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The map label for this gene is yjcE [H]

Identifier: 238895505

GI number: 238895505

Start: 3392198

End: 3393832

Strand: Direct

Name: yjcE [H]

Synonym: KP1_3578

Alternate gene names: 238895505

Gene position: 3392198-3393832 (Clockwise)

Preceding gene: 238895501

Following gene: 238895507

Centisome position: 64.63

GC content: 59.33

Gene sequence:

>1635_bases
ATGTCGCTAATTGCTATCGTGCTGGTCTTTATCATGGCCATCGTGGTGACCGTGTTCCTGTCCCATCTTCTGCCCGTTAA
AGTGCCGCTACCGCTGATCCAAATCGCCGCGGGCGCCGCGCTGGCCGCCAGTGGCTTTCAGGTCGATTTTGACCCGCATA
TTTTTTTACTGCTGTTTATCCCGCCGCTGCTGTTCCTCGATGGCTGGCGCATCCCCAAAGACGCTTTTTTCCGCGATATG
AAGCCGATTTTATCGCTGGCGATAGGCCTGGTGATGGTGACTATTCTCGGTATTGGCCTGTTTATTCACTGGCTGATCCC
GGCTATCACCGTGGCGGCAGGGTTCGCCCTCGCGGCTATTCTGTCGCCTACCGATCCGGTGGCGGTATCGGCAATGACCG
CCAGCTCGCCGCTTCCCTCAAGGATGGCGCATATTCTCGAAGGGGAGTCGCTGTTAAACGATGCTTCAGGGCTCGTCGCC
TTTAACTTCGCCATCGCCGCGGTGCTGACCGGCAGCTTCTCCCCGGGAGACGCGGTGGTGAAATTTTTCCTGATGGCCTT
CGGGGGCATCCTCAATGGCCTCGTGGTGGTGTGGGTCACCGGCAAATGTAATAACTTTCTGGTTCGGCGCACCCGCGAGG
AGCCAGCCATCCAGATCCTGATCAGCCTGCTTATCCCTTTCGCCGCCTACCTGCTGGCCGAGGCGTTCCATGTCTCGGGC
ATTCTTGCCGCCGTCGCCGCCGGCATTGCGATGCATTATGAGCAGCTGTCGGGGCCCCGGCTTCCGGCGACGCGCATGAA
AAGCAGCGCGGTATGGTCCATGCTGCAGACCACCCTCAACGGGATGATCTTTCTGATGCTGGGCGAGCAGCTGCCGCGCA
TGCTCAGGACGCTGCCGGCGGTAGCCAGCCAGGCCGGCGTCTCTTCGCCCTGGTATCTGCTGCTGTACGCCGTGGCCATC
ACCCTGGCGCTTGGTCTGATGCGCTTCGCCTGGGTATGGCTGTCGATGAAGCTGACAATTTTTCGCCGCAAACGTCGAGG
CAAGGCCATCACCGTCCGTCCACGCTTCAGTATCCTCGCCGTCATGGCGCTGGCGGGAGTGAAGGGCTCTGTGACCCTCG
CCGGTATTCTGACGCTGCCGGTGGTGCTGGCAGATGGTTCGCCGTTCCCGGGCCGTGAACTACTGATCTTTCTTTCGATG
GCAGTGATCCTGATGTCGCTGGTGGTGGCGGCTATCGGTCTGCCGTTTATGACCCGTTATCTTGCCGATGATCTACCGCA
TGACACCGGTAAGGACGACATTGGCGCCGTGATGACCGAGGTGGCCATTAACCGTCTTAACGCGCTACTGGACGAGCCGG
TGGAGGATCCCAGTGAGCAGGCCCTGCGGGCCGATGCCGGCAATATGCTGCTCGAAACCTATCAGCGGCGGCTTCACTAT
AACGACAATGACGAGGGGCAGGATGTCGGGCTGGAGCTGGCTAAGCGCGCCAGGCTGGAGAAATATATGCAACGAGAGGT
CATTATCGCCCAGCGTCAGGAGCTGTTCCGGCTGCGCCGCGCCCATAACATCAGCGATATCACTTTTTATGAGGTGCTGC
GGGAGATAGATCTGAAGGAAGAGAGTTTACGCTAA

Upstream 100 bases:

>100_bases
TCGGTGACTGGGTAAATAATCTGTTACCGAAACAACACCTGCGAAAAAGGATTAACAGTCTGATGTACAGAATGAATATT
GCCGTCAGAGGAGGGGATGA

Downstream 100 bases:

