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The map label for this gene is rnd [H]

Identifier: 238895380

GI number: 238895380

Start: 3265522

End: 3266649

Strand: Reverse

Name: rnd [H]

Synonym: KP1_3446

Alternate gene names: 238895380

Gene position: 3266649-3265522 (Counterclockwise)

Preceding gene: 238895381

Following gene: 238895376

Centisome position: 62.24

GC content: 62.23

Gene sequence:

>1128_bases
TTGAACTATCAGATGATCACTACCGACAATGGCCTGCGCGCTGTCTGCGAAGCGGCAAGCACGGCCTCCGCCGTCGCTCT
GGATACGGAATTTGTCCGCACCCGCACCTATTACCCGCAGCTGGGCCTGCTGCAGCTGTTCGACGGCCAGCAGGTCTCTC
TGATCGATCCCTTGACGATTAACGACTGGGCGCCGATGCGCGACCTGCTGCTCAACCAGGATGTGACTAAATACCTGCAT
GCCGGCAGCGAAGATTTAGAAGTCTTCCTTAATGCATTTAACCTGATGCCGCAGCCGCTGATTGACACCCAGATCCTGGC
GGCCTTCTGCGGCCGCCCAATGTCCTGGGGCTTCGCCTCGATGGTGGAAGAGTATTCCGGGGTAGCGCTGGATAAAAGCG
AATCCCGCACCGACTGGCTGGCGCGCCCGCTGACTGAGCGTCAGTGTGAATATGCCGCGGCCGACGTCTGGTATCTGCTG
CCGATCGCCAGCCAGTTAATGGCGGAGACCGATCGCGCTGGCTGGCTGCCGGCGGCGCTCGACGAGTGCCGCGTGATGCA
GCAGCGTCGTCAGGAGGTGGTCGACCCGGCCGAGGCCTGGCGCGATATCGGCAACGCCTGGCAGCTGCGTACCCGCCAGC
TGGGTTGTCTGCAGCTGTTGGCGGAGTGGCGCCTGCGCAAAGCGCGCGAGCGCGACCTGGCGGTAAACTTTGTGGTGCGG
GAAGAGCATCTGTGGAGCGTGGCGCGCTATATGCCCACCAGCCTGGGCGAGCTCGACAGCCTCGGGTTGTCCGGTAGCGA
AATTCGCTTCCACGGCAAAACGCTGATTAGCCTGGTCGAAAAAGCGCAGGCGCTGCCGGAGTCGGCCCTGCCGGCGCCGC
TGCAGAACCTGATCGACATGCCGGGCTACCGCAAAGCCTTTAAAGATATTAAAGCGCTGGTGCAGGAAGTGAGCACGGAG
AAGGGCGTAAGCGCGGAGCTGCTGGCGTCGCGTCGGCAGATCAACCAGCTGCTGAACTGGCACTGGCAGCTGAAAACGCA
AGCCGGTGAACCTGAGCTGATTTCCGGTTGGCGCGGGGAGCTGATGGCCGAGCGGCTGAAGACGCTGTTAAACGACTATC
CGCGCTAG

Upstream 100 bases:

>100_bases
AGCGCGCGCTAAAGTGGACAATAAAGGCTAAGTAACGAATGAGTCGCCTGACGCCGGCTACGCCGGCGTTTTTTATGGGC
GCAAGTTAAGAGAGTATGCT

Downstream 100 bases:

>100_bases
TTCGCGGCCAGGTTCAGACCATTAAAAAACCGGCGGCGCGTGGCGTAGCCGGTTTTTTTTCGCGATAGCGCGACAGGTCA
GGATTTCGACTCTTCCGTTT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MNYQMITTDNGLRAVCEAASTASAVALDTEFVRTRTYYPQLGLLQLFDGQQVSLIDPLTINDWAPMRDLLLNQDVTKYLH
AGSEDLEVFLNAFNLMPQPLIDTQILAAFCGRPMSWGFASMVEEYSGVALDKSESRTDWLARPLTERQCEYAAADVWYLL
PIASQLMAETDRAGWLPAALDECRVMQQRRQEVVDPAEAWRDIGNAWQLRTRQLGCLQLLAEWRLRKARERDLAVNFVVR
EEHLWSVARYMPTSLGELDSLGLSGSEIRFHGKTLISLVEKAQALPESALPAPLQNLIDMPGYRKAFKDIKALVQEVSTE
KGVSAELLASRRQINQLLNWHWQLKTQAGEPELISGWRGELMAERLKTLLNDYPR

