Click here to switch to the map view.

The map label for this gene is ahcY [H]

Identifier: 238895583

GI number: 238895583

Start: 3485319

End: 3486452

Strand: Direct

Name: ahcY [H]

Synonym: KP1_3666

Alternate gene names: 238895583

Gene position: 3485319-3486452 (Clockwise)

Preceding gene: 238895581

Following gene: 238895590

Centisome position: 66.41

GC content: 61.55

Gene sequence:

>1134_bases
TTGCGAATTGAAGGTCATAACCCAGTGAATAATAAAATCTCTTTAGCGAAAGAAGTGGCATGGGCCAGCCAGAATATGCC
GCGTACCCTGCGTCAGGTCGCCGCGCTGCCCGACCTCAGCGGCGTGCGTCTGGCCTGCTGTATGCACCTCGACATGAAAA
TGATCCCGCTGGTGCAGGGGATCCTCGACAAGGGCGCTCAGGTCTTTTTAACCACCTGTAACCCCACCACCGTGCAGGAC
GACGTGGTGGCCTGGCTGGTGGAGCGCGGCGCCGAGGCCTGCGCGTGGCGCAATATGAGCGATGCCGACTGGCAACAGTC
ATGGGAAAAAGCGATTGCCTGGCAGCCCACTCACCTGTGCGAGATGGGCGCCGATATCACCACCCTGCTCCACCAGCGCG
GCGAGTTTGGGAACATCGTGGCGGGTCTGGAAGCCACCGGCTCGGGCGTCAATCGGCTGGGGGATATTCAGCCAGGCTAT
CCGATCTTTAACTGGGACGATCTGCCGGTCAAAGAGGGGCTGCACAACCGCCATATGGTCGGTCTCACTGCCTGGCACAC
CTTCTTCCAGACCACTCACCTCACCCTGCATGAGAAAAAAGTGCTGGTGATCGGCTACGGCCTGGTCGGCCAGGGCGTCG
CGGCGGCGGCAAAAGCTTTTGGCGGTCAGGTGATGGTGGCGGAGATCGATCCTGCCCGCCGTCTGCAGGCGGCCTACGAC
GGCTGGCACGTGGTGGACCTCCAGGAGGCTATCGCCTCGGCGGACGTGGTGGCCACGGCGACAGGCGGTAAAAACGTGGT
TAATCGCCAGGCGCTGGACCGGGCGAAAGCGGGAGTATTTATCCTTAACGTCGGCCACGTGGCGGAAGAGATCGACGGCG
AGTACCTGCGCCAGTACCCCCAGGAAGAGGTGATGCCGTATATCAACGCCTACCGCATGGCCGACAAAACCGTCTATCTG
CTGGCCAATGGTTCAATGCTCAATCTGACCGCTGGCTTCGGCGACAGCCTGAACGCCTTTGACGTCACCCTCGCGGTGAT
GGCCAGCGGCATCCGCCATATTGTCACCGACGGCATGCGCGCCCCGGCGAAGGTTTATCTCCTGCCCCAGGCGGTCTGGC
AGCAGGCCCTGTAA

Upstream 100 bases:

>100_bases
TTTCGCAGGGGATAGCGCGCGCGGCGATGTCCGACGGCATTGTGCTGTGAATTCTCGCGGGGGCTGATAGAATCCCTTTT
CGGTCAGGGGGATACCCCTT

Downstream 100 bases:

>100_bases
ACCCGGCGCATCGCCCCCATCGCGGGACGATGCGCTTTACCATCAGGATGACGGCGCGCTATCGGGCAACACAATATTGC
TCTGCGCCAGCGTTCCCATC

Product: putative S-adenosylhomocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRIEGHNPVNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQGILDKGAQVFLTTCNPTTVQD
DVVAWLVERGAEACAWRNMSDADWQQSWEKAIAWQPTHLCEMGADITTLLHQRGEFGNIVAGLEATGSGVNRLGDIQPGY
PIFNWDDLPVKEGLHNRHMVGLTAWHTFFQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYD
GWHVVDLQEAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYPQEEVMPYINAYRMADKTVYL
LANGSMLNLTAGFGDSLNAFDVTLAVMASGIRHIVTDGMRAPAKVYLLPQAVWQQAL

