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The map label for this gene is fhuB [H]

Identifier: 238895151

GI number: 238895151

Start: 3031393

End: 3032418

Strand: Reverse

Name: fhuB [H]

Synonym: KP1_3194

Alternate gene names: 238895151

Gene position: 3032418-3031393 (Counterclockwise)

Preceding gene: 238895152

Following gene: 238895150

Centisome position: 57.78

GC content: 70.66

Gene sequence:

>1026_bases
ATGAGCGTGGCCATCCTGCTTTCCGCGCGGCGTCGCCCCCGCCCCCGGCTGGCGCTGCTTCTGCTAACGCTGCTGCTTAT
CGCCGCCTCGCTGGTGCATCTTGGCTTAGGCGCCCGCTGGATCGCCCCGCAGACGGTGCTGCAGGCGCTGCTGGAGTACG
ATCCGCGCAACTTTGAGCAGCGGATTATCATCGATCTGCGTCTGGTGCGGCTGGCGGCGGCGCTGCTGACCGGCGCGGCG
CTCGGCGTCGCCGGGCTGCTGCTGCAGACGGTGATCCGTAACCCGCTTGGCGAGCCGCATATTCTCGGCCTCAACGCCGG
CGCCTCGCTGGCGGTGGTGGCGACCTCGGCGCTGGGCCTGTCCTTCGGCGCTTTCCCCGCCGGGCGCCCGCTGACCGCCG
CCTGCGGCGCGGGGCTGCTGTTCGGTGGCGTGATGGCGCTGGCCTCTGCCGGGCGCGGCGGGGCGACGCCGCTGCGCATC
ACGTTGTGCGGAGTGGCGCTGTCAGGGTTTGCGTCGGCGGTGACGGCGGCGATATTAATTCTCGATGAACAGACGCTGCT
GGCGATGCGCACCTGGCTGGCCGGCGACCTGGCCGGACTGAACTGGAGCACGCTGCAGACGGCGCTGGTTCCGGCGCTGA
TCGGCCTAGGCGTCGCGCTGCTCATTGCCCCACGCCTCAACGTGCTGGCGCTGGGGGATAAGGTGGCGCTGGGCCTTGGC
GTTAATCTCGTCCAGACCCGGCTGCTGGGCCTGCTGGCGATTGCGCTGCTCTGCGGCGCGGCGGTGGCGGTGGCCGGGCC
GATCGGCTTCGTCGGGCTGGTGGTGCCGCACGTGGTGCGCCGTCTGGTGACGGAAGACATCCGCCTGGCGCTGCCCCTGG
CCGCGCCGGTGGGAGCGCTGGCGCTGGTGCTGGCGGATATCGCCGCCCGGACGCTGGTCGCGCCGCAGGAGCTGGCCACC
GGAGCGATGACCGCCCTGGTGGGCGCGCCGTTGTTTATCTTTATCGCCGCGAGGTTTTTTAAATGA

Upstream 100 bases:

>100_bases
TGATTAAACACGTGTTTGACGTTGACGTGCAGATGTCGATTAACCCGCAAACCGGCAAACCCTTCTTTATGCCGTTTCGC
GACCGCCAGGCAGCGGCACA

Downstream 100 bases:

>100_bases
CGCGCGCCGTTCACCGGGCCGGTTTTCGGCCGCTGGCTTTCGCCTCCCGCCAGCTGCTGCTGCGTCCTGCGGCGTTAAAA
ATTGCCGCCAGCATAGTGCT

Product: putative iron compound ABC transport system permease component

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSVAILLSARRRPRPRLALLLLTLLLIAASLVHLGLGARWIAPQTVLQALLEYDPRNFEQRIIIDLRLVRLAAALLTGAA
LGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGLSFGAFPAGRPLTAACGAGLLFGGVMALASAGRGGATPLRI
TLCGVALSGFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLG
VNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALALVLADIAARTLVAPQELAT
GAMTALVGAPLFIFIAARFFK

Sequences:

>Translated_341_residues
MSVAILLSARRRPRPRLALLLLTLLLIAASLVHLGLGARWIAPQTVLQALLEYDPRNFEQRIIIDLRLVRLAAALLTGAA
LGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGLSFGAFPAGRPLTAACGAGLLFGGVMALASAGRGGATPLRI
TLCGVALSGFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLG
VNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALALVLADIAARTLVAPQELAT
GAMTALVGAPLFIFIAARFFK
>Mature_340_residues
SVAILLSARRRPRPRLALLLLTLLLIAASLVHLGLGARWIAPQTVLQALLEYDPRNFEQRIIIDLRLVRLAAALLTGAAL
GVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGLSFGAFPAGRPLTAACGAGLLFGGVMALASAGRGGATPLRIT
LCGVALSGFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGV
NLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALALVLADIAARTLVAPQELATG
AMTALVGAPLFIFIAARFFK

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=304, Percent_Identity=41.1184210526316, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1790741, Length=294, Percent_Identity=39.1156462585034, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1790740, Length=322, Percent_Identity=36.3354037267081, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788004, Length=302, Percent_Identity=37.4172185430464, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786804, Length=323, Percent_Identity=34.3653250773994, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786347, Length=279, Percent_Identity=31.8996415770609, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34769; Mature: 34637

Theoretical pI: Translated: 11.87; Mature: 11.87

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAILLSARRRPRPRLALLLLTLLLIAASLVHLGLGARWIAPQTVLQALLEYDPRNFEQ
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCH
RIIIDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
SFGAFPAGRPLTAACGAGLLFGGVMALASAGRGGATPLRITLCGVALSGFASAVTAAILI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
LDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLG
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCC
VNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVLADIAARTLVAPQELATGAMTALVGAPLFIFIAARFFK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVAILLSARRRPRPRLALLLLTLLLIAASLVHLGLGARWIAPQTVLQALLEYDPRNFEQ
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCH
RIIIDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
SFGAFPAGRPLTAACGAGLLFGGVMALASAGRGGATPLRITLCGVALSGFASAVTAAILI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
LDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLG
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHCC
VNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVLADIAARTLVAPQELATGAMTALVGAPLFIFIAARFFK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]