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The map label for this gene is atoB [H]

Identifier: 238895095

GI number: 238895095

Start: 2972581

End: 2973762

Strand: Direct

Name: atoB [H]

Synonym: KP1_3131

Alternate gene names: 238895095

Gene position: 2972581-2973762 (Clockwise)

Preceding gene: 238895094

Following gene: 238895096

Centisome position: 56.64

GC content: 69.2

Gene sequence:

>1182_bases
ATGACCGATATTGCCATTGTTGCTGCCGTACGCACCCCGATAGGCAGCTTTCGCGGCGCCTTCGCCCCTCTTTCCGCCGT
CGACCTCGGCGCGGCGGTGGTGCGCGGCCTGCTTGAACGCTGCCAGCTGCCCGCCGCAGCGGTCGACGAACTAATTTTCG
GCCAGGTGCTCACCGCCGGCTGCGGGCAGAACCCGGCGCGCCAGACCGCGCTGCGGGCCGGCCTGCCGGTCGACACTCCG
GCGGTCACCGTCAATCTGGTGTGCGGCTCCGGGCTGAAAGCGGTTCAGCAGGCGGTGCAGGCGATCCGCTGCGGCGACGC
CGGGATCGTTATCGCCGGCGGCCAGGAGAGCATGAGCAATGCTCCCTATCTGATGCATGGCGCCCGCGACGGCCTGCGTT
TCGGCCACGCCAGCCTGCAGGACAGCATGATCCAGGACGGCCTGTGGGACGCCTTTAACGACTACCACATGGGCATTACC
GCCGAGAACCTCGCCGACGCCTTCGACATCAGCCGCGAGCGCCAGGACGCCTTCGCCGCCAGCTCCCAGCGCAAAGCAGC
GGCCGCTATCGCCGCCGGGCGCTTTCGCGAGGAGCTCGTTCCGGTCAGCGTCCCGCAGGGCAAAAAGCCGCCGCGAGTCG
TGACTGACGATGAGCAACCCCGCCCGGAGACCAGCGAGCAGCAGTTGGCCCAGCTGCGCCCGGCGTTTCGCCCGGCTGAC
GGCAGCGTCACCGCCGGGAATGCTTCGTCGCTGAACGACGGCGCAGCGGCGGTCCTGCTGATGCGTGTCGATAAAGCGCG
CGAGCTTGGGCTGCCGGTGCTGGCGCGCATTGTCAGCTCAGCGGTCGCCGGGGTCGACCCGTCGGTGATGGGCATCGGCC
CGGTGAGCGCCTGCCGCCAGGCGCTGCAGCGCGCCGGCTGGACGCTGGACGAGGTGGACCTTATCGAAGCCAACGAGGCT
TTTGCCGTCCAGGCGCTGGCCGTCGGCCAGCTGCTTGAATGGGACAGCGAGAAGGTCAACGTCAACGGCGGCGCCATCGC
CCTGGGCCATCCCATCGGCGCCTCCGGCTGCCGGATCCTCGTCAGCCTGGTGCATGAGATGCAGCGCCGGGGCGCCAGCA
AAGGGCTGGCCACCCTGTGCGTCGGCGGCGGCCAGGGCATCGCCATGACCCTTCAACGTTAA

Upstream 100 bases:

>100_bases
GGCCCCGGGGGTCAGCCCCGACGAGGTGATACGTAAAACGGCGGGACGGCTGATCGTCGCCGACGACGTGCGCGAAATGC
GCTTCAGTTAAGGAGAGATC

Downstream 100 bases:

>100_bases
CAGGAGCCACTATGTTTACACCACGCCTGGCGGTACTCGGCGCGGGACTGATGGGCGTCGGTATCGCCTGCCATTTCGCC
CGCCACGGTCACGCCGTCCG

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDIAIVAAVRTPIGSFRGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAGCGQNPARQTALRAGLPVDTP
AVTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSNAPYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGIT
AENLADAFDISRERQDAFAASSQRKAAAAIAAGRFREELVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPAD
GSVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQALQRAGWTLDEVDLIEANEA
FAVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRILVSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR

Sequences:

>Translated_393_residues
MTDIAIVAAVRTPIGSFRGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAGCGQNPARQTALRAGLPVDTP
AVTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSNAPYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGIT
AENLADAFDISRERQDAFAASSQRKAAAAIAAGRFREELVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPAD
GSVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQALQRAGWTLDEVDLIEANEA
FAVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRILVSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR
>Mature_392_residues
TDIAIVAAVRTPIGSFRGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAGCGQNPARQTALRAGLPVDTPA
VTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSNAPYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGITA
ENLADAFDISRERQDAFAASSQRKAAAAIAAGRFREELVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPADG
SVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQALQRAGWTLDEVDLIEANEAF
AVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRILVSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=51.6624040920716, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=43.5114503816794, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI167614485, Length=394, Percent_Identity=44.4162436548223, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=42.1717171717172, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=33.6470588235294, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=29.5918367346939, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=64.6310432569975, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=56.8527918781726, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=44.7761194029851, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=44.75, Blast_Score=284, Evalue=7e-78,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=37.3522458628842, Blast_Score=224, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI133906874, Length=395, Percent_Identity=43.0379746835443, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=39.6464646464646, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI25147385, Length=388, Percent_Identity=38.9175257731959, Blast_Score=254, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.3943661971831, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=32.0610687022901, Blast_Score=161, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=43.5443037974684, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=38.1074168797954, Blast_Score=239, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=53.4351145038168, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=42.4936386768448, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=41.0714285714286, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.5294117647059, Blast_Score=175, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40793; Mature: 40662

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIAIVAAVRTPIGSFRGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAG
CCCCEEEHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
CGQNPARQTALRAGLPVDTPAVTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSN
CCCCHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHCCC
APYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGITAENLADAFDISRERQDAFAA
CCEEEECCCCCHHHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SSQRKAAAAIAAGRFREELVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPAD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
GSVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQ
CCEECCCCCCCCCCHHEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ALQRAGWTLDEVDLIEANEAFAVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRIL
HHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCHHHHHH
VSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR
HHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC
>Mature Secondary Structure 
TDIAIVAAVRTPIGSFRGAFAPLSAVDLGAAVVRGLLERCQLPAAAVDELIFGQVLTAG
CCCEEEHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
CGQNPARQTALRAGLPVDTPAVTVNLVCGSGLKAVQQAVQAIRCGDAGIVIAGGQESMSN
CCCCHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHCCC
APYLMHGARDGLRFGHASLQDSMIQDGLWDAFNDYHMGITAENLADAFDISRERQDAFAA
CCEEEECCCCCHHHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SSQRKAAAAIAAGRFREELVPVSVPQGKKPPRVVTDDEQPRPETSEQQLAQLRPAFRPAD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
GSVTAGNASSLNDGAAAVLLMRVDKARELGLPVLARIVSSAVAGVDPSVMGIGPVSACRQ
CCEECCCCCCCCCCHHEEHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ALQRAGWTLDEVDLIEANEAFAVQALAVGQLLEWDSEKVNVNGGAIALGHPIGASGCRIL
HHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCHHHHHH
VSLVHEMQRRGASKGLATLCVGGGQGIAMTLQR
HHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]