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The map label for this gene is adhP [H]

Identifier: 238894895

GI number: 238894895

Start: 2781014

End: 2782024

Strand: Direct

Name: adhP [H]

Synonym: KP1_2916

Alternate gene names: 238894895

Gene position: 2781014-2782024 (Clockwise)

Preceding gene: 238894892

Following gene: 238894896

Centisome position: 52.99

GC content: 60.53

Gene sequence:

>1011_bases
ATGAAGGCAGCTGTTGTTACCCACGACCATCAGGTTAACGTCACGGAAAAAACGCTGCGCCCGCTGGAATACGGCGAAGC
GCTGTTGAAAATGGAATGCTGCGGCGTGTGTCATACTGACCTGCACGTGAAAAACGGCGATTTTGGCGATAAAACCGGCG
TCATTCTCGGCCATGAAGGGATCGGGGTGGTACAAAAAGTCGGCCCGGGCGTCACCTCCCTGAAGCCGGGCGACCGCGCC
AGCGTGGCGTGGTTCTTCGAAGGCTGCGGCCACTGCGATTACTGTAACAGCGGCAACGAGACGCTCTGCCGCTCGGTGAA
AAACGCCGGCTATACCGTCGATGGCGGCATGGCGGAAGAGTGCATCGTCACCGCCAACTACGCGGTAAAAGTTCCGGACG
GCCTCGACTCCGCCGCCGCCAGCAGCATCACCTGCGCGGGCGTCACCACCTACAAAGCGGTCAAGGTCTCCCACATCAAA
CCGGGCCAGTGGATCGCCATCTACGGCCTCGGCGGGCTGGGTAACCTCGCGCTGCAGTATGCGAAGAATGTGTTTAACGC
CAAAGTGATCGCTATCGACGTCAACGACGGACAGCTGGAGCTGGCGGCCTCGATGGGCGCCGACCTGACCATCAACTCCC
GCAATGAAGATGCGGCGAAAGTGATTCAGGAAAAAACCGGCGGCGCCCACGCTGCGGTAGTAACCGCGGTGGCTAAAGCG
GCCTTTAACTCGGCGGTGGATGCCGTTCGCGCCGGTGGCCGCGTGGTCGCGGTGGGCCTGCCGCCGGAGGCGATGAGCCT
CGATATTCCGCGTCTGGTGCTGGACGGCATCGAAGTGGTCGGTTCGCTGGTCGGCACCCGTCAGGATCTGGTGGAAGCCT
TCCAGTTTGCCGCCGAAGGCAAAGTGGTGCCGAAAGTCACCCTGCGTCCGCTGGAAGATATCAACGCTATCTTCAAAGAG
ATGGAGCAAGGTCAGATCCGTGGCCGTATGGTTATCGATCTGCGTAGCTAA

Upstream 100 bases:

>100_bases
TTCTGTACTAAGCGCCTTGTATTTTACCGCTCAGCGTCTAATCCTTATTGGGTACTATTGCATTAATTAAGTTAATCAAT
TCCCCCACAAGGAGACAGGC

Downstream 100 bases:

>100_bases
TCACCCGCGCCTCTCCCGTCCGGGAGAGGCGATCCCCCTGGCACGTCCTCTCGCTTCCCAACCCGGGAAGTAAATGCAAT
TTCCGCAAATGCTTAGCGCA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKAAVVTHDHQVNVTEKTLRPLEYGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVQKVGPGVTSLKPGDRA
SVAWFFEGCGHCDYCNSGNETLCRSVKNAGYTVDGGMAEECIVTANYAVKVPDGLDSAAASSITCAGVTTYKAVKVSHIK
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDGQLELAASMGADLTINSRNEDAAKVIQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPEAMSLDIPRLVLDGIEVVGSLVGTRQDLVEAFQFAAEGKVVPKVTLRPLEDINAIFKE
MEQGQIRGRMVIDLRS

Sequences:

>Translated_336_residues
MKAAVVTHDHQVNVTEKTLRPLEYGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVQKVGPGVTSLKPGDRA
SVAWFFEGCGHCDYCNSGNETLCRSVKNAGYTVDGGMAEECIVTANYAVKVPDGLDSAAASSITCAGVTTYKAVKVSHIK
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDGQLELAASMGADLTINSRNEDAAKVIQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPEAMSLDIPRLVLDGIEVVGSLVGTRQDLVEAFQFAAEGKVVPKVTLRPLEDINAIFKE
MEQGQIRGRMVIDLRS
>Mature_336_residues
MKAAVVTHDHQVNVTEKTLRPLEYGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVQKVGPGVTSLKPGDRA
SVAWFFEGCGHCDYCNSGNETLCRSVKNAGYTVDGGMAEECIVTANYAVKVPDGLDSAAASSITCAGVTTYKAVKVSHIK
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDGQLELAASMGADLTINSRNEDAAKVIQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPEAMSLDIPRLVLDGIEVVGSLVGTRQDLVEAFQFAAEGKVVPKVTLRPLEDINAIFKE
MEQGQIRGRMVIDLRS