>100_bases
AGCCGCAATCGCCGGAGGGTGGCCATTCGCCTTCCGGCAGAAGTACCGGCGCTGAAAAGCAAAAAGCCTGCTCGAAAGCA
GGCTTTTTTAAATTTGGCTC

Product: putative sodium:hydrogen antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MSLIAIVLVFIMAIVVTVFLSHLLPVKVPLPLIQIAAGAALAASGFQVDFDPHIFLLLFIPPLLFLDGWRIPKDAFFRDM
KPILSLAIGLVMVTILGIGLFIHWLIPAITVAAGFALAAILSPTDPVAVSAMTASSPLPSRMAHILEGESLLNDASGLVA
FNFAIAAVLTGSFSPGDAVVKFFLMAFGGILNGLVVVWVTGKCNNFLVRRTREEPAIQILISLLIPFAAYLLAEAFHVSG
ILAAVAAGIAMHYEQLSGPRLPATRMKSSAVWSMLQTTLNGMIFLMLGEQLPRMLRTLPAVASQAGVSSPWYLLLYAVAI
TLALGLMRFAWVWLSMKLTIFRRKRRGKAITVRPRFSILAVMALAGVKGSVTLAGILTLPVVLADGSPFPGRELLIFLSM
AVILMSLVVAAIGLPFMTRYLADDLPHDTGKDDIGAVMTEVAINRLNALLDEPVEDPSEQALRADAGNMLLETYQRRLHY
NDNDEGQDVGLELAKRARLEKYMQREVIIAQRQELFRLRRAHNISDITFYEVLREIDLKEESLR

Sequences:

>Translated_544_residues
MSLIAIVLVFIMAIVVTVFLSHLLPVKVPLPLIQIAAGAALAASGFQVDFDPHIFLLLFIPPLLFLDGWRIPKDAFFRDM
KPILSLAIGLVMVTILGIGLFIHWLIPAITVAAGFALAAILSPTDPVAVSAMTASSPLPSRMAHILEGESLLNDASGLVA
FNFAIAAVLTGSFSPGDAVVKFFLMAFGGILNGLVVVWVTGKCNNFLVRRTREEPAIQILISLLIPFAAYLLAEAFHVSG
ILAAVAAGIAMHYEQLSGPRLPATRMKSSAVWSMLQTTLNGMIFLMLGEQLPRMLRTLPAVASQAGVSSPWYLLLYAVAI
TLALGLMRFAWVWLSMKLTIFRRKRRGKAITVRPRFSILAVMALAGVKGSVTLAGILTLPVVLADGSPFPGRELLIFLSM
AVILMSLVVAAIGLPFMTRYLADDLPHDTGKDDIGAVMTEVAINRLNALLDEPVEDPSEQALRADAGNMLLETYQRRLHY
NDNDEGQDVGLELAKRARLEKYMQREVIIAQRQELFRLRRAHNISDITFYEVLREIDLKEESLR
>Mature_543_residues
SLIAIVLVFIMAIVVTVFLSHLLPVKVPLPLIQIAAGAALAASGFQVDFDPHIFLLLFIPPLLFLDGWRIPKDAFFRDMK
PILSLAIGLVMVTILGIGLFIHWLIPAITVAAGFALAAILSPTDPVAVSAMTASSPLPSRMAHILEGESLLNDASGLVAF
NFAIAAVLTGSFSPGDAVVKFFLMAFGGILNGLVVVWVTGKCNNFLVRRTREEPAIQILISLLIPFAAYLLAEAFHVSGI
LAAVAAGIAMHYEQLSGPRLPATRMKSSAVWSMLQTTLNGMIFLMLGEQLPRMLRTLPAVASQAGVSSPWYLLLYAVAIT
LALGLMRFAWVWLSMKLTIFRRKRRGKAITVRPRFSILAVMALAGVKGSVTLAGILTLPVVLADGSPFPGRELLIFLSMA
VILMSLVVAAIGLPFMTRYLADDLPHDTGKDDIGAVMTEVAINRLNALLDEPVEDPSEQALRADAGNMLLETYQRRLHYN
DNDEGQDVGLELAKRARLEKYMQREVIIAQRQELFRLRRAHNISDITFYEVLREIDLKEESLR

