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The map label for this gene is mrdA [H]

Identifier: 238894851

GI number: 238894851

Start: 2735634

End: 2737601

Strand: Reverse

Name: mrdA [H]

Synonym: KP1_2867

Alternate gene names: 238894851

Gene position: 2737601-2735634 (Counterclockwise)

Preceding gene: 238894852

Following gene: 238894850

Centisome position: 52.16

GC content: 59.25

Gene sequence:

>1968_bases
ATGCTTCCCGGCCGTTACGCCGTTGGCTTTTCCAGTGATTCAGGTGATGTACCGCTAATGCCCCTTTTGAGAGACGAAAT
TCGCGACCACTCCGCGGAAGAGATGCTGTTTATCCGCCGGGCCGCAATTGCTTTTCTGCTGGTGGTGGTCTGCTTTGGCG
TGCTGATCGTTAACCTCTACCATCTGCAGGTGGAGCAGCACGATTTTTACCAGACCCGGTCAAACCAGAACGACATCAAA
ATGCTGCCCATCGCCCCCAGCCGCGGGCTGATATTCGATCGCAACGGTATTCCGCTGGTGCAGAATATCACCCTGTATCG
CCTGCAGGTGATCCCGAGCAAAATTCCCGATATGGCCGCGCTGTTGCAGCAGCTGACGCCTATCGTCGACCTGACGCCGG
ACGACATCGCCAGCTTTCGCGACGATATGCACCACACCAGCCGCTACAAAGCGGTCACCCTCAAGTCAGACCTCAGCGAT
GTGGAGGTGGCCCGCTTCGCGGTCAACGAATTCCGTTTCCCCGGCGTGACGGTGGAGAGCTACCAACAACGGGAATACCC
CTACGGCGCAGAGCTGGCGCACGTGGTGGGCTATGTGTCGAAAATCAACGACAGCGATCTGCAGCGGCTGGCGAAAAACG
GCGAAGAGGAGAACTACGCCGCCGACCGCAATATCGGTAAGCAGGGCATCGAGGGCTATTATGAAAAAGCGCTCCACGGC
ACCACCGGCTATCAGGAAGTGGAGGTGGATAACCACGGCCGGGTGGTGCGTCTACTGAAAGAGGTGCCGCCGGTGGCCGG
AAAAAACCTCTATCTGACTCTCGACCTTCATCTCCAGCAGTATATTGAGTCGGTGCTGAAGGGACAGCGGGCGGCGGTGG
TGGTGGTCGACCCGCGGGATGGCGGCGTGCTGGCGATGGTCTCCAGTCCCAGCTACGATCCTAATCCGTTCGTCAAAGGT
ATCGGCTATCAGGCCTATAAATCGCTGCTGGAGAATCCGGACCGGCCGCTGATCAACCGCGTCACCCAGGGGCTATATCC
TCCGGCTTCGACGGTCAAACCCTATATGGCGCTGTCGGCGCTCTCCGCTGGGGTCATCACCCCGAACACCACCTTCTTCG
GGGCGCCGACGTGGACGCTGCCGGGCACGCAACGCCGCTACCGCGACTGGCTGAAAACCGGCCACGGCATGCTCAACGTG
ACTAAAGCCATCGAAGAGTCAGCGGACACCTTTTTCTATCAGGTCGCCTTCGAGATGGGCATTGACCGGATCCATGAATG
GCTGAGCAAGTTCGGCTACGGCCAGTCCACCGGCATCGACCTTAATGAGGAGTACGCCGGGGTGCTGCCCAGCCGGGAGT
GGAAACAGCGGGTGCATAAAAAGCCCTGGTATCAGGGGGACACCATCTCGGTCGGCATCGGCCAGGGGTACTGGATCGCC
ACCCCGATCCAGATGGTGAAGGCGCTTACCACTCTGCTGAACAATGGTAAAGTACAGGATCCGCATCTGCTCTATTCGAT
GAAGCAGGGCAACCATGTGGAACGTTATCAGCAGCCGGCGAACCTGCCGCAGGTGGGTGACCCGAAATCCCCGTACTGGG
GCATTGTGCGCAACGGCATGTATGGGATGGCGAATCAGCCCAACGGCACCGGCTATAAGCTGTTTCATACTGCGCCGTAT
CAGATCGCGGCGAAGTCCGGGACCTCGCAGGTCTTTAGCCTGAAGCAAAACCAGACCTATAACGCCAAAATGATCCCGGT
GCGTCTGCGCGACCATATCTTCTACACCCTGTTTGCCCCTTATCAGCATCCGAAGGTGGCGATGGCGCTGATTCTGGAGA
ACGGCGGCGGGGATGGGGTGGTGGCCGGACCGACGGCGCGCGCCATCCTGGACCATATTTTTGTCCCGCAGCAGGCATCT
TCGGCGGCAGCCGATGTGCCGCAGCGTGACAGCGCCGATGCCCAGTAA

Upstream 100 bases:

>100_bases
GTCACGGGCAAGGTTAAGAATAACGATCCCTCTAACATGCTGAAACATTTCTGCCAGATCATTAGCAACCTTTCAGTAGG
GCTGACGCTGCGATAAGGCT

Downstream 100 bases:

>100_bases
GCGACAGGACTTATTCCGCAGGCGCATCGTCCATAGTAATTGGTTATTTGTCCCATCGTCTTCCCGGCGGCATAGTGTTT
TACGGGAACATGACCCGGAG

Product: peptidoglycan synthetase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MLPGRYAVGFSSDSGDVPLMPLLRDEIRDHSAEEMLFIRRAAIAFLLVVVCFGVLIVNLYHLQVEQHDFYQTRSNQNDIK
MLPIAPSRGLIFDRNGIPLVQNITLYRLQVIPSKIPDMAALLQQLTPIVDLTPDDIASFRDDMHHTSRYKAVTLKSDLSD
VEVARFAVNEFRFPGVTVESYQQREYPYGAELAHVVGYVSKINDSDLQRLAKNGEEENYAADRNIGKQGIEGYYEKALHG
TTGYQEVEVDNHGRVVRLLKEVPPVAGKNLYLTLDLHLQQYIESVLKGQRAAVVVVDPRDGGVLAMVSSPSYDPNPFVKG
IGYQAYKSLLENPDRPLINRVTQGLYPPASTVKPYMALSALSAGVITPNTTFFGAPTWTLPGTQRRYRDWLKTGHGMLNV
TKAIEESADTFFYQVAFEMGIDRIHEWLSKFGYGQSTGIDLNEEYAGVLPSREWKQRVHKKPWYQGDTISVGIGQGYWIA
TPIQMVKALTTLLNNGKVQDPHLLYSMKQGNHVERYQQPANLPQVGDPKSPYWGIVRNGMYGMANQPNGTGYKLFHTAPY
QIAAKSGTSQVFSLKQNQTYNAKMIPVRLRDHIFYTLFAPYQHPKVAMALILENGGGDGVVAGPTARAILDHIFVPQQAS
SAAADVPQRDSADAQ

Sequences:

>Translated_655_residues
MLPGRYAVGFSSDSGDVPLMPLLRDEIRDHSAEEMLFIRRAAIAFLLVVVCFGVLIVNLYHLQVEQHDFYQTRSNQNDIK
MLPIAPSRGLIFDRNGIPLVQNITLYRLQVIPSKIPDMAALLQQLTPIVDLTPDDIASFRDDMHHTSRYKAVTLKSDLSD
VEVARFAVNEFRFPGVTVESYQQREYPYGAELAHVVGYVSKINDSDLQRLAKNGEEENYAADRNIGKQGIEGYYEKALHG
TTGYQEVEVDNHGRVVRLLKEVPPVAGKNLYLTLDLHLQQYIESVLKGQRAAVVVVDPRDGGVLAMVSSPSYDPNPFVKG
IGYQAYKSLLENPDRPLINRVTQGLYPPASTVKPYMALSALSAGVITPNTTFFGAPTWTLPGTQRRYRDWLKTGHGMLNV
TKAIEESADTFFYQVAFEMGIDRIHEWLSKFGYGQSTGIDLNEEYAGVLPSREWKQRVHKKPWYQGDTISVGIGQGYWIA
TPIQMVKALTTLLNNGKVQDPHLLYSMKQGNHVERYQQPANLPQVGDPKSPYWGIVRNGMYGMANQPNGTGYKLFHTAPY
QIAAKSGTSQVFSLKQNQTYNAKMIPVRLRDHIFYTLFAPYQHPKVAMALILENGGGDGVVAGPTARAILDHIFVPQQAS
SAAADVPQRDSADAQ
>Mature_655_residues
MLPGRYAVGFSSDSGDVPLMPLLRDEIRDHSAEEMLFIRRAAIAFLLVVVCFGVLIVNLYHLQVEQHDFYQTRSNQNDIK
MLPIAPSRGLIFDRNGIPLVQNITLYRLQVIPSKIPDMAALLQQLTPIVDLTPDDIASFRDDMHHTSRYKAVTLKSDLSD
VEVARFAVNEFRFPGVTVESYQQREYPYGAELAHVVGYVSKINDSDLQRLAKNGEEENYAADRNIGKQGIEGYYEKALHG
TTGYQEVEVDNHGRVVRLLKEVPPVAGKNLYLTLDLHLQQYIESVLKGQRAAVVVVDPRDGGVLAMVSSPSYDPNPFVKG
IGYQAYKSLLENPDRPLINRVTQGLYPPASTVKPYMALSALSAGVITPNTTFFGAPTWTLPGTQRRYRDWLKTGHGMLNV
TKAIEESADTFFYQVAFEMGIDRIHEWLSKFGYGQSTGIDLNEEYAGVLPSREWKQRVHKKPWYQGDTISVGIGQGYWIA
TPIQMVKALTTLLNNGKVQDPHLLYSMKQGNHVERYQQPANLPQVGDPKSPYWGIVRNGMYGMANQPNGTGYKLFHTAPY
QIAAKSGTSQVFSLKQNQTYNAKMIPVRLRDHIFYTLFAPYQHPKVAMALILENGGGDGVVAGPTARAILDHIFVPQQAS
SAAADVPQRDSADAQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=631, Percent_Identity=59.5879556259905, Blast_Score=782, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=624, Percent_Identity=23.8782051282051, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 73121; Mature: 73121