Sequences:

>Translated_375_residues
MNYQMITTDNGLRAVCEAASTASAVALDTEFVRTRTYYPQLGLLQLFDGQQVSLIDPLTINDWAPMRDLLLNQDVTKYLH
AGSEDLEVFLNAFNLMPQPLIDTQILAAFCGRPMSWGFASMVEEYSGVALDKSESRTDWLARPLTERQCEYAAADVWYLL
PIASQLMAETDRAGWLPAALDECRVMQQRRQEVVDPAEAWRDIGNAWQLRTRQLGCLQLLAEWRLRKARERDLAVNFVVR
EEHLWSVARYMPTSLGELDSLGLSGSEIRFHGKTLISLVEKAQALPESALPAPLQNLIDMPGYRKAFKDIKALVQEVSTE
KGVSAELLASRRQINQLLNWHWQLKTQAGEPELISGWRGELMAERLKTLLNDYPR
>Mature_375_residues
MNYQMITTDNGLRAVCEAASTASAVALDTEFVRTRTYYPQLGLLQLFDGQQVSLIDPLTINDWAPMRDLLLNQDVTKYLH
AGSEDLEVFLNAFNLMPQPLIDTQILAAFCGRPMSWGFASMVEEYSGVALDKSESRTDWLARPLTERQCEYAAADVWYLL
PIASQLMAETDRAGWLPAALDECRVMQQRRQEVVDPAEAWRDIGNAWQLRTRQLGCLQLLAEWRLRKARERDLAVNFVVR
EEHLWSVARYMPTSLGELDSLGLSGSEIRFHGKTLISLVEKAQALPESALPAPLQNLIDMPGYRKAFKDIKALVQEVSTE
KGVSAELLASRRQINQLLNWHWQLKTQAGEPELISGWRGELMAERLKTLLNDYPR

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Escherichia coli, GI1788105, Length=375, Percent_Identity=78.9333333333333, Blast_Score=624, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17531757, Length=259, Percent_Identity=26.2548262548263, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324574, Length=309, Percent_Identity=24.5954692556634, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42568; Mature: 42568

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYQMITTDNGLRAVCEAASTASAVALDTEFVRTRTYYPQLGLLQLFDGQQVSLIDPLTI
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEECCEEC
NDWAPMRDLLLNQDVTKYLHAGSEDLEVFLNAFNLMPQPLIDTQILAAFCGRPMSWGFAS
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
MVEEYSGVALDKSESRTDWLARPLTERQCEYAAADVWYLLPIASQLMAETDRAGWLPAAL
HHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DECRVMQQRRQEVVDPAEAWRDIGNAWQLRTRQLGCLQLLAEWRLRKARERDLAVNFVVR
HHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEH
EEHLWSVARYMPTSLGELDSLGLSGSEIRFHGKTLISLVEKAQALPESALPAPLQNLIDM
HHHHHHHHHHCCHHHCHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
PGYRKAFKDIKALVQEVSTEKGVSAELLASRRQINQLLNWHWQLKTQAGEPELISGWRGE
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHCCHHHH
LMAERLKTLLNDYPR
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MNYQMITTDNGLRAVCEAASTASAVALDTEFVRTRTYYPQLGLLQLFDGQQVSLIDPLTI
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEECCEEC
NDWAPMRDLLLNQDVTKYLHAGSEDLEVFLNAFNLMPQPLIDTQILAAFCGRPMSWGFAS
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
MVEEYSGVALDKSESRTDWLARPLTERQCEYAAADVWYLLPIASQLMAETDRAGWLPAAL
HHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DECRVMQQRRQEVVDPAEAWRDIGNAWQLRTRQLGCLQLLAEWRLRKARERDLAVNFVVR
HHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEH
EEHLWSVARYMPTSLGELDSLGLSGSEIRFHGKTLISLVEKAQALPESALPAPLQNLIDM
HHHHHHHHHHCCHHHCHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
PGYRKAFKDIKALVQEVSTEKGVSAELLASRRQINQLLNWHWQLKTQAGEPELISGWRGE
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHCCHHHH
LMAERLKTLLNDYPR
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]