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The map label for this gene is tdcA [H]

Identifier: 238895350

GI number: 238895350

Start: 3237056

End: 3237997

Strand: Reverse

Name: tdcA [H]

Synonym: KP1_3412

Alternate gene names: 238895350

Gene position: 3237997-3237056 (Counterclockwise)

Preceding gene: 238895352

Following gene: 238895349

Centisome position: 61.69

GC content: 55.31

Gene sequence:

>942_bases
ATGAATACTTTTTCTCTGCCTAAAACACAGCATCTGGTAGTTTTCCAGGAAGTGATCCGCAGCGGGTCAATCGGGGCCGG
AGCAAAAGCGTTAGGACTCACTCAGCCGGCGGTCAGTAAAATTATTGGCGACATGGAGAGTTATTTTGGCAGTGAATTAA
TCGTCCGGCGAAATACCGGCGTCTCGCTCACCGAGGCCGGGCAGGTATTTCTCAACTGGTCAGAAGCGATCACCCGTGAA
ATGAAAAATATGGTCAATGAAATGAATGCTCTGACCAACAGCGCGGTGGTGGATGTCTCCTTTGGTTTCCCTTCGCTGGT
CGGGTTTACCTTTATGTCGGAGATGGTGCATCAGTTTAAAATGACTTTCCCGAAGGCGCGGGTCTCGATGTATGAGGCGC
AGCTCTCCGCCTTTTTGCCGGCAATCCGCGACGGGCGCCTCGACTTCGCCATCGGGACGCTGAGCGATGAGATGAAACTG
CAGGACCTGCACGTCGAGCCGCTGTTTGAGTCTGAGTTTGTGCTGGTGGCGAACCGGGCGCGGATCGGCAACGGCACCGT
CCGCCTGGCCTCGCTCCAGCACGAGCAGTGGGTGCTGCCGGAGACCAATATGGGCTACTACAGCGAACTGCTGACCACCC
TGCAGCGCAGCGGTATCCGCCGTGAAAATATCGTTAATACCGATTCGGTGGTGACGATCTATAACCTGGTGCTCAATGCC
GATTTTCTGACGGTGATCCCCTGCGACATGACCACGCCGTTTGGCTCGAGCCAGTTTGTCACCATCCCCATTAAAGAGGC
CTTGCCGGTGGCGCGCTATGCGGCGGTATGGTCGAAAAATTACCGGTTAAAAACCGCCGCGGCGTCGCTGGTGGAGATGG
CGAAACACTATTCCTCGGGGCAGGGCAACCGCCACTGGCAGCCATTACAAATTATTGCGTAA

Upstream 100 bases:

>100_bases
TATCCGCCGCGGCGGAGCCTTTGTGAGAGCTCTCACATAACCCGGCAATTGCGATTTGTTACACTTTCCGCCGTCAACAA
AGGAATGAAAGTGAGACGCG

Downstream 100 bases:

>100_bases
CTGAAAGTCGTTAAATAATCCAACACACGTCCTCGCTGTTATCAGCAGGATGACGCCCGGTCATTGACTTTATATTCAGA
TACAGAGGCCATAATGCATA

Product: DNA-binding transcriptional activator TdcA

Products: NA

Alternate protein names: Tdc operon transcriptional activator [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNTFSLPKTQHLVVFQEVIRSGSIGAGAKALGLTQPAVSKIIGDMESYFGSELIVRRNTGVSLTEAGQVFLNWSEAITRE
MKNMVNEMNALTNSAVVDVSFGFPSLVGFTFMSEMVHQFKMTFPKARVSMYEAQLSAFLPAIRDGRLDFAIGTLSDEMKL
QDLHVEPLFESEFVLVANRARIGNGTVRLASLQHEQWVLPETNMGYYSELLTTLQRSGIRRENIVNTDSVVTIYNLVLNA
DFLTVIPCDMTTPFGSSQFVTIPIKEALPVARYAAVWSKNYRLKTAAASLVEMAKHYSSGQGNRHWQPLQIIA

Sequences:

>Translated_313_residues
MNTFSLPKTQHLVVFQEVIRSGSIGAGAKALGLTQPAVSKIIGDMESYFGSELIVRRNTGVSLTEAGQVFLNWSEAITRE
MKNMVNEMNALTNSAVVDVSFGFPSLVGFTFMSEMVHQFKMTFPKARVSMYEAQLSAFLPAIRDGRLDFAIGTLSDEMKL
QDLHVEPLFESEFVLVANRARIGNGTVRLASLQHEQWVLPETNMGYYSELLTTLQRSGIRRENIVNTDSVVTIYNLVLNA
DFLTVIPCDMTTPFGSSQFVTIPIKEALPVARYAAVWSKNYRLKTAAASLVEMAKHYSSGQGNRHWQPLQIIA
>Mature_313_residues
MNTFSLPKTQHLVVFQEVIRSGSIGAGAKALGLTQPAVSKIIGDMESYFGSELIVRRNTGVSLTEAGQVFLNWSEAITRE
MKNMVNEMNALTNSAVVDVSFGFPSLVGFTFMSEMVHQFKMTFPKARVSMYEAQLSAFLPAIRDGRLDFAIGTLSDEMKL
QDLHVEPLFESEFVLVANRARIGNGTVRLASLQHEQWVLPETNMGYYSELLTTLQRSGIRRENIVNTDSVVTIYNLVLNA
DFLTVIPCDMTTPFGSSQFVTIPIKEALPVARYAAVWSKNYRLKTAAASLVEMAKHYSSGQGNRHWQPLQIIA

Specific function: Transcriptional activator for the tdcABCDE operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789506, Length=311, Percent_Identity=75.8842443729904, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1787601, Length=285, Percent_Identity=26.3157894736842, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787879, Length=290, Percent_Identity=24.1379310344828, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788748, Length=299, Percent_Identity=23.0769230769231, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34799; Mature: 34799

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFSLPKTQHLVVFQEVIRSGSIGAGAKALGLTQPAVSKIIGDMESYFGSELIVRRNTG
CCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCEEEEEECCC
VSLTEAGQVFLNWSEAITREMKNMVNEMNALTNSAVVDVSFGFPSLVGFTFMSEMVHQFK
CCEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHH
MTFPKARVSMYEAQLSAFLPAIRDGRLDFAIGTLSDEMKLQDLHVEPLFESEFVLVANRA
HCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCCCCCCEEEEECCE
RIGNGTVRLASLQHEQWVLPETNMGYYSELLTTLQRSGIRRENIVNTDSVVTIYNLVLNA
ECCCCEEEEEEECCCCEECCCCCCHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHCC
DFLTVIPCDMTTPFGSSQFVTIPIKEALPVARYAAVWSKNYRLKTAAASLVEMAKHYSSG
CEEEEEECCCCCCCCCCCEEEEEHHHHCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCC
QGNRHWQPLQIIA
CCCCCCCCEEECC
>Mature Secondary Structure
MNTFSLPKTQHLVVFQEVIRSGSIGAGAKALGLTQPAVSKIIGDMESYFGSELIVRRNTG
CCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCEEEEEECCC
VSLTEAGQVFLNWSEAITREMKNMVNEMNALTNSAVVDVSFGFPSLVGFTFMSEMVHQFK
CCEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHH
MTFPKARVSMYEAQLSAFLPAIRDGRLDFAIGTLSDEMKLQDLHVEPLFESEFVLVANRA
HCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCCCCCCEEEEECCE
RIGNGTVRLASLQHEQWVLPETNMGYYSELLTTLQRSGIRRENIVNTDSVVTIYNLVLNA
ECCCCEEEEEEECCCCEECCCCCCHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHCC
DFLTVIPCDMTTPFGSSQFVTIPIKEALPVARYAAVWSKNYRLKTAAASLVEMAKHYSSG
CEEEEEECCCCCCCCCCCEEEEEHHHHCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCC
QGNRHWQPLQIIA
CCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]