Specific function: Preferred specificity is towards 1-propanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=363, Percent_Identity=28.9256198347107, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI262073058, Length=359, Percent_Identity=27.8551532033426, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI71743840, Length=359, Percent_Identity=27.8551532033426, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI34577061, Length=363, Percent_Identity=29.2011019283747, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4501929, Length=361, Percent_Identity=28.2548476454294, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI71565152, Length=353, Percent_Identity=25.7790368271955, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI156627571, Length=312, Percent_Identity=27.5641025641026, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71565154, Length=238, Percent_Identity=30.2521008403361, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI156523966, Length=356, Percent_Identity=26.9662921348315, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=26.4204545454545, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=335, Percent_Identity=89.5522388059701, Blast_Score=569, Evalue=1e-164,
Organism=Escherichia coli, GI1790045, Length=328, Percent_Identity=29.5731707317073, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87082401, Length=317, Percent_Identity=28.7066246056782, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786518, Length=320, Percent_Identity=27.8125, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1787863, Length=267, Percent_Identity=29.5880149812734, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788073, Length=246, Percent_Identity=31.3008130081301, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI226510992, Length=311, Percent_Identity=27.3311897106109, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790718, Length=334, Percent_Identity=28.1437125748503, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786552, Length=355, Percent_Identity=30.1408450704225, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=26, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788075, Length=305, Percent_Identity=25.2459016393443, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786825, Length=278, Percent_Identity=27.6978417266187, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788407, Length=230, Percent_Identity=30.8695652173913, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=314, Percent_Identity=36.9426751592357, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17562584, Length=321, Percent_Identity=35.5140186915888, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17562582, Length=315, Percent_Identity=37.1428571428571, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17562876, Length=254, Percent_Identity=30.7086614173228, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=207, Percent_Identity=31.8840579710145, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=220, Percent_Identity=29.0909090909091, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=205, Percent_Identity=29.7560975609756, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=221, Percent_Identity=28.5067873303167, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=314, Percent_Identity=40.7643312101911, Blast_Score=212, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6324486, Length=314, Percent_Identity=39.4904458598726, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6319621, Length=349, Percent_Identity=36.3896848137536, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6323729, Length=314, Percent_Identity=37.5796178343949, Blast_Score=195, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6323980, Length=342, Percent_Identity=27.1929824561404, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319949, Length=328, Percent_Identity=28.3536585365854, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=364, Percent_Identity=27.7472527472527, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=296, Percent_Identity=27.027027027027, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=296, Percent_Identity=27.027027027027, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=217, Percent_Identity=27.6497695852535, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=306, Percent_Identity=23.5294117647059, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137530, Length=212, Percent_Identity=29.7169811320755, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737897, Length=208, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17737895, Length=240, Percent_Identity=28.75, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35291; Mature: 35291

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVVTHDHQVNVTEKTLRPLEYGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEEECCCEECCHHHHHCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVQKVGPGVTSLKPGDRASVAWFFEGCGHCDYCNSGNETLCRSVKNAGYTVDGGMAEE
CCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCEEECCCCCCC
CIVTANYAVKVPDGLDSAAASSITCAGVTTYKAVKVSHIKPGQWIAIYGLGGLGNLALQY
EEEEECEEEECCCCCCCHHHCCEEEECEEEEEEEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDGQLELAASMGADLTINSRNEDAAKVIQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPEAMSLDIPRLVLDGIEVVGSLVGTRQDLVEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVTLRPLEDINAIFKEMEQGQIRGRMVIDLRS
CEECEEECCCHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAAVVTHDHQVNVTEKTLRPLEYGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEEECCCEECCHHHHHCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVQKVGPGVTSLKPGDRASVAWFFEGCGHCDYCNSGNETLCRSVKNAGYTVDGGMAEE
CCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCEEECCCCCCC
CIVTANYAVKVPDGLDSAAASSITCAGVTTYKAVKVSHIKPGQWIAIYGLGGLGNLALQY
EEEEECEEEECCCCCCCHHHCCEEEECEEEEEEEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDGQLELAASMGADLTINSRNEDAAKVIQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPEAMSLDIPRLVLDGIEVVGSLVGTRQDLVEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVTLRPLEDINAIFKEMEQGQIRGRMVIDLRS
CEECEEECCCHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 2158980 [H]