Sequences:

>Translated_377_residues
MRIEGHNPVNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQGILDKGAQVFLTTCNPTTVQD
DVVAWLVERGAEACAWRNMSDADWQQSWEKAIAWQPTHLCEMGADITTLLHQRGEFGNIVAGLEATGSGVNRLGDIQPGY
PIFNWDDLPVKEGLHNRHMVGLTAWHTFFQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYD
GWHVVDLQEAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYPQEEVMPYINAYRMADKTVYL
LANGSMLNLTAGFGDSLNAFDVTLAVMASGIRHIVTDGMRAPAKVYLLPQAVWQQAL
>Mature_377_residues
MRIEGHNPVNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQGILDKGAQVFLTTCNPTTVQD
DVVAWLVERGAEACAWRNMSDADWQQSWEKAIAWQPTHLCEMGADITTLLHQRGEFGNIVAGLEATGSGVNRLGDIQPGY
PIFNWDDLPVKEGLHNRHMVGLTAWHTFFQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYD
GWHVVDLQEAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYPQEEVMPYINAYRMADKTVYL
LANGSMLNLTAGFGDSLNAFDVTLAVMASGIRHIVTDGMRAPAKVYLLPQAVWQQAL

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI298286489, Length=375, Percent_Identity=31.4666666666667, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI195539349, Length=375, Percent_Identity=31.4666666666667, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI195539337, Length=376, Percent_Identity=31.6489361702128, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24308043, Length=376, Percent_Identity=31.6489361702128, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI21361647, Length=375, Percent_Identity=32.5333333333333, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI9951915, Length=373, Percent_Identity=26.0053619302949, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI239937451, Length=364, Percent_Identity=26.0989010989011, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17506425, Length=338, Percent_Identity=30.1775147928994, Blast_Score=148, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320882, Length=345, Percent_Identity=29.8550724637681, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24656245, Length=371, Percent_Identity=31.5363881401617, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45553387, Length=371, Percent_Identity=31.5363881401617, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45553385, Length=371, Percent_Identity=31.5363881401617, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24642172, Length=342, Percent_Identity=29.5321637426901, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 41221; Mature: 41221

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEGHNPVNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQG
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEHHHHCCHHHHHHHHH
ILDKGAQVFLTTCNPTTVQDDVVAWLVERGAEACAWRNMSDADWQQSWEKAIAWQPTHLC
HHCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHH
EMGADITTLLHQRGEFGNIVAGLEATGSGVNRLGDIQPGYPIFNWDDLPVKEGLHNRHMV
HHCCHHHHHHHCCCCCCCEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCCCCCEEE
GLTAWHTFFQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYD
EHHHHHHHHHHHEEEEECCEEEEEECCHHHCHHHHHHHHCCCEEEEEECCHHHHHHHHCC
GWHVVDLQEAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYP
CEEEEEHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCHHHHHCCHHHHHHCC
QEEVMPYINAYRMADKTVYLLANGSMLNLTAGFGDSLNAFDVTLAVMASGIRHIVTDGMR
HHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC
APAKVYLLPQAVWQQAL
CCEEEEEECHHHHHHCC
>Mature Secondary Structure
MRIEGHNPVNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQG
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEHHHHCCHHHHHHHHH
ILDKGAQVFLTTCNPTTVQDDVVAWLVERGAEACAWRNMSDADWQQSWEKAIAWQPTHLC
HHCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHH
EMGADITTLLHQRGEFGNIVAGLEATGSGVNRLGDIQPGYPIFNWDDLPVKEGLHNRHMV
HHCCHHHHHHHCCCCCCCEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCCCCCEEE
GLTAWHTFFQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYD
EHHHHHHHHHHHEEEEECCEEEEEECCHHHCHHHHHHHHCCCEEEEEECCHHHHHHHHCC
GWHVVDLQEAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYP
CEEEEEHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCHHHHHCCHHHHHHCC
QEEVMPYINAYRMADKTVYLLANGSMLNLTAGFGDSLNAFDVTLAVMASGIRHIVTDGMR
HHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC
APAKVYLLPQAVWQQAL
CCEEEEEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]