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPGRYAVGFSSDSGDVPLMPLLRDEIRDHSAEEMLFIRRAAIAFLLVVVCFGVLIVNLY
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLQVEQHDFYQTRSNQNDIKMLPIAPSRGLIFDRNGIPLVQNITLYRLQVIPSKIPDMAA
HEEEHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCHHHCCEEEEEEECCCCCCHHHH
LLQQLTPIVDLTPDDIASFRDDMHHTSRYKAVTLKSDLSDVEVARFAVNEFRFPGVTVES
HHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHH
YQQREYPYGAELAHVVGYVSKINDSDLQRLAKNGEEENYAADRNIGKQGIEGYYEKALHG
HHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHCC
TTGYQEVEVDNHGRVVRLLKEVPPVAGKNLYLTLDLHLQQYIESVLKGQRAAVVVVDPRD
CCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEEECCC
GGVLAMVSSPSYDPNPFVKGIGYQAYKSLLENPDRPLINRVTQGLYPPASTVKPYMALSA
CCEEEEEECCCCCCCHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
LSAGVITPNTTFFGAPTWTLPGTQRRYRDWLKTGHGMLNVTKAIEESADTFFYQVAFEMG
HHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IDRIHEWLSKFGYGQSTGIDLNEEYAGVLPSREWKQRVHKKPWYQGDTISVGIGQGYWIA
HHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCEEEEECCCCEEEE
TPIQMVKALTTLLNNGKVQDPHLLYSMKQGNHVERYQQPANLPQVGDPKSPYWGIVRNGM
CHHHHHHHHHHHHHCCCCCCCHHEEEECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHCCC
YGMANQPNGTGYKLFHTAPYQIAAKSGTSQVFSLKQNQTYNAKMIPVRLRDHIFYTLFAP
CCCCCCCCCCCEEEEECCCCEEEECCCCHHHEEECCCCCCCEEEEEEEECCCEEEEEECC
YQHPKVAMALILENGGGDGVVAGPTARAILDHIFVPQQASSAAADVPQRDSADAQ
CCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCC
>Mature Secondary Structure
MLPGRYAVGFSSDSGDVPLMPLLRDEIRDHSAEEMLFIRRAAIAFLLVVVCFGVLIVNLY
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLQVEQHDFYQTRSNQNDIKMLPIAPSRGLIFDRNGIPLVQNITLYRLQVIPSKIPDMAA
HEEEHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCCHHHCCEEEEEEECCCCCCHHHH
LLQQLTPIVDLTPDDIASFRDDMHHTSRYKAVTLKSDLSDVEVARFAVNEFRFPGVTVES
HHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHH
YQQREYPYGAELAHVVGYVSKINDSDLQRLAKNGEEENYAADRNIGKQGIEGYYEKALHG
HHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHCC
TTGYQEVEVDNHGRVVRLLKEVPPVAGKNLYLTLDLHLQQYIESVLKGQRAAVVVVDPRD
CCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEEECCC
GGVLAMVSSPSYDPNPFVKGIGYQAYKSLLENPDRPLINRVTQGLYPPASTVKPYMALSA
CCEEEEEECCCCCCCHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
LSAGVITPNTTFFGAPTWTLPGTQRRYRDWLKTGHGMLNVTKAIEESADTFFYQVAFEMG
HHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IDRIHEWLSKFGYGQSTGIDLNEEYAGVLPSREWKQRVHKKPWYQGDTISVGIGQGYWIA
HHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCEEEEECCCCEEEE
TPIQMVKALTTLLNNGKVQDPHLLYSMKQGNHVERYQQPANLPQVGDPKSPYWGIVRNGM
CHHHHHHHHHHHHHCCCCCCCHHEEEECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHCCC
YGMANQPNGTGYKLFHTAPYQIAAKSGTSQVFSLKQNQTYNAKMIPVRLRDHIFYTLFAP
CCCCCCCCCCCEEEEECCCCEEEECCCCHHHEEECCCCCCCEEEEEEEECCCEEEEEECC
YQHPKVAMALILENGGGDGVVAGPTARAILDHIFVPQQASSAAADVPQRDSADAQ
CCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 8930920 [H]