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The map label for this gene is treA [H]

Identifier: 238895361

GI number: 238895361

Start: 3246323

End: 3248068

Strand: Direct

Name: treA [H]

Synonym: KP1_3426

Alternate gene names: 238895361

Gene position: 3246323-3248068 (Clockwise)

Preceding gene: 238895351

Following gene: 238895362

Centisome position: 61.85

GC content: 62.31

Gene sequence:

>1746_bases
ATGACGAGTACTGATGCACGTCGTCCCGCTGCTTTGCCCTGTTCCCTGCGCCTGGCGATCGGCGGCGCTCTGATCGCCCT
GATGAGCCTGAACGCTCAGGCGGAAGACGGCAAAACCGCGCCGCCCCCCTCGCCGGATATTCTGCTGGGCCCGCTGTTCA
ATGATGTCCAGAGCGCGAAGCTGTTTGCCGATCAGAAAACCTTCGCCGACGCTATCCCTAACAGCGATCCGCTGATGATC
CTTGCCGATTACCGGATGCAAAAAAACCAGGCCAGCTTCGACCTGCGCCACTTCGTCGAACTGAACTTCACGCTGCCGAA
AGAGAACGACACCTATGCGCCGCCCAAAGGGCAAACTCTGCGTCAACATATCGATGGCCTGTGGCCGGTCCTGACCCGCA
GCACCGTCGAGGTGGAAAAATGGGACTCGCTGCTGCCGCTGCCTAAGCCCTACGTGGTGCCCGGAGGACGTTTCCGCGAA
GTCTATTACTGGGACAGCTATTTCACCATGCTGGGTCTTGCCGAAAGCGGTCACTGGGATAAAATCGAGGATATGGTCGC
CAACTTCGCCGCGGAAATTGACGCCTGGGGCCATATCCCCAACGGCAACCGCACCTATTATCTCAGCCGTTCGCAGCCCC
CCTTCTTCTCCTTTATGGTGAGCCTGCTGGCGACGCACGATGGCGACCAGGTGCTGAAAACCTACCAGCCGCAGCTGGAG
AAAGAGTATCGCTACTGGATGGCCGGAGCGGACGCGCTGGCTCCCGGCAGCGCCGACAAACGGGCGGTGCGGATGGCGGA
CGGCGCGCTGCTCAACCGCTACTGGGACGATAACGACACCCCGCGTCCCGAGTCCTGGCTTGACGACGTCAAAACCGCCA
AAAGCAACCCGAATCGTCCGGCAACCGAGATCTATCGCGACCTGCGCTCCGCCGCCGCCTCCGGCTGGGATTTCAGCTCC
CGCTGGATGGACAATCCGCAGCAGCTCGCCACCATTCGCACCACCTCGATTGTCCCGGTCGATCTCAATGCCCTGATGTT
CCATCTGGAGAAAACCCTCGCCCGCGCCAGCAAGGCATCCGGGGACAGCGCTGGCGCTACGCAGTACGATGCGCTGGCTA
ACGCCCGCCAGCAGGCCATCGAGAAATACCTGTGGAATGATAAAGAGGGATGGTACGCCGACTACGATCTGAAAAGCCAC
AAGGTGCGCAATCAACTGACCGCGGCGGCGCTGTTCCCGCTGTACGTCAATGCCGCGTCACGCGAGCGGGCGACGAAAGT
GGCCGCCGCCGCCGAGTCGCGCCTGCTTAAACCCGGCGGGCTGACCACCACCACCGTCAACAGCGGCCAGCAGTGGGACG
CTCCCAACGGCTGGGCGCCGCTGCAGTGGGTGGCGGTCGAGGGGCTGCAAAACTATGGTCAGCAGAAGATCGCCATGGAG
GTCACCTGGCGCTTCCTGACCAACGTGCAGCATACCTATGACAGTAAGCAAAAGCTGGTGGAGAAGTATGACGTGAGCTC
GACCGGCACCGGCGGCGGCGGCGGGGAATATCCGCTGCAGGACGGCTTTGGCTGGACCAACGGCGTCACCCTGAAGATGT
TGGATCTGATCTGCCCGCAGGAGAAACCCTGCGATGCGCTGCCCGCTACCCGTCCGGCGACAACCCCTTCACCGCAGGAC
AAACCTGTTGCGGCGCCCGCGGCTAACGACCCCGCCCCTGCGGAACCGCAAAAGACCGGCTCCTGA

Upstream 100 bases:

>100_bases
AAATGTTACCCCTGACACGCGCAGCGGCAGATATTCGTCTAAGGTTTTTGGATGGCCAAACGTCGTGGCCCGCAGTCGAT
AATGATAAGGAGAACTCCCC

Downstream 100 bases:

>100_bases
CGCTTCGCCGCCCCCTACCAAAATCGGTAGGGGGAAGCGGACTCCCTGGTCACTACCGTCCCGTGCAGACCCATTCTGCG
GCTCGCGGGAAACACCTCCC

Product: trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAKLFADQKTFADAIPNSDPLMI
LADYRMQKNQASFDLRHFVELNFTLPKENDTYAPPKGQTLRQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFRE
VYYWDSYFTMLGLAESGHWDKIEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLE
KEYRYWMAGADALAPGSADKRAVRMADGALLNRYWDDNDTPRPESWLDDVKTAKSNPNRPATEIYRDLRSAAASGWDFSS
RWMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKASGDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSH
KVRNQLTAAALFPLYVNAASRERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAME
VTWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDALPATRPATTPSPQD
KPVAAPAANDPAPAEPQKTGS

