Click here to switch to the map view.

The map label for this gene is ccmA [H]

Identifier: 238895117

GI number: 238895117

Start: 2993652

End: 2994275

Strand: Reverse

Name: ccmA [H]

Synonym: KP1_3156

Alternate gene names: 238895117

Gene position: 2994275-2993652 (Counterclockwise)

Preceding gene: 238895118

Following gene: 238895116

Centisome position: 57.05

GC content: 69.07

Gene sequence:

>624_bases
ATGCTGCATGCAGAGCGACTGACCTGCATCGTTGACGATCGACCGCTGTTTGCGGCGCTGACGCTGTCCCTCGCTGCCGG
CGAGCTGCTACAGGTCGCCGGTGATAACGGCGCGGGGAAAACCTCGCTGCTGCGGATCCTCTGCGGCCTGGCGCGCCCGG
AAAGCGGGGTGGTGAGCTGGCAGGGCCAGCCGCTGGCGAAGGTCCGGGAGTCATTTCACCGTCAGCTGCTGTGGCTGGGC
CATAAACCCGGCGTTAACGCGGCGCTGACCGCCGATGAAAACCTGCGTTTCTTCTTTCCGGCCAGCCGCCTTCAGCAGCG
GGAAAGCGCCCTCGCCGCCGTCGGCCTGGCGGGCTATGAAGATCTCCCCTTGAGCCAGCTCTCCGCCGGGCAGCAGCGTC
GGGTGGCGCTCACCCGCCTGTGGTTAACCGACGCGCCGCTGTGGATCCTCGATGAGCCGTTCACCGCCCTCGACGCCGCG
GCGATGGAAACCCTGACCCGTCGCCTGGAGCAGCACGCCCGGCAGGGGGGATGCGCCATCCTCACCACCCACCAGCCGCT
GCGGCCGCTGGGCTGTCCGTTGCGCACCCTGCGCCTCGGCGGCGACGCTGGAGGCGGGCAATGA

Upstream 100 bases:

>100_bases
CGGGGGCCGGACAGTAACCGTCAGGGTTGCGTCGCCCGCGCGGCGCAACCCATACTTAGCGACGACGTAAAATACTGTCT
GAATCAAGGAGTTTGCCTTC

Downstream 100 bases:

>100_bases
TGCGTGCGCTGTTGGCCCGGGAACTGCGCCTGGCGTGGCGCAGCGGGGCGGAGATCCTCAATCCGCTCTGGTTCTTTCTG
ATCGTCATCACCCTGTTTCC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLHAERLTCIVDDRPLFAALTLSLAAGELLQVAGDNGAGKTSLLRILCGLARPESGVVSWQGQPLAKVRESFHRQLLWLG
HKPGVNAALTADENLRFFFPASRLQQRESALAAVGLAGYEDLPLSQLSAGQQRRVALTRLWLTDAPLWILDEPFTALDAA
AMETLTRRLEQHARQGGCAILTTHQPLRPLGCPLRTLRLGGDAGGGQ

Sequences:

>Translated_207_residues
MLHAERLTCIVDDRPLFAALTLSLAAGELLQVAGDNGAGKTSLLRILCGLARPESGVVSWQGQPLAKVRESFHRQLLWLG
HKPGVNAALTADENLRFFFPASRLQQRESALAAVGLAGYEDLPLSQLSAGQQRRVALTRLWLTDAPLWILDEPFTALDAA
AMETLTRRLEQHARQGGCAILTTHQPLRPLGCPLRTLRLGGDAGGGQ
>Mature_207_residues
MLHAERLTCIVDDRPLFAALTLSLAAGELLQVAGDNGAGKTSLLRILCGLARPESGVVSWQGQPLAKVRESFHRQLLWLG
HKPGVNAALTADENLRFFFPASRLQQRESALAAVGLAGYEDLPLSQLSAGQQRRVALTRLWLTDAPLWILDEPFTALDAA
AMETLTRRLEQHARQGGCAILTTHQPLRPLGCPLRTLRLGGDAGGGQ

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=175, Percent_Identity=29.1428571428571, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI150417984, Length=176, Percent_Identity=29.5454545454545, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI42741659, Length=181, Percent_Identity=25.414364640884, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI27436953, Length=194, Percent_Identity=26.2886597938144, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI27262624, Length=174, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI27262626, Length=174, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082064, Length=199, Percent_Identity=57.286432160804, Blast_Score=217, Evalue=5e-58,
Organism=Escherichia coli, GI1789891, Length=183, Percent_Identity=32.7868852459016, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1788165, Length=183, Percent_Identity=29.5081967213115, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI87081709, Length=172, Percent_Identity=27.906976744186, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788761, Length=176, Percent_Identity=30.1136363636364, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787041, Length=185, Percent_Identity=30.8108108108108, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786563, Length=193, Percent_Identity=33.160621761658, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87081834, Length=177, Percent_Identity=30.5084745762712, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787105, Length=188, Percent_Identity=28.7234042553192, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789873, Length=183, Percent_Identity=27.3224043715847, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081791, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87081782, Length=190, Percent_Identity=25.2631578947368, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1787029, Length=176, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788506, Length=191, Percent_Identity=30.8900523560209, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787370, Length=180, Percent_Identity=28.8888888888889, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786698, Length=194, Percent_Identity=24.7422680412371, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1789962, Length=176, Percent_Identity=28.9772727272727, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI48995001, Length=177, Percent_Identity=28.8135593220339, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1787500, Length=179, Percent_Identity=29.0502793296089, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787112, Length=175, Percent_Identity=30.8571428571429, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI87082267, Length=196, Percent_Identity=25.5102040816327, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787792, Length=205, Percent_Identity=26.3414634146341, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787089, Length=193, Percent_Identity=27.4611398963731, Blast_Score=60, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=175, Percent_Identity=33.1428571428571, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115533592, Length=182, Percent_Identity=29.6703296703297, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=27.3224043715847, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=27.3224043715847, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574744, Length=183, Percent_Identity=31.1475409836066, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24666836, Length=175, Percent_Identity=29.7142857142857, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22372; Mature: 22372

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHAERLTCIVDDRPLFAALTLSLAAGELLQVAGDNGAGKTSLLRILCGLARPESGVVSW
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCCEEEE
QGQPLAKVRESFHRQLLWLGHKPGVNAALTADENLRFFFPASRLQQRESALAAVGLAGYE
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCC
DLPLSQLSAGQQRRVALTRLWLTDAPLWILDEPFTALDAAAMETLTRRLEQHARQGGCAI
CCCHHHHCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
LTTHQPLRPLGCPLRTLRLGGDAGGGQ
EECCCCCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MLHAERLTCIVDDRPLFAALTLSLAAGELLQVAGDNGAGKTSLLRILCGLARPESGVVSW
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCCEEEE
QGQPLAKVRESFHRQLLWLGHKPGVNAALTADENLRFFFPASRLQQRESALAAVGLAGYE
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCC
DLPLSQLSAGQQRRVALTRLWLTDAPLWILDEPFTALDAAAMETLTRRLEQHARQGGCAI
CCCHHHHCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
LTTHQPLRPLGCPLRTLRLGGDAGGGQ
EECCCCCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA