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The map label for this gene is prsA [H]

Identifier: 238895299

GI number: 238895299

Start: 3182468

End: 3183481

Strand: Direct

Name: prsA [H]

Synonym: KP1_3354

Alternate gene names: 238895299

Gene position: 3182468-3183481 (Clockwise)

Preceding gene: 238895298

Following gene: 238895300

Centisome position: 60.64

GC content: 53.94

Gene sequence:

>1014_bases
ATGGCGCCATCCCGCACATTATTGGCCCATTCATCCACCACTGGACGCATGCCTGAGGTTCTTCTCGTGCCTGATATGAA
GCTTTTTGCTGGTAACGCCACCCCGGAACTAGCACAACGTATTGCCAACCGCCTGTACACTTCTCTTGGCGACGCCGCTG
TAGGTCGTTTTAGCGACGGCGAAGTCAGCGTACAAATCAATGAAAACGTACGCGGTGGTGATATTTTCATCATCCAGTCC
ACTTGTGCTCCCACCAATGACAACCTGATGGAACTGGTTGTTATGGTTGATGCTCTGCGTCGTGCTTCGGCAGGTCGTAT
CACCGCCGTTATCCCTTACTTCGGTTATGCTCGTCAGGACCGTCGTGTTCGTTCTGCTCGTGTGCCAATCACCGCAAAAG
TGGTGGCGGATTTTCTGTCCAGCGTCGGCGTTGACCGCGTGCTGACCGTTGACCTGCACGCAGAACAGATCCAGGGCTTC
TTCGATGTGCCAGTCGATAACGTGTTCGGCAGCCCAATCCTGCTGGAAGATATGCTGCAGCTGAACCTGGACAACCCGAT
TGTGGTTTCTCCGGACATCGGCGGCGTCGTGCGTGCCCGCGCTATCGCTAAACTGCTGAATGATACCGATATGGCTATCA
TCGACAAGCGCCGTCCTCGCGCCAACGTCTCCCAGGTGATGCACATCATCGGCGACGTTGCCGGTCGTGACTGCGTGATG
GTCGACGATATGATCGACACCGGCGGCACCCTGTGTAAAGCGGCAGAAGCGCTGAAAGAGCGTGGCGCGAAACGCGTATT
CGCTTACGCGACGCACCCAATCTTCTCCGGCAACGCTATCCAGAACATCAAAAACTCTGTCATTGATGAATTTGTCGTCT
GCGATACCATTCCGCTGGCACCAGAAATTAAAGCGCTGGATAAAGTGCGTACTCTGACGCTCTCCGGTATGCTGGCTGAA
GCTATTCGCCGTATCAGCAATGAAGAATCTATCTCTGCTATGTTCGAACATTAA

Upstream 100 bases:

>100_bases
CACATTGATAATGAGTCAGCCGGGGAAATTGAGTTACGGTGACAACGTCACCCTGTTCCAGACGTTGCATCGTGCTCTTT
AAATACACCGACTGGATCGA

Downstream 100 bases:

>100_bases
TCGAGCCCAGCACAAAAACCCGCTGCGGCGGGTTTTTTTGTCTCCGCACCTTATTTGTATGATCAATGCCTCCTTCACCT
GCCATTTAGTTGACAGATGA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAPSRTLLAHSSTTGRMPEVLLVPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQS
TCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGF
FDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVM
VDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAIQNIKNSVIDEFVVCDTIPLAPEIKALDKVRTLTLSGMLAE
AIRRISNEESISAMFEH

Sequences:

>Translated_337_residues
MAPSRTLLAHSSTTGRMPEVLLVPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQS
TCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGF
FDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVM
VDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAIQNIKNSVIDEFVVCDTIPLAPEIKALDKVRTLTLSGMLAE
AIRRISNEESISAMFEH
>Mature_336_residues
APSRTLLAHSSTTGRMPEVLLVPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQST
CAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFF
DVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVMV
DDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAIQNIKNSVIDEFVVCDTIPLAPEIKALDKVRTLTLSGMLAEA
IRRISNEESISAMFEH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=317, Percent_Identity=47.9495268138801, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI4506127, Length=318, Percent_Identity=48.1132075471698, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI84875539, Length=319, Percent_Identity=47.6489028213166, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI28557709, Length=318, Percent_Identity=47.4842767295598, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=36.1516034985423, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=36.734693877551, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=32.4137931034483, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=32.4137931034483, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=32.4137931034483, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=32.4137931034483, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=96.1904761904762, Blast_Score=613, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17554702, Length=321, Percent_Identity=45.7943925233645, Blast_Score=294, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI25149168, Length=317, Percent_Identity=45.7413249211356, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=321, Percent_Identity=45.7943925233645, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=45.8333333333333, Blast_Score=286, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=34.2182890855457, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=45.7142857142857, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6321776, Length=314, Percent_Identity=47.7707006369427, Blast_Score=268, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6319403, Length=339, Percent_Identity=43.3628318584071, Blast_Score=268, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6322667, Length=202, Percent_Identity=40.5940594059406, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=41.7391304347826, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21355239, Length=318, Percent_Identity=46.8553459119497, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI45551540, Length=340, Percent_Identity=43.8235294117647, Blast_Score=277, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.9295774647887, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.9295774647887, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.9295774647887, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.9295774647887, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=33.1550802139037, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=33.1550802139037, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=33.1550802139037, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36614; Mature: 36483

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPSRTLLAHSSTTGRMPEVLLVPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDG
CCCCCEEEEECCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCHHCCCCCCC
EVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQD
EEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHH
RRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQ
HHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEEHHHHCCEECCCHHHHCCCHHHHHHHHH
LNLDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVM
HCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEE
VDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAIQNIKNSVIDEFVVCDTIPLA
ECCHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PEIKALDKVRTLTLSGMLAEAIRRISNEESISAMFEH
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure 
APSRTLLAHSSTTGRMPEVLLVPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDG
CCCCEEEEECCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCHHCCCCCCC
EVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQD
EEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHH
RRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQ
HHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEEHHHHCCEECCCHHHHCCCHHHHHHHHH
LNLDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVM
HCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEE
VDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAIQNIKNSVIDEFVVCDTIPLA
ECCHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PEIKALDKVRTLTLSGMLAEAIRRISNEESISAMFEH
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]