Sequences:

>Translated_581_residues
MTSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAKLFADQKTFADAIPNSDPLMI
LADYRMQKNQASFDLRHFVELNFTLPKENDTYAPPKGQTLRQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFRE
VYYWDSYFTMLGLAESGHWDKIEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLE
KEYRYWMAGADALAPGSADKRAVRMADGALLNRYWDDNDTPRPESWLDDVKTAKSNPNRPATEIYRDLRSAAASGWDFSS
RWMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKASGDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSH
KVRNQLTAAALFPLYVNAASRERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAME
VTWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDALPATRPATTPSPQD
KPVAAPAANDPAPAEPQKTGS
>Mature_580_residues
TSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAKLFADQKTFADAIPNSDPLMIL
ADYRMQKNQASFDLRHFVELNFTLPKENDTYAPPKGQTLRQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFREV
YYWDSYFTMLGLAESGHWDKIEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLEK
EYRYWMAGADALAPGSADKRAVRMADGALLNRYWDDNDTPRPESWLDDVKTAKSNPNRPATEIYRDLRSAAASGWDFSSR
WMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKASGDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSHK
VRNQLTAAALFPLYVNAASRERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAMEV
TWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDALPATRPATTPSPQDK
PVAAPAANDPAPAEPQKTGS

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=551, Percent_Identity=34.3012704174229, Blast_Score=260, Evalue=3e-69,
Organism=Escherichia coli, GI1787447, Length=542, Percent_Identity=76.3837638376384, Blast_Score=877, Evalue=0.0,
Organism=Escherichia coli, GI1789936, Length=487, Percent_Identity=51.7453798767967, Blast_Score=508, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17542196, Length=527, Percent_Identity=33.5863377609108, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI25148109, Length=560, Percent_Identity=30.5357142857143, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI25141398, Length=528, Percent_Identity=30.8712121212121, Blast_Score=225, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17565078, Length=515, Percent_Identity=31.0679611650485, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI71987755, Length=408, Percent_Identity=29.1666666666667, Blast_Score=187, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320204, Length=425, Percent_Identity=30.3529411764706, Blast_Score=163, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6319473, Length=455, Percent_Identity=30.989010989011, Blast_Score=160, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24656680, Length=528, Percent_Identity=35.2272727272727, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24656675, Length=528, Percent_Identity=35.2272727272727, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24656661, Length=528, Percent_Identity=35.2272727272727, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI17933716, Length=528, Percent_Identity=35.2272727272727, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24656670, Length=528, Percent_Identity=35.2272727272727, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24656685, Length=502, Percent_Identity=34.4621513944223, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI22024178, Length=528, Percent_Identity=30.8712121212121, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI45551104, Length=368, Percent_Identity=30.9782608695652, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28573474, Length=314, Percent_Identity=28.343949044586, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 64282; Mature: 64150

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAK
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHH
LFADQKTFADAIPNSDPLMILADYRMQKNQASFDLRHFVELNFTLPKENDTYAPPKGQTL
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHH
RQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFREVYYWDSYFTMLGLAESGHWD
HHHHHHHHHHHHCCEEEHHHHHCCCCCCCCEECCCCCEEEEEEECHHHHHHHCCCCCCHH
KIEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLE
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCHHHH
KEYRYWMAGADALAPGSADKRAVRMADGALLNRYWDDNDTPRPESWLDDVKTAKSNPNRP
HHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC
ATEIYRDLRSAAASGWDFSSRWMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKAS
HHHHHHHHHHHHCCCCCCHHHHCCCHHHEEEEEECEEEEECHHHHHHHHHHHHHHHHHCC
GDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSHKVRNQLTAAALFPLYVNAAS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHH
RERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAME
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHH
VTWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
EKPCDALPATRPATTPSPQDKPVAAPAANDPAPAEPQKTGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAK
CCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHH
LFADQKTFADAIPNSDPLMILADYRMQKNQASFDLRHFVELNFTLPKENDTYAPPKGQTL
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHH
RQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFREVYYWDSYFTMLGLAESGHWD
HHHHHHHHHHHHCCEEEHHHHHCCCCCCCCEECCCCCEEEEEEECHHHHHHHCCCCCCHH
KIEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLE
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCHHHH
KEYRYWMAGADALAPGSADKRAVRMADGALLNRYWDDNDTPRPESWLDDVKTAKSNPNRP
HHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC
ATEIYRDLRSAAASGWDFSSRWMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKAS
HHHHHHHHHHHHCCCCCCHHHHCCCHHHEEEEEECEEEEECHHHHHHHHHHHHHHHHHCC
GDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSHKVRNQLTAAALFPLYVNAAS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHH
RERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAME
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHH
VTWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
EKPCDALPATRPATTPSPQDKPVAAPAANDPAPAEPQKTGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA