEKTEATGKVTFYSRTKQRLWTKGETSGHVLNVVSITPDCDND
TLLVLVNPIGPTCHKGTTSCFGETGHQWLFLYQLEQLLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVN
DRFELKNEASDLMYHLLVLLQDQGLDLGEVIDNLRARHR
>Mature_199_residues
MLTEQLDWEKTDGMMPAIVQHAVSGEVLMHGYMNKEALEKTEATGKVTFYSRTKQRLWTKGETSGHVLNVVSITPDCDND
TLLVLVNPIGPTCHKGTTSCFGETGHQWLFLYQLEQLLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVN
DRFELKNEASDLMYHLLVLLQDQGLDLGEVIDNLRARHR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=203, Percent_Identity=85.7142857142857, Blast_Score=360, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319819, Length=169, Percent_Identity=36.6863905325444, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22262; Mature: 22262

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTEQLDWEKTDGMMPAIVQHAVSGEVLMHGYMNKEALEKTEATGKVTFYSRTKQRLWTK
CCCCCCCCCCCCCCHHHHHHHHHCCHHEEHHHCCHHHHHHHCCCCEEEEEEHHHHHHHCC
GETSGHVLNVVSITPDCDNDTLLVLVNPIGPTCHKGTTSCFGETGHQWLFLYQLEQLLAE
CCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCEEHHHHHHHHHHH
RKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVNDRFELKNEASDLMYHLLVLL
HHCCCCCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDQGLDLGEVIDNLRARHR
HCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLTEQLDWEKTDGMMPAIVQHAVSGEVLMHGYMNKEALEKTEATGKVTFYSRTKQRLWTK
CCCCCCCCCCCCCCHHHHHHHHHCCHHEEHHHCCHHHHHHHCCCCEEEEEEHHHHHHHCC
GETSGHVLNVVSITPDCDNDTLLVLVNPIGPTCHKGTTSCFGETGHQWLFLYQLEQLLAE
CCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCEEHHHHHHHHHHH
RKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVNDRFELKNEASDLMYHLLVLL
HHCCCCCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDQGLDLGEVIDNLRARHR
HCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9370271 [H]