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=487, Percent_Identity=23.2032854209446, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI15529998, Length=455, Percent_Identity=26.1538461538462, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI41872703, Length=485, Percent_Identity=23.2989690721649, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI294997330, Length=413, Percent_Identity=23.728813559322, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI110227626, Length=413, Percent_Identity=23.728813559322, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI5454070, Length=452, Percent_Identity=22.787610619469, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI14211919, Length=346, Percent_Identity=25.1445086705202, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI27734935, Length=269, Percent_Identity=24.907063197026, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI194239733, Length=385, Percent_Identity=25.1948051948052, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4759144, Length=260, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790501, Length=548, Percent_Identity=37.4087591240876, Blast_Score=334, Evalue=9e-93,
Organism=Caenorhabditis elegans, GI71980847, Length=476, Percent_Identity=23.5294117647059, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25150332, Length=399, Percent_Identity=23.5588972431078, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992107, Length=425, Percent_Identity=24, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71992101, Length=425, Percent_Identity=24, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71993590, Length=477, Percent_Identity=21.5932914046122, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993582, Length=477, Percent_Identity=21.8029350104822, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71987545, Length=397, Percent_Identity=24.6851385390428, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987559, Length=397, Percent_Identity=24.6851385390428, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25147678, Length=420, Percent_Identity=21.6666666666667, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71999821, Length=439, Percent_Identity=21.4123006833713, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71999817, Length=439, Percent_Identity=21.1845102505695, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71999819, Length=439, Percent_Identity=21.1845102505695, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71987535, Length=460, Percent_Identity=24.1304347826087, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71987537, Length=460, Percent_Identity=24.1304347826087, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=261, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281364513, Length=462, Percent_Identity=22.0779220779221, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221473222, Length=462, Percent_Identity=22.0779220779221, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221473212, Length=440, Percent_Identity=22.5, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221473215, Length=425, Percent_Identity=22.5882352941176, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281360447, Length=221, Percent_Identity=28.5067873303167, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221510734, Length=380, Percent_Identity=25.2631578947368, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221510738, Length=380, Percent_Identity=25.2631578947368, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221510732, Length=380, Percent_Identity=25, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510736, Length=380, Percent_Identity=25, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585580, Length=380, Percent_Identity=25, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585578, Length=380, Percent_Identity=25, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221510740, Length=380, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59474; Mature: 59342

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIAIVLVFIMAIVVTVFLSHLLPVKVPLPLIQIAAGAALAASGFQVDFDPHIFLLLFI
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHCCCCEECCCCHHHHHHHH
PPLLFLDGWRIPKDAFFRDMKPILSLAIGLVMVTILGIGLFIHWLIPAITVAAGFALAAI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSPTDPVAVSAMTASSPLPSRMAHILEGESLLNDASGLVAFNFAIAAVLTGSFSPGDAVV
CCCCCCCEEEEECCCCCCHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHH
KFFLMAFGGILNGLVVVWVTGKCNNFLVRRTREEPAIQILISLLIPFAAYLLAEAFHVSG
HHHHHHHHHHHHCEEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAAVAAGIAMHYEQLSGPRLPATRMKSSAVWSMLQTTLNGMIFLMLGEQLPRMLRTLPA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASQAGVSSPWYLLLYAVAITLALGLMRFAWVWLSMKLTIFRRKRRGKAITVRPRFSILA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
VMALAGVKGSVTLAGILTLPVVLADGSPFPGRELLIFLSMAVILMSLVVAAIGLPFMTRY
HHHHHCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LADDLPHDTGKDDIGAVMTEVAINRLNALLDEPVEDPSEQALRADAGNMLLETYQRRLHY
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHCC
NDNDEGQDVGLELAKRARLEKYMQREVIIAQRQELFRLRRAHNISDITFYEVLREIDLKE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCH
ESLR
HCCC
>Mature Secondary Structure 
SLIAIVLVFIMAIVVTVFLSHLLPVKVPLPLIQIAAGAALAASGFQVDFDPHIFLLLFI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHCCCCEECCCCHHHHHHHH
PPLLFLDGWRIPKDAFFRDMKPILSLAIGLVMVTILGIGLFIHWLIPAITVAAGFALAAI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSPTDPVAVSAMTASSPLPSRMAHILEGESLLNDASGLVAFNFAIAAVLTGSFSPGDAVV
CCCCCCCEEEEECCCCCCHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHH
KFFLMAFGGILNGLVVVWVTGKCNNFLVRRTREEPAIQILISLLIPFAAYLLAEAFHVSG
HHHHHHHHHHHHCEEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAAVAAGIAMHYEQLSGPRLPATRMKSSAVWSMLQTTLNGMIFLMLGEQLPRMLRTLPA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASQAGVSSPWYLLLYAVAITLALGLMRFAWVWLSMKLTIFRRKRRGKAITVRPRFSILA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
VMALAGVKGSVTLAGILTLPVVLADGSPFPGRELLIFLSMAVILMSLVVAAIGLPFMTRY
HHHHHCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LADDLPHDTGKDDIGAVMTEVAINRLNALLDEPVEDPSEQALRADAGNMLLETYQRRLHY
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHCC
NDNDEGQDVGLELAKRARLEKYMQREVIIAQRQELFRLRRAHNISDITFYEVLREIDLKE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCH
ESLR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]